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| | CaO19.229 | Ubiquitin-protein ligase. (417 aa) |
| | CDC5 | Serine/threonine-protein kinase. (653 aa) |
| | HGC1 | Hypha-specific G1 cyclin-related protein 1; Hypha-specific G1 cyclin-related protein involved in regulation of morphogenesis and opaque cells filamentous growth, and required for both conventional and pheromone-stimulated biofilm formation. Required to maintain hyphal tip localization of actin and SPA2. Regulates the CDC28 kinase during hyphal growth. The CDC28-HGC1 complex phosphorylates and prevents RGA2 from localizing to hyphal tips, leading to localized CDC42 activation for hyphal extension. The CDC28-HGC1 complex also phosphorylates SEC2 and maintains CDC11 phosphorylation throug [...] (785 aa) |
| | BNR1 | Formin BNR1; May organize microtubules by mediating spindle positioning and movement in the budding process. Required for cytokinesis and the maintenance of polarized hyphal growth; Belongs to the formin homology family. BNI1 subfamily. (1485 aa) |
| | NPL4 | Nuclear protein localization protein 4; Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity); Belongs to the NPL4 family. (598 aa) |
| | CaO19.2472 | Rtf2 domain-containing protein. (230 aa) |
| | CDC4 | SCF ubiquitin ligase complex subunit. (768 aa) |
| | CaO19.3248 | Uncharacterized protein. (333 aa) |
| | PAC1 | Nuclear distribution protein PAC1; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein- mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck. (486 aa) |
| | PFY1 | Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. (126 aa) |
| | CaO19.504 | Uncharacterized protein; Belongs to the actin family. (776 aa) |
| | SGS1 | ATP-dependent DNA helicase. (1189 aa) |
| | CHS1 | Chitin synthase. (1026 aa) |
| | BUD2 | GTPase activating protein BUD2; GTPase activating protein (GAP) for RSR1 which is involved in the polarization of yeast and hyphal cells. Directs the site of new daughter cell growth in yeast and hyphal cells. Important for hyphae to maintain linear growth and necessary for hyphal responses to directional cues in the environment (tropisms). Required for correct localization of the septin rings and stabilization of the polarisome at hyphal tips. Involved in cell adhesion. (1237 aa) |
| | CaO19.955 | Uncharacterized protein. (325 aa) |
| | SMC4 | Structural maintenance of chromosomes protein. (1368 aa) |
| | CRZ1 | Transcriptional regulator CRZ1; Transcription factor involved in the regulation of calcium ion homeostasis and required for the maintenance of membrane integrity. Binds to the calcineurin-dependent response element. Plays a role in azole tolerance. (731 aa) |
| | CDC23 | Anaphase promoting complex subunit. (582 aa) |
| | NDC80 | Probable kinetochore protein NDC80; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. (788 aa) |
| | NUF2 | Probable kinetochore protein NUF2; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. (485 aa) |
| | CLN3 | G1/S-specific cyclin CLN3; G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition. CLN3 may be an upstream activator of the G1 cyclins which directly catalyze start. Required for budding and for cell cycle progression and morphogenesis in environment-induced hyphae. Degradation is mediated by GRR1. Through binding to CDC28, controls the phosphorylation of SLA1 which regulates cortical actin patch dynamics. (465 aa) |
| | CaO19.3130 | GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (273 aa) |
| | CLB4 | G2/mitotic-specific cyclin-4; 2/mitotic-specific cyclin essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Degradation is necessary for the cell to exit from mitosis. Plays a role in morphogenesis by negatively regulating polarized growth. Through binding to CDC28 regulates cytokinesis, partly by phosphorylation of the actomyosin ring component IQG1. (486 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (903 aa) |
| | YPI2 | Type 1 phosphatases regulator YPI2; Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control; Belongs to the YPI1 family. (147 aa) |
| | DAD2 | DASH complex subunit DAD2; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity). (125 aa) |
