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lon lon rho rho ccmA ccmA HNE_3509 HNE_3509 cobS cobS HNE_3440 HNE_3440 ftsE ftsE pspF pspF HNE_3264 HNE_3264 HNE_3241 HNE_3241 HNE_3192 HNE_3192 HNE_3165 HNE_3165 HNE_3089 HNE_3089 HNE_3039 HNE_3039 HNE_2924 HNE_2924 HNE_2920 HNE_2920 recA recA HNE_2695 HNE_2695 HNE_2642 HNE_2642 sufC sufC HNE_2517 HNE_2517 phnC phnC dnaB dnaB hslU hslU pstB pstB glnG glnG ntrX ntrX HNE_1899 HNE_1899 atpD atpD HNE_1881 HNE_1881 gspE gspE lolD lolD HNE_1661 HNE_1661 HNE_1660 HNE_1660 macB macB HNE_1534 HNE_1534 HNE_1517 HNE_1517 HNE_1366 HNE_1366 HNE_1242 HNE_1242 HNE_1219 HNE_1219 HNE_1205 HNE_1205 HNE_1145 HNE_1145 clpA clpA HNE_0950 HNE_0950 HNE_0796 HNE_0796 HNE_0754 HNE_0754 HNE_0723 HNE_0723 radA radA clpB clpB dnaA dnaA HNE_0498 HNE_0498 HNE_0385 HNE_0385 dnaX dnaX HNE_0284 HNE_0284 fliI fliI HNE_0205 HNE_0205 HNE_0186 HNE_0186 HNE_0172 HNE_0172 ftsH ftsH ruvB ruvB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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lonATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (806 aa)
rhoTranscription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (418 aa)
ccmAHeme exporter protein CcmA; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. (193 aa)
HNE_3509ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (243 aa)
cobSCobaltochelatase, CobS subunit; Identified by similarity to SP:P29933; match to protein family HMM TIGR01650. (327 aa)
HNE_3440Putative uridine kinase; Identified by similarity to SP:O32033; match to protein family HMM PF00485; match to protein family HMM TIGR00235; Belongs to the uridine kinase family. (228 aa)
ftsECell division ATP-binding protein FtsE; Identified by similarity to GB:AAK20881.1; match to protein family HMM PF00005; match to protein family HMM TIGR02673. (252 aa)
pspFPsp operon transcription activator; Identified by similarity to SP:P37344; match to protein family HMM PF00158; match to protein family HMM PF02954; match to protein family HMM TIGR01199. (368 aa)
HNE_3264Conserved hypothetical protein; Identified by similarity to GB:AAS82622.1. (445 aa)
HNE_3241Putative multidrug ABC transporter, permease/ATP-binding protein; Identified by similarity to GB:BAB70471.1; match to protein family HMM PF00005. (622 aa)
HNE_3192Efflux ABC transporter, permease/ATP-binding protein; Identified by match to protein family HMM PF00005; match to protein family HMM PF00664. (610 aa)
HNE_3165ABC transporter, ATP-binding protein; Identified by similarity to GB:AAC36155.1; match to protein family HMM PF00005. (323 aa)
HNE_3089ABC transporter, permease/ATP-binding protein; Identified by similarity to SP:P33116; match to protein family HMM PF00005. (622 aa)
HNE_3039Sigma-54 dependent DNA-binding response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00158; match to protein family HMM PF02954; match to protein family HMM TIGR01199. (491 aa)
HNE_2924ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (637 aa)
HNE_2920ABC transporter, ATP-binding protein; Identified by similarity to GB:AAS95092.1; match to protein family HMM PF00005. (255 aa)
recArecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (356 aa)
HNE_2695Iron ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005; Belongs to the ABC transporter superfamily. (335 aa)
HNE_2642ATPase, AAA family; Identified by match to protein family HMM PF00004. (436 aa)
sufCFeS assembly ATPase SufC; Identified by match to protein family HMM PF00005; match to protein family HMM TIGR01978. (253 aa)
HNE_2517Type II secretion system protein; Identified by match to protein family HMM PF00437. (540 aa)
phnCPhosphonate ABC transporter, ATP-binding protein; Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family. (261 aa)
dnaBReplicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (496 aa)
hslUHeat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (434 aa)
pstBPhosphate ABC transporter, ATP-binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (275 aa)
glnGNitrogen regulation protein NR(I); Identified by similarity to SP:P06713; match to protein family HMM PF00072; match to protein family HMM PF00158; match to protein family HMM PF02954; match to protein family HMM TIGR01199. (457 aa)
