STRINGSTRING
RPD31 RPD31 VID21 VID21 HDA1 HDA1 SWC4 SWC4 ARP4 ARP4 SIN3 SIN3 SNT1 SNT1 SET3 SET3 CaO19.808 CaO19.808 TAF14 TAF14 CaO19.187 CaO19.187 CaO19.3625 CaO19.3625 PHO23 PHO23 ARP6 ARP6 CaO19.4615 CaO19.4615 RVB2 RVB2 HTZ1 HTZ1 HOS2 HOS2 CaO19.314 CaO19.314 CaO19.6952 CaO19.6952 CaO19.4677 CaO19.4677 HOS1 HOS1 CaO19.6667 CaO19.6667 CaO19.132 CaO19.132 CaO19.5617 CaO19.5617 CaO19.6506 CaO19.6506 UME1 UME1 RPD3 RPD3 CaO19.1856 CaO19.1856 CaO19.7344 CaO19.7344 EAF3 EAF3 YAF9 YAF9 CaO19.190 CaO19.190 HAT2 HAT2 SWR1 SWR1 CaO19.3581 CaO19.3581 RVB1 RVB1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPD31Histone deacetylase. (577 aa)
VID21Chromatin modification-related protein EAF1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (686 aa)
HDA1Histone deacetylase HDA1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates the YNG2 subunit of NuA4 histone acetyltransferase (HAT) module, leading to the reduction of YNG2 and NuA4 HAT at the promoters of hypha-specific genes. Plays a key role in the regulation o [...] (833 aa)
SWC4SWR1-complex protein 4; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (635 aa)
ARP4Actin-related protein 4; Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes [...] (468 aa)
SIN3Transcriptional regulator. (1411 aa)
SNT1Snt1p. (1001 aa)
SET3Histone-binding protein. (1069 aa)
CaO19.808Rpd3L histone deacetylase complex subunit. (610 aa)
TAF14TATA-binding protein-associated factor. (263 aa)
CaO19.187Uncharacterized protein. (816 aa)
CaO19.3625Uncharacterized protein. (349 aa)
PHO23Chromatin modification-related protein. (481 aa)
ARP6Actin-like protein ARP6; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity). (446 aa)
CaO19.4615RXT2_N domain-containing protein. (318 aa)
RVB2RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (498 aa)
HTZ1Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...] (133 aa)
HOS2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (454 aa)
CaO19.314Uncharacterized protein. (999 aa)
CaO19.6952Uncharacterized protein. (669 aa)
CaO19.4677HIT-type domain-containing protein. (236 aa)
HOS1Histone deacetylase. (436 aa)
CaO19.6667SAP30_Sin3_bdg domain-containing protein. (168 aa)
CaO19.132Uncharacterized protein. (593 aa)
CaO19.5617PHD domain-containing protein. (479 aa)
CaO19.6506PHD-type domain-containing protein. (688 aa)
UME1Ume1p. (485 aa)
RPD3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa)
CaO19.1856Uncharacterized protein. (340 aa)
CaO19.7344Uncharacterized protein. (835 aa)
EAF3Chromatin modification-related protein EAF3; Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (369 aa)
YAF9Protein AF-9 homolog; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity). (254 aa)
CaO19.190Uncharacterized protein. (324 aa)
HAT2Histone acetyltransferase type B subunit 2; Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-14' of histone H4 which is required for telomeric silencing. (382 aa)
SWR1Helicase SWR1; Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (1641 aa)
CaO19.3581WD_REPEATS_REGION domain-containing protein. (435 aa)
RVB1RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (458 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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