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| | purD | KEGG: mta:Moth_2043 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp; protein of unknown function DUF201; Belongs to the GARS family. (402 aa) |
| | Acid_0052 | KEGG: mja:MJ0571 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (490 aa) |
| | Acid_0058 | Aminotransferase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase, class I and II; KEGG: dps:DP2938 probable aspartate aminotransferase. (402 aa) |
| | Acid_0128 | KEGG: tte:TTE2394 hypoxanthine-guanine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (189 aa) |
| | Acid_0253 | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: bja:bll5948 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. (368 aa) |
| | Acid_0272 | KEGG: tbd:Tbd_0292 asparagine synthase, glutamine-hydrolyzing; TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase, class-II; asparagine synthase. (644 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (147 aa) |
| | Acid_0526 | PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase, NAD-binding; KEGG: mca:MCA0597 homoserine dehydrogenase. (450 aa) |
| | Acid_0546 | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: aba:Acid345_4034 threonine synthase. (407 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (347 aa) |
| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (257 aa) |
| | Acid_0725 | N-acetylglutamate synthase; PFAM: GCN5-related N-acetyltransferase; KEGG: sth:STH2891 GNAT family acetyltransferase; Belongs to the acetyltransferase family. (201 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (176 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (304 aa) |
| | Acid_0987 | Anthranilate synthase, component II / anthranilate synthase, component I; TIGRFAM: glutamine amidotransferase of anthranilate synthase; anthranilate synthase; PFAM: glutamine amidotransferase class-I; Anthranilate synthase component I and chorismate binding protein; Anthranilate synthase component I domain protein; KEGG: ava:Ava_4890 glutamine amidotransferase of anthranilate synthase. (723 aa) |
| | Acid_1065 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA; KEGG: aba:Acid345_3110 phospho-2-dehydro-3-deoxyheptonate aldolase. (345 aa) |
| | katG | Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (743 aa) |
| | Acid_1182 | PFAM: Pyridoxal-dependent decarboxylase; KEGG: tyrosine decarboxylase, putative. (470 aa) |
| | Acid_1183 | PFAM: Pyrrolo-quinoline quinone; KEGG: gcd-1; glucose dehydrogenase. (706 aa) |
| | Acid_1294 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase; PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: cac:CAC1963 5'-nucleotidase/2',3'-cyclic phosphodiesterase related enzyme; Belongs to the 5'-nucleotidase family. (524 aa) |
| | Acid_1323 | KEGG: bur:Bcep18194_B2301 hypothetical protein. (200 aa) |
| | Acid_1432 | TIGRFAM: methionine biosynthesis protein MetW; PFAM: Methionine biosynthesis MetW; Methyltransferase type 11; Methyltransferase type 12; KEGG: mag:amb3971 SAM-dependent methyltransferase. (194 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (368 aa) |
| | Acid_1434 | Hypothetical protein. (217 aa) |
| | Acid_1559 | L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (435 aa) |
| | Acid_1665 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (944 aa) |
| | Acid_1719 | PFAM: Semialdehyde dehydrogenase, dimerisation region; KEGG: aba:Acid345_2358 semialdehyde dehydrogenase. (337 aa) |
| | Acid_1729 | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: pae:PA0851 hypothetical protein. (319 aa) |
| | Acid_1869 | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: fnu:FN1055 cysteine synthase. (356 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (434 aa) |
| | Acid_2030 | PFAM: aminotransferase, class I and II; KEGG: ccr:CC1071 histidinol-phosphate aminotransferase, putative. (372 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (412 aa) |
| | Acid_2224 | TIGRFAM: acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: sru:SRU_2799 acetylornithine deacetylase. (383 aa) |
| | Acid_2258 | PFAM: dihydrodipicolinate synthetase; KEGG: rba:RB4605 dihydrodipicolinate synthase. (337 aa) |
| | Acid_2317 | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: dsy:DSY4244 hypothetical protein. (313 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (204 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase, small chain; KEGG: aba:Acid345_2194 carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (375 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: phosphoribosylglycinamide synthetase; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain, oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; KEGG: aba:Acid345_2197 carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family. (1070 aa) |
| | Acid_2438 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: aba:Acid345_2952 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (437 aa) |
