STRINGSTRING
SMC4 SMC4 TAF12 TAF12 SSN6 SSN6 SUS1 SUS1 HIR3 HIR3 CaO19.340 CaO19.340 CLF1 CLF1 HTZ1 HTZ1 CaO19.2728 CaO19.2728 HIR2 HIR2 PAB1 PAB1 SPP1 SPP1 CaO19.1668 CaO19.1668 MHF1 MHF1 POB3 POB3 ESC4 ESC4 ARP6 ARP6 CaO19.2964 CaO19.2964 CDC73 CDC73 ORC1 ORC1 CaO19.3027 CaO19.3027 CaO19.3035 CaO19.3035 REC8 REC8 CaO19.6247 CaO19.6247 TAF145 TAF145 CaO19.4437 CaO19.4437 RPA190 RPA190 CDC6 CDC6 KEM1 KEM1 IRR1 IRR1 DPB4 DPB4 CaO19.2041 CaO19.2041 SNF2 SNF2 CaO19.5212 CaO19.5212 MCM3 MCM3 SMC2 SMC2 CDC47 CDC47 CaO19.200 CaO19.200 CaO19.1363 CaO19.1363 RAP1 RAP1 CaO19.1368 CaO19.1368 YCG1 YCG1 CaO19.6952 CaO19.6952 A0A1D8PJT8 A0A1D8PJT8 POL1 POL1 CaO19.7452 CaO19.7452 TAF60 TAF60 CaO19.7453 CaO19.7453 CaO19.7441 CaO19.7441 CaO19.4677 CaO19.4677 CaO19.3792 CaO19.3792 BRN1 BRN1 CaO19.1259 CaO19.1259 A0A1D8PMJ7 A0A1D8PMJ7 CaO19.3080 CaO19.3080 CaO19.5689 CaO19.5689 CaO19.3170 CaO19.3170 CaO19.1111 CaO19.1111 CaO19.3949 CaO19.3949 CaO19.5569 CaO19.5569 TSM1 TSM1 GBP2 GBP2 HHO1 HHO1 CaO19.7197 CaO19.7197 KTI12 KTI12 CaO19.4388 CaO19.4388 CaO19.474 CaO19.474 TAF12L TAF12L CaO19.536 CaO19.536 CaO19.6625 CaO19.6625 SPT10 SPT10 CaO19.3890 CaO19.3890 CDC45 CDC45 DCP2 DCP2 LSM1 LSM1 CaO19.7344 CaO19.7344 MCD1 MCD1 SPT6 SPT6 IPI1 IPI1 CDC46 CDC46 SWD2 SWD2 RIX1 RIX1 RTT106 RTT106 ORC3 ORC3 CaO19.6923 CaO19.6923 CaO19.5666 CaO19.5666 HAT1 HAT1 GON7 GON7 ADA2 ADA2 CaO19.91 CaO19.91 CaO19.5358 CaO19.5358 HIR1 HIR1 ISW2 ISW2 CDC68 CDC68 VID21 VID21 NCB2 NCB2 MCM2 MCM2 CaO19.3613 CaO19.3613 KAE1 KAE1 CaO19.3242 CaO19.3242 HDA1 HDA1 NAP1 NAP1 IPI3 IPI3 ARP4 ARP4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMC4Structural maintenance of chromosomes protein. (1368 aa)
TAF12TFIID_20kDa domain-containing protein. (515 aa)
SSN6Transcription regulator. (1080 aa)
SUS1Transcription and mRNA export factor SUS1; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex required for deubiquitination of [...] (119 aa)
HIR3Histone transcription regulator 3 homolog; Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation. Belongs to the HIR3 family. (1591 aa)
CaO19.340ESCRT-I subunit protein. (199 aa)
CLF1Pre-mRNA-splicing factor CLF1; Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication (By similarity). (701 aa)
HTZ1Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...] (133 aa)
CaO19.2728Uncharacterized protein. (589 aa)
HIR2Protein HIR2; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (1017 aa)
PAB1Polyadenylate-binding protein, cytoplasmic and nuclear; Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and [...] (629 aa)
SPP1Spp1p. (406 aa)
CaO19.1668Uncharacterized protein. (623 aa)
MHF1Inner kinetochore subunit MHF1; dsDNA-binding component of a FANCM-MHF complex involved in DNA damage repair and genome maintenance (By similarity). FANCM-MHF promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork (By similarity). Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere- associated network (CCAN), wh [...] (117 aa)
POB3FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (538 aa)
ESC4Esc4p. (903 aa)
ARP6Actin-like protein ARP6; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity). (446 aa)
CaO19.2964Uncharacterized protein. (795 aa)
CDC73Cdc73p. (370 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (805 aa)
CaO19.3027Uncharacterized protein; Belongs to the actin family. (378 aa)
CaO19.3035Chromatin-remodeling ATPase. (1410 aa)
REC8Rad21_Rec8_N domain-containing protein. (635 aa)
CaO19.6247Chromatin-binding protein. (871 aa)
TAF145Taf145p. (1260 aa)
CaO19.4437Chromatin-remodeling ATPase. (1017 aa)
RPA190DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1665 aa)
CDC6Cell division control protein; Belongs to the CDC6/cdc18 family. (481 aa)
KEM15'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins. (1504 aa)
IRR1Irr1p. (1089 aa)
DPB4DNA polymerase epsilon noncatalytic subunit. (261 aa)
CaO19.2041Uncharacterized protein. (636 aa)
SNF2SWI/SNF catalytic subunit. (1690 aa)
CaO19.5212SUMO ligase. (366 aa)
MCM3DNA helicase; Belongs to the MCM family. (878 aa)
SMC2Structural maintenance of chromosomes protein. (1171 aa)
CDC47DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (781 aa)
CaO19.200SAP domain-containing protein. (193 aa)
CaO19.1363SWIRM domain-containing protein. (392 aa)
RAP1DNA-binding transcription factor. (430 aa)
CaO19.1368Uncharacterized protein. (607 aa)
YCG1Condensin subunit. (1259 aa)
CaO19.6952Uncharacterized protein. (669 aa)
A0A1D8PJT8Ubiquinol--cytochrome-c reductase subunit 6. (135 aa)
POL1DNA polymerase. (1470 aa)
CaO19.7452SLD3 domain-containing protein. (736 aa)
TAF60Taf60p. (519 aa)
CaO19.7453Uncharacterized protein. (273 aa)
