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xptA xptA ANIA_08985 ANIA_08985 acuD acuD facA facA xptB xptB aldA aldA ANIA_08078 ANIA_08078 laeA laeA hxnZ hxnZ hxnY hxnY hxnP hxnP hxnR hxnR ANIA_05644 ANIA_05644 hxnT hxnT hxnS hxnS orsB orsB xptC xptC
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xptAXanthone prenyltransferase A; Dehydrogenase involved in the conversion of monodictyphenone to the prenyl xanthones such as emericellin, shamixanthone and epishamixanthone. Monodictyphenone is first converted to variecoxanthone A via a paeciloxanthone intermediate by the consecutive actions of the FAD-dependent monooxygenase mdpD and the xanthone prenyltransferase xptB. XptB catalyzes regular O-prenylation at the hydroxy group of C-7 of the xanthone ring. Variecoxanthone A is further prenylated to emericellin by xptA before being reduced to shamixanthone and epishamixanthone by the dehy [...] (446 aa)
ANIA_08985Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (530 aa)
acuDIsocitrate lyase; Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2- methylisocitrate. (538 aa)
facAAcetyl-coenzyme A synthetase; Belongs to the ATP-dependent AMP-binding enzyme family. (670 aa)
xptBXanthone prenyltransferase B; Dehydrogenase involved in the conversion of monodictyphenone to the prenyl xanthones such as emericellin, shamixanthone and epishamixanthone. Monodictyphenone is first converted to variecoxanthone A via a paeciloxanthone intermediate by the consecutive actions of the FAD-dependent monooxygenase mdpD and the xanthone prenyltransferase xptB. XptB catalyzes regular O-prenylation at the hydroxy group of C-7 of the xanthone ring. Variecoxanthone A is further prenylated to emericellin by xptA before being reduced to shamixanthone and epishamixanthone by the dehy [...] (463 aa)
aldAAldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (497 aa)
ANIA_08078Uncharacterized protein. (518 aa)
laeASecondary metabolism regulator laeA; Methyltransferase that performs automethylation at Met-207. No other methyl-accepting substrate has been identified yet. Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression. Controls the expression of the sterigmatocystin, penicillin, and lovastatin gene clusters. Controls light-dependent formation of the velB-vosA complex, veA protein modification, and is required for light-mediated inhibition of sexual development. Within the velvet complex, controls light-dependent secondar [...] (374 aa)
hxnZMajor facilitator-type transporter hxnZ; Major facilitator-type transporter, part of the hnx cluster involved in the purine degradation. The nicotinate hydroxylase hnxS accepts nicotinate as a substrate and catalyzes the first step of nicotinate catabolism. The major facilitator-type transporters hxnP and hxnZ are probably involved in the uptake of nicotinate-derived metabolites, and the oxidoreductases hxnT and hxnY in the further metabolism of 6-OH nicotinic acid. (553 aa)
hxnY2-oxoglutarate-Fe(II) type oxidoreductase hxnY; 2-oxoglutarate-Fe(II) type oxidoreductase, part of the hnx cluster involved in the purine degradation. The nicotinate hydroxylase hnxS accepts nicotinate as a substrate and catalyzes the first step of nicotinate catabolism. The major facilitator-type transporters hxnP and hxnZ are probably involved in the uptake of nicotinate-derived metabolites, and the oxidoreductases hxnT and hxnY in the further metabolism of 6-OH nicotinic acid. (349 aa)
hxnPMajor facilitator-type transporter hxnP; Major facilitator-type transporter, part of the hnx cluster involved in the purine degradation. The nicotinate hydroxylase hnxS accepts nicotinate as a substrate and catalyzes the first step of nicotinate catabolism. The major facilitator-type transporters hxnP and hxnZ are probably involved in the uptake of nicotinate-derived metabolites, and the oxidoreductases hxnT and hxnY in the further metabolism of 6-OH nicotinic acid. (495 aa)
hxnRNicotinate catabolism cluster-specific transcription factor; Transcription factor that specifically regulates the expression of the hxn gene cluster that mediates the degradation of nicotinate and related metabolites. (865 aa)
ANIA_05644Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (505 aa)
hxnTFlavin oxidoreductase hxnT; Flavin oxidoreductase, part of the hnx cluster involved in the purine degradation. The nicotinate hydroxylase hnxS accepts nicotinate as a substrate and catalyzes the first step of nicotinate catabolism. The major facilitator-type transporters hxnP and hxnZ are probably involved in the uptake of nicotinate-derived metabolites, and the oxidoreductases hxnT and hxnY in the further metabolism of 6-OH nicotinic acid. (388 aa)
hxnSNicotinate hydroxylase hnxS; Nicotinate hydroxylase, part of the hnx cluster involved in the purine degradation. The nicotinate hydroxylase hnxS accepts nicotinate as a substrate and catalyzes the first step of nicotinate catabolism. HnxS accepts also hypoxanthine, but not xanthine, as a substrate. The major facilitator-type transporters hxnP and hxnZ are probably involved in the uptake of nicotinate-derived metabolites, and the oxidoreductases hxnT and hxnY in the further metabolism of 6-OH nicotinic acid. (1350 aa)
orsBDecarboxylase orsB; Decarboxylase; part of the gene cluster that mediates the biosynthesis of orsellinic acid, as well as of the cathepsin K inhibitors F9775 A and F9775 B. The non-reducing polyketide synthase orsA produces orsellinic acid by condensing acetyl-CoA with 3 malonyl-CoA units. Further modifications by the decarboxylase orsB and the tyrosinase-like protein orsC lead to the production of F9775 A and F9775 B. The functions of orsD and orsE remain unclear since only orsB and orsC are required to convert orsellinic acid into F9775 A and F9775 B. Belongs to the metallo-dependent [...] (331 aa)
xptCDehydrogenase xptC; Dehydrogenase involved in the conversion of monodictyphenone to the prenyl xanthones such as emericellin, shamixanthone and epishamixanthone. Monodictyphenone is first converted to variecoxanthone A via a paeciloxanthone intermediate by the consecutive actions of the FAD-dependent monooxygenase mdpD and the xanthone prenyltransferase xptB. XptB catalyzes regular O-prenylation at the hydroxy group of C-7 of the xanthone ring. Variecoxanthone A is further prenylated to emericellin by xptA before being reduced to shamixanthone and epishamixanthone by the dehydrogenase xptC. (622 aa)
Your Current Organism:
Aspergillus nidulans
NCBI taxonomy Id: 227321
Other names: A. nidulans FGSC A4, Aspergillus nidulans FGSC A4, Emericella nidulans FGSC A4
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