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ilvC ilvC aroE aroE leuB leuB maeB maeB murB murB HNE_0560 HNE_0560 HNE_0672 HNE_0672 HNE_0715 HNE_0715 rfbD rfbD HNE_0812 HNE_0812 HNE_0895 HNE_0895 HNE_0923 HNE_0923 gpsA gpsA HNE_1177 HNE_1177 hisD hisD HNE_1475 HNE_1475 HNE_1493 HNE_1493 zwf zwf dxr dxr guaB guaB mmsB mmsB HNE_2058 HNE_2058 HNE_2119 HNE_2119 pdxA pdxA HNE_2186 HNE_2186 hom hom serA serA mdh mdh HNE_3236 HNE_3236 gyaR gyaR HNE_3469 HNE_3469 HNE_3486 HNE_3486
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (270 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (350 aa)
maeBNADP-dependent malic enzyme; Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949. (755 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (323 aa)
HNE_0560S-(hydroxymethyl)glutathione dehydrogenase/alcohol dehydrogenase, class III; Identified by similarity to SP:P45382; match to protein family HMM PF00107; match to protein family HMM TIGR02818; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (368 aa)
HNE_0672Enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; Identified by match to protein family HMM PF00378; match to protein family HMM PF00725; match to protein family HMM PF02737. (743 aa)
HNE_0715Oxidoreductase, Gfo/Idh/MocA family; Identified by match to protein family HMM PF01408; match to protein family HMM PF02894. (308 aa)
rfbDdTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (296 aa)
HNE_0812Oxidoreductase, NAD-binding; Identified by match to protein family HMM PF01408; match to protein family HMM PF02894. (326 aa)
HNE_0895Identified by similarity to SP:O33730; match to protein family HMM PF03446. (288 aa)
HNE_0923Oxidoreductase, zinc-binding dehydrogenase family; Identified by match to protein family HMM PF00107. (353 aa)
gpsANAD-dependent glycerol-3-phosphate dehydrogenase family protein; Identified by match to protein family HMM PF01210; match to protein family HMM PF02558; match to protein family HMM PF07479; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (336 aa)
HNE_1177Isocitrate dehydrogenase, NADP-dependent; Identified by match to protein family HMM PF00180; match to protein family HMM TIGR00127; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (405 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (432 aa)
HNE_1475D-isomer specific 2-hydroxyacid dehydrogenase family protein; Identified by match to protein family HMM PF00389; match to protein family HMM PF02826; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (337 aa)
HNE_1493Aryl-alcohol dehydrogenase; Identified by similarity to SP:P39849; match to protein family HMM PF00107. (372 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (489 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (397 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (485 aa)
mmsB3-hydroxyisobutyrate dehydrogenase; Identified by similarity to SP:P28811; match to protein family HMM PF03446; match to protein family HMM PF03807; match to protein family HMM TIGR01692. (296 aa)
HNE_2058Riboflavin biosynthesis protein RibD C-terminal domain protein; Identified by match to protein family HMM PF01872; match to protein family HMM TIGR00227. (217 aa)
HNE_2119Aryl-alcohol dehydrogenase; Identified by similarity to SP:P39849; match to protein family HMM PF00107. (366 aa)
pdxA4-hydroxythreonine-4-phosphate dehydrogenase; Identified by match to protein family HMM PF04166; Belongs to the PdxA family. (335 aa)
HNE_2186Oxidoreductase, NAD-binding; Identified by match to protein family HMM PF01408; match to protein family HMM PF02894. (374 aa)
homHomoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF01113; match to protein family HMM PF01842; match to protein family HMM PF03447. (427 aa)
serAD-3-phosphoglycerate dehydrogenase; Identified by match to protein family HMM PF00389; match to protein family HMM PF01842; match to protein family HMM PF02826; match to protein family HMM TIGR01327; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (531 aa)
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)
HNE_3236UDP-glucose dehydrogenase; Identified by match to protein family HMM PF00070; match to protein family HMM PF00984; match to protein family HMM PF01210; match to protein family HMM PF02737; match to protein family HMM PF03720; match to protein family HMM PF03721; match to protein family HMM TIGR03026. (436 aa)
gyaRGlyoxylate reductase; Identified by similarity to SP:Q9C4M5; match to protein family HMM PF00389; match to protein family HMM PF02826; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (328 aa)
HNE_34693-hydroxybutyryl-CoA dehydrogenase; Identified by match to protein family HMM PF00725; match to protein family HMM PF02737. (292 aa)
HNE_3486Alcohol dehydrogenase, class III; Identified by similarity to GB:AAK24991.1; match to protein family HMM PF00107. (366 aa)
Your Current Organism:
Hyphomonas neptunium
NCBI taxonomy Id: 228405
Other names: H. neptunium ATCC 15444, Hyphomonas neptunium ATCC 15444, Hyphomonas neptunium str. ATCC 15444, Hyphomonas neptunium strain ATCC 15444
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