STRINGSTRING
PIF1 PIF1 HSP60 HSP60 UBC2 UBC2 CDC45 CDC45 CaO19.4383 CaO19.4383 CaO19.2376 CaO19.2376 MCM6 MCM6 MRE11 MRE11 CaO19.7088 CaO19.7088 CaO19.1310 CaO19.1310 CaO19.5040 CaO19.5040 CaO19.3021 CaO19.3021 DLH1 DLH1 CDC54 CDC54 MCM3 MCM3 RAD57 RAD57 MHR1 MHR1 RFA2 RFA2 POL1 POL1 CaO19.6718 CaO19.6718 RAD2 RAD2 GIS2 GIS2 CaO19.4441 CaO19.4441 RAD51 RAD51 SLD2 SLD2 SMC5 SMC5 STN1 STN1 RAD1 RAD1 RAD50 RAD50 SBP1 SBP1 MGM101 MGM101 SMC6 SMC6 CaO19.6722 CaO19.6722 RFA1 RFA1 CaO19.6090 CaO19.6090 RAD10 RAD10 RIM1 RIM1 RPB7 RPB7 PIM1 PIM1 RAD18 RAD18 RPC82 RPC82
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (906 aa)
HSP60Heat shock protein 60, mitochondrial; May participate in assembly and/or disassembly of proteins imported into the mitochondrion. HSP60 are ATPases and have affinity for unfolded proteins (By similarity); Belongs to the chaperonin (HSP60) family. (566 aa)
UBC2Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation. (179 aa)
CDC45DNA replication initiation factor. (579 aa)
CaO19.4383DNA 5'-adenosine monophosphate hydrolase. (259 aa)
CaO19.2376zf-C2HE domain-containing protein. (259 aa)
MCM6DNA helicase; Belongs to the MCM family. (880 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (682 aa)
CaO19.7088Threonylcarbamoyl-AMP synthase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (382 aa)
CaO19.1310Uncharacterized protein. (543 aa)
CaO19.5040FG-nucleoporin. (592 aa)
CaO19.3021Putative peptide hydrolase. (376 aa)
DLH1Recombinase; Belongs to the RecA family. (324 aa)
CDC54DNA helicase; Belongs to the MCM family. (912 aa)
MCM3DNA helicase; Belongs to the MCM family. (878 aa)
RAD57Putative DNA-dependent ATPase. (511 aa)
MHR1Mitochondrial homologous recombination protein 1; Transcription factor involved in regulation of RNA polymerase II-dependent transcription. Also involved in regulation of mitochondrial DNA recombination, maintenance and repair, and generation of homoplasmic cells (By similarity); Belongs to the mitochondrion-specific ribosomal protein mL67 family. (239 aa)
RFA2Rfa2p. (272 aa)
POL1DNA polymerase. (1470 aa)
CaO19.6718Uncharacterized protein. (250 aa)
RAD2SsDNA endodeoxyribonuclease. (990 aa)
GIS2mRNA-binding translational activator. (175 aa)
CaO19.4441Zf-primase domain-containing protein. (598 aa)
RAD51DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (361 aa)
SLD2DNA replication regulator SLD2; Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity); Belongs to the SLD2 family. (354 aa)
SMC5DNA repair ATPase. (1073 aa)
STN1Stn1p. (587 aa)
RAD1SsDNA endodeoxyribonuclease. (970 aa)
RAD50MRX complex DNA-binding subunit. (1332 aa)
SBP1Sbp1p. (282 aa)
MGM101Mitochondrial genome maintenance protein MGM101; Performs an essential function in the repair of oxidatively damaged mtDNA that is required for the maintenance of the mitochondrial genome. Binds to DNA (By similarity); Belongs to the MGM101 family. (275 aa)
SMC6DNA repair protein. (1128 aa)
CaO19.6722Uncharacterized protein. (709 aa)
RFA1Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (624 aa)
CaO19.6090Uncharacterized protein. (400 aa)
RAD10Rad10p. (338 aa)
RIM1Rim1p. (143 aa)
RPB7DNA-directed RNA polymerase II subunit. (173 aa)
PIM1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. (1078 aa)
RAD18Postreplication repair E3 ubiquitin-protein ligase RAD18; E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA. (378 aa)
RPC82DNA-directed RNA polymerase III subunit RPC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (By similarity). (595 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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