| | ARP3 | Actin-related protein 3; Belongs to the actin family. (419 aa) |
| | CCN1 | G1/S-specific cyclin CCN1; G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. Through binding to CDC28 controls the phosphorylation of CDC11 and SEC2 upon induction of filamentous growth. (693 aa) |
| | MTW1 | MIND complex subunit. (314 aa) |
| | CTF8 | Ctf8p. (162 aa) |
| | RPN10 | Proteasome regulatory particle base subunit. (279 aa) |
| | CaO19.91 | Uncharacterized protein. (299 aa) |
| | CDC48 | AAA family ATPase; Belongs to the AAA ATPase family. (826 aa) |
| | SKP1 | SCF ubiquitin ligase subunit; Belongs to the SKP1 family. (164 aa) |
| | STU1 | Protein STU1; Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation (By similarity). (1303 aa) |
| | GIN4 | Serine/threonine-protein kinase GIN4; Serine/threonine-protein kinase which regulates the localization and the function of the septins during mitosis. Involved in the formation of the septin ring but not the basal septin band. Phosphorylates septins CDC11 and SEP7. Required for the transition from pseudohyphae to hyphae. Acts upstream of IRS4 and INP51 in regulating cell wall integrity responses. Involved in propolis-induced cell death. (1349 aa) |
| | SMT3 | SUMO family protein. (102 aa) |
| | SEP7 | Septation protein 7; Septins are GTPases involved in cytokinesis that assemble early in the cell cycle as a patch at the incipient bud site and form a ring before bud emergence, which transforms into an hour-glass shaped collar of cortical filaments that spans both sides of the mother-bud neck. This collar persists until just before cytokinesis, when it splits into two rings that occupy opposite sides of the neck. The septins at the bud neck serve as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Many pro [...] (670 aa) |
| | MAD2 | Spindle assembly checkpoint component MAD2; Central component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. Plays a key role in virulence, probably through cell cycle checkpoint functions, especially those monitoring the integrity of DNA and chromosome segregation, which might be required for the pathogen to repair damage caused by host defense. Belongs to the MAD2 family. (214 aa) |
| | DAD3 | DASH complex subunit DAD2; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity). (138 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (361 aa) |
| | HOF1 | Formin-binding protein. (607 aa) |
| | SLD2 | DNA replication regulator SLD2; Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity); Belongs to the SLD2 family. (354 aa) |
| | CaO19.6874 | Uncharacterized protein. (607 aa) |
| | RRD2 | Serine/threonine-protein phosphatase 2A activator 2; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A- phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex (By similarity). (358 aa) |
| | IPL1 | Spindle assembly checkpoint kinase; Required for high-fidelity chromosome segregation during the later part of each cell cycle. Acts in opposition to the phosphatase PP1. Has a role in attaching the kinetochores to the microtubules and ensuring that sister kinetochores connect to opposite poles. The promotion of bi-orientation is achieved by selectively detaching kinetochore-microtubule attachments that are not under tension. Phosphorylates histone H3 to form H3S10ph during mitosis and meiosis (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Au [...] (528 aa) |
| | PSF1 | DNA replication complex GINS protein PSF1; The GINS complex plays an essential role in the initiation of DNA replication. (236 aa) |
| | ARP1 | Actin-related protein 1; Belongs to the actin family. (414 aa) |
| | CaO19.2642 | Uncharacterized protein. (171 aa) |
| | BUB3 | Bub3p. (373 aa) |
| | RTS1 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (850 aa) |
| | CaO19.708 | Spindle pole body component. (871 aa) |
| | MAD1 | Spindle assembly checkpoint component MAD1; Central component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. (696 aa) |
| | DUO1 | Duo1p. (171 aa) |
| | MEC3 | Checkpoint protein; Belongs to the HUS1 family. (319 aa) |
