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| | pyrR | Pyrimidine operon regulatory protein; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (179 aa) |
| | GK1163 | Fibronectin/fibrinogen-binding protein. (579 aa) |
| | GK1165 | Hypothetical conserved protein. (291 aa) |
| | rpoZ | DNA-directed RNA polymerase omega subunit (transcriptase omega chain); Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (66 aa) |
| | def | Polypeptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (157 aa) |
| | fmt | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (319 aa) |
| | GK1173 | RNA-binding Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (444 aa) |
| | rlmN | Hypothetical conserved protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (365 aa) |
| | rpmB | 50S ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (61 aa) |
| | rnc | dsRNA-specific ribonuclease; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (246 aa) |
| | rpsP | 30S ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (90 aa) |
| | rimM | 16S rRNA processing protein; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (175 aa) |
| | trmD | tRNA (guanine-N(1)-)-methyltransferase (M1G-methyltransferase); Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (244 aa) |
| | rplS | 50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (120 aa) |
| | GK1203 | Type I signal peptidase; Belongs to the peptidase S26 family. (184 aa) |
| | lepA | GTP-binding protein; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (609 aa) |
| | sigD | DNA-directed RNA polymerase sigma-28 factor (sigma-D); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (251 aa) |
| | rpsB | 30S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (235 aa) |
| | tsf | Translation elongation factor Ts (EF-Ts); Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity); Belongs to the EF-Ts family. (294 aa) |
| | frr | Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (185 aa) |
| | proS | proline-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves de [...] (567 aa) |
| | nusA | Transcription termination-antitermination factor; Participates in both transcription termination and antitermination. (383 aa) |
| | infB | Translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (709 aa) |
| | rbfA | Ribosome-binding factor A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. (112 aa) |
| | truB | tRNA pseudouridine 5S synthase; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (285 aa) |
| | rpsO | 30S ribosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (89 aa) |
| | pnp | Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase); Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (723 aa) |
| | rnj-2 | Hypothetical conserved protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily. (556 aa) |
| | miaB | Hypothetical conserved protein; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (531 aa) |
| | miaA | tRNA delta(2)-isopentenylpyrophosphate transferase (IPP transferase); Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (315 aa) |
| | GK1392 | glutamyl-tRNA(Gln) amidotransferase subunit A; Belongs to the amidase family. (470 aa) |
| | GK1543 | Hypothetical conserved protein; Belongs to the methyltransferase superfamily. (380 aa) |
| | GK1726 | DNA-directed RNA polymerase ECF-type sigma factor; Belongs to the sigma-70 factor family. ECF subfamily. (161 aa) |
| | larC | Hypothetical conserved protein; Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes. Belongs to the LarC family. (411 aa) |
| | GK1997 | Repressor in the phenylacetic acid catabolism. (291 aa) |
| | GK2034 | Repressor in the phenylacetic acid catabolism. (285 aa) |
| | GK2066 | Hypothetical conserved protein; Belongs to the sulfur carrier protein TusA family. (189 aa) |
| | GK2067 | Hypothetical conserved protein. (98 aa) |
| | GK2068 | Hypothetical conserved protein. (121 aa) |
| | GK2070 | Hypothetical conserved protein; Belongs to the sulfur carrier protein TusA family. (75 aa) |
| | GK2091 | Hypothetical conserved protein. (547 aa) |
| | asnS | asparaginyl-tRNA synthetase. (431 aa) |
| | birA | Biotin [acetyl-CoA carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. (329 aa) |
| | cca | tRNA nucleotidyltransferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. (404 aa) |
| | mtrB | Transcription attenuation protein (tryptophan RNA-binding attenuator protein) (trp RNA-binding attenuation protein). (74 aa) |
| | GK2225 | 30S ribosomal protein S1. (387 aa) |
| | GK2242 | Hypothetical conserved protein. (194 aa) |
| | sigX | DNA-directed RNA polymerase ECF-type sigma factor (sigma-X); Belongs to the sigma-70 factor family. ECF subfamily. (181 aa) |
| | GK2283 | Ribosomal large subunit pseudouridine synthaseB (pseudouridylate synthase) (uracil hydrolyase); Belongs to the pseudouridine synthase RsuA family. (243 aa) |
| | sigF | RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (250 aa) |
| | rnz | Hypothetical conserved protein; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (307 aa) |
| | nusB | Transcription termination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (130 aa) |
| | efp | Translation elongation factor P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. (185 aa) |
| | lipM | Lipoate protein ligase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation. (278 aa) |
