STRINGSTRING
aflR aflR pacC pacC apdG apdG apdR apdR apdA apdA apdE apdE apdD apdD apdC apdC apdB apdB dbaG dbaG dbaF dbaF dbaD dbaD atnN atnN inpA inpA inpF inpF inpE inpE scpR scpR inpD inpD inpC inpC afoA afoA mdpE mdpE mdpD mdpD mirB mirB mirA mirA inpB inpB dbaA dbaA dbaC dbaC mdpA mdpA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
aflRSterigmatocystin biosynthesis regulatory protein; Involved in the regulation of sterigmatocystin biosynthesis. (433 aa)
pacCpH-response transcription factor pacC/RIM101 closed form; Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including pacC itself) and represses transcription of acid- expressed genes. Specifically recognizes and binds the consensus sequence 5'-GCCARG-3'. Required for virulence in invasive pulmonary aspergillosis (IPA). (678 aa)
apdGAcyl-CoA dehydrogenase apdG; Acyl-CoA dehydrogenase; part of the gene cluster that mediates the biosynthesis of aspyridones. The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha-methylation step during polyketide synthesis i [...] (438 aa)
apdRAspyridones cluster regulator apdR; Transcription factor involved in regulation of gene cluster that mediates the biosynthesis of aspyridones. (730 aa)
apdAHybrid PKS-NRPS synthetase apdA; Hybrid PKS-NRPS synthetase; part of the gene cluster that mediates the biosynthesis of aspyridones (Ref.5). The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha-methylation step during polyke [...] (3930 aa)
apdECytochrome P450 monooxygenase apdE; Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of aspyridones. The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha-methylation step during polyketi [...] (519 aa)
apdDFAD-dependent monooxygenase apdD; FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of aspyridones. The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha-methylation step during polyketide s [...] (624 aa)
apdCTrans-enoyl reductase apdC; Trans-enoyl reductase; part of the gene cluster that mediates the biosynthesis of aspyridones (Ref.5). The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha- methylation step during polyketide synt [...] (333 aa)
apdBCytochrome P450 monooxygenase apdB; Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of aspyridones. The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA. The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit. The growing polyketide chain then elongates into a tetraketide. The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation. Alpha-methylation step during polyketi [...] (498 aa)
dbaGTranscription factor dbaG; Transcription factor that coregulates the expression of the gene cluster that mediates the biosynthesis of the antibiotic 2,4- dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde (DHMBA) and its derivatives. Specifically positively regulates the expression of the FAD-dependent oxidoreductase dbaF. (420 aa)
dbaFFAD-dependent oxidoreductase dbaF; FAD-dependent oxidoreductase; part of the gene cluster that mediates the biosynthesis of the antibiotic 2,4-dihydroxy-3-methyl-6- (2-oxopropyl)benzaldehyde (DHMBA) and its derivatives. The direct non-reducing polyketide synthase dbaI product is 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde (DHMBA), produced by condensation of one acetyl-CoA starter unit with 4 malonyl- CoA units and one methylation step. The FAD-dependent monooxygenase dbaH is responsible for the synthesis of yellow pigments derived from the oxidation of DHMBA. The roles of dbaB, [...] (467 aa)
dbaDMFS-type transporter dbaD; MFS-type transporter; part of the gene cluster that mediates the biosynthesis of the antibiotic 2,4- dihydroxy-3-methyl-6-(2- oxopropyl)benzaldehyde (DHMBA) and its derivatives. Is probably involved in the transport of the metabolites to the environment (Probable); Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. (444 aa)
atnNAspercryptin biosynthesis cluster-specific transcription regulator atnN; Transcription factor that positively regulates the cluster that mediate the production of aspercryptins, linear lipopeptides built from six amino acids including 2 highly unusual and nonproteogenic amino acids, 2-amino-octanoic acid (2aoa) and 2-amino-dodecanol (2adol). (610 aa)
inpANonribosomal peptide synthase inpA; Nonribosomal peptide synthase; part of the inp gene cluster that mediates the biosynthesis of fellutamide B, a mycotoxin that acts as a proteasome inhibitor. In the first step of fellutabmide B biosynthesis, inpC activates 3-hydroxydodecanoic acid to generate 3- hydroxydodecanoyl-AMP that is then loaded onto the T0 domain of inpB. The 3-hydroxydodecanoyl-S-phosphopantetheinyl-T0 is sequentially extended with L-Asn and L-Gln by the two CAT modules of inpB. The linear lipodipeptide from inpB is then transferred onto inpA for the addition of the third a [...] (1480 aa)
inpFEsterase inpF; Esterase; part of the inp gene cluster that mediates the biosynthesis of fellutamide B, a mycotoxin that acts as a proteasome inhibitor. In the first step of fellutabmide B biosynthesis inpC activates 3-hydroxydodecanoic acid to generate 3-hydroxydodecanoyl-AMP that is then loaded onto the T0 domain of inpB. The 3-hydroxydodecanoyl-S- phosphopantetheinyl-T0 is sequentially extended with L-Asn and L-Gln by the two CAT modules of inpB. The linear lipodipeptide from inpB is then transferred onto inpA for the addition of the third amino acid, L-Leu. Reductive releasing of th [...] (437 aa)
