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| | Acid_0052 | KEGG: mja:MJ0571 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (490 aa) |
| | Acid_0058 | Aminotransferase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase, class I and II; KEGG: dps:DP2938 probable aspartate aminotransferase. (402 aa) |
| | Acid_0253 | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: bja:bll5948 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. (368 aa) |
| | Acid_0526 | PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase, NAD-binding; KEGG: mca:MCA0597 homoserine dehydrogenase. (450 aa) |
| | Acid_0546 | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: aba:Acid345_4034 threonine synthase. (407 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (347 aa) |
| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (257 aa) |
| | Acid_0725 | N-acetylglutamate synthase; PFAM: GCN5-related N-acetyltransferase; KEGG: sth:STH2891 GNAT family acetyltransferase; Belongs to the acetyltransferase family. (201 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (176 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (304 aa) |
| | Acid_0987 | Anthranilate synthase, component II / anthranilate synthase, component I; TIGRFAM: glutamine amidotransferase of anthranilate synthase; anthranilate synthase; PFAM: glutamine amidotransferase class-I; Anthranilate synthase component I and chorismate binding protein; Anthranilate synthase component I domain protein; KEGG: ava:Ava_4890 glutamine amidotransferase of anthranilate synthase. (723 aa) |
| | Acid_1065 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA; KEGG: aba:Acid345_3110 phospho-2-dehydro-3-deoxyheptonate aldolase. (345 aa) |
| | katG | Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (743 aa) |
| | Acid_1182 | PFAM: Pyridoxal-dependent decarboxylase; KEGG: tyrosine decarboxylase, putative. (470 aa) |
| | Acid_1183 | PFAM: Pyrrolo-quinoline quinone; KEGG: gcd-1; glucose dehydrogenase. (706 aa) |
| | Acid_1323 | KEGG: bur:Bcep18194_B2301 hypothetical protein. (200 aa) |
| | Acid_1432 | TIGRFAM: methionine biosynthesis protein MetW; PFAM: Methionine biosynthesis MetW; Methyltransferase type 11; Methyltransferase type 12; KEGG: mag:amb3971 SAM-dependent methyltransferase. (194 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (368 aa) |
| | Acid_1434 | Hypothetical protein. (217 aa) |
| | Acid_1559 | L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (435 aa) |
| | Acid_1719 | PFAM: Semialdehyde dehydrogenase, dimerisation region; KEGG: aba:Acid345_2358 semialdehyde dehydrogenase. (337 aa) |
| | Acid_1729 | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: pae:PA0851 hypothetical protein. (319 aa) |
| | Acid_1869 | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: fnu:FN1055 cysteine synthase. (356 aa) |
| | Acid_2030 | PFAM: aminotransferase, class I and II; KEGG: ccr:CC1071 histidinol-phosphate aminotransferase, putative. (372 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (412 aa) |
| | Acid_2224 | TIGRFAM: acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: sru:SRU_2799 acetylornithine deacetylase. (383 aa) |
| | Acid_2258 | PFAM: dihydrodipicolinate synthetase; KEGG: rba:RB4605 dihydrodipicolinate synthase. (337 aa) |
| | Acid_2317 | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: dsy:DSY4244 hypothetical protein. (313 aa) |
| | Acid_2446 | PFAM: dihydrodipicolinate synthetase; KEGG: jan:Jann_4114 dihydrodipicolinate synthetase. (320 aa) |
| | Acid_2501 | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: tdcB; pyridoxal-phosphate dependent enzyme. (305 aa) |
| | argR | Transcriptional regulator, ArgR family; Regulates arginine biosynthesis genes. (145 aa) |
| | argH | Argininosuccinate lyase; KEGG: dsy:DSY0786 hypothetical protein; TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase. (460 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (325 aa) |
| | Acid_2676 | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: sso:SSO0407 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase. (399 aa) |
| | Acid_2719 | TIGRFAM: acetylornithine and succinylornithine aminotransferases; PFAM: aminotransferase class-III; KEGG: aba:Acid345_0626 acetylornithine and succinylornithine aminotransferases. (406 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (389 aa) |
| | argJ | N-acetylglutamate synthase / glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (392 aa) |
