(96 nodes) Purine metabolism network (Coprinopsis marcescibilis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A5C3L7R5	Adenosine kinase. (346 aa)
	A0A5C3L7X1	Ribonucleotide reductase small subunit. (408 aa)
	A0A5C3L8K1	Pseudouridine synthase. (503 aa)
	A0A5C3L8M6	Meiotically up-regulated 71 protein. (662 aa)
	A0A5C3L987	Rab escort protein. (532 aa)
	A0A5C3L988	Phosphoribosylaminoimidazole carboxylase; In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily. (583 aa)
	A0A5C3L9G0	Adenosine deaminase-like protein. (352 aa)
	A0A5C3L9G5	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (313 aa)
	A0A5C3L9K3	Pseudouridylate synthase. (505 aa)
	A0A5C3L9T2	Nudix hydrolase domain-containing protein. (206 aa)
	A0A5C3LA86	Phosphoglucomutase; Belongs to the phosphohexose mutase family. (565 aa)
	A0A5C3LAB2	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (189 aa)
	A0A5C3LAB6	Adenylate kinase; Belongs to the adenylate kinase family. (345 aa)
	A0A5C3LAF7	Uncharacterized protein. (106 aa)
	A0A5C3LAX1	Amidophosphoribosyltransferase. (538 aa)
	A0A5C3LBJ1	Ribose-phosphate pyrophosphokinase 3. (317 aa)
	A0A5C3LBL8	Cytoplasm protein. (323 aa)
	A0A5C3LBM8	Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (748 aa)
	A0A5C3KD82	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (799 aa)
	A0A5C3LBQ2	Uncharacterized protein. (85 aa)
	A0A5C3LBS9	Guanine deaminase. (511 aa)
	A0A5C3LE81	Uncharacterized protein. (867 aa)
	A0A5C3LEG0	MFS general substrate transporter. (653 aa)
	A0A5C3LEM9	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation. (174 aa)
	A0A5C3LHC3	GMP synthase. (538 aa)
	A0A5C3LJL7	Adenine phosphoribosyltransferase. (183 aa)
	A0A5C3LQ33	Bifunctional purine ADE1. (780 aa)
	A0A5C3LBX8	DNA ATP-dependent helicase. (1639 aa)
	A0A5C3LC39	DHH phosphoesterase. (440 aa)
	A0A5C3LCN1	Pyruvate kinase; Belongs to the pyruvate kinase family. (532 aa)
	A0A5C3LCV4	5-hydroxyisourate hydrolase; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (126 aa)
	A0A5C3LCW5	Tubulin-tyrosine ligase. (438 aa)
	A0A5C3LDJ5	Uncharacterized protein. (186 aa)
	A0A5C3K9I8	SAICAR_synt domain-containing protein. (166 aa)
	A0A5C3KBQ4	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (871 aa)
	A0A5C3KC46	Ribonucleotide reductase. (199 aa)
	ADK1	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. (257 aa)
	A0A5C3LBP8	Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase. (176 aa)
	A0A5C3KD88	Uncharacterized protein. (1241 aa)
	A0A5C3KDH9	Uncharacterized protein. (65 aa)
	A0A5C3KE53	Guanylate kinase. (204 aa)
	A0A5C3KF35	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (733 aa)
	A0A5C3KG34	MFS general substrate transporter. (525 aa)
	A0A5C3KHM8	Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. (394 aa)
	A0A5C3KI07	ARM repeat-containing protein. (1021 aa)
	A0A5C3KI87	Phosphodiesterase. (655 aa)
	A0A5C3KJH5	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (555 aa)
	A0A5C3KJY5	Transcription activator snf2l1. (1106 aa)
	A0A5C3KKL0	Phosphoribosylformylglycinamidin. (1363 aa)
	MET3	Sulfate adenylyltransferase; Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids. In the N-terminal section; belongs to the sulfate adenylyltransferase family. (575 aa)
	A0A5C3KNP0	SNF2 family DNA-dependent ATPase. (900 aa)
	A0A5C3KNX5	Adenylate cyclase. (1847 aa)
	A0A5C3KPB2	Allantoinase. (460 aa)
	A0A5C3KPP9	GRIP domain-containing protein. (493 aa)
	A0A5C3KPT1	Metallo-dependent phosphatase; Belongs to the 5'-nucleotidase family. (472 aa)
	A0A5C3KPW7	Metallo-dependent phosphatase. (791 aa)
	A0A5C3KQ44	Ribose-phosphate pyrophosphokinase 2. (332 aa)
	A0A5C3KQH0	Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. (199 aa)
	A0A5C3KQK1	Metallo-dependent phosphatase; Belongs to the 5'-nucleotidase family. (699 aa)
	A0A5C3KRZ9	SAICAR synthetase. (311 aa)
	A0A5C3KSL3	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (427 aa)
	A0A5C3KSY4	HIT-like protein. (140 aa)
	A0A5C3KTP4	Nudix hydrolase domain-containing protein. (134 aa)
	A0A5C3KU46	Cytoplasmic protein. (314 aa)
	A0A5C3KU73	Metallo-dependent hydrolase. (455 aa)
	A0A5C3KUL5	DUF21-domain-containing protein. (486 aa)
	A0A5C3KUT4	ATP adenylyltransferase. (341 aa)
	A0A5C3KV73	DUF21-domain-containing protein. (527 aa)
	A0A5C3KVG4	DUF21-domain-containing protein. (643 aa)
	A0A5C3KW32	Uncharacterized protein. (527 aa)
	A0A5C3KWA4	5'-nucleotidase; Belongs to the 5'-nucleotidase family. (622 aa)
	A0A5C3KWD7	Uricase. (372 aa)
	A0A5C3KWH5	Phosphoglucomutase 1; Belongs to the phosphohexose mutase family. (594 aa)
	A0A5C3KWX3	Allantoicase. (573 aa)
	A0A5C3KX00	NDK domain-containing protein. (516 aa)
	A0A5C3KX12	Flagellar associated protein; Belongs to the 5'-nucleotidase family. (663 aa)
	A0A5C3KY77	Bifunctional purine biosynthesis protein ade10. (600 aa)
	A0A5C3KYE1	PRTase-like protein. (204 aa)
	A0A5C3KYZ7	3',5'-cyclic-nucleotide phosphodiesterase. (403 aa)
	A0A5C3L1E2	zf-4CXXC_R1 domain-containing protein. (854 aa)
	A0A5C3L1P3	Copper homeostasis protein cutC. (232 aa)
	A0A5C3L2G3	MFS general substrate transporter. (521 aa)
	A0A5C3L2M5	Nucleoside diphosphate kinase. (151 aa)
	A0A5C3L2X0	Guanosine-diphosphatase; Belongs to the GDA1/CD39 NTPase family. (565 aa)
	A0A5C3L370	Uncharacterized protein. (291 aa)
	A0A5C3L394	Calcineurin-like phosphoesterase. (464 aa)
	A0A5C3L3C0	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (484 aa)
	A0A5C3L3Q5	RNI-like protein. (1013 aa)
	A0A5C3L407	Uncharacterized protein. (119 aa)
	A0A5C3L462	MFS general substrate transporter. (514 aa)
	A0A5C3L4F8	DUF427-domain-containing protein. (98 aa)
	A0A5C3L4Y3	Ribonucleotide reductase. (341 aa)
	A0A5C3L502	Urease; In the C-terminal section; belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family. (838 aa)
	A0A5C3L6L3	Protein kinase domain-containing protein. (1319 aa)
	A0A5C3L6T3	Uncharacterized protein. (323 aa)
	A0A5C3L763	Ribonucleotide reductase small subunit. (361 aa)

