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dapF dapF asnA asnA mtn mtn glmS glmS pdxT pdxT guaA guaA aspC aspC dapB dapB argA argA serC serC lysC lysC sucB sucB argG argG serS serS folA folA folD folD dapA dapA argH argH cysK cysK argD argD argB argB argC argC pheA pheA asd asd cysZ cysZ glnA glnA dtd dtd metJ metJ cysE cysE dapE dapE dapD dapD alr alr selD selD argE argE aspA aspA HD_0464 HD_0464 pyrG pyrG ansB ansB argR argR carA carA carB carB arcB1 arcB1 lysA lysA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
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dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (274 aa)
asnAAsparagine synthetase A; Aspartate--ammonia ligase. (330 aa)
mtnMTA/SAH nucleosidase (P46); Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (232 aa)
glmSGlucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (610 aa)
pdxTPutative 2-deoxy-scyllo-inosose synthase subunit; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (189 aa)
guaAGMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. (523 aa)
aspCAspartate aminotransferase; Transaminase A; ASPAT. (396 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (269 aa)
argAAmino-acid acetyltransferase; N-acetylglutamate synthetase; Belongs to the acetyltransferase family. ArgA subfamily. (437 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa)
lysCLysine-sensitive aspartokinase III; Belongs to the aspartokinase family. (451 aa)
sucBDihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (403 aa)
argGArgininosuccinate synthetase; Citrulline--aspartate ligase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (443 aa)
serSseryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (435 aa)
folADihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (161 aa)
folDMethylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (287 aa)
dapADihydrodipicolinate synthase (DHDPS); Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (297 aa)
argHArgininosuccinate lyase. (458 aa)
cysKCysteine synthase; O-acetylserine sulfhydrylase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (316 aa)
argDAcetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (394 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (284 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase. (314 aa)
pheAP-protein; Includes: chorismate mutase; prephenate dehydratase. (387 aa)
asdAspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (372 aa)
cysZCysteine synthetase; High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway; Belongs to the CysZ family. (295 aa)
glnAGlutamine synthetase; Glutamate--ammonia ligase. (476 aa)
dtdD-tyrosyl-tRNA (Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (148 aa)
metJMet repressor; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. (105 aa)
cysESerine acetyltransferase. (271 aa)
dapESuccinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (376 aa)
dapD2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (274 aa)
alrAlanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (374 aa)
selDSelenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. (323 aa)
argEAcetylornithine deacetylase. (340 aa)
aspAAspartate ammonia-lyase. (475 aa)
HD_0464Putative aminotransferase. (400 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa)
ansBL-asparaginase II; Belongs to the asparaginase 1 family. (349 aa)
argRArginine repressor; Regulates arginine biosynthesis genes. (153 aa)
carACarbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (389 aa)
carBCarbamoyl-phosphate synthase, large subunit. (1075 aa)
arcB1Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (334 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (417 aa)
Your Current Organism:
Haemophilus ducreyi
NCBI taxonomy Id: 233412
Other names: Haemophilus ducreyi 35000HP, Haemophilus ducreyi str. 35000HP, [. ducreyi 35000HP, [Haemophilus] ducreyi 35000HP
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