STRINGSTRING
pkiA pkiA ANIA_08643 ANIA_08643 napA napA ANIA_04562 ANIA_04562 hog1 hog1 ANIA_02911 ANIA_02911 ipnA ipnA abaA abaA penDE penDE wetA wetA stuA stuA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
pkiAPyruvate kinase; Belongs to the pyruvate kinase family. (526 aa)
ANIA_08643BZIP transcription factor (Atf21), putative (AFU_orthologue AFUA_5G12960). (359 aa)
napAAP-1-like transcription factor napA; Transcription activator involved in oxidative stress response, specifically during hyphal growth. Regulates the transcription of genes encoding antioxidant enzymes and components of the cellular thiol-reducing pathways including the mycelium-specific catalase catB (but not the conidia-specific catalase catA), thioredoxin reductase trxB and thioredoxin thiO. Preferentially binds to promoters with the core binding site 5'-TTA[CG]TAA-3'. Activity of the transcription factor is controlled through oxidation of specific cysteine residues resulting in the [...] (577 aa)
ANIA_04562BZIP transcription factor (Fcr3), putative (AFU_orthologue AFUA_2G02540). (317 aa)
hog1Mitogen-activated protein kinase hog1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily. (379 aa)
ANIA_02911AtfA. (485 aa)
ipnAIsopenicillin N synthase; Removes, in the presence of oxygen, 4 hydrogen atoms from delta-L-(alpha-aminoadipyl)-L-cysteinyl-D-valine (ACV) to form the azetidinone and thiazolidine rings of isopenicillin. (331 aa)
abaAConidiophore development regulator abaA; BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation. They act individually and together to regulate their own expression and that of numerous other sporulation-specific gene. Controls temporal and spatial specificity in Aspergillus development. Directs the differentiation of phialides and is continuously required for maintenance of their function. Expression of abaA leads to activation of brlA and wetA, cessation of vegetative growth, and accentuated cellular vacuolization. Binds to the sequence 5'-CATT [...] (796 aa)
penDEAcyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 11 kDa subunit; Last enzyme in penicillin biosynthetic pathway, which converts isopenicillin N (IPN) to penicillin G, using phenyl-acetyl-CoA or phenoxyacetyl-CoA as acyl donors; Belongs to the peptidase C45 family. (357 aa)
wetADevelopmental regulatory protein wetA; BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation. They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes. Responsible for activating a set of genes whose products make up the final two conidial wall layers or direct their assembly and, through this activity, is responsible for acquisition of spore dormancy. (555 aa)
stuACell pattern formation-associated protein stuA; Transcription factor that regulates asexual reproduction. Binds the StuA-response elements (StRE) with the consensus sequence 5'- (A/T)CGCG(T/A)N(A/C)-3' at the promoters of target genes. Required from the very earliest events of asexual reproduction until completion of conidiophore development, but is not specifically required for differentiation of conidia. Represses transcription of the abaA developmental regulatory gene and of the developmentally regulated awh11 gene. Controls the expression of the catalase- peroxidase gene cpeA. Play [...] (622 aa)
Your Current Organism:
Aspergillus nidulans
NCBI taxonomy Id: 227321
Other names: A. nidulans FGSC A4, Aspergillus nidulans FGSC A4, Emericella nidulans FGSC A4
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