(156 nodes) Preribosome, and mRNA decay by 3 to 5 exoribonuclease network (Coprinopsis marcescibilis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A5C3KE57	U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2. (642 aa)
	A0A5C3KEC0	Uncharacterized protein. (562 aa)
	A0A5C3KEC5	Uncharacterized protein. (667 aa)
	A0A5C3KF63	Protein MAK16; Belongs to the MAK16 family. (290 aa)
	A0A5C3KFB3	Uncharacterized protein. (529 aa)
	A0A5C3KFQ7	Uncharacterized protein. (971 aa)
	A0A5C3KFX1	Uncharacterized protein. (665 aa)
	A0A5C3KGK1	Fibrillarin-like protein. (218 aa)
	A0A5C3KGL8	Uncharacterized protein. (89 aa)
	A0A5C3KGN5	Exosome component 4. (259 aa)
	A0A5C3KGU2	FHA domain-containing protein. (928 aa)
	A0A5C3KHC5	DEAD-domain-containing protein; Belongs to the DEAD box helicase family. (746 aa)
	A0A5C3KJ19	DEAD-domain-containing protein; Belongs to the DEAD box helicase family. (622 aa)
	A0A5C3KJ46	CBF-domain-containing protein. (613 aa)
	A0A5C3KJF4	Ribosomal protein L1. (315 aa)
	A0A5C3KJG3	Exosome complex exonuclease RRP40. (234 aa)
	A0A5C3KJX9	WD40 repeat-like protein. (579 aa)
	A0A5C3KJY3	Ribosomal protein S5 domain 2-like protein. (284 aa)
	A0A5C3KKC3	Uncharacterized protein. (240 aa)
	A0A5C3KKG0	Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (4884 aa)
	A0A5C3KKL9	Uncharacterized protein. (1010 aa)
	A0A5C3KKQ8	WD repeat-containing protein. (767 aa)
	A0A5C3KL69	Transducin family protein/WD-40 repeat family protein. (566 aa)
	A0A5C3KLD5	Uncharacterized protein. (322 aa)
	A0A5C3KLJ0	RNA-binding domain-containing protein. (198 aa)
	A0A5C3KLW8	Uncharacterized protein. (592 aa)
	A0A5C3KLX5	U3 small nucleolar RNA-associated protein 22. (1218 aa)
	A0A5C3KNW3	Nucleolar protein NOP58. (567 aa)
	A0A5C3KP73	WD40 repeat-like protein. (871 aa)
	A0A5C3KPC0	ATP-dependent RNA helicase DBP10. (932 aa)
	A0A5C3KPX8	SURF6-domain-containing protein. (426 aa)
	NAT10	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1098 aa)
	A0A5C3KQH3	Exosome component Rrp46. (234 aa)
	A0A5C3KQW7	Alpha-L RNA-binding motif-containing protein. (183 aa)
	A0A5C3KR82	U3 small nucleolar RNA-associated protein 4. (1006 aa)
	A0A5C3KRK5	CP-type G domain-containing protein. (577 aa)
	A0A5C3KRM2	KDa Trp-Asp repeat-containing protein. (515 aa)
	A0A5C3KS63	Ribosome biogenesis protein YTM1. (438 aa)
	A0A5C3KSM8	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. (1447 aa)
	A0A5C3KSZ0	Uncharacterized protein. (324 aa)
	A0A5C3KT54	Pre-rRNA-processing protein IPI3. (504 aa)
	A0A5C3KT74	WD repeat-containing protein 46. (739 aa)
	A0A5C3KT99	Uncharacterized protein. (956 aa)
	A0A5C3KTT4	MI domain-containing protein. (872 aa)
	A0A5C3KTZ0	Ribosomal RNA-processing protein 12. (1240 aa)
	A0A5C3KUA8	DUF663-domain-containing protein. (1134 aa)
	A0A5C3KUQ6	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43. (779 aa)
	A0A5C3KUV0	DEAD-domain-containing protein; Belongs to the DEAD box helicase family. (839 aa)
	A0A5C3KUV2	Antiviral helicase. (1027 aa)
	A0A5C3KV33	C2H2-type domain-containing protein. (133 aa)
	A0A5C3KVD3	ATP-dependent RNA helicase Prh1. (766 aa)