| | Acid_2446 | PFAM: dihydrodipicolinate synthetase; KEGG: jan:Jann_4114 dihydrodipicolinate synthetase. (320 aa) |
| | Acid_2501 | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: tdcB; pyridoxal-phosphate dependent enzyme. (305 aa) |
| | argR | Transcriptional regulator, ArgR family; Regulates arginine biosynthesis genes. (145 aa) |
| | argH | Argininosuccinate lyase; KEGG: dsy:DSY0786 hypothetical protein; TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase. (460 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (325 aa) |
| | Acid_2599 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: mag:amb2697 deoxycytidylate deaminase. (133 aa) |
| | Acid_2632 | PFAM: metallophosphoesterase; KEGG: sat:SYN_02264 UDP-sugar diphosphatase / 5'-nucleotidase; Belongs to the 5'-nucleotidase family. (439 aa) |
| | Acid_2676 | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: sso:SSO0407 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase. (399 aa) |
| | Acid_2719 | TIGRFAM: acetylornithine and succinylornithine aminotransferases; PFAM: aminotransferase class-III; KEGG: aba:Acid345_0626 acetylornithine and succinylornithine aminotransferases. (406 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (389 aa) |
| | argJ | N-acetylglutamate synthase / glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (392 aa) |
| | Acid_2800 | Arginase; TIGRFAM: arginase; PFAM: Arginase/agmatinase/formiminoglutamase; KEGG: aba:Acid345_4596 arginase; Belongs to the arginase family. (304 aa) |
| | Acid_3092 | PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding, N-terminal domain protein; KEGG: rso:RSp1398 shikimate 5-dehydrogenase; Belongs to the shikimate dehydrogenase family. (286 aa) |
| | Acid_3182 | PFAM: phosphoribulokinase/uridine kinase; KEGG: aba:Acid345_3054 uridine kinase; Belongs to the uridine kinase family. (207 aa) |
| | tdk | PFAM: thymidine kinase; KEGG: bba:Bd3420 thymidine kinase. (205 aa) |
| | cysS | KEGG: aba:Acid345_3992 cysteinyl-tRNA synthetase; TIGRFAM: cysteinyl-tRNA synthetase; PFAM: cysteinyl-tRNA synthetase, class Ia; Belongs to the class-I aminoacyl-tRNA synthetase family. (466 aa) |
| | Acid_3250 | Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: tte:TTE1574 cystathionine gamma-synthase. (391 aa) |
| | Acid_3332 | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: sso:SSO0407 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase. (336 aa) |
| | Acid_3339 | PFAM: aminotransferase, class I and II; KEGG: aba:Acid345_3031 aminotransferase class I and II. (381 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (340 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (285 aa) |
| | Acid_3645 | PFAM: dihydrodipicolinate synthetase; KEGG: rsp:RSP_3456 putative dihydrodipicolinate synthase; Belongs to the DapA family. (300 aa) |
| | Acid_3849 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis; KEGG: aba:Acid345_3688 histidine biosynthesis. (227 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (254 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (186 aa) |
| | hisB | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: aba:Acid345_3685 imidazoleglycerol-phosphate dehydratase. (195 aa) |
| | Acid_3853 | TIGRFAM: HAD superfamily (subfamily IA) hydrolase, TIGR01548; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: sru:SRU_2236 HAD superfamily (subfamily IA) hydrolase, TIGR01548. (220 aa) |
| | hisC | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class V; aminotransferase, class I and II; KEGG: aba:Acid345_3684 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (357 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (423 aa) |
| | hisG | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (289 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (126 aa) |
| | Acid_3866 | PFAM: Asp/Glu racemase; KEGG: rso:RSc0212 putative aspartate racemase protein. (222 aa) |
| | Acid_3878 | KEGG: tte:TTE2316 serine acetyltransferase; TIGRFAM: serine O-acetyltransferase; PFAM: transferase hexapeptide repeat containing protein. (218 aa) |
| | Acid_3954 | PFAM: aminotransferase, class I and II; KEGG: aba:Acid345_3031 aminotransferase class I and II. (388 aa) |
| | tmk | Thymidylate kinase / thymidylate synthase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (259 aa) |
| | Acid_4098 | Phenylalanine 4-hydroxylase; PFAM: aromatic amino acid hydroxylase; KEGG: bur:Bcep18194_A3259 phenylalanine-4-hydroxylase, monomeric form. (306 aa) |
| | Acid_4105 | Asparagine synthase (glutamine-hydrolyzing); KEGG: dvu:DVU3014 asparagine synthetase, glutamine-hydrolyzing; TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase, class-II; asparagine synthase. (639 aa) |
| | hisC-2 | Aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: pfo:Pfl_4075 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (370 aa) |
| | Acid_4167 | KEGG: sru:SRU_1370 4-hydroxyphenylpyruvate dioxygenase; TIGRFAM: 4-hydroxyphenylpyruvate dioxygenase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase. (375 aa) |
