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sho1 sho1 brlA brlA pyrG pyrG abaA abaA chsA chsA aflR aflR alp1 alp1 chsB chsB hog1 hog1 ste20 ste20 ANIA_04263 ANIA_04263 mpkB mpkB laeA laeA veA veA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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sho1High osmolarity signaling protein sho1; Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity. (287 aa)
brlAC2H2 type master regulator of conidiophore development brlA; BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation. They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes. Binds promoters of target genes at brlA response elements (BREs) containing the conserved sequence 5'- (C/A)(A/G)AGGG(G/A)-3'. Controls the expression of the conidiophore-specific phenol oxidase ivoB. Controls the expression of the hydrophobin rodA. Mediates the developmental switch from the indeterminate, apic [...] (432 aa)
pyrGOrotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (274 aa)
abaAConidiophore development regulator abaA; BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation. They act individually and together to regulate their own expression and that of numerous other sporulation-specific gene. Controls temporal and spatial specificity in Aspergillus development. Directs the differentiation of phialides and is continuously required for maintenance of their function. Expression of abaA leads to activation of brlA and wetA, cessation of vegetative growth, and accentuated cellular vacuolization. Binds to the sequence 5'-CATT [...] (796 aa)
chsAChitin synthase A; Plays a major role in cell wall biogenesis. (1013 aa)
aflRSterigmatocystin biosynthesis regulatory protein; Involved in the regulation of sterigmatocystin biosynthesis. (433 aa)
alp1Alkaline protease 1; Secreted alkaline protease that allows assimilation of proteinaceous substrates; Belongs to the peptidase S8 family. (403 aa)
chsBChitin synthase B; Plays a major role in cell wall biogenesis. (916 aa)
hog1Mitogen-activated protein kinase hog1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily. (379 aa)
ste20Serine/threonine-protein kinase ste20; MAP4K component of the MAPK pathway required for the mating pheromone response and the regulation of cell polarity and cell cycle. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (848 aa)
ANIA_04263NSDC. (667 aa)
mpkBMitogen-activated protein kinase. (354 aa)
laeASecondary metabolism regulator laeA; Methyltransferase that performs automethylation at Met-207. No other methyl-accepting substrate has been identified yet. Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression. Controls the expression of the sterigmatocystin, penicillin, and lovastatin gene clusters. Controls light-dependent formation of the velB-vosA complex, veA protein modification, and is required for light-mediated inhibition of sexual development. Within the velvet complex, controls light-dependent secondar [...] (374 aa)
veADevelopmental and secondary metabolism regulator veA; Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination. The velvet complex acts as a global regulator for secondary metabolite gene expression. Controls the expression of the sterigmatocystin and penicillin gene clusters. Represses the cryptic ors gene cluster producing orsellinic acid and its F9775 derivatives in a laeA-independent manner. Required for full induct [...] (573 aa)
Your Current Organism:
Aspergillus nidulans
NCBI taxonomy Id: 227321
Other names: A. nidulans FGSC A4, Aspergillus nidulans FGSC A4, Emericella nidulans FGSC A4
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