| | Acid_2800 | Arginase; TIGRFAM: arginase; PFAM: Arginase/agmatinase/formiminoglutamase; KEGG: aba:Acid345_4596 arginase; Belongs to the arginase family. (304 aa) |
| | Acid_3092 | PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding, N-terminal domain protein; KEGG: rso:RSp1398 shikimate 5-dehydrogenase; Belongs to the shikimate dehydrogenase family. (286 aa) |
| | cysS | KEGG: aba:Acid345_3992 cysteinyl-tRNA synthetase; TIGRFAM: cysteinyl-tRNA synthetase; PFAM: cysteinyl-tRNA synthetase, class Ia; Belongs to the class-I aminoacyl-tRNA synthetase family. (466 aa) |
| | Acid_3250 | Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: tte:TTE1574 cystathionine gamma-synthase. (391 aa) |
| | Acid_3332 | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: sso:SSO0407 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase. (336 aa) |
| | Acid_3339 | PFAM: aminotransferase, class I and II; KEGG: aba:Acid345_3031 aminotransferase class I and II. (381 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (340 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (285 aa) |
| | Acid_3645 | PFAM: dihydrodipicolinate synthetase; KEGG: rsp:RSP_3456 putative dihydrodipicolinate synthase; Belongs to the DapA family. (300 aa) |
| | Acid_3849 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis; KEGG: aba:Acid345_3688 histidine biosynthesis. (227 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (254 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (186 aa) |
| | hisB | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: aba:Acid345_3685 imidazoleglycerol-phosphate dehydratase. (195 aa) |
| | Acid_3853 | TIGRFAM: HAD superfamily (subfamily IA) hydrolase, TIGR01548; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: sru:SRU_2236 HAD superfamily (subfamily IA) hydrolase, TIGR01548. (220 aa) |
| | hisC | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class V; aminotransferase, class I and II; KEGG: aba:Acid345_3684 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (357 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (423 aa) |
| | hisG | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (289 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (126 aa) |
| | Acid_3878 | KEGG: tte:TTE2316 serine acetyltransferase; TIGRFAM: serine O-acetyltransferase; PFAM: transferase hexapeptide repeat containing protein. (218 aa) |
| | Acid_3954 | PFAM: aminotransferase, class I and II; KEGG: aba:Acid345_3031 aminotransferase class I and II. (388 aa) |
| | Acid_4098 | Phenylalanine 4-hydroxylase; PFAM: aromatic amino acid hydroxylase; KEGG: bur:Bcep18194_A3259 phenylalanine-4-hydroxylase, monomeric form. (306 aa) |
| | hisC-2 | Aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: pfo:Pfl_4075 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (370 aa) |
| | Acid_4167 | KEGG: sru:SRU_1370 4-hydroxyphenylpyruvate dioxygenase; TIGRFAM: 4-hydroxyphenylpyruvate dioxygenase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase. (375 aa) |
| | Acid_4184 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1185 aa) |
| | argG | PFAM: argininosuccinate synthase; KEGG: pol:Bpro_1599 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (453 aa) |
| | Acid_4459 | PFAM: aminotransferase, class I and II; KEGG: ccr:CC1071 histidinol-phosphate aminotransferase, putative. (383 aa) |
| | Acid_4482 | KEGG: bur:Bcep18194_B2301 hypothetical protein. (184 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (268 aa) |
| | Acid_4622 | Homoserine O-acetyltransferase; PFAM: alpha/beta hydrolase fold; KEGG: bxe:Bxe_B0598 homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. (358 aa) |
| | Acid_4974 | L-serine ammonia-lyase; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; KEGG: gvi:glr2358 L-serine dehydratase. (543 aa) |
| | Acid_5081 | PFAM: tyrosinase. (340 aa) |
| | Acid_5239 | PFAM: transcriptional coactivator/pterin dehydratase; KEGG: cyb:CYB_2873 putative pterin-4A-carbinolamine dehydratase. (95 aa) |
| | ahcY | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (475 aa) |
| | metK | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (389 aa) |
| | Acid_5467 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; PFAM: DAHP synthetase, class II; KEGG: xcb:XC_3313 family II 2-keto-3-deoxy-D-arabino-heptulosonate 7-phosphate synthase. (471 aa) |