| | GK2421 | Hypothetical conserved protein. (124 aa) |
| | rpmG2 | 50S ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (49 aa) |
| | GK2479 | Hypothetical conserved protein. (234 aa) |
| | sigA | DNA-directed RNA polymerase major sigma-43 factor (sigma-A); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (375 aa) |
| | ybeY | Hypothetical conserved protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (156 aa) |
| | rpsU | 30S ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family. (57 aa) |
| | GK2500 | Hypothetical conserved protein. (449 aa) |
| | GK2501 | Hypothetical conserved protein; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (258 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (424 aa) |
| | tadA | Hypothetical conserved protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (165 aa) |
| | rsmI | Hypothetical conserved protein; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (303 aa) |
| | metG | methionyl-tRNA synthetase (methionine--tRNA ligase); Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (650 aa) |
| | rnmV | Hypothetical conserved protein; Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step. (182 aa) |
| | rsmA | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (293 aa) |
| | rplY | 50S ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (210 aa) |
| | spoVC | Stage V sporulation protein C (peptidyl-tRNA hydrolase); The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (186 aa) |
| | GK0056 | Polyribonucleotide nucleotidyltransferase. (132 aa) |
| | tilS | Hypothetical conserved protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (464 aa) |
| | GK0073 | Transcriptional regulator involved in nitrogen regulation (NifR3/Smm1 family); Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (333 aa) |
| | lysS | lysyl-tRNA synthetase (lysine--tRNA ligase); Belongs to the class-II aminoacyl-tRNA synthetase family. (494 aa) |
| | gltX | glutamyl-tRNA synthetase (glutamate--tRNA ligase); Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (490 aa) |
| | cysS | cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (466 aa) |
| | mrnC | Hypothetical conserved protein; Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors; Belongs to the MrnC RNase family. (140 aa) |
| | rpmH | 50S ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. (44 aa) |
| | rnpA | Ribonuclease P (protein component); RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (121 aa) |
| | thdF | Thiophen/furan oxidation protein; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (462 aa) |
| | gidA | Glucose-inhibited division protein; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family. (629 aa) |
| | gidB | Glucose-inhibited division protein; Specifically methylates the N7 position of guanine in position 535 of 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. (238 aa) |
| | rpsF | 30S ribosomal protein S6 (BS9); Binds together with S18 to 16S ribosomal RNA. (95 aa) |
| | rpsR | 30S ribosomal protein S18 (BS21); Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (78 aa) |
| | rplI | 50S ribosomal protein L9 (BL17); Binds to the 23S rRNA. (149 aa) |
| | GK3470 | Hypothetical conserved protein. (264 aa) |
| | rlmH | Hypothetical conserved protein; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. (159 aa) |
| | trmH | rRNA methylase; Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (247 aa) |
| | GK3447 | Hypothetical conserved protein. (411 aa) |
| | glyQS | glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (460 aa) |
| | GK3424 | DNA-directed RNA polymerase sigma-37 factor (sigma-B); Belongs to the sigma-70 factor family. (256 aa) |
| | lipL | Hypothetical conserved protein; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes; Belongs to the octanoyltransferase LipL family. (283 aa) |
| | argS | arginyl-tRNA synthetase. (557 aa) |
| | rpoE | DNA-directed RNA polymerase delta subunit; Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; Belongs to the RpoE family. (185 aa) |
| | rho | Transcriptional terminator; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (424 aa) |
| | rpmE | 50S ribosomal protein L31; Binds the 23S rRNA. (66 aa) |
| | prfA | Peptide chain release factor 1 (RF-1) in translation; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (358 aa) |
| | GK3375 | Hypothetical conserved protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (349 aa) |
| | GK3125 | methionyl-tRNA formyltransferase. (299 aa) |
| | prfB | Peptide chain release factor 2 in translation; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (327 aa) |
| | GK3061 | DNA-directed RNA polymerase sigma-54 factor (sigma-L). (435 aa) |
| | smpB | ssrA RNA (tmRNA)-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then [...] (155 aa) |
| | gcvH | Protein H involved in glycine cleavage system; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (127 aa) |
| | GK3002 | Hypothetical conserved protein. (119 aa) |
| | lipA | Lipoic acid synthetase (lipoate synthase); Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (311 aa) |
| | GK2927 | Polyribonucleotide nucleotidyltransferase. (121 aa) |
| | leuS | leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (805 aa) |
| | GK2841 | Hypothetical conserved protein. (104 aa) |