| | CDC14 | Tyrosine-protein phosphatase CDC14; Protein phosphatase which antagonizes mitotic cyclin- dependent kinase CDC28, the inactivation of which is essential for exit from mitosis. To access its substrates, is released from nucleolar sequestration during mitosis. Plays an essential in coordinating the nuclear division cycle with cytokinesis through the cytokinesis checkpoint. Involved in chromosome segregation, where it is required for meiosis I spindle dissambly as well as for establishing two consecutive chromosome segregation phases (By similarity). Plays a role in the expression of hydr [...] (542 aa) |
| | MUS81 | Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (614 aa) |
| | GLC7 | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa) |
| | MYO5 | Myosin-5; Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization and for the internalization step in endocytosis. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex (By similarity). Plays a role in chitin deposition in the cell wall, in determination of the budding pattern, and is required for hyphae formation. (1316 aa) |
| | PSF2 | DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity). (203 aa) |
| | CSE4 | Histone H3-like centromeric protein CSE4; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). (211 aa) |
| | RVS167 | Regulator of cytoskeleton and endocytosis RVS167; Component of a cytoskeletal structure that is required for the formation of endocytic vesicles at the plasma membrane level. Plays an important role in virulence. (440 aa) |
| | SIT4 | Serine/threonine-protein phosphatase SIT4; Serine/threonine protein phosphatase which is involved in the dephosphorylation of the large subunit of RNA polymerase II. Is required in late G1 for normal G1 cyclin expression, bud initiation and expression of certain genes that are periodically expressed during late G1 (By similarity). Plays a role during hyphal growth through the regulation of cell wall biogenesis, osmosensing and protein translation. Involved in virulence in a mouse systemic infection model. (314 aa) |
| | DBF2 | Cell cycle protein kinase DBF2; Ser/Thr-protein kinase involved in the mitotic exit network (MEN) and required after the metaphase to anaphase cell cycle transition. Required for proper nuclear segregation, mitotic spindle organization, actomyosin ring contraction, primary septum assembly, and normal hyphal morphogenesis. (710 aa) |
| | BUD4 | Bud site selection protein BUD4; Required for establishment of the axial budding pattern in yeast cells. May be involved in the selection of future sites of septation in hyphal cells. Contributes to morphogenesis and is important for induction of hyphal growth. Also plays a role in epithelial adherence, and is involved in intestinal colonization and systemic infection. The role in adhesion is probably minor compared with its role in morphogenesis. Belongs to the BUD4 family. (1709 aa) |
| | CDC28 | Cyclin-dependent kinase 1; Cyclin-dependent kinase essential for the completion of the start, the controlling event, in the cell cycle. Plays a role in the expression of morphology-related transcription factors, and especially hyphae-specific genes. Binds distinct cyclin subunits as cells progress through the division cycle or flamentous growth. The CDC28-CLB2 complex regulates cytokinesis partly by phosphorylating the actomyosin ring component IQG1. The CDC28-CLN3 complex phosphorylates SLA1 which regulates cortical actin patch dynamics. The CDC28-CCN1 complex phosphorylates CDC11 and [...] (317 aa) |
| | CHT3 | Chitinase 3; Chitinase involved in the remodeling of chitin in the fungal cell wall. Plays a role in cell separation. (567 aa) |
| | CDC10 | Cell division control protein 10; Plays a role in the cell cycle. Involved in the formation of the ring of filaments in the neck region at the mother-bud junction during mitosis. (357 aa) |
| | UBC2 | Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation. (179 aa) |
| | CDC11 | Septin CDC11; Septins are GTPases involved in cytokinesis that assemble early in the cell cycle as a patch at the incipient bud site and form a ring before bud emergence, which transforms into an hour-glass shaped collar of cortical filaments that spans both sides of the mother-bud neck. This collar persists until just before cytokinesis, when it splits into two rings that occupy opposite sides of the neck. The septins at the bud neck serve as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Many proteins b [...] (402 aa) |
