STRINGSTRING
GK2374 GK2374 spo0A spo0A dnaK dnaK GK2732 GK2732 mdh mdh pgi pgi gpmI gpmI tpi tpi pgk pgk GK3150 GK3150 GK3208 GK3208 ldh ldh spo0F spo0F GK3474 GK3474 cysS cysS infA infA glmM glmM GK0205 GK0205 GK0306 GK0306 GK0331 GK0331 cysC cysC GK0434 GK0434 kdpB kdpB GK0558 GK0558 GK0729 GK0729 GK0908 GK0908 GK1039 GK1039 acpP acpP codY codY cheY cheY cheB cheB cheA cheA glnA glnA GK1340 GK1340 glpK glpK GK1468 GK1468 GK1480 GK1480 GK1690 GK1690 GK1911 GK1911 GK1981 GK1981 GK2086 GK2086 GK2087 GK2087 GK2157 GK2157 ndk ndk GK2272 GK2272 GK2279 GK2279 GK2340 GK2340
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GK2374Two-component response regulator. (224 aa)
spo0AStage 0 sporulation protein A (two-component response regulator); May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. (259 aa)
dnaKChaperone protein (heat shock protein 70) (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family. (607 aa)
GK2732Two-component response regulator (phosphate regulation). (235 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (312 aa)
pgiGlucose-6-phosphate isomerase A (phosphoglucose isomerase A). (449 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase (phosphoglyceromutase); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (511 aa)
tpiTriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (253 aa)
pgk3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (394 aa)
GK3150Two-component response regulator (extracellular proteinase response regulator). (224 aa)
GK3208Two-component response regulator. (513 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (317 aa)
spo0FStage 0 sporulation protein F (two-component response regulator, sporulation initiation phosphotransferase F). (120 aa)
GK3474Two-component response regulator. (237 aa)
cysScysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (466 aa)
infATranslation initiation factor IF-I; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (72 aa)
glmMPhosphoglucomutase (glycolysis); Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (449 aa)
GK0205Two-component response regulator. (221 aa)
GK0306Lantibiotic biosynthesis protein (response regulator). (232 aa)
GK0331Transcriptional regulator. (223 aa)
cysCAdenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (203 aa)
GK0434Two-component response regulator. (210 aa)
kdpBK+-transporting ATPase b chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (677 aa)
GK0558Two-component response regulator. (226 aa)
GK0729Transcriptional regulator. (484 aa)
GK0908Two-component response regulator. (224 aa)
GK1039Hypothetical conserved protein. (588 aa)
acpPAcyl carrier protein (ACP); Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (77 aa)
codYTranscription pleiotropic repressor; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. (259 aa)
cheYTwo-component response regulator involved in modulation of flagellar. (119 aa)
cheBProtein-glutamate methylesterase/protein-glutamine glutaminase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (349 aa)
cheATwo-component sensor histidine kinase (chemotaxis protein). (666 aa)
glnAGlutamine synthetase (glutamate-ammonia ligase). (444 aa)
GK1340Two-component response regulator. (118 aa)
glpKGlycerol kinase (ATP:glycerol 3-phosphotransferase); Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (496 aa)
GK1468Hypothetical conserved protein. (542 aa)
GK1480Transcriptional regulator. (246 aa)
GK1690Two-component response regulator. (226 aa)
GK1911Two-component response regulator. (401 aa)
GK1981Two-component response regulator. (299 aa)
GK2086Two component response regulator. (209 aa)
GK2087Two-component sensor histidine kinase. (340 aa)
GK2157Two-component response regulator. (224 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (149 aa)
GK2272Two-component response regulator. (233 aa)
GK2279Two-component response regulator. (241 aa)
GK2340Two-component response regulator. (228 aa)
Your Current Organism:
Geobacillus kaustophilus
NCBI taxonomy Id: 235909
Other names: G. kaustophilus HTA426, Geobacillus kaustophilus HTA426
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