STRINGSTRING
CAS1 CAS1 DLH1 DLH1 RAD57 RAD57 RAD50 RAD50 RAD59 RAD59 EXO1 EXO1 DNA2 DNA2 MRE11 MRE11 YKU80 YKU80 LIG4 LIG4 RAD52 RAD52 MUS81 MUS81 DED81 DED81 RAD51 RAD51 SLX1 SLX1 RDH54 RDH54 PSO2 PSO2 SGS1 SGS1 NCE4 NCE4 RAD54 RAD54 CaO19.5934 CaO19.5934
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CAS1ATP-dependent DNA helicase. (811 aa)
DLH1Recombinase; Belongs to the RecA family. (324 aa)
RAD57Putative DNA-dependent ATPase. (511 aa)
RAD50MRX complex DNA-binding subunit. (1332 aa)
RAD59DNA repair protein RAD59; Involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing. Anneals complementary single-stranded DNA. (215 aa)
EXO1Rad2 family nuclease. (699 aa)
DNA2Bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease. (1426 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (682 aa)
YKU80ATP-dependent DNA helicase. (609 aa)
LIG4DNA ligase 4; Involved in ds DNA break (DSB) repair. Has a role in non- homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining (NHEJ). Not required for the repair of DSBs induced by ionizing radiation or UV light. Has an important role in morphogenesis, positively affecting the capacity to form hyphae. (928 aa)
RAD52Recombinase. (564 aa)
MUS81Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (614 aa)
DED81Asparagine--tRNA ligase. (552 aa)
RAD51DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (361 aa)
SLX1Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (286 aa)
RDH54DNA-dependent ATPase. (796 aa)
PSO2Pso2p. (537 aa)
SGS1ATP-dependent DNA helicase. (1189 aa)
NCE4Nce4p. (168 aa)
RAD54DNA-dependent ATPase. (848 aa)
CaO19.5934DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (629 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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