Your Current Organism:

Coprinopsis marcescibilis

NCBI taxonomy Id: 230819
Other names: C. marcescibilis, Coprinopsis marcescibilis (Britzelm.) Oerstadius & E. Larss. 2008, Psathyrella marcescibilis

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A5C3K9I8	A0A5C3KJH5	A0A5C3K9I8	A0A5C3KJH5	SAICAR_synt domain-containing protein.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	0.552
A0A5C3K9I8	A0A5C3KKL0	A0A5C3K9I8	A0A5C3KKL0	SAICAR_synt domain-containing protein.	Phosphoribosylformylglycinamidin.	0.952
A0A5C3K9I8	A0A5C3KSL3	A0A5C3K9I8	A0A5C3KSL3	SAICAR_synt domain-containing protein.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	0.823
A0A5C3K9I8	A0A5C3KY77	A0A5C3K9I8	A0A5C3KY77	SAICAR_synt domain-containing protein.	Bifunctional purine biosynthesis protein ade10.	0.883
A0A5C3K9I8	A0A5C3L3C0	A0A5C3K9I8	A0A5C3L3C0	SAICAR_synt domain-containing protein.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.980
A0A5C3K9I8	A0A5C3L6L3	A0A5C3K9I8	A0A5C3L6L3	SAICAR_synt domain-containing protein.	Protein kinase domain-containing protein.	0.957
A0A5C3K9I8	A0A5C3L988	A0A5C3K9I8	A0A5C3L988	SAICAR_synt domain-containing protein.	Phosphoribosylaminoimidazole carboxylase; In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.	0.966
A0A5C3K9I8	A0A5C3LAX1	A0A5C3K9I8	A0A5C3LAX1	SAICAR_synt domain-containing protein.	Amidophosphoribosyltransferase.	0.953
A0A5C3K9I8	A0A5C3LHC3	A0A5C3K9I8	A0A5C3LHC3	SAICAR_synt domain-containing protein.	GMP synthase.	0.583
A0A5C3K9I8	A0A5C3LJL7	A0A5C3K9I8	A0A5C3LJL7	SAICAR_synt domain-containing protein.	Adenine phosphoribosyltransferase.	0.489
A0A5C3K9I8	A0A5C3LQ33	A0A5C3K9I8	A0A5C3LQ33	SAICAR_synt domain-containing protein.	Bifunctional purine ADE1.	0.970
A0A5C3KBQ4	A0A5C3KC46	A0A5C3KBQ4	A0A5C3KC46	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Ribonucleotide reductase.	0.976
A0A5C3KBQ4	A0A5C3KE53	A0A5C3KBQ4	A0A5C3KE53	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Guanylate kinase.	0.828
A0A5C3KBQ4	A0A5C3KHM8	A0A5C3KBQ4	A0A5C3KHM8	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.	0.616
A0A5C3KBQ4	A0A5C3KJY5	A0A5C3KBQ4	A0A5C3KJY5	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Transcription activator snf2l1.	0.610
A0A5C3KBQ4	A0A5C3KNP0	A0A5C3KBQ4	A0A5C3KNP0	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	SNF2 family DNA-dependent ATPase.	0.638
A0A5C3KBQ4	A0A5C3KPP9	A0A5C3KBQ4	A0A5C3KPP9	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	GRIP domain-containing protein.	0.674
A0A5C3KBQ4	A0A5C3KX00	A0A5C3KBQ4	A0A5C3KX00	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	NDK domain-containing protein.	0.679
A0A5C3KBQ4	A0A5C3L2M5	A0A5C3KBQ4	A0A5C3L2M5	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Nucleoside diphosphate kinase.	0.828
A0A5C3KBQ4	A0A5C3L3C0	A0A5C3KBQ4	A0A5C3L3C0	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.471