STRINGSTRING
ANIA_01430 ANIA_01430 mdpG mdpG mdpE mdpE mdpC mdpC katG katG hog1 hog1 ANIA_04772 ANIA_04772 ANIA_08042 ANIA_08042 srrA srrA esa1 esa1 cyn1 cyn1 ANIA_08396 ANIA_08396 orlA orlA ANIA_02911 ANIA_02911 AN10233 AN10233 mdpL mdpL mdpA mdpA laeA laeA sskB sskB velB velB veA veA ANIA_00285 ANIA_00285 chiB chiB treB treB tpiA tpiA facA facA gpdA gpdA hhtA hhtA fluG fluG aflR aflR catA catA pdcA pdcA pacC pacC creA creA ANIA_08709 ANIA_08709 ANIA_08654 ANIA_08654 ANIA_08546 ANIA_08546 orsC orsC orsB orsB sskA sskA ANIA_07691 ANIA_07691 ANIA_07588 ANIA_07588 atg17 atg17 ANIA_05908 ANIA_05908 ANIA_03806 ANIA_03806 ANIA_02875 ANIA_02875 ANIA_02583 ANIA_02583 easB easB ANIA_02336 ANIA_02336 ANIA_02334 ANIA_02334 ANIA_01993 ANIA_01993 ANIA_01888 ANIA_01888
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ANIA_01430Betaine aldehyde dehydrogenase (BadH), putative (AFU_orthologue AFUA_8G04080); Belongs to the aldehyde dehydrogenase family. (497 aa)
mdpGAtrochrysone carboxylic acid synthase; Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of monodictyphenone, a prenyl xanthone derivative. The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) mdpG. The atrochrysone carboxyl ACP thioesterase mdpF then breaks the thioester bond and releases the atrochrysone carboxylic acid from mdpG. The atrochrysone carboxylic acid is then converted to atrochrysone which is further transformed into emodin anthrone. The next step is performed by the anthrone oxygenase md [...] (1806 aa)
mdpEMonodictyphenone cluster transcription factor; Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of monodictyphenone, a prenyl xanthone derivative. (435 aa)
mdpCShort chain dehydrogenase mdpC; Short chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of monodictyphenone, a prenyl xanthone derivative. The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) mdpG. The atrochrysone carboxyl ACP thioesterase mdpF then breaks the thioester bond and releases the atrochrysone carboxylic acid from mdpG. The atrochrysone carboxylic acid is then converted to atrochrysone which is further transformed into emodin anthrone. The next step is performed by the anthrone oxygenase mdpH that cataly [...] (265 aa)
katGCatalase-peroxidase; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (739 aa)
hog1Mitogen-activated protein kinase hog1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily. (379 aa)
ANIA_04772Deoxyribose-phosphate aldolase, putative (AFU_orthologue AFUA_3G06590). (544 aa)
ANIA_08042Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (766 aa)
srrAStress response regulator SrrA. (558 aa)
esa1Histone acetyltransferase esa1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double- strand break repair through homologous recombination. Involved in cell cycle progression. Recru [...] (508 aa)
cyn1Cyanate hydratase; Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide; Belongs to the cyanase family. (160 aa)
ANIA_08396Pyruvate decarboxylase, putative (AFU_orthologue AFUA_6G00750). (575 aa)
orlATrehalose-6-phosphate phosphatase. (908 aa)
ANIA_02911AtfA. (485 aa)
AN102336-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (496 aa)
mdpLQuestin oxidase; Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of monodictyphenone, a prenyl xanthone derivative. The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) mdpG. The atrochrysone carboxyl ACP thioesterase mdpF then breaks the thioester bond and releases the atrochrysone carboxylic acid from mdpG. The atrochrysone carboxylic acid is then converted to atrochrysone which is further transformed into emodin anthrone. The next step is performed by the anthrone oxygenase mdpH that catalyzes the [...] (446 aa)
mdpAMonodictyphenone cluster transcriptional coactivator mdpA; Transcriptional coactivator; part of the gene cluster that mediates the biosynthesis of monodictyphenone, a prenyl xanthone derivative. With mdpE, coregulates the production of monodictyphenone. (479 aa)
laeASecondary metabolism regulator laeA; Methyltransferase that performs automethylation at Met-207. No other methyl-accepting substrate has been identified yet. Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression. Controls the expression of the sterigmatocystin, penicillin, and lovastatin gene clusters. Controls light-dependent formation of the velB-vosA complex, veA protein modification, and is required for light-mediated inhibition of sexual development. Within the velvet complex, controls light-dependent secondar [...] (374 aa)
sskBMAP kinase kinase kinase. (1313 aa)
velBVelvet complex subunit B; Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination. The velvet complex acts as a global regulator for secondary metabolite gene expression. Component of the velB-VosA heterodimeric complex that plays a dual role in activating genes associated with spore maturation and repressing certain development-associated genes. The velB-VosA complex binds DNA through the DNA-binding domain of vosA th [...] (369 aa)
veADevelopmental and secondary metabolism regulator veA; Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination. The velvet complex acts as a global regulator for secondary metabolite gene expression. Controls the expression of the sterigmatocystin and penicillin gene clusters. Represses the cryptic ors gene cluster producing orsellinic acid and its F9775 derivatives in a laeA-independent manner. Required for full induct [...] (573 aa)
