STRINGSTRING
CaO19.6843 CaO19.6843 A0A1D8PHE3 A0A1D8PHE3 PHO13 PHO13 NAT4 NAT4 HOS3 HOS3 CaO19.2743 CaO19.2743 CaO19.2730 CaO19.2730 HOS1 HOS1 SDC1 SDC1 HPA2 HPA2 SWD3 SWD3 MIF2 MIF2 CaO19.5555 CaO19.5555 CaO19.7086 CaO19.7086 HHO1 HHO1 CaO19.3863 CaO19.3863 SPT10 SPT10 CTM1 CTM1 SIR2 SIR2 HTB1 HTB1 HAT2 HAT2 CHZ1 CHZ1 HTA1 HTA1 HAT1 HAT1 HHT21 HHT21 HHF1 HHF1 HTB2 HTB2 HTA2 HTA2 SET6 SET6 SET2 SET2 CaO19.3581 CaO19.3581 DOT1 DOT1 SWD1 SWD1 JHD1 JHD1 CaO19.2442 CaO19.2442 NAP1 NAP1 SET1 SET1 SAS2 SAS2 HHT3 HHT3 HTZ1 HTZ1 FEX1 FEX1 SPP1 SPP1 ASH2 ASH2 CaO19.5933 CaO19.5933 CaO19.4763 CaO19.4763
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CaO19.6843SHNi-TPR domain-containing protein. (373 aa)
A0A1D8PHE3Uncharacterized protein. (84 aa)
PHO134-nitrophenylphosphatase. (321 aa)
NAT4Nat4p. (203 aa)
HOS3Histone deacetylase. (713 aa)
CaO19.2743Uncharacterized protein. (606 aa)
CaO19.2730Uncharacterized protein. (606 aa)
HOS1Histone deacetylase. (436 aa)
SDC1Sdc1p. (128 aa)
HPA2D-amino-acid N-acetyltransferase. (152 aa)
SWD3Swd3p. (383 aa)
MIF2Mif2p. (520 aa)
CaO19.5555Uncharacterized protein. (1131 aa)
CaO19.7086Importin N-terminal domain-containing protein. (971 aa)
HHO1Histone. (180 aa)
CaO19.3863SET domain-containing protein. (630 aa)
SPT10Spt10p. (469 aa)
CTM1Cytochrome c lysine N-methyltransferase. (686 aa)
SIR2NAD-dependent histone deacetylase SIR2; NAD-dependent deacetylase. Heterochromatin component that silences transcription at silent mating loci, telomeres and the ribosomal DNA, and that also suppresses recombination in the rDNA and extends replicative life span. It acts as a NAD-dependent histone deacetylase, which deacetylates 'Lys-9' and 'Lys-14' of Histone H3 and 'Lys-16' of Histone H4. Functions in the distribution of oxidatively damaged proteins during cell division. Mediates phenotypic switching. (519 aa)
HTB1Histone H2B.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (130 aa)
HAT2Histone acetyltransferase type B subunit 2; Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-14' of histone H4 which is required for telomeric silencing. (382 aa)
CHZ1Histone H2A.Z-specific chaperone CHZ1; Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin. (167 aa)
HTA1Histone H2A.1; Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (132 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-14' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family. (413 aa)
HHT21Histone H3.1/H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (136 aa)
HHF1Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (105 aa)
HTB2Histone H2B.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (130 aa)
HTA2Histone H2A.2; Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (131 aa)
SET6Set6p. (379 aa)
SET2Histone-lysine N-methyltransferase, H3 lysine-36 specific; Histone methyltransferase that trimethylates histone H3 'Lys- 36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. (844 aa)
CaO19.3581WD_REPEATS_REGION domain-containing protein. (435 aa)
DOT1Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone. (1343 aa)
SWD1COMPASS subunit protein. (447 aa)
JHD1JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. (478 aa)
CaO19.2442Uncharacterized protein. (234 aa)
NAP1Nucleosome assembly protein 1; Acidic protein, which assembles histones into an octamer (By similarity). Involved in the regulation of the localization and the function of the septins during mitosis. (435 aa)
SET1Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance, transcription elongation regulation and pathogenesis of invasive candidiasis; Belongs to the class V-like SAM-binding methyltransferase superfamily. (1040 aa)
SAS2Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (352 aa)
HHT3Histone H3.3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (136 aa)
HTZ1Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...] (133 aa)
FEX1Fluoride export protein 1; Fluoride channel required for the rapid expulsion of cytoplasmic fluoride. (390 aa)
SPP1Spp1p. (406 aa)
ASH2Ash2p. (466 aa)
CaO19.5933Uncharacterized protein. (475 aa)
CaO19.4763Uncharacterized protein. (226 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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