| | Acid_4184 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1185 aa) |
| | pyrD | Dihydroorotate oxidase B, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (304 aa) |
| | argG | PFAM: argininosuccinate synthase; KEGG: pol:Bpro_1599 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (453 aa) |
| | Acid_4459 | PFAM: aminotransferase, class I and II; KEGG: ccr:CC1071 histidinol-phosphate aminotransferase, putative. (383 aa) |
| | Acid_4482 | KEGG: bur:Bcep18194_B2301 hypothetical protein. (184 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (268 aa) |
| | Acid_4622 | Homoserine O-acetyltransferase; PFAM: alpha/beta hydrolase fold; KEGG: bxe:Bxe_B0598 homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. (358 aa) |
| | Acid_4624 | KEGG: eba:ebA4265 amidotransferase, similar to asparagine synthase (glutamine-hydrolyzing); TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase, class-II; asparagine synthase. (631 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (234 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (306 aa) |
| | Acid_4806 | PFAM: glutaredoxin 2; KEGG: cte:CT0237 hypothetical protein. (81 aa) |
| | Acid_4974 | L-serine ammonia-lyase; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; KEGG: gvi:glr2358 L-serine dehydratase. (543 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (197 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (156 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (381 aa) |
| | Acid_5081 | PFAM: tyrosinase. (340 aa) |
| | Acid_5231 | TIGRFAM: pyrimidine-nucleoside phosphorylase; PFAM: glycosyl transferase, family 3; Pyrimidine nucleoside phosphorylase, C-terminal domain; KEGG: ade:Adeh_0617 glycosyl transferase, family 3. (434 aa) |
| | Acid_5232 | PFAM: Na+ dependent nucleoside transporter; nucleoside recognition domain protein; Na+ dependent nucleoside transporter domain protein; KEGG: aba:Acid345_3056 Na+ dependent nucleoside transporter; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. (407 aa) |
| | Acid_5233 | Inosine guanosine and xanthosine phosphorylase family; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (269 aa) |
| | Acid_5234 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (131 aa) |
| | Acid_5239 | PFAM: transcriptional coactivator/pterin dehydratase; KEGG: cyb:CYB_2873 putative pterin-4A-carbinolamine dehydratase. (95 aa) |
| | purC | KEGG: aba:Acid345_2258 phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (311 aa) |
| | ahcY | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (475 aa) |
| | metK | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (389 aa) |
| | Acid_5467 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; PFAM: DAHP synthetase, class II; KEGG: xcb:XC_3313 family II 2-keto-3-deoxy-D-arabino-heptulosonate 7-phosphate synthase. (471 aa) |
| | Acid_5487 | KEGG: tte:TTE2151 O-acetylhomoserine (thiol)-lyase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; DegT/DnrJ/EryC1/StrS aminotransferase; aromatic amino acid beta-eliminating lyase/threonine aldolase. (437 aa) |
| | pyrR | Uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. (187 aa) |
| | pyrB | KEGG: pca:Pcar_1615 aspartate carbamoyltransferase; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (302 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (430 aa) |
| | Acid_5610 | KEGG: ilo:IL1526 asparagine synthase (glutamine-hydrolyzing); TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase, class-II; asparagine synthase. (632 aa) |
| | Acid_5643 | Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; KEGG: aba:Acid345_1913 cystathionine gamma-synthase. (374 aa) |
| | Acid_5665 | KEGG: lsa:LSA1598 hypoxanthine phosphoribosyltranferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (177 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (452 aa) |
| | arcA | Arginine deiminase; KEGG: bja:bll7310 probable ArcA2 arginine deiminase; TIGRFAM: arginine deiminase; PFAM: amidinotransferase. (431 aa) |
| | Acid_5877 | PFAM: alpha/beta hydrolase fold; KEGG: aba:Acid345_2278 alpha/beta hydrolase. (355 aa) |
| | Acid_5884 | KEGG: eba:ebA4678 cysteine synthase A; TIGRFAM: cysteine synthases; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; Belongs to the cysteine synthase/cystathionine beta- synthase family. (319 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (232 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (742 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (472 aa) |
| | Acid_6097 | KEGG: bur:Bcep18194_B2301 hypothetical protein. (202 aa) |
| | purA-2 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (535 aa) |
| | Acid_6369 | Tryptophanase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: aba:Acid345_3931 tryptophanase. (448 aa) |
| | nadA | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (309 aa) |
| | purH | KEGG: aba:Acid345_4470 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme, formylation region. (509 aa) |