	A0A5C3KVJ8	P-loop containing nucleoside triphosphate hydrolase protein. (1863 aa)
	A0A5C3KVY1	Puf family RNA-binding protein. (673 aa)
	A0A5C3KWI3	BP28CT domain-containing protein. (2012 aa)
	A0A5C3KWW7	Uncharacterized protein. (538 aa)
	A0A5C3KXF1	Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (724 aa)
	A0A5C3KXL8	RTC domain-containing 1. (393 aa)
	A0A5C3KXM4	RNA helicase. (760 aa)
	A0A5C3KXV1	Superkiller protein 3 SKI3. (1429 aa)
	A0A5C3KXW6	Fcf1-domain-containing protein. (194 aa)
	A0A5C3KXZ0	Uncharacterized protein. (672 aa)
	A0A5C3KY40	rRNA binding protein. (429 aa)
	A0A5C3KY96	TRAUB-domain-containing protein. (498 aa)
	A0A5C3KYI5	Ribosomal protein S8e. (260 aa)
	A0A5C3KYV2	CBF-domain-containing protein. (945 aa)
	A0A5C3KZ00	U3 snoRNP protein. (660 aa)
	A0A5C3KZD7	Utp14-domain-containing protein. (1016 aa)
	A0A5C3KZF0	Brix-domain-containing protein. (378 aa)
	A0A5C3KZH7	Ribosomal protein S5 domain 2-like protein. (337 aa)
	A0A5C3KZU6	Cytosine-5--methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (737 aa)
	A0A5C3KZV1	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (309 aa)
	A0A5C3KZV6	Brix-domain-containing protein. (371 aa)
	A0A5C3L0L3	Nucleolar protein 14. (916 aa)
	A0A5C3L0S6	ATP-dependent RNA helicase dbp9. (636 aa)
	A0A5C3L1Z9	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (659 aa)
	A0A5C3L236	C1D-domain-containing protein. (260 aa)
	A0A5C3L259	Ebp2-domain-containing protein. (498 aa)
	A0A5C3L291	U3 snoRNP protein Utp20. (2860 aa)
	A0A5C3L2J5	RNA-binding domain-containing protein. (766 aa)
	A0A5C3L2L9	Uncharacterized protein. (99 aa)
	A0A5C3L2P5	RRM domain-containing protein. (716 aa)
	ERB1	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (759 aa)
	A0A5C3L2Z2	Uncharacterized protein. (59 aa)
	A0A5C3L3H8	S-adenosyl-L-methionine-dependent methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (470 aa)
	A0A5C3L3S1	DNA-directed DNA polymerase. (1212 aa)
	A0A5C3L3W3	ATP-dependent rRNA helicase RRP3; Belongs to the DEAD box helicase family. (461 aa)
	A0A5C3L4D0	Nop-domain-containing protein. (543 aa)
	A0A5C3L4J9	Uncharacterized protein. (355 aa)
	A0A5C3L5F3	Sas10 domain-containing protein. (641 aa)
	A0A5C3L5N3	P-loop containing nucleoside triphosphate hydrolase protein. (1237 aa)
	A0A5C3L5N9	Fcf2-domain-containing protein. (292 aa)
	A0A5C3L665	DEAD-domain-containing protein. (778 aa)
	TIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export; Belongs to the eIF-6 family. (245 aa)
	A0A5C3L724	WD40 repeat-like protein. (661 aa)
	A0A5C3L7B4	Uncharacterized protein. (664 aa)
	A0A5C3L7K3	RNA helicase. (674 aa)
	A0A5C3L7K4	Exosome complex exonuclease rrp4. (314 aa)
	A0A5C3L7N9	KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. (394 aa)
	A0A5C3L7W1	Nep1-domain-containing protein. (409 aa)
	A0A5C3L7Z7	Uncharacterized protein. (157 aa)
	A0A5C3L815	ARM repeat-containing protein. (775 aa)
	A0A5C3L819	Brix-domain-containing protein. (304 aa)
	A0A5C3L858	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (465 aa)
	A0A5C3L864	Uncharacterized protein. (281 aa)
	A0A5C3L873	Mitotic control protein dis3; Belongs to the RNR ribonuclease family. (1017 aa)