| | GK2833 | 16S pseudouridylate synthase; Belongs to the pseudouridine synthase RsuA family. (248 aa) |
| | trmB | Hypothetical conserved protein; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (217 aa) |
| | GK2817 | Hypothetical conserved protein; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (201 aa) |
| | tyrS | tyrosyl-tRNA synthetase (tyrosine--tRNA ligase); Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (419 aa) |
| | rpsD | 30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (200 aa) |
| | thiI | Thiamine biosynthesis; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (401 aa) |
| | thrS | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). (652 aa) |
| | infC | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (239 aa) |
| | rpmI | 50S ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (66 aa) |
| | rplT | 50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (119 aa) |
| | GK2709 | rRNA methylase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (251 aa) |
| | pheS | phenylalanyl-tRNA synthetase alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (344 aa) |
| | pheT | phenylalanyl-tRNA synthetase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (804 aa) |
| | rph | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (257 aa) |
| | GK2664 | Hypothetical conserved protein. (168 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (880 aa) |
| | GK2625 | Signal peptidase (late competence protein); Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. (248 aa) |
| | rplU | 50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (102 aa) |
| | rpmA | 50S ribosomal protein L27 (BL30); Belongs to the bacterial ribosomal protein bL27 family. (96 aa) |
| | tgt | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (380 aa) |
| | hisS | histidyl-tRNA synthetase. (426 aa) |
| | aspS | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (590 aa) |
| | GK2571 | Hypothetical conserved protein. (254 aa) |
| | mnmA2 | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (371 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (887 aa) |
| | GK2554 | Hypothetical conserved protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family. (138 aa) |
| | GK2551 | caffeoyl-CoA O-methyltransferase. (217 aa) |
| | GK2535 | RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (237 aa) |
| | GK2523 | Hypothetical conserved protein. (97 aa) |
| | rpsT | 30S ribosomal protein S20; Binds directly to 16S ribosomal RNA. (89 aa) |
| | GK0087 | tRNA/rRNA methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (245 aa) |
| | GK0089 | DNA-directed RNA polymerase sigma-30 factor (sigma-H); Belongs to the sigma-70 factor family. (216 aa) |
| | rpmG | 50S ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (49 aa) |
| | nusG | Transcription antitermination factor; Participates in transcription elongation, termination and antitermination. (177 aa) |
| | rplK | 50S ribosomal protein L11 (BL11); Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (141 aa) |
| | rplA | 50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (233 aa) |
| | rplJ | 50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (166 aa) |
| | rplL | 50S ribosomal protein L7/L12 (BL13); Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (123 aa) |
| | rpoB | DNA-directed RNA polymerase beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1190 aa) |
| | rpoC | DNA-directed RNA polymerase beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1199 aa) |
| | GK0100 | Ribosomal protein (L7AE family); Belongs to the eukaryotic ribosomal protein eL8 family. (82 aa) |
| | rpsL | 30S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy. (140 aa) |
| | rpsG | 30S ribosomal protein S7 (BS7); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa) |
| | fus | Translation elongation factor G (EF-G); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G [...] (692 aa) |
| | tufA | Translation elongation factor Tu (EF-Tu); This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (395 aa) |
| | rpsJ | 30S ribosomal protein S10 (BS13); Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa) |
| | rplC | 50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (213 aa) |
| | rplD | 50S ribosomal protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (207 aa) |
| | rplW | 50S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (95 aa) |
| | rplB | 50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (276 aa) |
| | rpsS | 30S ribosomal protein S19 (BS19); Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (92 aa) |
| | rplV | 50S ribosomal protein L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). (113 aa) |
| | rpsC | 30S ribosomal protein S3 (BS2); Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (218 aa) |
| | rplP | 50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (141 aa) |
| | rpmC | 50S ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (66 aa) |
| | rpsQ | 30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (87 aa) |
| | rplN | 50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa) |
| | rplX | 50S ribosomal protein L24; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (103 aa) |
| | rplE | 50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (179 aa) |
| | rpsN | 30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa) |
| | rpsH | 30S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa) |