CaO19.7441Brr6_like_C_C domain-containing protein. (308 aa)
CaO19.4677HIT-type domain-containing protein. (236 aa)
CaO19.3792Uncharacterized protein. (785 aa)
BRN1Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (744 aa)
CaO19.1259DNA-binding E3 ubiquitin-protein ligase. (1443 aa)
A0A1D8PMJ7Chromatin DNA-binding EKC/KEOPS complex subunit. (98 aa)
CaO19.3080Sister chromatid cohesion protein. (1046 aa)
CaO19.5689Coatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Belongs to the COPE family. (311 aa)
CaO19.3170DUF3835 domain-containing protein. (728 aa)
CaO19.1111Chromatin modification protein. (231 aa)
CaO19.3949Bromo domain-containing protein. (1314 aa)
CaO19.5569Uncharacterized protein. (932 aa)
TSM1Tsm1p. (1425 aa)
GBP2Single-stranded telomeric DNA-binding/mRNA-binding protein. (436 aa)
HHO1Histone. (180 aa)
CaO19.7197Nucleolar complex-associated protein 3; Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm. Belongs to the CBF/MAK21 family. (745 aa)
KTI12Kti12p. (288 aa)
CaO19.4388BTP domain-containing protein. (364 aa)
CaO19.474Brr6_like_C_C domain-containing protein. (433 aa)
TAF12LTFIID_20kDa domain-containing protein. (750 aa)
CaO19.536Chromatin modification protein. (798 aa)
CaO19.6625Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (275 aa)
SPT10Spt10p. (469 aa)
CaO19.3890DNA-dependent ATPase. (1097 aa)
CDC45DNA replication initiation factor. (579 aa)
DCP2Decapping enzyme complex catalytic subunit. (907 aa)
LSM1U6 snRNA-associated Sm-like protein LSm1; Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation. (167 aa)
CaO19.7344Uncharacterized protein. (835 aa)
MCD1Kleisin alpha. (564 aa)
SPT6Transcription elongation factor SPT6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity); Belongs to the SPT6 family. (1401 aa)
IPI1Pre-rRNA-processing protein IPI1-1; Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA. (366 aa)
CDC46DNA helicase; Belongs to the MCM family. (728 aa)
SWD2WD-repeat containing protein. (364 aa)
RIX1Pre-rRNA-processing protein RIX1; Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre- 60S ribosomal subunits. Regulates pre-60S association of the critical remodeling factor MDN1. (769 aa)
RTT106Histone chaperone RTT106; Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter (By similarity). (409 aa)
ORC3Origin recognition complex subunit 3. (682 aa)
CaO19.6923TAFII28 domain-containing protein. (343 aa)
CaO19.5666Chromatin-binding transcription coactivator. (146 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-14' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family. (413 aa)
GON7EKC/KEOPS complex subunit GON7; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptiona [...] (121 aa)
ADA2Transcriptional adapter 2; Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulati [...] (445 aa)
CaO19.91Uncharacterized protein. (299 aa)
CaO19.5358Origin recognition complex subunit 2. (688 aa)
HIR1Protein HIR1; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (907 aa)
ISW2ISWI chromatin-remodeling complex ATPase ISW2; Catalytic component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing (By similarity). ISW2 is required for chlamydospore formation, distinctive morphological feature of the fungal pathogen C.albicans that can be induced to form in oxygen-limited environments and has been reported in clinical specimens; Belongs to the SNF2/RAD54 helicase fa [...] (1056 aa)
CDC68FACT complex subunit SPT16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (1060 aa)
VID21Chromatin modification-related protein EAF1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (686 aa)
NCB2Negative cofactor 2 transcription regulator complex subunit. (149 aa)
MCM2DNA helicase; Belongs to the MCM family. (903 aa)
CaO19.3613Uncharacterized protein. (467 aa)
KAE1tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (372 aa)
CaO19.3242Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...] (244 aa)
HDA1Histone deacetylase HDA1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates the YNG2 subunit of NuA4 histone acetyltransferase (HAT) module, leading to the reduction of YNG2 and NuA4 HAT at the promoters of hypha-specific genes. Plays a key role in the regulation o [...] (833 aa)
NAP1Nucleosome assembly protein 1; Acidic protein, which assembles histones into an octamer (By similarity). Involved in the regulation of the localization and the function of the septins during mitosis. (435 aa)
IPI3Pre-rRNA-processing protein IPI3; Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA. (505 aa)
ARP4Actin-related protein 4; Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes [...] (468 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.