node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANIA_02583 | gpdA | Q5BA47 | P20445 | Glyceraldehyde-3-phosphate dehydrogenase (Eurofung); Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | Glyceraldehyde-3-phosphate dehydrogenase; Involved in osmoadaptation; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | 0.903 |
ANIA_03592 | gpdA | C8V4D7 | P20445 | Calnexin, putative (Eurofung). | Glyceraldehyde-3-phosphate dehydrogenase; Involved in osmoadaptation; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | 0.449 |
ANIA_03592 | hacA | C8V4D7 | Q8TFU8 | Calnexin, putative (Eurofung). | Transcriptional activator hacA; Transcriptional activator involved in the unfolded protein response (UPR) pathway. Recognizes and binds to the UPR element (UPRE) in the promoter of UPR-regulated genes. Increases the synthesis of endoplasmic reticulum-resident proteins required for protein folding as well as components of the secretory pathway (By similarity). | 0.698 |
brlA | flbA | P10069 | P38093 | C2H2 type master regulator of conidiophore development brlA; BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation. They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes. Binds promoters of target genes at brlA response elements (BREs) containing the conserved sequence 5'- (C/A)(A/G)AGGG(G/A)-3'. Controls the expression of the conidiophore-specific phenol oxidase ivoB. Controls the expression of the hydrophobin rodA. Mediates the developmental switch from the indeterminate, apic [...] | Developmental regulator flbA; Required for asexual sporulation and normal colony development. May be involved in brlA activation. Could play a regulatory role in controlling the flug-initiated signal transduction pathway that triggers the asexual reproduction. | 0.926 |
brlA | gpdA | P10069 | P20445 | C2H2 type master regulator of conidiophore development brlA; BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation. They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes. Binds promoters of target genes at brlA response elements (BREs) containing the conserved sequence 5'- (C/A)(A/G)AGGG(G/A)-3'. Controls the expression of the conidiophore-specific phenol oxidase ivoB. Controls the expression of the hydrophobin rodA. Mediates the developmental switch from the indeterminate, apic [...] | Glyceraldehyde-3-phosphate dehydrogenase; Involved in osmoadaptation; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | 0.576 |
brlA | laeA | P10069 | C8VQG9 | C2H2 type master regulator of conidiophore development brlA; BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation. They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes. Binds promoters of target genes at brlA response elements (BREs) containing the conserved sequence 5'- (C/A)(A/G)AGGG(G/A)-3'. Controls the expression of the conidiophore-specific phenol oxidase ivoB. Controls the expression of the hydrophobin rodA. Mediates the developmental switch from the indeterminate, apic [...] | Secondary metabolism regulator laeA; Methyltransferase that performs automethylation at Met-207. No other methyl-accepting substrate has been identified yet. Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression. Controls the expression of the sterigmatocystin, penicillin, and lovastatin gene clusters. Controls light-dependent formation of the velB-vosA complex, veA protein modification, and is required for light-mediated inhibition of sexual development. Within the velvet complex, controls light-dependent secondar [...] | 0.979 |
brlA | mpkB | P10069 | C8V7D1 | C2H2 type master regulator of conidiophore development brlA; BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation. They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes. Binds promoters of target genes at brlA response elements (BREs) containing the conserved sequence 5'- (C/A)(A/G)AGGG(G/A)-3'. Controls the expression of the conidiophore-specific phenol oxidase ivoB. Controls the expression of the hydrophobin rodA. Mediates the developmental switch from the indeterminate, apic [...] | Mitogen-activated protein kinase. | 0.712 |
brlA | stuA | P10069 | P36011 | C2H2 type master regulator of conidiophore development brlA; BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation. They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes. Binds promoters of target genes at brlA response elements (BREs) containing the conserved sequence 5'- (C/A)(A/G)AGGG(G/A)-3'. Controls the expression of the conidiophore-specific phenol oxidase ivoB. Controls the expression of the hydrophobin rodA. Mediates the developmental switch from the indeterminate, apic [...] | Cell pattern formation-associated protein stuA; Transcription factor that regulates asexual reproduction. Binds the StuA-response elements (StRE) with the consensus sequence 5'- (A/T)CGCG(T/A)N(A/C)-3' at the promoters of target genes. Required from the very earliest events of asexual reproduction until completion of conidiophore development, but is not specifically required for differentiation of conidia. Represses transcription of the abaA developmental regulatory gene and of the developmentally regulated awh11 gene. Controls the expression of the catalase- peroxidase gene cpeA. Play [...] | 0.982 |
cbhA | creA | Q5B2Q4 | Q01981 | Probable 1,4-beta-D-glucan cellobiohydrolase A; The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose. Belongs to the glycosyl hydrolase 7 (cellulase C) family. | DNA-binding protein creA; Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC- rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity. Belongs to the creA/MIG C2H2-type zinc-finger protein family. | 0.446 |
