(28 nodes) Efflux transmembrane transporter activity, and RND efflux pump, membrane fusion protein network (Nitrosomonas europaea)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

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co-expression

protein homology

Your Input:
	mexE	HlyD family secretion protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (388 aa)
	NE0157	Probable transmembrane multidrug-efflux system lipoprotein transmembrane. (1048 aa)
	NE0168	Multidrug resistance protein MexB. (1064 aa)
	acrA,mtcA,lir	HlyD family secretion protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (399 aa)
	oprM	Outer membrane efflux protein. (516 aa)
	NE0345	Acriflavin resistance protein:Heavy metal efflux pump CzcA; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1042 aa)
	NE0346	Possible cation transporter transmembrane protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (393 aa)
	NE0371	Glycerophosphoryl diester phosphodiesterase. (244 aa)
	NE0372	Hypothetical protein. (218 aa)
	NE0373	Outer membrane efflux protein. (418 aa)
	NE0374	Putative cation efflux protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (387 aa)
	NE0375	Acriflavin resistance protein:Heavy metal efflux pump CzcA; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1034 aa)
	NE0537	Conserved hypothetical protein; COGs COG3182. (422 aa)
	NE0538	Outer membrane efflux protein. (471 aa)
	yegM	Possible putitive HlyD family secretion protein. (397 aa)
	NE0540	Acriflavin resistance protein; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1040 aa)
	NE1080	Outer membrane efflux protein. (460 aa)
	macB	Probable ATP-binding/permease fusion ABC transporter; Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP- binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. (659 aa)
	NE1082	Conserved hypothetical protein; COGs COG0845; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (398 aa)
	NE1111	Outer membrane efflux protein. (470 aa)
	NE1112	Similar to (NC_002516) RND multidrug efflux transporter [Pseudomonas aeruginosa], evalue=0.00e+00, 71% identity. (1033 aa)
	NE1113	HlyD family secretion protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (386 aa)
	czcA	Acriflavin resistance protein:Heavy metal efflux pump CzcA; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1072 aa)
	czcB	HlyD family secretion protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (497 aa)
	czcC	Outer membrane efflux protein. (468 aa)
	NE1641	Hypothetical protein. (123 aa)
	acrD4	Acriflavin resistance protein; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1028 aa)
	NE2037	Putative cation-efflux system signal peptide protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (364 aa)

Your Current Organism:

Nitrosomonas europaea

NCBI taxonomy Id: 228410
Other names: N. europaea ATCC 19718, Nitrosomonas europaea ATCC 19718, Nitrosomonas europaea str. ATCC 19718

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NE0157	NE0346	NE0157	NE0346	Probable transmembrane multidrug-efflux system lipoprotein transmembrane.	Possible cation transporter transmembrane protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.648
NE0157	NE0374	NE0157	NE0374	Probable transmembrane multidrug-efflux system lipoprotein transmembrane.	Putative cation efflux protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.583
NE0157	NE0538	NE0157	NE0538	Probable transmembrane multidrug-efflux system lipoprotein transmembrane.	Outer membrane efflux protein.	0.674
NE0157	NE1080	NE0157	NE1080	Probable transmembrane multidrug-efflux system lipoprotein transmembrane.	Outer membrane efflux protein.	0.714
NE0157	NE1082	NE0157	NE1082	Probable transmembrane multidrug-efflux system lipoprotein transmembrane.	Conserved hypothetical protein; COGs COG0845; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.497
NE0157	NE1111	NE0157	NE1111	Probable transmembrane multidrug-efflux system lipoprotein transmembrane.	Outer membrane efflux protein.	0.771
NE0157	NE1113	NE0157	NE1113	Probable transmembrane multidrug-efflux system lipoprotein transmembrane.	HlyD family secretion protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.849
NE0157	NE2037	NE0157	NE2037	Probable transmembrane multidrug-efflux system lipoprotein transmembrane.	Putative cation-efflux system signal peptide protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.401
NE0157	acrA,mtcA,lir	NE0157	NE0169	Probable transmembrane multidrug-efflux system lipoprotein transmembrane.	HlyD family secretion protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.847
NE0157	czcB	NE0157	NE1639	Probable transmembrane multidrug-efflux system lipoprotein transmembrane.	HlyD family secretion protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.435
NE0157	mexE	NE0157	NE0156	Probable transmembrane multidrug-efflux system lipoprotein transmembrane.	HlyD family secretion protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.951
NE0157	oprM	NE0157	NE0170	Probable transmembrane multidrug-efflux system lipoprotein transmembrane.	Outer membrane efflux protein.	0.770
NE0157	yegM	NE0157	NE0539	Probable transmembrane multidrug-efflux system lipoprotein transmembrane.	Possible putitive HlyD family secretion protein.	0.505
NE0168	NE0346	NE0168	NE0346	Multidrug resistance protein MexB.	Possible cation transporter transmembrane protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.661
NE0168	NE0374	NE0168	NE0374	Multidrug resistance protein MexB.	Putative cation efflux protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.590
NE0168	NE0538	NE0168	NE0538	Multidrug resistance protein MexB.	Outer membrane efflux protein.	0.940
NE0168	NE1080	NE0168	NE1080	Multidrug resistance protein MexB.	Outer membrane efflux protein.	0.949
NE0168	NE1082	NE0168	NE1082	Multidrug resistance protein MexB.	Conserved hypothetical protein; COGs COG0845; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.500
NE0168	NE1111	NE0168	NE1111	Multidrug resistance protein MexB.	Outer membrane efflux protein.	0.962
NE0168	NE1112	NE0168	NE1112	Multidrug resistance protein MexB.	Similar to (NC_002516) RND multidrug efflux transporter [Pseudomonas aeruginosa], evalue=0.00e+00, 71% identity.	0.907