| | CSM1 | Csm1 domain-containing protein. (225 aa) |
| | MCD1 | Kleisin alpha. (564 aa) |
| | CaO19.6610 | Uncharacterized protein. (924 aa) |
| | MPS1 | Serine/threonine/tyrosine protein kinase. (690 aa) |
| | TUB1 | Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa) |
| | RPN7 | Proteasome regulatory particle lid subunit. (400 aa) |
| | TPM2 | Tropomyosin. (161 aa) |
| | DAD4 | Dad4p. (77 aa) |
| | CDC45 | DNA replication initiation factor. (579 aa) |
| | YPT31 | Rab family GTPase. (222 aa) |
| | POL2 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2211 aa) |
| | CaO19.1841 | Uncharacterized protein. (374 aa) |
| | KIP1 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (911 aa) |
| | CaO19.3854 | Serine/threonine protein kinase. (630 aa) |
| | NIP100 | Nip100p. (895 aa) |
| | NAT5 | Peptide alpha-N-acetyltransferase subunit. (175 aa) |
| | SMC1 | Structural maintenance of chromosomes protein. (1240 aa) |
| | MLC1 | Mlc1p. (143 aa) |
| | RSR1 | Ras family GTPase. (248 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (880 aa) |
| | SPC98 | Spindle pole body component. (785 aa) |
| | SHP1 | Protein phosphatase regulator. (371 aa) |
| | CDC27 | Anaphase promoting complex subunit. (875 aa) |
| | ACC1 | Acetyl-CoA carboxylase. (2271 aa) |
| | SLA2 | Sla2p. (1063 aa) |
| | POL3 | DNA polymerase. (1038 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (682 aa) |
| | RFC2 | Replication factor C subunit 2. (363 aa) |
| | DCC1 | Dcc1p. (339 aa) |
| | CaO19.4557 | Spc7 domain-containing protein. (1083 aa) |
| | MIF2 | Mif2p. (520 aa) |
| | CaO19.5534 | Uncharacterized protein. (350 aa) |
| | CDC20 | Ubiquitin-protein transferase activating protein. (634 aa) |
| | TOP1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (780 aa) |
| | CaO19.3648 | ERCC4 domain-containing protein. (587 aa) |
| | CaO19.1185 | Ubiquitin-conjugating protein. (369 aa) |
| | CaO19.3976 | Uncharacterized protein. (373 aa) |
| | CAC2 | Cac2p. (460 aa) |
| | SPR28 | Spr28p; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (393 aa) |
| | CaO19.3169 | GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (352 aa) |
| | MYO1 | Myosin 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1948 aa) |
| | AFL1 | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (735 aa) |
| | CaO19.3080 | Sister chromatid cohesion protein. (1046 aa) |
| | TUB4 | Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (498 aa) |
| | BRN1 | Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (744 aa) |
| | CaO19.1792 | Anaphase promoting complex subunit. (785 aa) |
| | SPC34 | Spc34p. (247 aa) |
| | SEC15 | Exocyst complex component SEC15; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (892 aa) |
| | BUB1 | Protein kinase. (900 aa) |
| | HOS3 | Histone deacetylase. (713 aa) |
| | CaO19.6170 | CAP-Gly domain-containing protein. (301 aa) |
| | KIP3 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (972 aa) |
| | DYN1 | Dynein heavy chain. (4161 aa) |
| | POL1 | DNA polymerase. (1470 aa) |
| | RAD53 | Serine/threonine-protein kinase RAD53; Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. (699 aa) |
| | MBP1 | Transcription factor. (852 aa) |
| | DDC1 | DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. (488 aa) |
| | HRT1 | SCF ubiquitin ligase complex subunit. (123 aa) |
| | SMC3 | Structural maintenance of chromosomes protein. (1237 aa) |
| | YCG1 | Condensin subunit. (1259 aa) |
| | PPH21 | Serine/threonine-protein phosphatase. (360 aa) |
| | CaO19.6155 | DNA ligase. (770 aa) |
| | MIH1 | Putative tyrosine protein phosphatase. (894 aa) |
| | GCN1 | Gcn1p. (2415 aa) |
| | KAR3 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (687 aa) |
| | SMC2 | Structural maintenance of chromosomes protein. (1171 aa) |
| | CaO19.1434 | Protein kinase activating protein. (716 aa) |
| | YCS4 | Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1172 aa) |
| | PDS5 | Pds5p. (1303 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (878 aa) |
| | CDC7 | Serine/threonine protein kinase. (656 aa) |