ntrXSigma-54 dependent DNA-binding response regulator; Identified by similarity to SP:Q06065; match to protein family HMM PF00072; match to protein family HMM PF00158; match to protein family HMM PF02954; match to protein family HMM TIGR01199. (461 aa)
HNE_1899ATPase, AAA family; Identified by match to protein family HMM PF07728. (330 aa)
atpDATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (475 aa)
HNE_1881ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (313 aa)
gspEGeneral secretory pathway protein E; Identified by match to protein family HMM PF00437; match to protein family HMM TIGR02533. (496 aa)
lolDLipoprotein releasing system, ATP-binding protein, homolog; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner. (228 aa)
HNE_1661Putative amino acid ABC transporter, ATP-binding protein CydC; Identified by similarity to SP:P23886; match to protein family HMM PF00005. (546 aa)
HNE_1660Amino acid ABC transporter, permease/ATP-binding protein CydD, putaive; Identified by similarity to SP:P29018; match to protein family HMM PF00005; match to protein family HMM TIGR02857. (559 aa)
macBPutative macrolide efflux ABC transporter, permease/ATP-binding protein; Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP- binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. (645 aa)
HNE_1534ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (575 aa)
HNE_1517Iron compound ABC transporter, ATP-binding protein; Identified by similarity to SP:P07821; match to protein family HMM PF00005. (253 aa)
HNE_1366Efflux ABC transporter, permease/ATP-binding protein; Identified by match to protein family HMM PF00005; match to protein family HMM PF00664. (608 aa)
HNE_1242Efflux ABC transporter, heavy metal transporter (HMT) family (ABCB), permease/ATP-binding protein; Identified by match to protein family HMM PF00005; match to protein family HMM PF00664. (618 aa)
HNE_1219ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (554 aa)
HNE_1205ATPase, AAA family; Identified by match to protein family HMM PF07726; match to protein family HMM PF07728. (318 aa)
HNE_1145Iron compound ABC transporter, ATP-binding protein; Identified by similarity to SP:P15031; match to protein family HMM PF00005. (249 aa)
clpAATP-dependent Clp protease, ATP-binding subunit ClpA; Identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM TIGR02639; Belongs to the ClpA/ClpB family. (771 aa)
HNE_0950ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (527 aa)
HNE_0796Lipopolysaccharide ABC transporter, ATP-binding protein; Identified by similarity to GB:AAF04381.1; match to protein family HMM PF00005. (417 aa)
HNE_0754ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (608 aa)
HNE_0723ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (254 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (460 aa)
clpBATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (872 aa)
dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. (457 aa)
HNE_0498Conserved hypothetical protein; Identified by similarity to GB:AAK23436.1; match to protein family HMM PF00004; match to protein family HMM PF07728. (294 aa)
HNE_0385Putative DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (594 aa)
dnaXDNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (578 aa)
HNE_0284Conserved domain protein; Identified by similarity to SP:P55386. (793 aa)
fliIFlagellar protein export ATPase FliI; Identified by match to protein family HMM PF00006; match to protein family HMM TIGR01026; match to protein family HMM TIGR02545. (462 aa)
HNE_0205ABC transporter, ATP-binding protein; Identified by similarity to GB:AAK25562.1; match to protein family HMM PF00005. (244 aa)
HNE_0186ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (231 aa)
HNE_0172Peptide ABC transporter, ATP-binding protein; Identified by similarity to SP:P75796; match to protein family HMM PF00005; match to protein family HMM TIGR01727; Belongs to the ABC transporter superfamily. (623 aa)
ftsHATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (639 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (344 aa)
Your Current Organism:
Hyphomonas neptunium
NCBI taxonomy Id: 228405
Other names: H. neptunium ATCC 15444, Hyphomonas neptunium ATCC 15444, Hyphomonas neptunium str. ATCC 15444, Hyphomonas neptunium strain ATCC 15444
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