STRINGSTRING
ORC1 ORC1 CaO19.6247 CaO19.6247 CDC6 CDC6 CDC54 CDC54 CDC7 CDC7 MCM3 MCM3 CDC47 CDC47 ORC4 ORC4 MCM6 MCM6 CDC45 CDC45 SLD5 SLD5 PSF2 PSF2 YBL053 YBL053 CDC46 CDC46 CaO19.29 CaO19.29 PSF1 PSF1 CaO19.2369 CaO19.2369 ORC3 ORC3 IME2 IME2 CaO19.4441 CaO19.4441 CSM3 CSM3 MCM2 MCM2 DBF4 DBF4 CaO19.5358 CaO19.5358 CaO19.5429 CaO19.5429 CaO19.3289 CaO19.3289 PSF3 PSF3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (805 aa)
CaO19.6247Chromatin-binding protein. (871 aa)
CDC6Cell division control protein; Belongs to the CDC6/cdc18 family. (481 aa)
CDC54DNA helicase; Belongs to the MCM family. (912 aa)
CDC7Serine/threonine protein kinase. (656 aa)
MCM3DNA helicase; Belongs to the MCM family. (878 aa)
CDC47DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (781 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (564 aa)
MCM6DNA helicase; Belongs to the MCM family. (880 aa)
CDC45DNA replication initiation factor. (579 aa)
SLD5DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (236 aa)
PSF2DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity). (203 aa)
YBL053Topoisomerase 1-associated factor 1; Forms a fork protection complex (FPC) with CSM3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (1263 aa)
CDC46DNA helicase; Belongs to the MCM family. (728 aa)
CaO19.29CDT1_C domain-containing protein. (323 aa)
PSF1DNA replication complex GINS protein PSF1; The GINS complex plays an essential role in the initiation of DNA replication. (236 aa)
CaO19.2369Origin recognition complex subunit 5. (496 aa)
ORC3Origin recognition complex subunit 3. (682 aa)
IME2Protein kinase. (520 aa)
CaO19.4441Zf-primase domain-containing protein. (598 aa)
CSM3Chromosome segregation in meiosis protein 3; Forms a fork protection complex (FPC) with TOF1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (316 aa)
MCM2DNA helicase; Belongs to the MCM family. (903 aa)
DBF4Protein serine/threonine kinase activating protein. (506 aa)
CaO19.5358Origin recognition complex subunit 2. (688 aa)
CaO19.5429DNA-binding SCF ubiquitin ligase subunit. (675 aa)
CaO19.3289Origin recognition complex subunit 6. (363 aa)
PSF3DNA replication complex GINS protein PSF3; The GINS complex plays an essential role in the initiation of DNA replication. (177 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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