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gpdA gpdA brlA brlA csnA csnA hulA hulA AN1226 AN1226 sumO sumO dot1 dot1 creD creD csnD csnD mpkC mpkC hog1 hog1 csnB csnB creC creC hisHF hisHF set1 set1 ANIA_06324 ANIA_06324 set2 set2 ANIA_09399 ANIA_09399 creA creA fadA fadA pacC pacC aflR aflR hhfB hhfB hhfA hhfA AN10449 AN10449 ANIA_10526 ANIA_10526 grrA grrA mpkB mpkB laeA laeA rgsC rgsC velB velB veA veA ANIA_03402 ANIA_03402 ANIA_02018 ANIA_02018 fphA fphA pkaA pkaA rri1 rri1 ANIA_03308 ANIA_03308 ANIA_03309 ANIA_03309 ANIA_03388 ANIA_03388 ANIA_04507 ANIA_04507
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
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gpdAGlyceraldehyde-3-phosphate dehydrogenase; Involved in osmoadaptation; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
brlAC2H2 type master regulator of conidiophore development brlA; BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation. They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes. Binds promoters of target genes at brlA response elements (BREs) containing the conserved sequence 5'- (C/A)(A/G)AGGG(G/A)-3'. Controls the expression of the conidiophore-specific phenol oxidase ivoB. Controls the expression of the hydrophobin rodA. Mediates the developmental switch from the indeterminate, apic [...] (432 aa)
csnACOP9 signalosome complex subunit 1; Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin- protein ligase complexes (By similarity). The CSN complex seems to link protein degradation to sexual development. Required for fruit body formation. (498 aa)
hulAE3 ubiquitin-protein ligase RSP5; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Probably involved in the regulatory network controlling carbon source utilization. Ubiquitinates 'Lys-528' of the uric acid/xanthine transporter uapA at the cell membrane, leading to its internalization, sorting into the endosomal pathway to the vacuolar lumen where it is eventually degraded. (821 aa)
AN1226NAD-dependent protein deacetylase hst4; NAD-dependent histone deacetylase, which could function in telomeric silencing, cell cycle progression and chromosome stability. Belongs to the sirtuin family. Class I subfamily. (595 aa)
sumOUbiquitin-like domain-containing protein. (94 aa)
dot1Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone. (501 aa)
creDHECT-type ubiquitin ligase-interacting protein creD; Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. May be involved in signaling by recognizing appropriately phosphorylated substrates via its arrestin domains and then recruit a HECT-type ubiquitin ligase such as hulA, leading to ubiquitination of the substrate, providing a link between ubiquitination and phosphorylation in protein regulation and stability. (597 aa)
csnDCOP9 signalosome complex subunit 4; Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin- protein ligase complexes (By similarity). The CSN complex seems to link protein degradation to sexual development. Required for fruit body formation. (408 aa)
mpkCMitogen-activated protein kinase mpkC; Mitogen-activated protein kinase required for growth on media where sorbitol or mannitol is the sole carbon source. (415 aa)
hog1Mitogen-activated protein kinase hog1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily. (379 aa)
csnBCOP9 signalosome complex subunit 2; Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin- protein ligase complexes (By similarity). The CSN complex seems to link protein degradation to sexual development. Required for fruit body formation. (506 aa)
creCCatabolite repression protein creC; Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Required to prevent the proteolysis of the CreB deubiquitinating enzyme in the absence of carbon catabolite repression. CreB deubiquitinating enzyme stabilized in a complex with the CreC leads to the expression of genes such as those in the proline and quinate pathways. Belongs to the WD repeat creC family. (592 aa)
hisHFImidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. In the C-terminal section; belongs to the HisA/HisF family. (553 aa)
set1Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. Belongs to the class V-like SAM-binding methyltransferase superfamily. (1220 aa)
ANIA_06324Alpha-amylase. (559 aa)
set2Histone-lysine N-methyltransferase, H3 lysine-36 specific; Histone methyltransferase that trimethylates histone H3 'Lys- 36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. (980 aa)
ANIA_09399Histone-lysine N-methyltransferase (Bre2), putative (AFU_orthologue AFUA_3G04120). (607 aa)
creADNA-binding protein creA; Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC- rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity. Belongs to the creA/MIG C2H2-type zinc-finger protein family. (416 aa)
fadAGuanine nucleotide-binding protein subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. G(q) subfamily. (353 aa)
pacCpH-response transcription factor pacC/RIM101 closed form; Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including pacC itself) and represses transcription of acid- expressed genes. Specifically recognizes and binds the consensus sequence 5'-GCCARG-3'. Required for virulence in invasive pulmonary aspergillosis (IPA). (678 aa)
aflRSterigmatocystin biosynthesis regulatory protein; Involved in the regulation of sterigmatocystin biosynthesis. (433 aa)
hhfBHistone H4.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
hhfAHistone H4.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
AN10449NAD-dependent protein deacetylase hst1; NAD-dependent histone deacetylase, which could function in telomeric silencing, cell cycle progression and chromosome stability. Belongs to the sirtuin family. Class I subfamily. (489 aa)
ANIA_10526RmtA; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (345 aa)
grrASCF E3 ubiquitin ligase complex F-box protein grrA; Involved in meiosis and required for ascospore formation. Involved in substrate recognition in ubiquitin-dependent degradation. (585 aa)
mpkBMitogen-activated protein kinase. (354 aa)
laeASecondary metabolism regulator laeA; Methyltransferase that performs automethylation at Met-207. No other methyl-accepting substrate has been identified yet. Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression. Controls the expression of the sterigmatocystin, penicillin, and lovastatin gene clusters. Controls light-dependent formation of the velB-vosA complex, veA protein modification, and is required for light-mediated inhibition of sexual development. Within the velvet complex, controls light-dependent secondar [...] (374 aa)
rgsCIntermediate filament, regulator of G-protein signaling (Eurofung). (1224 aa)
velBVelvet complex subunit B; Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination. The velvet complex acts as a global regulator for secondary metabolite gene expression. Component of the velB-VosA heterodimeric complex that plays a dual role in activating genes associated with spore maturation and repressing certain development-associated genes. The velB-VosA complex binds DNA through the DNA-binding domain of vosA th [...] (369 aa)
veADevelopmental and secondary metabolism regulator veA; Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination. The velvet complex acts as a global regulator for secondary metabolite gene expression. Controls the expression of the sterigmatocystin and penicillin gene clusters. Represses the cryptic ors gene cluster producing orsellinic acid and its F9775 derivatives in a laeA-independent manner. Required for full induct [...] (573 aa)
ANIA_03402CBM20 domain-containing protein. (623 aa)
ANIA_02018Alpha-amylase. (490 aa)
fphAUncharacterized protein. (1280 aa)
pkaAUncharacterized protein; Belongs to the protein kinase superfamily. (472 aa)
rri1COP9 signalosome complex subunit 5; Catalytic component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity). The CSN complex seems to link protein degradation to sexual development. Required for fruit body formation. (335 aa)
ANIA_03308Aamy domain-containing protein. (552 aa)
ANIA_03309Alpha-amylase, putative (AFU_orthologue AFUA_1G15150). (576 aa)
ANIA_03388Alpha-amylase. (462 aa)
ANIA_04507Aamy domain-containing protein. (521 aa)
Your Current Organism:
Aspergillus nidulans
NCBI taxonomy Id: 227321
Other names: A. nidulans FGSC A4, Aspergillus nidulans FGSC A4, Emericella nidulans FGSC A4
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