(63 nodes) Pyrimidine metabolism network (Coprinopsis marcescibilis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	A0A5C3KBK0	Translation initiation inhibitor. (136 aa)
	A0A5C3KBQ4	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (871 aa)
	A0A5C3KC46	Ribonucleotide reductase. (199 aa)
	A0A5C3KF35	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (733 aa)
	A0A5C3KG34	MFS general substrate transporter. (525 aa)
	A0A5C3KHM8	Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. (394 aa)
	A0A5C3KKB4	Carbamoyl-phosphate synthase subunit arginine-specific large. (1162 aa)
	A0A5C3KKE2	Uncharacterized protein. (469 aa)
	A0A5C3KNP6	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (159 aa)
	A0A5C3KNX8	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (612 aa)
	A0A5C3KNZ1	Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] (396 aa)
	A0A5C3KPF3	Orotate phosphoribosyltransferase. (226 aa)
	A0A5C3KPT1	Metallo-dependent phosphatase; Belongs to the 5'-nucleotidase family. (472 aa)
	A0A5C3KPW7	Metallo-dependent phosphatase. (791 aa)
	A0A5C3KQK1	Metallo-dependent phosphatase; Belongs to the 5'-nucleotidase family. (699 aa)
	A0A5C3KRG9	F-box domain-containing protein. (676 aa)
	A0A5C3KTP4	Nudix hydrolase domain-containing protein. (134 aa)
	A0A5C3KUJ1	Armadillo/beta-catenin/plakoglobin. (241 aa)
	A0A5C3KVY3	Hsp10-like protein; Belongs to the GroES chaperonin family. (107 aa)
	A0A5C3KWA4	5'-nucleotidase; Belongs to the 5'-nucleotidase family. (622 aa)
	A0A5C3KWI0	Uridine phosphorylase. (328 aa)
	A0A5C3KWS5	HD domain-containing protein. (211 aa)
	A0A5C3KX00	NDK domain-containing protein. (516 aa)
	A0A5C3KX12	Flagellar associated protein; Belongs to the 5'-nucleotidase family. (663 aa)
	A0A5C3KY84	Uncharacterized protein. (452 aa)
	A0A5C3KZ03	Got1-domain-containing protein. (138 aa)
	A0A5C3KZ83	Thymidylate_kin domain-containing protein. (256 aa)
	A0A5C3KZ99	Nucleoside hydrolase. (430 aa)
	A0A5C3KZA0	Uridine nucleosidase. (361 aa)
	A0A5C3L0Z7	Uridylate kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (212 aa)
	A0A5C3L1D6	ARM repeat-containing protein. (1051 aa)
	A0A5C3L2G3	MFS general substrate transporter. (521 aa)
	A0A5C3L2M5	Nucleoside diphosphate kinase. (151 aa)
	A0A5C3L2Q0	dUTP pyrophosphatase. (178 aa)
	A0A5C3L2X0	Guanosine-diphosphatase; Belongs to the GDA1/CD39 NTPase family. (565 aa)
	A0A5C3L3Q5	RNI-like protein. (1013 aa)
	A0A5C3L3T0	Aspartate carbamoyltransferase. (2230 aa)
	A0A5C3L462	MFS general substrate transporter. (514 aa)
	A0A5C3L4Q0	Thymidylate synthase. (311 aa)
	A0A5C3L4Y3	Ribonucleotide reductase. (341 aa)
	A0A5C3L6S4	Carbamoyl-phosphate synthase. (438 aa)
	A0A5C3L763	Ribonucleotide reductase small subunit. (361 aa)
	A0A5C3L7X1	Ribonucleotide reductase small subunit. (408 aa)
	A0A5C3L9G5	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (313 aa)
	A0A5C3L9N2	UDP-N-acetylglucosamine 1-carboxyvinyltransferase. (220 aa)
	A0A5C3LAF7	Uncharacterized protein. (106 aa)
	A0A5C3LB69	Uncharacterized protein. (293 aa)
	A0A5C3LBC0	Short-chain dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (270 aa)
	A0A5C3LBF6	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (500 aa)
	A0A5C3LBL8	Cytoplasm protein. (323 aa)
	A0A5C3LBM8	Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (748 aa)
	FA15DRAFT_6045	Endoribonuclease L-PSP. (128 aa)
	A0A5C3LCW5	Tubulin-tyrosine ligase. (438 aa)
	A0A5C3LCY7	Indigoidine synthase A family protein. (826 aa)
	A0A5C3LCZ0	CMP/dCMP-type deaminase domain-containing protein. (310 aa)
	A0A5C3LDW9	DUF887-domain-containing protein. (283 aa)
	A0A5C3LE63	Endoribonuclease L-PSP. (127 aa)
	A0A5C3LE81	Uncharacterized protein. (867 aa)
	A0A5C3LEG0	MFS general substrate transporter. (653 aa)
	A0A5C3LEW5	FMN-linked oxidoreductase. (324 aa)
	A0A5C3LEW9	Dihydroorotase. (348 aa)
	A0A5C3LF71	Uridine/cytidine kinase. (535 aa)
	A0A5C3LL77	Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (279 aa)

Your Current Organism:

Coprinopsis marcescibilis

NCBI taxonomy Id: 230819
Other names: C. marcescibilis, Coprinopsis marcescibilis (Britzelm.) Oerstadius & E. Larss. 2008, Psathyrella marcescibilis

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A5C3KBQ4	A0A5C3KC46	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Ribonucleotide reductase.	0.976
A0A5C3KBQ4	A0A5C3KHM8	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.	0.616
A0A5C3KBQ4	A0A5C3KNX8	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	0.759
A0A5C3KBQ4	A0A5C3KUJ1	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Armadillo/beta-catenin/plakoglobin.	0.561
A0A5C3KBQ4	A0A5C3KX00	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	NDK domain-containing protein.	0.679
A0A5C3KBQ4	A0A5C3KZ83	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Thymidylate_kin domain-containing protein.	0.890
A0A5C3KBQ4	A0A5C3L0Z7	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Uridylate kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	0.825
A0A5C3KBQ4	A0A5C3L2M5	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Nucleoside diphosphate kinase.	0.828
A0A5C3KBQ4	A0A5C3L2Q0	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	dUTP pyrophosphatase.	0.919
A0A5C3KBQ4	A0A5C3L4Q0	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Thymidylate synthase.	0.804
A0A5C3KBQ4	A0A5C3L4Y3	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Ribonucleotide reductase.	0.977
A0A5C3KBQ4	A0A5C3L763	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Ribonucleotide reductase small subunit.	0.976
A0A5C3KBQ4	A0A5C3L7X1	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Ribonucleotide reductase small subunit.	0.976
A0A5C3KBQ4	A0A5C3L9N2	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	UDP-N-acetylglucosamine 1-carboxyvinyltransferase.	0.561
A0A5C3KBQ4	A0A5C3LAF7	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Uncharacterized protein.	0.616
A0A5C3KBQ4	A0A5C3LBM8	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family.	0.790
A0A5C3KBQ4	A0A5C3LE81	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Uncharacterized protein.	0.492
A0A5C3KBQ4	A0A5C3LF71	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Uridine/cytidine kinase.	0.561
A0A5C3KC46	A0A5C3KBQ4	Ribonucleotide reductase.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.976
A0A5C3KC46	A0A5C3KF35	Ribonucleotide reductase.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.976