	A0A5C3L8E9	Ribosomal protein S5 domain 2-like protein. (283 aa)
	A0A5C3L8G9	DEAD-domain-containing protein; Belongs to the DEAD box helicase family. (588 aa)
	A0A5C3L8K7	WD-repeat-containing protein. (954 aa)
	A0A5C3L936	EF Tu GTP binding domain-containing protein. (420 aa)
	A0A5C3L959	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (668 aa)
	A0A5C3L970	WD repeat-containing protein 61. (324 aa)
	A0A5C3L985	WD40 repeat-like protein. (345 aa)
	A0A5C3L9S5	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (249 aa)
	A0A5C3L9T0	Uncharacterized protein. (250 aa)
	A0A5C3L9Y9	NOL1/NOP2/sun family putative RNA met; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (678 aa)
	A0A5C3L9Z4	Uncharacterized protein. (110 aa)
	A0A5C3LA51	RIX1 domain-containing protein. (719 aa)
	A0A5C3LA56	Ribosome assembly protein. (527 aa)
	A0A5C3LAL2	SnoRNA binding protein. (464 aa)
	A0A5C3LAN3	Uncharacterized protein. (370 aa)
	A0A5C3LAP1	Nucleolar complex-associated protein 3; Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm. Belongs to the CBF/MAK21 family. (801 aa)
	A0A5C3LAU6	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (126 aa)
	A0A5C3LB53	RNA helicase. (677 aa)
	A0A5C3LB96	Uncharacterized protein. (419 aa)
	A0A5C3LBD3	Utp21-domain-containing protein. (963 aa)
	A0A5C3LBI6	mRNA transport regulator 3. (260 aa)
	A0A5C3LBQ5	18S rRNA biogenesis protein. (365 aa)
	A0A5C3LBW9	S1 motif domain-containing protein. (188 aa)
	A0A5C3LBX3	Uncharacterized protein. (505 aa)
	NOP7	Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (611 aa)
	A0A5C3LC34	NUC153 domain-containing protein. (717 aa)
	A0A5C3LCA6	P-loop containing nucleoside triphosphate hydrolase protein; Belongs to the DEAD box helicase family. (560 aa)
	A0A5C3LCH9	60S ribosome subunit biogenesis protein NIP7; Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (180 aa)
	A0A5C3LCI9	Pre-mRNA-splicing factor ATP-dependent RNA helicase prp22. (1445 aa)
	A0A5C3LCN3	DUF947-domain-containing protein. (381 aa)
	A0A5C3LCP6	Glutamate-rich WD repeat containing 1. (513 aa)
	A0A5C3LCT5	DEAH box polypeptide 36. (1493 aa)
	A0A5C3LCV7	ATP-dependent RNA helicase drs1; Belongs to the DEAD box helicase family. (738 aa)
	A0A5C3LCW2	GTPase. (644 aa)
	A0A5C3LDD2	U3 snoRNP-associated protein Rrp5. (1456 aa)
	A0A5C3LDD5	U3 small nucleolar ribonucleoprotein protein MPP10; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the MPP10 family. (700 aa)
	A0A5C3LDH3	NUC189-domain-containing protein. (767 aa)
	A0A5C3LDJ6	TRASH domain-containing protein. (174 aa)
	A0A5C3LDK1	U3 small nucleolar RNA-associated protein 11. (339 aa)
	A0A5C3LDN5	P-loop containing nucleoside triphosphate hydrolase protein. (598 aa)
	A0A5C3LDP2	Ribosomal RNA processing protein. (316 aa)
	A0A5C3LE42	Translation repressor. (1241 aa)
	A0A5C3LEQ6	Uncharacterized protein. (745 aa)
	A0A5C3LF18	Ipi1_N domain-containing protein. (617 aa)
	A0A5C3LGE4	ARM repeat-containing protein. (1039 aa)
	A0A5C3LKA4	Noc2-domain-containing protein. (720 aa)
	A0A5C3LN10	Ribosome biogenesis protein BRX1. (299 aa)
	A0A5C3LNQ7	Uncharacterized protein. (230 aa)