| | rplF | 50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (178 aa) |
| | rplR | 50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (120 aa) |
| | rpsE | 30S ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (166 aa) |
| | rpmD | 50S ribosomal protein L30. (62 aa) |
| | rplO | 50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (146 aa) |
| | infA | Translation initiation factor IF-I; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (72 aa) |
| | rpmJ | 50S ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (37 aa) |
| | rpsM | 30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (121 aa) |
| | rpsK | 30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (129 aa) |
| | rpoA | DNA-directed RNA polymerase alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (314 aa) |
| | rplQ | 50S ribosomal protein L17. (120 aa) |
| | truA | Pseudouridylate synthaseI; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (258 aa) |
| | rplM | 50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (145 aa) |
| | rpsI | 30S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (130 aa) |
| | GK0150 | DNA-directed RNA polymerase ECF-type sigma factor (sigma-W); Belongs to the sigma-70 factor family. ECF subfamily. (187 aa) |
| | GK0236 | Hypothetical conserved protein. (152 aa) |
| | GK0237 | Glycoprotein endopeptidase. (246 aa) |
| | GK0238 | Ribosomal protein (S18)-alanine acetyltransferase; Acetylates the N-terminal alanine of ribosomal protein S18. (150 aa) |
| | tsaD | Glycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (342 aa) |
| | GK0240 | ABC transporter (ATP-binding protein). (641 aa) |
| | GK0246 | Hypothetical conserved protein. (244 aa) |
| | gatC | aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C (Glu-ADT subunit C); Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (96 aa) |
| | gatA | aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit A (Glu-ADT subunit A); Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (485 aa) |
| | gatB | aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B (Asp/Glu-ADT subunit B); Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (476 aa) |
| | GK0342 | RNA methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (457 aa) |
| | GK0357 | RNA methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (462 aa) |
| | GK0402 | Hypothetical conserved protein. (123 aa) |
| | acyP | Acylphosphatase. (94 aa) |
| | GK0429 | RNA methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (462 aa) |
| | GK0481 | Hypothetical conserved protein. (221 aa) |
| | queG | Hypothetical conserved protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (380 aa) |
| | GK0484 | rRNA methylase; Could methylate the ribose at the nucleotide 34 wobble position in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily. (157 aa) |
| | GK0521 | Phage-related protein. (150 aa) |
| | GK0542 | Phage-related protein. (451 aa) |
| | GK0565 | Ribosomal large subunit pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (299 aa) |
| | GK0667 | Hypothetical conserved protein. (244 aa) |
| | GK0680 | Signal peptidase I (SPase I); Belongs to the peptidase S26 family. (182 aa) |
| | GK0741 | Hypothetical conserved protein. (236 aa) |
| | GK0755 | Hypothetical protein; Similar to N-terminal region of hypothetical protein (PF0693 158 aa) of Pyrococcus furiosus DSM3638. (69 aa) |
| | GK0756 | Hypothetical protein; Similar to N-terminal region of hypothetical protein (SMa1256 176 aa) of Sinorhizobium meliloti. (82 aa) |
| | trpS | tryptophan-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (328 aa) |
| | GK0831 | Hypothetical conserved protein; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (303 aa) |
| | GK0927 | Acetyltransferase (GNAT family). (163 aa) |
| | sigI | DNA-directed RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; Belongs to the sigma-70 factor family. SigI subfamily. (246 aa) |
| | GK0983 | Hypothetical protein. (224 aa) |
| | mnmA1 | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (370 aa) |
| | rnj | Hypothetical conserved protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily. (555 aa) |
| | GK1054 | Hypothetical conserved protein; Belongs to the UPF0356 family. (71 aa) |
| | def-2 | Peptide deformylase2 (PDF 2) N-formylmethionylaminoacyl-tRNA deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (184 aa) |
| | GK1098 | Hypothetical conserved protein. (198 aa) |
| | tmcAL | Hypothetical conserved protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac- AMP) and then transfers the acetyl group to tRNA to form ac(4)C34. (406 aa) |
| | rpmF | 50S ribosomal protein L32 (Ribosomal protein I) (BL37); Belongs to the bacterial ribosomal protein bL32 family. (57 aa) |
| | rsmH | Hypothetical conserved protein; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (310 aa) |
| | sigE | DNA-directed RNA polymerase sigma-29 factor precursor (sigma-E) (stage II sporulation protein GB); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (239 aa) |
| | sigG | DNA-directed RNA polymerase sporulation-specific sigma factor (sigma-G); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (259 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (924 aa) |
| | GK1146 | Hypothetical conserved protein; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (304 aa) |
