(34 nodes) Nervous system development network (Fusarium graminearum)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	FG08822.1	ADF-H domain-containing protein. (711 aa)
	A0A098DFV5	Protein kinase domain-containing protein. (211 aa)
	A0A098DQP4	Zn(2)-C6 fungal-type domain-containing protein. (889 aa)
	FG07295.1	Protein kinase domain-containing protein. (524 aa)
	A0A1C3YHW7	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (987 aa)
	A0A1C3YIN0	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (437 aa)
	A0A1C3YIZ8	Protein kinase domain-containing protein. (518 aa)
	A0A1C3YK51	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1683 aa)
	A0A1C3YKL2	Uncharacterized protein. (276 aa)
	A0A1C3YKQ0	Homeobox domain-containing protein. (464 aa)
	A0A1C3YLU9	Zn(2)-C6 fungal-type domain-containing protein. (519 aa)
	A0A1C3YM01	Zn(2)-C6 fungal-type domain-containing protein. (700 aa)
	FG00147.1	Zn(2)-C6 fungal-type domain-containing protein. (722 aa)
	FG00799.1	Structure-specific endonuclease subunit SLX4; Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (879 aa)
	FG01458.1	Uncharacterized protein. (406 aa)
	FG01459.1	Uncharacterized protein. (227 aa)
	I1RE15_GIBZE	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (239 aa)
	FG06385.1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
	FG06433.1	Amidohydro-rel domain-containing protein. (453 aa)
	FG06707.1	PH domain-containing protein. (389 aa)
	FG08656.1	Uncharacterized protein. (611 aa)
	FG08691.1	Protein kinase domain-containing protein. (647 aa)
	FG09734.1	Rad60-SLD_2 domain-containing protein. (260 aa)
	FG10212.1	Uncharacterized protein. (139 aa)
	FG10513.1	LITAF domain-containing protein. (166 aa)
	FG10934.1	Amidohydro-rel domain-containing protein. (530 aa)
	FG11200.1	HET domain-containing protein. (1260 aa)
	FG11205.1	Uncharacterized protein. (140 aa)
	I1S9D4_GIBZE	Uncharacterized protein. (171 aa)
	COF1	Cofilin; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. Binding to F-actin is regulated by tropomyosin. It is the major component of intranuclear and cytoplasmic actin rods. Required for accumulation of actin at the cell division site via depolymerizing actin at the cell ends. In association with myosin II has a role in the assembly of the contractile ring via severing actin filaments. Involved in the maintenance of the contractile ring once formed. In association with [...] (153 aa)
	APS2	AP-2 complex subunit sigma; Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity). (143 aa)
	FG06317.1	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (747 aa)
	FG09735.1	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (713 aa)
	FG08857.1	Uncharacterized protein. (199 aa)

Your Current Organism:

Fusarium graminearum

NCBI taxonomy Id: 229533
Other names: F. graminearum PH-1, Fusarium graminearum PH-1, Gibberella zeae PH-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A098DFV5	FG06385.1	A0A098DFV5	I1RQN9	Protein kinase domain-containing protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.450
A0A098DQP4	A0A1C3YK51	A0A098DQP4	A0A1C3YK51	Zn(2)-C6 fungal-type domain-containing protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.461
A0A1C3YHW7	A0A1C3YIN0	A0A1C3YHW7	A0A1C3YIN0	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	0.999
A0A1C3YHW7	A0A1C3YK51	A0A1C3YHW7	A0A1C3YK51	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.780
A0A1C3YHW7	APS2	A0A1C3YHW7	Q4ICG5	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	AP-2 complex subunit sigma; Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity).	0.998
A0A1C3YHW7	FG06317.1	A0A1C3YHW7	V6RKE4	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.830
A0A1C3YHW7	FG09734.1	A0A1C3YHW7	I1RZA4	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Rad60-SLD_2 domain-containing protein.	0.830
A0A1C3YHW7	FG09735.1	A0A1C3YHW7	V6RQ48	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.982
A0A1C3YHW7	I1RE15_GIBZE	A0A1C3YHW7	I1RE15	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.769
A0A1C3YIN0	A0A1C3YHW7	A0A1C3YIN0	A0A1C3YHW7	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.999
A0A1C3YIN0	A0A1C3YK51	A0A1C3YIN0	A0A1C3YK51	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.939
A0A1C3YIN0	APS2	A0A1C3YIN0	Q4ICG5	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	AP-2 complex subunit sigma; Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity).	0.999
A0A1C3YIN0	FG06317.1	A0A1C3YIN0	V6RKE4	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.927
A0A1C3YIN0	FG06385.1	A0A1C3YIN0	I1RQN9	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.500
A0A1C3YIN0	FG09734.1	A0A1C3YIN0	I1RZA4	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	Rad60-SLD_2 domain-containing protein.	0.909
A0A1C3YIN0	FG09735.1	A0A1C3YIN0	V6RQ48	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.993
A0A1C3YIN0	I1RE15_GIBZE	A0A1C3YIN0	I1RE15	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.914
A0A1C3YIZ8	FG06385.1	A0A1C3YIZ8	I1RQN9	Protein kinase domain-containing protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.998
A0A1C3YIZ8	FG07295.1	A0A1C3YIZ8	A0A0E0SGT0	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.618
A0A1C3YIZ8	FG08691.1	A0A1C3YIZ8	I1RWL6	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.752