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| | sucC | ATP-citrate lyase/succinyl-CoA ligases:ATP-grasp domain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (397 aa) |
| | sucD | ATP-citrate lyase/succinyl-CoA ligases:DUF184; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (291 aa) |
| | hprA | D-isomer specific 2-hydroxyacid dehydrogenase. (322 aa) |
| | ilvD | Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (557 aa) |
| | plsY | DUF205; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (200 aa) |
| | pta | Phosphate acetyl/butaryl transferase:Phosphate acetyltransferase; Involved in acetate metabolism; In the N-terminal section; belongs to the CobB/CobQ family. (695 aa) |
| | cbbA, | Fructose-bisphosphate aldolase, class-II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa) |
| | pykA1 | Pyruvate kinase family; Belongs to the pyruvate kinase family. (496 aa) |
| | cbbK, | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (392 aa) |
| | cbbG, | Glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (333 aa) |
| | cbbT, | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (672 aa) |
| | aceF | aceF; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (453 aa) |
| | aceE | aceE; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (885 aa) |
| | folD | Tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (295 aa) |
| | eryB | NAD binding site:D-amino acid oxidase. (391 aa) |
| | NE0397 | 6-phosphogluconate dehydrogenase. (304 aa) |
| | zwf | Glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (496 aa) |
| | NE0438 | Putative malate oxidoreductase (malic enzyme). (580 aa) |
| | cbbF, | Fructose-1,6-bisphosphatase/sedoheptulose-1, 7-bisphosphatase. (334 aa) |
| | ppc | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (933 aa) |
| | gcvT | Glycine cleavage T-protein (aminomethyl transferase); The glycine cleavage system catalyzes the degradation of glycine. (363 aa) |
| | gcvH1 | Glycine cleavage H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa) |
| | gcvPA | Glycine cleavage system P-protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (453 aa) |
| | gcvPB | Glycine cleavage system P-protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (483 aa) |
| | plsC | Phospholipid and glycerol acyltransferase (from 'motifs_6.msf'). (267 aa) |
| | accB1 | Possible accB1; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (152 aa) |
| | accC1 | accC1; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (452 aa) |
| | leuC | leuC; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (470 aa) |
| | leuD | leuD; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (221 aa) |
| | leuB | leuB, 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (356 aa) |
| | accD | Acetyl-CoA carboxylase carboxyl transferase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (297 aa) |
| | mdh | Lactate/malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (327 aa) |
| | NE0774 | Pyridine nucleotide-disulfide oxidoreductase, class I; Product taken from KEGG top hit (ev=e-98). (472 aa) |
| | TGL2 | Esterase/lipase/thioesterase family active site. (250 aa) |
| | ldhA | D-isomer specific 2-hydroxyacid dehydrogenase. (330 aa) |
| | acnA1 | acnA1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (948 aa) |
| | NE1003 | Aldose 1-epimerase; Belongs to the glucose-6-phosphate 1-epimerase family. (301 aa) |
| | NE1009 | D-lactate dehydrogenase. (455 aa) |
| | accA | Carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (322 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa) |
| | NE1046 | Succinate dehydrogenase, cytochrome b subunit. (130 aa) |
| | sdhD | Succinate dehydrogenase, cytochrome b subunit. (117 aa) |
| | sdhA | Succinate dehydrogenase/fumarate reductase, flavoprotein subunits; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (587 aa) |
| | leuA1 | HMG-CoA Lyase-like family; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (510 aa) |
| | ilvC | Probable ketol-acid reductoisomerase oxidoreductase protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa) |
| | ilvH | Similar to (NC_003295) PROBABLE ACETOLACTATE SYNTHASE ISOZYME III (SMALL SUBUNIT) PROTEIN [Ralstonia solanacearum] evalue=3.00e-61, 71% identity. (163 aa) |
| | ilvI | Thiamine pyrophosphate dependent enzyme. (567 aa) |
| | rkpA | Similar to (AF285636) putative type I polyketide synthase WcbR [Burkholderia mallei], evalue=0.00e+00, 41% identity. (2544 aa) |
