STRINGSTRING
KAR3 KAR3 DAM1 DAM1 CaO19.5934 CaO19.5934 MHF1 MHF1 RAD54 RAD54 CaO19.6537 CaO19.6537 TPD3 TPD3 RFA1 RFA1 CDC5 CDC5 CaO19.3306 CaO19.3306 SKI8 SKI8 SGS1 SGS1 RDH54 RDH54 CaO19.955 CaO19.955 SMC4 SMC4 CDC23 CDC23 NDC80 NDC80 NUF2 NUF2 CaO19.3130 CaO19.3130 MTW1 MTW1 CTF8 CTF8 STU1 STU1 GIN4 GIN4 SEP7 SEP7 MAD2 MAD2 RAD51 RAD51 MLH1 MLH1 IPL1 IPL1 HRR25 HRR25 CaO19.6142 CaO19.6142 RTS1 RTS1 MAD1 MAD1 CDC14 CDC14 MUS81 MUS81 CSE4 CSE4 CDC28 CDC28 CDC10 CDC10 CSM1 CSM1 MCD1 MCD1 CaO19.7594 CaO19.7594 TUB1 TUB1 RPN7 RPN7 CaO19.1841 CaO19.1841 KIP1 KIP1 NAT5 NAT5 CaO19.2579 CaO19.2579 ACC1 ACC1 MRE11 MRE11 DCC1 DCC1 CaO19.4557 CaO19.4557 MIF2 MIF2 CaO19.5534 CaO19.5534 TOP1 TOP1 CaO19.3648 CaO19.3648 CAC2 CAC2 CaO19.3169 CaO19.3169 AFL1 AFL1 CaO19.3080 CaO19.3080 TOP2 TOP2 CaO19.2922 CaO19.2922 CaO19.4715 CaO19.4715 TUB4 TUB4 BRN1 BRN1 CaO19.1792 CaO19.1792 BUB1 BUB1 CaO19.2713 CaO19.2713 CaO19.366 CaO19.366 KIP3 KIP3 CaO19.5954 CaO19.5954 SMC3 SMC3 YCG1 YCG1 PPH21 PPH21 RAD1 RAD1 SPO11 SPO11 SMC2 SMC2 YCS4 YCS4 PDS5 PDS5 CaO19.5212 CaO19.5212 CDC7 CDC7 CDC15 CDC15 CaO19.4492 CaO19.4492 RAD32 RAD32 DLH1 DLH1 CaO19.5281 CaO19.5281 CaO19.1834 CaO19.1834 CaO19.5069 CaO19.5069 CaO19.5053 CaO19.5053 VPS34 VPS34 REC8 REC8 TEM1 TEM1 ESP1 ESP1 CaO19.3295 CaO19.3295 TUB2 TUB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KAR3Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (687 aa)
DAM1DASH complex subunit DAM1; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity). (277 aa)
CaO19.5934DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (629 aa)
MHF1Inner kinetochore subunit MHF1; dsDNA-binding component of a FANCM-MHF complex involved in DNA damage repair and genome maintenance (By similarity). FANCM-MHF promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork (By similarity). Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere- associated network (CCAN), wh [...] (117 aa)
RAD54DNA-dependent ATPase. (848 aa)
CaO19.6537MIND complex subunit. (230 aa)
TPD3Protein phosphatase 2A structural subunit. (643 aa)
RFA1Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (624 aa)
CDC5Serine/threonine-protein kinase. (653 aa)
CaO19.3306HORMA domain-containing protein. (607 aa)
SKI8SKI complex subunit WD repeat protein. (384 aa)
SGS1ATP-dependent DNA helicase. (1189 aa)
RDH54DNA-dependent ATPase. (796 aa)
CaO19.955Uncharacterized protein. (325 aa)
SMC4Structural maintenance of chromosomes protein. (1368 aa)
CDC23Anaphase promoting complex subunit. (582 aa)
NDC80Probable kinetochore protein NDC80; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. (788 aa)
NUF2Probable kinetochore protein NUF2; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. (485 aa)
CaO19.3130GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (273 aa)
MTW1MIND complex subunit. (314 aa)
CTF8Ctf8p. (162 aa)
STU1Protein STU1; Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation (By similarity). (1303 aa)
GIN4Serine/threonine-protein kinase GIN4; Serine/threonine-protein kinase which regulates the localization and the function of the septins during mitosis. Involved in the formation of the septin ring but not the basal septin band. Phosphorylates septins CDC11 and SEP7. Required for the transition from pseudohyphae to hyphae. Acts upstream of IRS4 and INP51 in regulating cell wall integrity responses. Involved in propolis-induced cell death. (1349 aa)
SEP7Septation protein 7; Septins are GTPases involved in cytokinesis that assemble early in the cell cycle as a patch at the incipient bud site and form a ring before bud emergence, which transforms into an hour-glass shaped collar of cortical filaments that spans both sides of the mother-bud neck. This collar persists until just before cytokinesis, when it splits into two rings that occupy opposite sides of the neck. The septins at the bud neck serve as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Many pro [...] (670 aa)
MAD2Spindle assembly checkpoint component MAD2; Central component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. Plays a key role in virulence, probably through cell cycle checkpoint functions, especially those monitoring the integrity of DNA and chromosome segregation, which might be required for the pathogen to repair damage caused by host defense. Belongs to the MAD2 family. (214 aa)
RAD51DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (361 aa)
MLH1Mismatch repair ATPase. (717 aa)
IPL1Spindle assembly checkpoint kinase; Required for high-fidelity chromosome segregation during the later part of each cell cycle. Acts in opposition to the phosphatase PP1. Has a role in attaching the kinetochores to the microtubules and ensuring that sister kinetochores connect to opposite poles. The promotion of bi-orientation is achieved by selectively detaching kinetochore-microtubule attachments that are not under tension. Phosphorylates histone H3 to form H3S10ph during mitosis and meiosis (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Au [...] (528 aa)