ANIA_002856-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (265 aa)
chiBEndochitinase B; Major secreted chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Plays a role in the morphogenesis and autolysis. Has also significant antifungal activity against various fungal species; Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily. (398 aa)
treBNeutral trehalase; Belongs to the glycosyl hydrolase 37 family. (751 aa)
tpiATriosephosphate isomerase; Belongs to the triosephosphate isomerase family. (249 aa)
facAAcetyl-coenzyme A synthetase; Belongs to the ATP-dependent AMP-binding enzyme family. (670 aa)
gpdAGlyceraldehyde-3-phosphate dehydrogenase; Involved in osmoadaptation; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
hhtAHistone H3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
fluGProtein fluG; May function as a GSI-related enzyme in synthesizing a small diffusible factor that acts as an extracellular signal directing asexual sporulation and perhaps other aspects of colony growth. May be involved in brlA activation (an early transcriptional regulator for conidiation specific gene); Belongs to the glutamine synthetase family. (865 aa)
aflRSterigmatocystin biosynthesis regulatory protein; Involved in the regulation of sterigmatocystin biosynthesis. (433 aa)
catACatalase A; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide; Belongs to the catalase family. (744 aa)
pdcAPyruvate decarboxylase; Belongs to the TPP enzyme family. (568 aa)
pacCpH-response transcription factor pacC/RIM101 closed form; Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including pacC itself) and represses transcription of acid- expressed genes. Specifically recognizes and binds the consensus sequence 5'-GCCARG-3'. Required for virulence in invasive pulmonary aspergillosis (IPA). (678 aa)
creADNA-binding protein creA; Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC- rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity. Belongs to the creA/MIG C2H2-type zinc-finger protein family. (416 aa)
ANIA_08709Aspartate aminotransferase. (416 aa)
ANIA_08654N,N-dimethylglycine oxidase, putative (AFU_orthologue AFUA_8G06470). (948 aa)
ANIA_08546Phosphatidylglycerol specific phospholipase, putative (AFU_orthologue AFUA_3G01530). (508 aa)
orsCTyrosinase-like protein orsC; Tyrosinase-like protein; part of the gene cluster that mediates the biosynthesis of orsellinic acid, as well as of the cathepsin K inhibitors F9775 A and F9775 B. The non-reducing polyketide synthase orsA produces orsellinic acid by condensing acetyl-CoA with 3 malonyl-CoA units. Further modifications by the decarboxylase orsB and the tyrosinase-like protein orsC lead to the production of F9775 A and F9775 B. The functions of orsD and orsE remain unclear since only orsB and orsC are required to convert orsellinic acid into F9775 A and F9775 B. (369 aa)
orsBDecarboxylase orsB; Decarboxylase; part of the gene cluster that mediates the biosynthesis of orsellinic acid, as well as of the cathepsin K inhibitors F9775 A and F9775 B. The non-reducing polyketide synthase orsA produces orsellinic acid by condensing acetyl-CoA with 3 malonyl-CoA units. Further modifications by the decarboxylase orsB and the tyrosinase-like protein orsC lead to the production of F9775 A and F9775 B. The functions of orsD and orsE remain unclear since only orsB and orsC are required to convert orsellinic acid into F9775 A and F9775 B. Belongs to the metallo-dependent [...] (331 aa)
sskACytoplasmic response regulator (Eurofung). (838 aa)
ANIA_07691Phosphoesterase superfamily protein (AFU_orthologue AFUA_1G17590). (455 aa)
ANIA_07588Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (252 aa)
atg17Autophagy-related protein 17; Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy (By similarity); Belongs to the ATG17 family. (557 aa)
ANIA_05908Triosephosphate isomerase. (284 aa)
ANIA_03806Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
ANIA_02875Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (360 aa)
ANIA_02583Glyceraldehyde-3-phosphate dehydrogenase (Eurofung); Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (354 aa)
easBHighly reducing polyketide synthase easB; Polyketide synthase; part of the gene cluster that mediates the biosynthesis of emericellamides, secondary metabolites acting as antibiotics. The biosynthesis of emericellamides initiates from the highly reducing polyketide synthase easB which catalyzes the formation of the linear polyketide chain. EasB produces several polyketides that can be further processed by the downstream enzymes. The polyketides are released from easB as linear polyketide carboxylic acids, which are converted to CoA thioesters by the acyl-CoA ligase easD. The substrates [...] (2534 aa)
ANIA_02336Uncharacterized protein. (466 aa)
ANIA_02334Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (286 aa)
ANIA_01993Aspartate aminotransferase. (429 aa)
ANIA_01888Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (288 aa)
Your Current Organism:
Aspergillus nidulans
NCBI taxonomy Id: 227321
Other names: A. nidulans FGSC A4, Aspergillus nidulans FGSC A4, Emericella nidulans FGSC A4
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