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| | RFC52 | Rfc52p. (43 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (805 aa) |
| | CaO19.3019 | SsDNA-dependent ATPase. (678 aa) |
| | POL32 | DNA polymerase delta subunit. (403 aa) |
| | CaO19.6247 | Chromatin-binding protein. (871 aa) |
| | CaO19.2796 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (664 aa) |
| | CaO19.667 | Uncharacterized protein. (726 aa) |
| | GIN1 | Chromatin-modulating protein. (1234 aa) |
| | CAS1 | ATP-dependent DNA helicase. (811 aa) |
| | CDC6 | Cell division control protein; Belongs to the CDC6/cdc18 family. (481 aa) |
| | DLH1 | Recombinase; Belongs to the RecA family. (324 aa) |
| | CDC54 | DNA helicase; Belongs to the MCM family. (912 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1214 aa) |
| | MLH3 | Mismatch repair protein. (636 aa) |
| | DPB4 | DNA polymerase epsilon noncatalytic subunit. (261 aa) |
| | RFC5 | Replication factor C subunit 5. (362 aa) |
| | RAD7 | UV-damaged DNA-binding protein. (652 aa) |
| | CDC7 | Serine/threonine protein kinase. (656 aa) |
| | RFC1 | Replication factor C subunit 1. (888 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (878 aa) |
| | CaO19.1434 | Protein kinase activating protein. (716 aa) |
| | RAD57 | Putative DNA-dependent ATPase. (511 aa) |
| | CDC47 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (781 aa) |
| | PMS1 | ATP-binding mismatch repair protein. (910 aa) |
| | RAD1 | SsDNA endodeoxyribonuclease. (970 aa) |
| | CaO19.6155 | DNA ligase. (770 aa) |
| | RAD50 | MRX complex DNA-binding subunit. (1332 aa) |
| | DDC1 | DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. (488 aa) |
| | RAD53 | Serine/threonine-protein kinase RAD53; Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. (699 aa) |
| | POL1 | DNA polymerase. (1470 aa) |
| | REV3 | DNA polymerase. (1630 aa) |
| | CaO19.366 | DNA damage checkpoint control protein RAD17; Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes; Belongs to the rad1 family. (336 aa) |
| | CaO19.5675 | Translocase. (1102 aa) |
| | CaO19.4163 | Uncharacterized protein. (1072 aa) |
| | CaO19.2713 | MutS family protein. (802 aa) |
| | RAD2 | SsDNA endodeoxyribonuclease. (990 aa) |
| | RAD59 | DNA repair protein RAD59; Involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing. Anneals complementary single-stranded DNA. (215 aa) |
| | PRI2 | DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (543 aa) |
| | EXO1 | Rad2 family nuclease. (699 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (564 aa) |
| | RAD9 | Chromatin-binding protein. (1174 aa) |
| | RFC3 | Replication factor C subunit 3. (347 aa) |
| | DUN1 | Serine/threonine protein kinase. (530 aa) |
| | CaO19.4030 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (424 aa) |
| | DNA2 | Bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease. (1426 aa) |
| | DCC1 | Dcc1p. (339 aa) |
| | RFC2 | Replication factor C subunit 2. (363 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (682 aa) |
| | POL3 | DNA polymerase. (1038 aa) |
| | RRM3 | ATP-dependent DNA helicase RRM3; 5' to 3' DNA replicative helicase recruited to paused replisomes to promote fork progression throughout nonhistone protein- DNA complexes, naturally occurring impediments that are encountered in each S phase where replication forks pauses. Required for timely replication of the telomere and subtelomeric DNA and for wild-type levels of telomeric silencing. Involved in DNA repair during stalled replication fork, regulation of fragile sites expression and essential for genome stability. Plays also a role in mtDNA replication. Has G- quadruplex (G4) unwindi [...] (618 aa) |
| | CaO19.2579 | MutS family protein. (803 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (880 aa) |
| | YKU80 | ATP-dependent DNA helicase. (609 aa) |
| | CaO19.496 | Mismatch repair ATPase. (923 aa) |
| | POL2 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2211 aa) |
| | CaO19.6286 | Uncharacterized protein. (198 aa) |
| | CDC45 | DNA replication initiation factor. (579 aa) |
| | CaO19.607 | DNA-dependent ATPase. (1055 aa) |
| | DPB2 | DNA polymerase epsilon noncatalytic subunit. (708 aa) |
| | CaO19.7621 | Uncharacterized protein. (897 aa) |
| | RFC4 | Replication factor C subunit 4. (323 aa) |
| | SLD5 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (236 aa) |
