node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aflR | laeA | P52957 | C8VQG9 | Sterigmatocystin biosynthesis regulatory protein; Involved in the regulation of sterigmatocystin biosynthesis. | Secondary metabolism regulator laeA; Methyltransferase that performs automethylation at Met-207. No other methyl-accepting substrate has been identified yet. Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression. Controls the expression of the sterigmatocystin, penicillin, and lovastatin gene clusters. Controls light-dependent formation of the velB-vosA complex, veA protein modification, and is required for light-mediated inhibition of sexual development. Within the velvet complex, controls light-dependent secondar [...] | 0.913 |
aflR | nsdD | P52957 | G5EB07 | Sterigmatocystin biosynthesis regulatory protein; Involved in the regulation of sterigmatocystin biosynthesis. | GATA-type domain-containing protein. | 0.418 |
aflR | stcU | P52957 | Q00791 | Sterigmatocystin biosynthesis regulatory protein; Involved in the regulation of sterigmatocystin biosynthesis. | Versicolorin reductase; Catalyzes the conversion of versicolorin A to sterigmatocystin; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.765 |
aflR | velB | P52957 | C8VTS4 | Sterigmatocystin biosynthesis regulatory protein; Involved in the regulation of sterigmatocystin biosynthesis. | Velvet complex subunit B; Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination. The velvet complex acts as a global regulator for secondary metabolite gene expression. Component of the velB-VosA heterodimeric complex that plays a dual role in activating genes associated with spore maturation and repressing certain development-associated genes. The velB-VosA complex binds DNA through the DNA-binding domain of vosA th [...] | 0.663 |
creA | hog1 | Q01981 | Q9P419 | DNA-binding protein creA; Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC- rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity. Belongs to the creA/MIG C2H2-type zinc-finger protein family. | Mitogen-activated protein kinase hog1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily. | 0.675 |
creA | laeA | Q01981 | C8VQG9 | DNA-binding protein creA; Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC- rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity. Belongs to the creA/MIG C2H2-type zinc-finger protein family. | Secondary metabolism regulator laeA; Methyltransferase that performs automethylation at Met-207. No other methyl-accepting substrate has been identified yet. Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression. Controls the expression of the sterigmatocystin, penicillin, and lovastatin gene clusters. Controls light-dependent formation of the velB-vosA complex, veA protein modification, and is required for light-mediated inhibition of sexual development. Within the velvet complex, controls light-dependent secondar [...] | 0.848 |
creA | pacC | Q01981 | Q00202 | DNA-binding protein creA; Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC- rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity. Belongs to the creA/MIG C2H2-type zinc-finger protein family. | pH-response transcription factor pacC/RIM101 closed form; Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including pacC itself) and represses transcription of acid- expressed genes. Specifically recognizes and binds the consensus sequence 5'-GCCARG-3'. Required for virulence in invasive pulmonary aspergillosis (IPA). | 0.977 |
creA | pkaA | Q01981 | G5EB66 | DNA-binding protein creA; Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC- rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity. Belongs to the creA/MIG C2H2-type zinc-finger protein family. | Uncharacterized protein; Belongs to the protein kinase superfamily. | 0.707 |
fadA | ganB | Q00743 | G5EB53 | Guanine nucleotide-binding protein subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. G(q) subfamily. | Uncharacterized protein. | 0.907 |
fadA | hog1 | Q00743 | Q9P419 | Guanine nucleotide-binding protein subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. G(q) subfamily. | Mitogen-activated protein kinase hog1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily. | 0.563 |
fadA | nsdD | Q00743 | G5EB07 | Guanine nucleotide-binding protein subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. G(q) subfamily. | GATA-type domain-containing protein. | 0.449 |
fadA | pkaA | Q00743 | G5EB66 | Guanine nucleotide-binding protein subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. G(q) subfamily. | Uncharacterized protein; Belongs to the protein kinase superfamily. | 0.811 |
ganB | fadA | G5EB53 | Q00743 | Uncharacterized protein. | Guanine nucleotide-binding protein subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. G(q) subfamily. | 0.907 |
ganB | hog1 | G5EB53 | Q9P419 | Uncharacterized protein. | Mitogen-activated protein kinase hog1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily. | 0.510 |
ganB | pkaA | G5EB53 | G5EB66 | Uncharacterized protein. | Uncharacterized protein; Belongs to the protein kinase superfamily. | 0.733 |
hog1 | creA | Q9P419 | Q01981 | Mitogen-activated protein kinase hog1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily. | DNA-binding protein creA; Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC- rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity. Belongs to the creA/MIG C2H2-type zinc-finger protein family. | 0.675 |
hog1 | fadA | Q9P419 | Q00743 | Mitogen-activated protein kinase hog1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily. | Guanine nucleotide-binding protein subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. G(q) subfamily. | 0.563 |
hog1 | ganB | Q9P419 | G5EB53 | Mitogen-activated protein kinase hog1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily. | Uncharacterized protein. | 0.510 |
hog1 | pacC | Q9P419 | Q00202 | Mitogen-activated protein kinase hog1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily. | pH-response transcription factor pacC/RIM101 closed form; Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including pacC itself) and represses transcription of acid- expressed genes. Specifically recognizes and binds the consensus sequence 5'-GCCARG-3'. Required for virulence in invasive pulmonary aspergillosis (IPA). | 0.522 |
hog1 | pkaA | Q9P419 | G5EB66 | Mitogen-activated protein kinase hog1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily. | Uncharacterized protein; Belongs to the protein kinase superfamily. | 0.414 |