| | Acid_6467 | TIGRFAM: GMP synthase, small subunit; PFAM: glutamine amidotransferase class-I; GMP synthase domain protein; KEGG: lic:LIC11831 guanine monophosphate synthase. (578 aa) |
| | Acid_6516 | Fumarylacetoacetate hydrolase; KEGG: aba:Acid345_2007 fumarylacetoacetase; TIGRFAM: fumarylacetoacetase; PFAM: fumarylacetoacetate (FAA) hydrolase. (402 aa) |
| | Acid_6517 | KEGG: aba:Acid345_2006 hypothetical protein. (262 aa) |
| | hmgA | Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate. (426 aa) |
| | Acid_6566 | PFAM: aspartate--ammonia ligase; KEGG: aba:Acid345_0576 aspartate--ammonia ligase. (376 aa) |
| | Acid_6659 | PFAM: PfkB domain protein; KEGG: atc:AGR_C_3442 hypothetical protein. (299 aa) |
| | psuG | Indigoidine synthase A family protein; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family. (299 aa) |
| | Acid_6665 | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: bja:bll1413 threonine dehydratase. (313 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (499 aa) |
| | purM | KEGG: aba:Acid345_3011 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein. (357 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (199 aa) |
| | Acid_6745 | Asparaginase; KEGG: ade:Adeh_2142 asparaginase. (164 aa) |
| | Acid_6978 | PFAM: response regulator receiver; KEGG: sru:SRU_2062 sensory box sensor histidine kianse/response regulator. (124 aa) |
| | Acid_6979 | KEGG: aba:Acid345_2087 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (276 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (296 aa) |
| | Acid_6981 | PFAM: dihydrodipicolinate reductase; KEGG: aba:Acid345_2492 dihydrodipicolinate reductase; Belongs to the DapB family. (229 aa) |
| | Acid_6982 | KEGG: aba:Acid345_2491 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (463 aa) |
| | Acid_6983 | KEGG: aba:Acid345_2490 aspartate-semialdehyde dehydrogenase; TIGRFAM: aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase, NAD - binding; Semialdehyde dehydrogenase, dimerisation region; Belongs to the aspartate-semialdehyde dehydrogenase family. (349 aa) |
| | Acid_6984 | PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: aba:Acid345_1040 peptidase dimerisation. (339 aa) |
| | Acid_6995 | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (338 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa) |
| | Acid_7030 | PFAM: homoserine dehydrogenase; homoserine dehydrogenase, NAD-binding; KEGG: ade:Adeh_3931 homoserine dehydrogenase. (323 aa) |
| | Acid_7054 | PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; KEGG: aba:Acid345_2043 prephenate dehydratase. (284 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (173 aa) |
| | Acid_7115 | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: aba:Acid345_3426 homocysteine S-methyltransferase. (622 aa) |
| | aroD | Shikimate dehydrogenase / 3-dehydroquinate dehydratase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA); Belongs to the type-I 3-dehydroquinase family. (509 aa) |
| | Acid_7181 | PFAM: dihydrodipicolinate synthetase; KEGG: bcl:ABC0222 dihydrodipicolinate synthase; Belongs to the DapA family. (310 aa) |
| | Acid_7274 | PFAM: aminotransferase, class I and II; KEGG: aba:Acid345_0568 aminotransferase, class I and II. (397 aa) |
| | pyrE-2 | Phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (204 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (81 aa) |
| | tmk-2 | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (224 aa) |
| | Acid_7332 | KEGG: ava:Ava_4057 hypothetical protein. (618 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (426 aa) |
| | Acid_7334 | KEGG: aba:Acid345_0045 adenosine deaminase; TIGRFAM: adenosine deaminase; PFAM: adenosine/AMP deaminase. (307 aa) |
| | Acid_7341 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (500 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (357 aa) |
| | Acid_7506 | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: sco:SCO0821 putative threonine dehydratase. (339 aa) |
| | Acid_7560 | KEGG: gme:Gmet_1988 nicotinate-nucleotide pyrophosphorylase; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. (270 aa) |
| | speA | Arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. (637 aa) |
| | Acid_7884 | PFAM: Prephenate dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding; KEGG: aba:Acid345_1162 prephenate dehydrogenase. (281 aa) |
| | Acid_7885 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; KEGG: tte:TTE1013 phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA. (337 aa) |
| | Acid_7886 | PFAM: Chorismate mutase; KEGG: gme:Gmet_1955 chorismate mutase. (100 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (267 aa) |
| | trpB-2 | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (398 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: tbd:Tbd_1915 N-(5'phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (199 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; KEGG: aba:Acid345_1156 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (262 aa) |
