STRINGSTRING
secE secE secY secY GK0177 GK0177 GK0178 GK0178 GK0286 GK0286 GK0294 GK0294 GK0300 GK0300 GK0303 GK0303 GK0304 GK0304 GK0306 GK0306 GK0307 GK0307 GK0309 GK0309 GK0310 GK0310 GK0311 GK0311 GK0312 GK0312 GK0469 GK0469 GK0668 GK0668 comK comK GK0811 GK0811 GK0812 GK0812 GK0813 GK0813 GK0814 GK0814 GK0815 GK0815 GK1030 GK1030 ftsY ftsY ffh ffh hfq hfq GK1475 GK1475 GK1491 GK1491 GK1660 GK1660 GK1661 GK1661 GK1662 GK1662 GK1663 GK1663 GK1664 GK1664 GK1674 GK1674 yidC yidC GK2008 GK2008 GK2009 GK2009 GK2010 GK2010 GK2011 GK2011 GK2136 GK2136 trpE trpE GK2297 GK2297 spo0A spo0A secDF secDF GK2586 GK2586 spo0B spo0B GK2690 GK2690 GK2782 GK2782 luxS luxS GK2976 GK2976 GK2977 GK2977 GK2978 GK2978 GK2979 GK2979 GK2980 GK2980 GK3022 GK3022 GK3023 GK3023 GK3024 GK3024 GK3025 GK3025 GK3026 GK3026 GK3046 GK3046 secA1 secA1 secA2 secA2 spo0F spo0F yidC-2 yidC-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
secEPreprotein translocase subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. (61 aa)
secYPreprotein translocase subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (430 aa)
GK0177Hypothetical conserved protein. (293 aa)
GK0178Hypothetical conserved protein. (337 aa)
GK0286Lantibiotic precursor; Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores. (56 aa)
GK0294Lantibiotic precursor; Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores. (50 aa)
GK0300Similar to N-terminal region of lantibiotic biosynthesis protein (spaB 1030 aa) of Bacillus subtilis (GK0300 divided by IS-like element (GK0301) is possibly continued to 329,833 bp). (717 aa)
GK0303Lantibiotic ABC transporter (ATP-binding protein). (609 aa)
GK0304Lantibiotic biosynthesis protein. (429 aa)
GK0306Lantibiotic biosynthesis protein (response regulator). (232 aa)
GK0307Lantibiotic biosynthesis protein (sensory transduction protein kinase). (472 aa)
GK0309Lantibiotic biosynthesis protein. (127 aa)
GK0310Lantibiotic ABC transporter (permease). (262 aa)
GK0311Lantibiotic ABC transporter (permease). (248 aa)
GK0312Lantibiotic ABC transporter (ATP-binding protein). (229 aa)
GK0469Dipeptide ABC transporter (permease). (299 aa)
GK0668Long-chain fatty-acid-CoA ligase. (514 aa)
comKCompetence transcription factor. (185 aa)
GK0811Oligopeptide ABC transporter (oligopeptide-binding protein). (528 aa)
GK0812Oligopeptide ABC transporter (permease). (309 aa)
GK0813Oligopeptide ABC transporter (permease). (339 aa)
GK0814Oligopeptide ABC transporter (ATP-binding protein); Belongs to the ABC transporter superfamily. (353 aa)
GK0815Oligopeptide ABC transporter (ATP-binding protein); Belongs to the ABC transporter superfamily. (311 aa)
GK1030Long-chain fatty-acid-CoA ligase. (539 aa)
ftsYSignal recognition particle GTPase (docking protein); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). (328 aa)
ffhSignal recognition particle GTPase; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (446 aa)
hfqHost factor-1 protein; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. (75 aa)
GK1475Hypothetical conserved protein. (495 aa)
GK1491Long-chain fatty-acid-CoA ligase. (511 aa)
GK1660Branched-chain amino acid ABC transporter (permease); Belongs to the binding-protein-dependent transport system permease family. (287 aa)
GK1661Branched-chain amino acid ABC transporter (permease); Belongs to the binding-protein-dependent transport system permease family. (345 aa)
GK1662Branched-chain amino acid ABC transporter (ATP-binding protein). (254 aa)
GK1663Branched-chain amino acid ABC transporter (ATP-binding protein). (235 aa)
GK1664Branched-chain amino acid ABC transporter (substrate-binding protein). (404 aa)
GK1674Hypothetical conserved protein. (144 aa)
yidCStage III sporulation protein J; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins; Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily. (249 aa)
GK2008Polyamine ABC transporter (permease). (264 aa)
GK2009ABC transporter (permease). (310 aa)
GK2010ABC transporter (ATP-binding protein); Belongs to the ABC transporter superfamily. (367 aa)
GK2011ABC transporter (substrate-binding protein). (368 aa)
GK2136Long-chain fatty-acid-CoA ligase. (551 aa)
trpEAnthranilate synthasecomponent I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentra [...] (508 aa)
GK2297Riboflavin-specific deaminase (diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (380 aa)
spo0AStage 0 sporulation protein A (two-component response regulator); May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. (259 aa)
secDFPreprotein translocase subunits D and F; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily. (750 aa)
GK2586Hypothetical conserved protein. (90 aa)
spo0BStage 0 sporulation protein B (sporulation initiation phosphoprotein). (182 aa)
GK2690Long chain acyl-CoA synthetase. (566 aa)
GK2782Long-chain fatty-acid-CoA ligase. (511 aa)
luxSAutoinducer-2 production protein (AI-2 synthesis protein); Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (158 aa)
GK2976Branched-chain amino acid ABC transporter (ATP-binding protein). (235 aa)
GK2977Branched-chain amino acid ABC transporter (ATP-binding protein). (259 aa)
GK2978Branched-chain amino acid ABC transporter (permease); Belongs to the binding-protein-dependent transport system permease family. (324 aa)
GK2979Branched-chain amino acid ABC transporter (permease); Belongs to the binding-protein-dependent transport system permease family. (292 aa)
GK2980Branched chain amino acid ABC transporter (substrate-binding protein). (398 aa)
GK3022Branched chain amino acid ABC transporter (ATP-binding protein). (241 aa)
GK3023Branched chain amino acid ABC transporter (ATP-binding protein). (256 aa)
GK3024Branched amino acid ABC transporter (permease); Belongs to the binding-protein-dependent transport system permease family. (348 aa)
GK3025Branched amino acid ABC transporter (permease); Belongs to the binding-protein-dependent transport system permease family. (293 aa)
GK3026Branched amino acid ABC transporter (substrate-binding protein). (389 aa)
GK3046Protein translocation subunit; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (78 aa)
secA1Preprotein translocase subunit (ATPase, RNA helicase); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family. (837 aa)
secA2Preprotein translocase subunit (ATPase, RNA helicase); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (797 aa)
spo0FStage 0 sporulation protein F (two-component response regulator, sporulation initiation phosphotransferase F). (120 aa)
yidC-2Stage III sporulation protein J; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins; Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily. (254 aa)
Your Current Organism:
Geobacillus kaustophilus
NCBI taxonomy Id: 235909
Other names: G. kaustophilus HTA426, Geobacillus kaustophilus HTA426
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