STRINGSTRING
MCM3 MCM3 CDC53 CDC53 CLF1 CLF1 CaO19.3289 CaO19.3289 CaO19.5429 CaO19.5429 CaO19.5358 CaO19.5358 DBF4 DBF4 MCM2 MCM2 SKP1 SKP1 CaO19.4441 CaO19.4441 SLD2 SLD2 ORC3 ORC3 CaO19.2369 CaO19.2369 CaO19.29 CaO19.29 CDC46 CDC46 HSP60 HSP60 CDC45 CDC45 MCM6 MCM6 ORC4 ORC4 POL1 POL1 RAD53 RAD53 CDC47 CDC47 CDC54 CDC54 CDC6 CDC6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MCM3DNA helicase; Belongs to the MCM family. (878 aa)
CDC53Cullin; Belongs to the cullin family. (752 aa)
CLF1Pre-mRNA-splicing factor CLF1; Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication (By similarity). (701 aa)
CaO19.3289Origin recognition complex subunit 6. (363 aa)
CaO19.5429DNA-binding SCF ubiquitin ligase subunit. (675 aa)
CaO19.5358Origin recognition complex subunit 2. (688 aa)
DBF4Protein serine/threonine kinase activating protein. (506 aa)
MCM2DNA helicase; Belongs to the MCM family. (903 aa)
SKP1SCF ubiquitin ligase subunit; Belongs to the SKP1 family. (164 aa)
CaO19.4441Zf-primase domain-containing protein. (598 aa)
SLD2DNA replication regulator SLD2; Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity); Belongs to the SLD2 family. (354 aa)
ORC3Origin recognition complex subunit 3. (682 aa)
CaO19.2369Origin recognition complex subunit 5. (496 aa)
CaO19.29CDT1_C domain-containing protein. (323 aa)
CDC46DNA helicase; Belongs to the MCM family. (728 aa)
HSP60Heat shock protein 60, mitochondrial; May participate in assembly and/or disassembly of proteins imported into the mitochondrion. HSP60 are ATPases and have affinity for unfolded proteins (By similarity); Belongs to the chaperonin (HSP60) family. (566 aa)
CDC45DNA replication initiation factor. (579 aa)
MCM6DNA helicase; Belongs to the MCM family. (880 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (564 aa)
POL1DNA polymerase. (1470 aa)
RAD53Serine/threonine-protein kinase RAD53; Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. (699 aa)
CDC47DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (781 aa)
CDC54DNA helicase; Belongs to the MCM family. (912 aa)
CDC6Cell division control protein; Belongs to the CDC6/cdc18 family. (481 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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