cbhA | xlnR | Q5B2Q4 | Q5AVS0 | Probable 1,4-beta-D-glucan cellobiohydrolase A; The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose. Belongs to the glycosyl hydrolase 7 (cellulase C) family. | Xylanolytic transcriptional activator xlnR; Transcriptional activator of the xylanolytic system. Involved in the regulation of extracellular cellulolytic and xylanolytic genes and in the regulation of the intracellular activities of D-xylose catabolic genes in the pentose catabolic pathway (PCP) in response to the presence of D-xylose. Binds to the DNA sequence 5'-GGNTAAA-3'. Belongs to the xlnR/xlr1 family. | 0.985 |
creA | cbhA | Q01981 | Q5B2Q4 | DNA-binding protein creA; Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC- rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity. Belongs to the creA/MIG C2H2-type zinc-finger protein family. | Probable 1,4-beta-D-glucan cellobiohydrolase A; The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose. Belongs to the glycosyl hydrolase 7 (cellulase C) family. | 0.446 |
creA | gpdA | Q01981 | P20445 | DNA-binding protein creA; Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC- rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity. Belongs to the creA/MIG C2H2-type zinc-finger protein family. | Glyceraldehyde-3-phosphate dehydrogenase; Involved in osmoadaptation; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | 0.464 |
creA | laeA | Q01981 | C8VQG9 | DNA-binding protein creA; Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC- rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity. Belongs to the creA/MIG C2H2-type zinc-finger protein family. | Secondary metabolism regulator laeA; Methyltransferase that performs automethylation at Met-207. No other methyl-accepting substrate has been identified yet. Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression. Controls the expression of the sterigmatocystin, penicillin, and lovastatin gene clusters. Controls light-dependent formation of the velB-vosA complex, veA protein modification, and is required for light-mediated inhibition of sexual development. Within the velvet complex, controls light-dependent secondar [...] | 0.848 |
creA | stuA | Q01981 | P36011 | DNA-binding protein creA; Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC- rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity. Belongs to the creA/MIG C2H2-type zinc-finger protein family. | Cell pattern formation-associated protein stuA; Transcription factor that regulates asexual reproduction. Binds the StuA-response elements (StRE) with the consensus sequence 5'- (A/T)CGCG(T/A)N(A/C)-3' at the promoters of target genes. Required from the very earliest events of asexual reproduction until completion of conidiophore development, but is not specifically required for differentiation of conidia. Represses transcription of the abaA developmental regulatory gene and of the developmentally regulated awh11 gene. Controls the expression of the catalase- peroxidase gene cpeA. Play [...] | 0.737 |
creA | xlnR | Q01981 | Q5AVS0 | DNA-binding protein creA; Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC- rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity. Belongs to the creA/MIG C2H2-type zinc-finger protein family. | Xylanolytic transcriptional activator xlnR; Transcriptional activator of the xylanolytic system. Involved in the regulation of extracellular cellulolytic and xylanolytic genes and in the regulation of the intracellular activities of D-xylose catabolic genes in the pentose catabolic pathway (PCP) in response to the presence of D-xylose. Binds to the DNA sequence 5'-GGNTAAA-3'. Belongs to the xlnR/xlr1 family. | 0.999 |
flbA | brlA | P38093 | P10069 | Developmental regulator flbA; Required for asexual sporulation and normal colony development. May be involved in brlA activation. Could play a regulatory role in controlling the flug-initiated signal transduction pathway that triggers the asexual reproduction. | C2H2 type master regulator of conidiophore development brlA; BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation. They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes. Binds promoters of target genes at brlA response elements (BREs) containing the conserved sequence 5'- (C/A)(A/G)AGGG(G/A)-3'. Controls the expression of the conidiophore-specific phenol oxidase ivoB. Controls the expression of the hydrophobin rodA. Mediates the developmental switch from the indeterminate, apic [...] | 0.926 |
flbA | mpkB | P38093 | C8V7D1 | Developmental regulator flbA; Required for asexual sporulation and normal colony development. May be involved in brlA activation. Could play a regulatory role in controlling the flug-initiated signal transduction pathway that triggers the asexual reproduction. | Mitogen-activated protein kinase. | 0.697 |
flbA | stuA | P38093 | P36011 | Developmental regulator flbA; Required for asexual sporulation and normal colony development. May be involved in brlA activation. Could play a regulatory role in controlling the flug-initiated signal transduction pathway that triggers the asexual reproduction. | Cell pattern formation-associated protein stuA; Transcription factor that regulates asexual reproduction. Binds the StuA-response elements (StRE) with the consensus sequence 5'- (A/T)CGCG(T/A)N(A/C)-3' at the promoters of target genes. Required from the very earliest events of asexual reproduction until completion of conidiophore development, but is not specifically required for differentiation of conidia. Represses transcription of the abaA developmental regulatory gene and of the developmentally regulated awh11 gene. Controls the expression of the catalase- peroxidase gene cpeA. Play [...] | 0.614 |
gpdA | ANIA_02583 | P20445 | Q5BA47 | Glyceraldehyde-3-phosphate dehydrogenase; Involved in osmoadaptation; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | Glyceraldehyde-3-phosphate dehydrogenase (Eurofung); Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | 0.903 |
gpdA | ANIA_03592 | P20445 | C8V4D7 | Glyceraldehyde-3-phosphate dehydrogenase; Involved in osmoadaptation; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | Calnexin, putative (Eurofung). | 0.449 |