| | Acid_5487 | KEGG: tte:TTE2151 O-acetylhomoserine (thiol)-lyase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; DegT/DnrJ/EryC1/StrS aminotransferase; aromatic amino acid beta-eliminating lyase/threonine aldolase. (437 aa) |
| | Acid_5643 | Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; KEGG: aba:Acid345_1913 cystathionine gamma-synthase. (374 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (452 aa) |
| | arcA | Arginine deiminase; KEGG: bja:bll7310 probable ArcA2 arginine deiminase; TIGRFAM: arginine deiminase; PFAM: amidinotransferase. (431 aa) |
| | Acid_5877 | PFAM: alpha/beta hydrolase fold; KEGG: aba:Acid345_2278 alpha/beta hydrolase. (355 aa) |
| | Acid_5884 | KEGG: eba:ebA4678 cysteine synthase A; TIGRFAM: cysteine synthases; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; Belongs to the cysteine synthase/cystathionine beta- synthase family. (319 aa) |
| | Acid_6097 | KEGG: bur:Bcep18194_B2301 hypothetical protein. (202 aa) |
| | Acid_6369 | Tryptophanase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: aba:Acid345_3931 tryptophanase. (448 aa) |
| | Acid_6516 | Fumarylacetoacetate hydrolase; KEGG: aba:Acid345_2007 fumarylacetoacetase; TIGRFAM: fumarylacetoacetase; PFAM: fumarylacetoacetate (FAA) hydrolase. (402 aa) |
| | Acid_6517 | KEGG: aba:Acid345_2006 hypothetical protein. (262 aa) |
| | hmgA | Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate. (426 aa) |
| | Acid_6665 | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: bja:bll1413 threonine dehydratase. (313 aa) |
| | Acid_6978 | PFAM: response regulator receiver; KEGG: sru:SRU_2062 sensory box sensor histidine kianse/response regulator. (124 aa) |
| | Acid_6979 | KEGG: aba:Acid345_2087 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (276 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (296 aa) |
| | Acid_6981 | PFAM: dihydrodipicolinate reductase; KEGG: aba:Acid345_2492 dihydrodipicolinate reductase; Belongs to the DapB family. (229 aa) |
| | Acid_6982 | KEGG: aba:Acid345_2491 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (463 aa) |
| | Acid_6983 | KEGG: aba:Acid345_2490 aspartate-semialdehyde dehydrogenase; TIGRFAM: aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase, NAD - binding; Semialdehyde dehydrogenase, dimerisation region; Belongs to the aspartate-semialdehyde dehydrogenase family. (349 aa) |
| | Acid_6984 | PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: aba:Acid345_1040 peptidase dimerisation. (339 aa) |
| | Acid_7030 | PFAM: homoserine dehydrogenase; homoserine dehydrogenase, NAD-binding; KEGG: ade:Adeh_3931 homoserine dehydrogenase. (323 aa) |
| | Acid_7054 | PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; KEGG: aba:Acid345_2043 prephenate dehydratase. (284 aa) |
| | Acid_7115 | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: aba:Acid345_3426 homocysteine S-methyltransferase. (622 aa) |
| | aroD | Shikimate dehydrogenase / 3-dehydroquinate dehydratase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA); Belongs to the type-I 3-dehydroquinase family. (509 aa) |
| | Acid_7181 | PFAM: dihydrodipicolinate synthetase; KEGG: bcl:ABC0222 dihydrodipicolinate synthase; Belongs to the DapA family. (310 aa) |
| | Acid_7274 | PFAM: aminotransferase, class I and II; KEGG: aba:Acid345_0568 aminotransferase, class I and II. (397 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (426 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (357 aa) |
| | Acid_7506 | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: sco:SCO0821 putative threonine dehydratase. (339 aa) |
| | speA | Arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. (637 aa) |
| | Acid_7884 | PFAM: Prephenate dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding; KEGG: aba:Acid345_1162 prephenate dehydrogenase. (281 aa) |
| | Acid_7885 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; KEGG: tte:TTE1013 phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA. (337 aa) |
| | Acid_7886 | PFAM: Chorismate mutase; KEGG: gme:Gmet_1955 chorismate mutase. (100 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (267 aa) |
| | trpB-2 | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (398 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: tbd:Tbd_1915 N-(5'phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (199 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; KEGG: aba:Acid345_1156 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (262 aa) |
