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MVD MVD ERG2 ERG2 HMG1 HMG1 ERG12 ERG12 ERG10 ERG10 ERG20 ERG20 ERG9 ERG9 ERG24 ERG24 CaO19.1397 CaO19.1397 ERG4 ERG4 ERG251 ERG251 ERG8 ERG8 IDI1 IDI1 NCP1 NCP1 BTS1 BTS1 CYB5 CYB5 ALK2 ALK2 CaO19.7512 CaO19.7512 ERG13 ERG13 CaO19.7307 CaO19.7307 ERG5 ERG5 ERG25 ERG25 ERG6 ERG6 ERG11 ERG11 ERG7 ERG7 ALK8 ALK8 MCR1 MCR1 CBR1 CBR1 CaO19.4522 CaO19.4522 ERG3 ERG3 ERG26 ERG26 ERG27 ERG27 ERG28 ERG28 ERG1 ERG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MVDDiphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family. (362 aa)
ERG2C-8 sterol isomerase. (217 aa)
HMG13-hydroxy-3-methylglutaryl coenzyme A reductase. (1073 aa)
ERG12Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (431 aa)
ERG10Acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)
ERG20Bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase; Belongs to the FPP/GGPP synthase family. (351 aa)
ERG9Bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase. (448 aa)
ERG24Delta(14)-sterol reductase. (448 aa)
CaO19.1397Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (236 aa)
ERG4Delta(24(24(1)))-sterol reductase. (469 aa)
ERG251Erg251p; Belongs to the sterol desaturase family. (321 aa)
ERG8Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (432 aa)
IDI1Isopentenyl-diphosphate delta-isomerase. (284 aa)
NCP1NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (680 aa)
BTS1Farnesyltranstransferase; Belongs to the FPP/GGPP synthase family. (332 aa)
CYB5Cyb5p; Belongs to the cytochrome b5 family. (126 aa)
ALK2Alk2p. (522 aa)
CaO19.7512Uncharacterized protein. (538 aa)
ERG133-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (451 aa)
CaO19.7307NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (285 aa)
ERG5C-22 sterol desaturase; Belongs to the cytochrome P450 family. (517 aa)
ERG25Methylsterol monooxygenase; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family. (308 aa)
ERG6Sterol 24-C-methyltransferase; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. (376 aa)
ERG11Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'- dimethyl cholesta-8,14,24-triene-3-beta-ol. (528 aa)
ERG7Lanosterol synthase; Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. (728 aa)
ALK8Alk8p. (515 aa)
MCR1NADH-cytochrome b5 reductase 2; May mediate the reduction of outer membrane cytochrome b5. Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (301 aa)
CBR1NADH-cytochrome b5 reductase 1; Electron donor reductase for cytochrome b5. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes (By similarity). (294 aa)
CaO19.4522Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (147 aa)
ERG3C-5 sterol desaturase; Belongs to the sterol desaturase family. (386 aa)
ERG26Sterol-4-alpha-carboxylate 3-dehydrogenase (Decarboxylating). (350 aa)
ERG273-keto-steroid reductase. (346 aa)
ERG28Erg28p. (138 aa)
ERG1Squalene monooxygenase; Catalyzes the stereospecific oxidation of squalene to (S)- 2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. (496 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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