| | UBC2 | Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation. (179 aa) |
| | LIG4 | DNA ligase 4; Involved in ds DNA break (DSB) repair. Has a role in non- homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining (NHEJ). Not required for the repair of DSBs induced by ionizing radiation or UV light. Has an important role in morphogenesis, positively affecting the capacity to form hyphae. (928 aa) |
| | RAD14 | DNA repair protein RAD14; Involved in DNA excision repair; Belongs to the XPA family. (396 aa) |
| | MEC1 | Serine/threonine-protein kinase MEC1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Required for cell growth and meiotic recombina [...] (2325 aa) |
| | PSF2 | DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity). (203 aa) |
| | RAD52 | Recombinase. (564 aa) |
| | MUS81 | Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (614 aa) |
| | YBL053 | Topoisomerase 1-associated factor 1; Forms a fork protection complex (FPC) with CSM3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (1263 aa) |
| | CDC46 | DNA helicase; Belongs to the MCM family. (728 aa) |
| | MEC3 | Checkpoint protein; Belongs to the HUS1 family. (319 aa) |
| | CaO19.29 | CDT1_C domain-containing protein. (323 aa) |
| | CaO19.4412 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1113 aa) |
| | DED81 | Asparagine--tRNA ligase. (552 aa) |
| | PSF1 | DNA replication complex GINS protein PSF1; The GINS complex plays an essential role in the initiation of DNA replication. (236 aa) |
| | MLH1 | Mismatch repair ATPase. (717 aa) |
| | CaO19.2369 | Origin recognition complex subunit 5. (496 aa) |
| | ORC3 | Origin recognition complex subunit 3. (682 aa) |
| | IME2 | Protein kinase. (520 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (361 aa) |
| | RFX1 | Transcriptional regulator RFX1; Transcription factor involved in DNA damage responses, morphogenesis, and virulence. (851 aa) |
| | CaO19.4441 | Zf-primase domain-containing protein. (598 aa) |
| | CSM3 | Chromosome segregation in meiosis protein 3; Forms a fork protection complex (FPC) with TOF1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (316 aa) |
| | CTF8 | Ctf8p. (162 aa) |
| | MSH3 | DNA mismatch repair protein MSH3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bindi [...] (1037 aa) |
| | CaO19.1406 | Uncharacterized protein. (256 aa) |
| | RFA2 | Rfa2p. (272 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (903 aa) |
| | MSH2 | Mismatch repair ATPase; Component of the post-replicative DNA mismatch repair system (MMR). (873 aa) |
| | RAD18 | Postreplication repair E3 ubiquitin-protein ligase RAD18; E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA. (378 aa) |
| | SLX1 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (286 aa) |
| | DBF4 | Protein serine/threonine kinase activating protein. (506 aa) |
| | RDH54 | DNA-dependent ATPase. (796 aa) |
| | PSO2 | Pso2p. (537 aa) |
| | CaO19.5358 | Origin recognition complex subunit 2. (688 aa) |
| | SGS1 | ATP-dependent DNA helicase. (1189 aa) |
| | NCE4 | Nce4p. (168 aa) |
| | RAD27 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (372 aa) |
| | CaO19.5429 | DNA-binding SCF ubiquitin ligase subunit. (675 aa) |
| | CTF18 | Ctf18p. (853 aa) |
| | CaO19.3289 | Origin recognition complex subunit 6. (363 aa) |
| | RAD10 | Rad10p. (338 aa) |
| | TEL1 | Serine/threonine-protein kinase TEL1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity). (2873 aa) |
| | RAD5 | DNA repair protein RAD5; Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity). (1084 aa) |
| | RFA1 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (624 aa) |
| | CaO19.2728 | Uncharacterized protein. (589 aa) |
| | PSF3 | DNA replication complex GINS protein PSF3; The GINS complex plays an essential role in the initiation of DNA replication. (177 aa) |
| | RAD16 | DNA repair protein. (852 aa) |
| | CaO19.1667 | Uncharacterized protein. (1250 aa) |
| | HYS2 | DNA-directed DNA polymerase delta subunit. (474 aa) |
| | RAD54 | DNA-dependent ATPase. (848 aa) |
| | ESC4 | Esc4p. (903 aa) |
| | POL30 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (259 aa) |
| | CaO19.5970 | DNA helicase. (862 aa) |
| | CaO19.5934 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (629 aa) |
| | CaO19.4830 | Uncharacterized protein. (110 aa) |