| | CDC15 | Serine/threonine protein kinase. (1126 aa) |
| | RAD32 | DNA-directed DNA polymerase eta. (640 aa) |
| | BUB2 | Bub2p. (314 aa) |
| | MSB2 | Msb2p. (1409 aa) |
| | A0A1D8PGE0 | Dynein light chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. (91 aa) |
| | DAD1 | Dad1p. (99 aa) |
| | CaO19.4963 | TPR_REGION domain-containing protein. (391 aa) |
| | SPA2 | Spa2p. (1466 aa) |
| | CDC54 | DNA helicase; Belongs to the MCM family. (912 aa) |
| | RAX2 | Rax2p. (1393 aa) |
| | CDC6 | Cell division control protein; Belongs to the CDC6/cdc18 family. (481 aa) |
| | CaO19.1834 | Uncharacterized protein. (910 aa) |
| | SWI6 | Transcriptional regulator. (729 aa) |
| | BUD6 | Bud6p. (703 aa) |
| | CaO19.5053 | Uncharacterized protein. (260 aa) |
| | CaO19.6247 | Chromatin-binding protein. (871 aa) |
| | REI1 | Rei1p. (382 aa) |
| | PHO85 | Cyclin-dependent serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (332 aa) |
| | CDC3 | Septin; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (428 aa) |
| | CDC12 | Septin; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (397 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (805 aa) |
| | TEM1 | Ras family GTPase. (200 aa) |
| | SWI4 | SBF complex DNA-binding subunit. (1019 aa) |
| | ESP1 | Separase. (1598 aa) |
| | CaO19.3295 | Uncharacterized protein. (474 aa) |
| | APC1 | Anaphase promoting complex subunit 1. (1535 aa) |
| | TUB2 | Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa) |
| | BFA1 | Bfa1p. (428 aa) |
| | DAM1 | DASH complex subunit DAM1; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity). (277 aa) |
| | BUD31 | U2 snRNP complex subunit. (150 aa) |
| | PKC1 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (1097 aa) |
| | MEA1 | Mea1p. (629 aa) |
| | CaO19.5934 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (629 aa) |
| | CaO19.4597 | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (291 aa) |
| | POL30 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (259 aa) |
| | ASK1 | Ask1p. (594 aa) |
| | CLB2 | G2/mitotic-specific cyclin CLB2; 2/mitotic-specific cyclin essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Degradation is necessary for the cell to exit from mitosis. Plays a role in morphogenesis by negatively regulating polarized growth. Through binding to CDC28 regulates cytokinesis, partly by phosphorylation of the actomyosin ring component IQG1. Also involved in the phosphorylation of CDC6 and CDC54. (492 aa) |
| | HSK3 | Hsk3p. (106 aa) |
| | BNI1 | Formin BNI1; Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and acts as leaky capper, slowing both polymerization and depolymerization. Protects the growing actin fiber from tight capping proteins and so increases the time of elongation and the total amount of F-actin. May organize microtubules by mediating spindle positioning and movement in the budding process. Required for the maintenance of polarized hyphal growth. BNI1-mediated actin cables are necessary for positioni [...] (1732 aa) |
| | RAD54 | DNA-dependent ATPase. (848 aa) |
| | KAR9 | Kar9p. (758 aa) |
| | CDC53 | Cullin; Belongs to the cullin family. (752 aa) |
| | CDC34 | SCF E2 ubiquitin-protein ligase catalytic subunit; Belongs to the ubiquitin-conjugating enzyme family. (244 aa) |
| | IQG1 | Ras GTPase-activating-like protein IQG1; Required for the assembly and the contraction of the actomyosin ring at the bud neck during cytokinesis. (1647 aa) |
| | CaO19.6537 | MIND complex subunit. (230 aa) |
| | PSF3 | DNA replication complex GINS protein PSF3; The GINS complex plays an essential role in the initiation of DNA replication. (177 aa) |
| | CaO19.2728 | Uncharacterized protein. (589 aa) |
| | HTZ1 | Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...] (133 aa) |
| | RRD1 | Serine/threonine-protein phosphatase 2A activator 1; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A- phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex (By similarity). (424 aa) |
| | RPD31 | Histone deacetylase. (577 aa) |
| | TPD3 | Protein phosphatase 2A structural subunit. (643 aa) |
| | CaO19.6821 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (807 aa) |
| | MOB1 | Mob1p. (273 aa) |