	SPB1	AdoMet-dependent rRNA methyltransferase SPB1; Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (878 aa)
	A0A5C3LQA9	WD40 repeat-like protein. (909 aa)
	A0A5C3LQC9	U3 small nucleolar RNA-associated protein. (908 aa)

Your Current Organism:

Coprinopsis marcescibilis

NCBI taxonomy Id: 230819
Other names: C. marcescibilis, Coprinopsis marcescibilis (Britzelm.) Oerstadius & E. Larss. 2008, Psathyrella marcescibilis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A5C3KE57	A0A5C3KEC0	A0A5C3KE57	A0A5C3KEC0	U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.	Uncharacterized protein.	0.766
A0A5C3KE57	A0A5C3KEC5	A0A5C3KE57	A0A5C3KEC5	U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.	Uncharacterized protein.	0.766
A0A5C3KE57	A0A5C3KF63	A0A5C3KE57	A0A5C3KF63	U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.	Protein MAK16; Belongs to the MAK16 family.	0.642
A0A5C3KE57	A0A5C3KFB3	A0A5C3KE57	A0A5C3KFB3	U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.	Uncharacterized protein.	0.766
A0A5C3KE57	A0A5C3KFQ7	A0A5C3KE57	A0A5C3KFQ7	U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.	Uncharacterized protein.	0.766
A0A5C3KE57	A0A5C3KFX1	A0A5C3KE57	A0A5C3KFX1	U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.	Uncharacterized protein.	0.766
A0A5C3KE57	A0A5C3KGK1	A0A5C3KE57	A0A5C3KGK1	U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.	Fibrillarin-like protein.	0.498
A0A5C3KE57	A0A5C3KGL8	A0A5C3KE57	A0A5C3KGL8	U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.	Uncharacterized protein.	0.502
A0A5C3KE57	A0A5C3KGN5	A0A5C3KE57	A0A5C3KGN5	U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.	Exosome component 4.	0.702
A0A5C3KE57	A0A5C3KHC5	A0A5C3KE57	A0A5C3KHC5	U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	0.823
A0A5C3KE57	A0A5C3KJ19	A0A5C3KE57	A0A5C3KJ19	U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	0.832
A0A5C3KE57	A0A5C3KJ46	A0A5C3KE57	A0A5C3KJ46	U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.	CBF-domain-containing protein.	0.893
A0A5C3KE57	A0A5C3KJF4	A0A5C3KE57	A0A5C3KJF4	U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.	Ribosomal protein L1.	0.525
A0A5C3KE57	A0A5C3KJG3	A0A5C3KE57	A0A5C3KJG3	U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.	Exosome complex exonuclease RRP40.	0.716
A0A5C3KE57	A0A5C3KJX9	A0A5C3KE57	A0A5C3KJX9	U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.	WD40 repeat-like protein.	0.877
A0A5C3KE57	A0A5C3KJY3	A0A5C3KE57	A0A5C3KJY3	U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.	Ribosomal protein S5 domain 2-like protein.	0.777
A0A5C3KE57	A0A5C3KKL9	A0A5C3KE57	A0A5C3KKL9	U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.	Uncharacterized protein.	0.959
A0A5C3KE57	A0A5C3KKQ8	A0A5C3KE57	A0A5C3KKQ8	U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.	WD repeat-containing protein.	0.573
A0A5C3KE57	A0A5C3KL69	A0A5C3KE57	A0A5C3KL69	U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.	Transducin family protein/WD-40 repeat family protein.	0.524
A0A5C3KE57	A0A5C3KLD5	A0A5C3KE57	A0A5C3KLD5	U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.	Uncharacterized protein.	0.791