HRR25Serine/threonine protein kinase; Belongs to the protein kinase superfamily. (433 aa)
CaO19.6142Meiotic nuclear division protein 1; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (201 aa)
RTS1Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (850 aa)
MAD1Spindle assembly checkpoint component MAD1; Central component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. (696 aa)
CDC14Tyrosine-protein phosphatase CDC14; Protein phosphatase which antagonizes mitotic cyclin- dependent kinase CDC28, the inactivation of which is essential for exit from mitosis. To access its substrates, is released from nucleolar sequestration during mitosis. Plays an essential in coordinating the nuclear division cycle with cytokinesis through the cytokinesis checkpoint. Involved in chromosome segregation, where it is required for meiosis I spindle dissambly as well as for establishing two consecutive chromosome segregation phases (By similarity). Plays a role in the expression of hydr [...] (542 aa)
MUS81Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (614 aa)
CSE4Histone H3-like centromeric protein CSE4; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). (211 aa)
CDC28Cyclin-dependent kinase 1; Cyclin-dependent kinase essential for the completion of the start, the controlling event, in the cell cycle. Plays a role in the expression of morphology-related transcription factors, and especially hyphae-specific genes. Binds distinct cyclin subunits as cells progress through the division cycle or flamentous growth. The CDC28-CLB2 complex regulates cytokinesis partly by phosphorylating the actomyosin ring component IQG1. The CDC28-CLN3 complex phosphorylates SLA1 which regulates cortical actin patch dynamics. The CDC28-CCN1 complex phosphorylates CDC11 and [...] (317 aa)
CDC10Cell division control protein 10; Plays a role in the cell cycle. Involved in the formation of the ring of filaments in the neck region at the mother-bud junction during mitosis. (357 aa)
CSM1Csm1 domain-containing protein. (225 aa)
MCD1Kleisin alpha. (564 aa)
CaO19.7594Uncharacterized protein. (213 aa)
TUB1Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
RPN7Proteasome regulatory particle lid subunit. (400 aa)
CaO19.1841Uncharacterized protein. (374 aa)
KIP1Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (911 aa)
NAT5Peptide alpha-N-acetyltransferase subunit. (175 aa)
CaO19.2579MutS family protein. (803 aa)
ACC1Acetyl-CoA carboxylase. (2271 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (682 aa)
DCC1Dcc1p. (339 aa)
CaO19.4557Spc7 domain-containing protein. (1083 aa)
MIF2Mif2p. (520 aa)
CaO19.5534Uncharacterized protein. (350 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (780 aa)
CaO19.3648ERCC4 domain-containing protein. (587 aa)
CAC2Cac2p. (460 aa)
CaO19.3169GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (352 aa)
AFL1Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (735 aa)
CaO19.3080Sister chromatid cohesion protein. (1046 aa)
TOP2DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1461 aa)
CaO19.2922TBPIP domain-containing protein. (205 aa)
CaO19.4715PH domain-containing protein. (3826 aa)
TUB4Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (498 aa)
BRN1Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (744 aa)
CaO19.1792Anaphase promoting complex subunit. (785 aa)
BUB1Protein kinase. (900 aa)
CaO19.2713MutS family protein. (802 aa)
CaO19.366DNA damage checkpoint control protein RAD17; Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes; Belongs to the rad1 family. (336 aa)
KIP3Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (972 aa)
CaO19.5954WD_REPEATS_REGION domain-containing protein. (510 aa)
SMC3Structural maintenance of chromosomes protein. (1237 aa)
YCG1Condensin subunit. (1259 aa)
PPH21Serine/threonine-protein phosphatase. (360 aa)
RAD1SsDNA endodeoxyribonuclease. (970 aa)
SPO11Spo11p. (309 aa)
SMC2Structural maintenance of chromosomes protein. (1171 aa)
YCS4Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1172 aa)
PDS5Pds5p. (1303 aa)
CaO19.5212SUMO ligase. (366 aa)
CDC7Serine/threonine protein kinase. (656 aa)
CDC15Serine/threonine protein kinase. (1126 aa)
CaO19.4492Uncharacterized protein. (427 aa)
RAD32DNA-directed DNA polymerase eta. (640 aa)
DLH1Recombinase; Belongs to the RecA family. (324 aa)
CaO19.5281Uncharacterized protein. (1220 aa)
CaO19.1834Uncharacterized protein. (910 aa)
CaO19.5069Uncharacterized protein. (243 aa)
CaO19.5053Uncharacterized protein. (260 aa)
VPS34Phosphatidylinositol 3-kinase VPS34. (1020 aa)
REC8Rad21_Rec8_N domain-containing protein. (635 aa)
TEM1Ras family GTPase. (200 aa)
ESP1Separase. (1598 aa)
CaO19.3295Uncharacterized protein. (474 aa)
TUB2Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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