inpEProteasome subunit beta inpE; Proteasome subunit beta type-6; part of the inp gene cluster that mediates the biosynthesis of fellutamide B, a mycotoxin that acts as a proteasome inhibitor. In the first step of fellutabmide B biosynthesis inpC activates 3- hydroxydodecanoic acid to generate 3-hydroxydodecanoyl-AMP that is then loaded onto the T0 domain of inpB. The 3- hydroxydodecanoyl-S-phosphopantetheinyl-T0 is sequentially extended with L-Asn and L-Gln by the two CAT modules of inpB. The linear lipodipeptide from inpB is then transferred onto inpA for the addition of the third amino [...] (215 aa)
scpRC2H2-type zinc-finger transcription factor; C2H2-type zinc-finger transcription factor that controls the expression of the nonribosomal peptide synthases inpA and inpB, as well as of the other inp cluster-associated genes. Mediates also the expression of the asperfuranone biosynthesis gene cluster by binding to the afoA promoter. Probably recognizes the 5'-CT/C/AAAAGGAT/AT/GG/CA-3' motif in the promoters of teget genes. (277 aa)
inpDMFS efflux transporter inpD; MFS efflux transporter; part of the inp gene cluster that mediates the biosynthesis of fellutamide B, a mycotoxin that acts as a proteasome inhibitor. In the first step of fellutabmide B biosynthesis inpC activates 3-hydroxydodecanoic acid to generate 3-hydroxydodecanoyl-AMP that is then loaded onto the T0 domain of inpB. The 3-hydroxydodecanoyl-S- phosphopantetheinyl-T0 is sequentially extended with L-Asn and L-Gln by the two CAT modules of inpB. The linear lipodipeptide from inpB is then transferred onto inpA for the addition of the third amino acid, L-Le [...] (517 aa)
inpCAcyl-CoA ligase inpC; Acyl-CoA ligase; part of the inp gene cluster that mediates the biosynthesis of fellutamide B, a mycotoxin that acts as a proteasome inhibitor. In the first step of fellutabmide B biosynthesis inpC activates 3-hydroxydodecanoic acid to generate 3-hydroxydodecanoyl-AMP that is then loaded onto the T0 domain of inpB. The 3-hydroxydodecanoyl-S- phosphopantetheinyl-T0 is sequentially extended with L-Asn and L-Gln by the two CAT modules of inpB. The linear lipodipeptide from inpB is then transferred onto inpA for the addition of the third amino acid, L-Leu. Reductive r [...] (583 aa)
afoAAsperfuranone cluster transcription factor afoA; Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of asperfuranone, a probable antitumor agent. (666 aa)
mdpEMonodictyphenone cluster transcription factor; Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of monodictyphenone, a prenyl xanthone derivative. (435 aa)
mdpDFAD-dependent monooxygenase mdpD; FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of monodictyphenone, a prenyl xanthone derivative. The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) mdpG. The atrochrysone carboxyl ACP thioesterase mdpF then breaks the thioester bond and releases the atrochrysone carboxylic acid from mdpG. The atrochrysone carboxylic acid is then converted to atrochrysone which is further transformed into emodin anthrone. The next step is performed by the anthrone oxygenase mdpH that ca [...] (521 aa)
mirBSiderophore iron transporter mirB; Involved in the transport of siderophore triacestylfusarinine C and so has a role in iron homeostasis; Belongs to the major facilitator superfamily. (604 aa)
mirASiderophore iron transporter mirA; Involved in the transport of siderophore enterobactin and so has a role in iron homeostasis; Belongs to the major facilitator superfamily. (609 aa)
inpBNonribosomal peptide synthase inpB; Nonribosomal peptide synthase; part of the inp gene cluster that mediates the biosynthesis of fellutamide B, a mycotoxin that acts as a proteasome inhibitor. In the first step of fellutabmide B biosynthesis inpC activates 3-hydroxydodecanoic acid to generate 3-hydroxydodecanoyl-AMP that is then loaded onto the T0 domain of inpB. The 3-hydroxydodecanoyl-S-phosphopantetheinyl-T0 is sequentially extended with L-Asn and L-Gln by the two CAT modules of inpB. The linear lipodipeptide from inpB is then transferred onto inpA for the addition of the third ami [...] (2326 aa)
dbaAC6 finger domain transcription factor dbaA; Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of the antibiotic 2,4- dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde (DHMBA) and its derivatives. Probably binds the conserved motif 5'- CT/CCG/AGA/CG/CT/A/CA/TT/A/GC-3' found in all dba cluster promoters and that shows significant similarities to the binding sites of other fungal C6 finger domain transcription factors (Probable). (584 aa)
dbaCDerivative of benzaldehyde biosynthesis cluster protein C; Part of the gene cluster that mediates the biosynthesis of the antibiotic 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde (DHMBA) and its derivatives. The direct non-reducing polyketide synthase dbaI product is 2,4-dihydroxy- 3-methyl-6-(2-oxopropyl)benzaldehyde (DHMBA), produced by condensation of one acetyl-CoA starter unit with 4 malonyl-CoA units and one methylation step. The FAD-dependent monooxygenase dbaH is responsible for the synthesis of yellow pigments derived from the oxidation of DHMBA. The roles of dbaB, C, E a [...] (98 aa)
mdpAMonodictyphenone cluster transcriptional coactivator mdpA; Transcriptional coactivator; part of the gene cluster that mediates the biosynthesis of monodictyphenone, a prenyl xanthone derivative. With mdpE, coregulates the production of monodictyphenone. (479 aa)
Your Current Organism:
Aspergillus nidulans
NCBI taxonomy Id: 227321
Other names: A. nidulans FGSC A4, Aspergillus nidulans FGSC A4, Emericella nidulans FGSC A4
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.