31 items (Aspergillus nidulans) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	ANIA_07423	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (603 aa)
	ANIA_00946	Ribosome assembly protein Noc2, putative (AFU_orthologue AFUA_1G16330). (774 aa)
	ANIA_01272	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (264 aa)
	ANIA_01485	Casein kinase II (Eurofung); Belongs to the protein kinase superfamily. (333 aa)
	mdm34	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm34 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10. (561 aa)
	bud32	EKC/KEOPS complex subunit bud32; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is r [...] (285 aa)
	ANIA_04555	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (629 aa)
	ANIA_05092	Telomere-associated RecQ helicase, putative (AFU_orthologue AFUA_6G14720). (1571 aa)
	spt16	FACT complex subunit spt16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (1019 aa)
	ANIA_05248	Uncharacterized protein. (787 aa)
	ANIA_05494	DNA damage checkpoint effector kinase (Eurofung). (534 aa)
	ANIA_05680	3'-5' exonuclease/helicase (Wrn), putative (AFU_orthologue AFUA_7G04270). (320 aa)
	pob3	FACT complex subunit pob3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (575 aa)
	ANIA_06896	BRCT domain protein (Eurofung). (796 aa)
	ANIA_06971	Uncharacterized protein. (232 aa)
	ANIA_07563	Protein kinase (Eurofung). (1007 aa)
	ANIA_07678	Pom1 kinase homologue pomA (Eurofung). (1452 aa)
	ANIA_08618	Uncharacterized protein. (335 aa)
	ANIA_08830	Protein kinase domain-containing protein. (524 aa)
	ANIA_09507	Uncharacterized protein. (285 aa)
	ANIA_02087	Uncharacterized protein. (1534 aa)
	ANIA_04872	Ubiquitin-like domain-containing protein. (154 aa)
	ANIA_10019	Protein kinase, putative (AFU_orthologue AFUA_5G11840). (826 aa)
	ANIA_02943	Protein kinase domain-containing protein. (448 aa)
	ANIA_10360	Uncharacterized protein. (308 aa)
	ANIA_06975	UVSB; Belongs to the PI3/PI4-kinase family. (2454 aa)
	ANIA_04324	Putative b-zip transcription factor (Eurofung). (263 aa)
	ANIA_10546	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (368 aa)
	ANIA_08079	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit. (680 aa)
	ANIA_04104	Uncharacterized protein. (430 aa)
	ANIA_04279	Cell-cycle checkpoint serine-threonine kinase (Eurofung). (630 aa)

Your Current Organism:

Aspergillus nidulans

NCBI taxonomy Id: 227321
Other names: A. nidulans FGSC A4, Aspergillus nidulans FGSC A4, Emericella nidulans FGSC A4

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANIA_00946	ANIA_01272	Q5BET4	Q5BDV8	Ribosome assembly protein Noc2, putative (AFU_orthologue AFUA_1G16330).	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family.	0.540
ANIA_00946	ANIA_08079	Q5BET4	C8V6D9	Ribosome assembly protein Noc2, putative (AFU_orthologue AFUA_1G16330).	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit.	0.540
ANIA_00946	ANIA_10546	Q5BET4	C8V966	Ribosome assembly protein Noc2, putative (AFU_orthologue AFUA_1G16330).	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family.	0.551
ANIA_01272	ANIA_00946	Q5BDV8	Q5BET4	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family.	Ribosome assembly protein Noc2, putative (AFU_orthologue AFUA_1G16330).	0.540
ANIA_01272	ANIA_01485	Q5BDV8	Q5BD95	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family.	Casein kinase II (Eurofung); Belongs to the protein kinase superfamily.	0.999
ANIA_01272	ANIA_08079	Q5BDV8	C8V6D9	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family.	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit.	0.559
ANIA_01272	ANIA_10546	Q5BDV8	C8V966	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family.	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family.	0.986
ANIA_01272	mdm34	Q5BDV8	Q5BBM5	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family.	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm34 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10.	0.811
ANIA_01272	pob3	Q5BDV8	Q5AYE3	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family.	FACT complex subunit pob3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	0.949
ANIA_01272	spt16	Q5BDV8	Q5B2X8	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family.	FACT complex subunit spt16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]	0.960
ANIA_01485	ANIA_01272	Q5BD95	Q5BDV8	Casein kinase II (Eurofung); Belongs to the protein kinase superfamily.	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family.	0.999
ANIA_01485	ANIA_02943	Q5BD95	C8VJ38	Casein kinase II (Eurofung); Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.492
ANIA_01485	ANIA_08079	Q5BD95	C8V6D9	Casein kinase II (Eurofung); Belongs to the protein kinase superfamily.	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit.	0.909
ANIA_01485	ANIA_10546	Q5BD95	C8V966	Casein kinase II (Eurofung); Belongs to the protein kinase superfamily.	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family.	0.987
ANIA_01485	pob3	Q5BD95	Q5AYE3	Casein kinase II (Eurofung); Belongs to the protein kinase superfamily.	FACT complex subunit pob3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	0.953
ANIA_01485	spt16	Q5BD95	Q5B2X8	Casein kinase II (Eurofung); Belongs to the protein kinase superfamily.	FACT complex subunit spt16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]	0.952
ANIA_02087	ANIA_04104	G5EB35	C8V5A3	Uncharacterized protein.	Uncharacterized protein.	0.568
ANIA_02087	ANIA_04555	G5EB35	Q5B4H5	Uncharacterized protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.841
ANIA_02087	ANIA_05092	G5EB35	Q5B2Y8	Uncharacterized protein.	Telomere-associated RecQ helicase, putative (AFU_orthologue AFUA_6G14720).	0.540
ANIA_02087	ANIA_05494	G5EB35	Q5B1T6	Uncharacterized protein.	DNA damage checkpoint effector kinase (Eurofung).	0.512