| | glyA | Serine hydroxymethyltransferase (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (416 aa) |
| | NE1527 | Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa) |
| | NE1528 | Putative 3-hydroxyacyl-CoA dehydrogenase oxidoreductase protein. (836 aa) |
| | NE1548 | Acyl-CoA dehydrogenase. (777 aa) |
| | NE1549 | AMP-dependent synthetase and ligase. (612 aa) |
| | plsX | Fatty acid synthesis plsX protein; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (339 aa) |
| | fabH | fabH; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (318 aa) |
| | fabD | fabD; malonyl CoA-acyl carrier protein transacylase. (312 aa) |
| | fabG1 | Short-chain dehydrogenase/reductase (SDR) superfamily; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa) |
| | acpP | Acyl carrier protein (ACP):Phosphopantetheine attachment site; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (81 aa) |
| | fabF1 | Beta-ketoacyl synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (413 aa) |
| | pgl | Glucosamine/galactosamine-6-phosphate isomerase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (228 aa) |
| | glk | Glucokinase; Belongs to the bacterial glucokinase family. (335 aa) |
| | fabZ | Bacterial thioester dehydrase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (153 aa) |
| | icd | Icd; isocitrate dehydrogenase [NADP] oxidoreductase protein. (415 aa) |
| | cbbI, | Ribose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (219 aa) |
| | cbbJ, | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (252 aa) |
| | sucC-2 | ATP-citrate lyase/succinyl-CoA ligases:ATP-grasp domain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (390 aa) |
| | sucD-2 | ATP-citrate lyase/succinyl-CoA ligases:DUF184; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (295 aa) |
| | ilvE | Aminotransferases class-IV; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (307 aa) |
| | pfp | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (419 aa) |
| | gabD | Aldehyde dehydrogenase family. (443 aa) |
| | ackA2 | Acetate and butyrate kinase:Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (416 aa) |
| | NE2135 | Conserved hypothetical protein; COGs COG0021. (790 aa) |
| | tal | Transaldolase:Transaldolase subfamily; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (364 aa) |
| | cbbE, | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (226 aa) |
| | NE2157 | Dihydrolipoamide dehydrogenase. (600 aa) |
| | NE2205 | Possible transcriptional regulator; NE2204 and an unannotated ORF overlapping the 3' end are 2 parts of a dead gene due to a frameshift. (264 aa) |
| | gpsA | NAD-dependent glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (329 aa) |
| | NE2235 | AMP-dependent synthetase and ligase. (615 aa) |
| | bktB | Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa) |
| | pgi | Phosphoglucose isomerase (PGI). (544 aa) |
| | fumC | Fumarate lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (462 aa) |
| | lpdA3 | pdA3; dihydrolipoamide dehydrogenase E3 component. (490 aa) |
| | acsA | AMP-dependent synthetase and ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (655 aa) |
| | NE2347 | General substrate transporters. (400 aa) |
| | fadE1 | Acyl-CoA dehydrogenase. (399 aa) |
| | ydiD,ppsA | AMP-dependent synthetase and ligase. (560 aa) |
| | NE2350 | CAIB/BAIF family; Belongs to the CoA-transferase III family. (628 aa) |
| | ppsA | ppsA; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (791 aa) |
| | sdhB | sdhB; succinate dehydrogenase (iron-sulfur subunit) oxidoreductase protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (231 aa) |
| | gltA | Citrate synthase; Belongs to the citrate synthase family. (427 aa) |
| | odhA | Transketolase:Dehydrogenase, E1 component. (952 aa) |
| | sucB | sucB; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (425 aa) |
| | NE2416 | Probable Sensory transduction histidine kinases; 3' remnant of gene interrupted by an IS element. (780 aa) |
| | NE2417 | Conserved hypothetical protein; COGs COG3665. (219 aa) |
| | NE2418 | Conserved hypothetical protein. (242 aa) |
| | NE2419 | Amino acid permease. (505 aa) |
| | NE2420 | Biotin / Lipoyl attachment:Carbamoyl-phosphate synthase:DUF183. (1211 aa) |
| | ttuD2 | Putative hydroxypyruvate reductase oxidoreductase protein. (427 aa) |
