STRINGSTRING
CaO19.2730 CaO19.2730 CSR1 CSR1 PHO4 PHO4 ZCF5 ZCF5 A0A1D8PMG2 A0A1D8PMG2 HMS1 HMS1 HAP5 HAP5 FCR3 FCR3 TAC1 TAC1 ZNC1 ZNC1 HAL9 HAL9 LEU3 LEU3 CTA7 CTA7 SUT1 SUT1 GLN3 GLN3 CaO19.3928 CaO19.3928 PPR1 PPR1 GRF10 GRF10 CaO19.1189 CaO19.1189 CaO19.3643 CaO19.3643 CaO19.3644 CaO19.3644 MET28 MET28 YOX1 YOX1 ZCF29 ZCF29 ZCF38 ZCF38 REP1 REP1 KAR4 KAR4 CaO19.3722 CaO19.3722 CaO19.173 CaO19.173 CIRT4B CIRT4B ZCF11 ZCF11 ZCF19 ZCF19 CaO19.2624 CaO19.2624 TBP1 TBP1 SUC1 SUC1 CPH1 CPH1 PZF1 PZF1 ASG1 ASG1 CWT1 CWT1 UME6 UME6 MRR2 MRR2 FGR27 FGR27 EFH1 EFH1 UPC2 UPC2 CPH2 CPH2 ACE2 ACE2 MNL1 MNL1 CaO19.211 CaO19.211 STB3 STB3 CRZ2 CRZ2 CaO19.6874 CaO19.6874 ZCF3 ZCF3 CaO19.1150 CaO19.1150 BCR1 BCR1 CaO19.1897 CaO19.1897 SEF1 SEF1 RFX1 RFX1 RPN4 RPN4 WAR1 WAR1 SKO1 SKO1 ZCF23 ZCF23 RME1 RME1 EFG1 EFG1 AFT2 AFT2 FHL1 FHL1 NRG1 NRG1 CaO19.5841 CaO19.5841 CZF1 CZF1 CBF1 CBF1 GZF3 GZF3 RFG1 RFG1 SFL1 SFL1 ZCF30 ZCF30 GAT1 GAT1 MTLA2 MTLA2 AHR1 AHR1 MRR1 MRR1 CRZ1 CRZ1 TRY5 TRY5 SKN7 SKN7 ASH1 ASH1 MET4 MET4 BAS1 BAS1 HAP31 HAP31 CAT8 CAT8 CaO19.5390 CaO19.5390 FKH2 FKH2 DAL81 DAL81 STB5 STB5 PUT3 PUT3 RCA1 RCA1 RBF1 RBF1 NDT80 NDT80 ADR1 ADR1 MAC1 MAC1 MCM1 MCM1 CUP9 CUP9 STP4 STP4 CAP1 CAP1 SFL2 SFL2 CaO19.5026 CaO19.5026 CUP2 CUP2 STP2 STP2 TYE7 TYE7 CaO19.4918 CaO19.4918 HSK3 HSK3 CAS5 CAS5 RFX2 RFX2 WOR2 WOR2 TRY4 TRY4 SFP1 SFP1 STP3 STP3 TEC1 TEC1 WOR1 WOR1 SFU1 SFU1 HCM1 HCM1 CTA8 CTA8 RTG1 RTG1 HOT1 HOT1 ZCF24 ZCF24 MTLA1 MTLA1 SWI4 SWI4 ARO80 ARO80 HAC1 HAC1 HAP2 HAP2 ARG81 ARG81 CaO19.4749 CaO19.4749 ZCF28 ZCF28 LYS143 LYS143 CaO19.4768 CaO19.4768 CaO19.4911 CaO19.4911 HAP43 HAP43 RTG3 RTG3 OFI1 OFI1 CaO19.1496 CaO19.1496 ADAEC ADAEC CaO19.5210 CaO19.5210 CaO19.3146 CaO19.3146 ZCF10 ZCF10 CaO19.217 CaO19.217 CaO19.1600 CaO19.1600 RAP1 RAP1 GCN4 GCN4 CaO19.1757 CaO19.1757 ZCF1 ZCF1 MBP1 MBP1 ZCF16 ZCF16 TEA1 TEA1 CaO19.7397 CaO19.7397 RLM1 RLM1 HAP3 HAP3 CaO19.2743 CaO19.2743 UME7 UME7 RGT1 RGT1 ARG83 ARG83
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CaO19.2730Uncharacterized protein. (606 aa)
CSR1Csr1p. (618 aa)
PHO4Phosphate-sensing transcription factor. (659 aa)
ZCF5Zcf5p. (971 aa)
A0A1D8PMG2Fungal_trans domain-containing protein. (563 aa)
HMS1Hms1p. (685 aa)
HAP5Hap5p. (348 aa)
FCR3Fcr3p. (399 aa)
TAC1Tac1p. (981 aa)
ZNC1Znc1p. (922 aa)
HAL9Hal9p. (1010 aa)
LEU3Leucine-responsive transcriptional regulator. (984 aa)
CTA7Cta7p. (834 aa)
SUT1Sut1p. (356 aa)
GLN3Nitrogen-responsive transcriptional regulator. (682 aa)
CaO19.3928Uncharacterized protein. (380 aa)
PPR1Ppr1p. (860 aa)
GRF10Grf10p. (685 aa)
CaO19.1189NDC10_II domain-containing protein. (684 aa)
CaO19.3643Uncharacterized protein. (390 aa)
CaO19.3644Uncharacterized protein. (715 aa)
MET28Met28p. (173 aa)
YOX1Yox1p. (335 aa)
ZCF29Zcf29p. (1105 aa)
ZCF38Zcf38p. (582 aa)
REP1Rep1p. (693 aa)
KAR4Kar4p; Belongs to the MT-A70-like family. (369 aa)
CaO19.3722Uncharacterized protein. (849 aa)
CaO19.173Uncharacterized protein. (1100 aa)
CIRT4BCirt4bp. (555 aa)
ZCF11Zcf11p. (561 aa)
ZCF19Zcf19p. (619 aa)
CaO19.2624Uncharacterized protein. (607 aa)
TBP1TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. (238 aa)
SUC1Probable sucrose utilization protein SUC1; Affects sucrose utilization and alpha-glucosidase activity. Probable transcriptional activator; Belongs to the MAL13 family. (501 aa)
CPH1Transcription factor CPH1; Transcription factor involved in the formation of pseudohyphae and hyphae. It is likely to play a role in the developmental switch between yeast and mycelial forms. May be involved in a signal transduction system, strengthening the possibility of a sexual phase up to now undetected, and similar to that of the yeast mating pathway. (656 aa)
PZF1Transcription factor IIIA; Transcription factor required for transcription of 5S rRNA by RNA polymerase III. (412 aa)
ASG1Activator of stress genes protein 1; Transcription factor necessary to sustain growth on non- fermentative carbon sources such as sodium acetate, acetic acid, or ethanol. Plays a role in hyphal formation. (990 aa)
CWT1Cwt1p. (578 aa)
UME6Transcriptional regulatory protein UME6; Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). UME6 controls the level and duration of gene expression in the filamentous growth program such as HGC1; and is specifically important for hyphal elongation and germ tube formation. Promo [...] (843 aa)
MRR2Multidrug resistance regulator 2; Transcription factor that controls the expression of CDR1, the major multidrug efflux pump. Required for yeast cell adherence to silicone substrate and plays a role in virulence. (710 aa)
FGR27Filamentous growth regulator 27; Transcription factor involved in yeast cell adherence to silicone substrate, filamentous growth, and biofilm formation. (787 aa)
EFH1Transcriptional regulator EFH1; Transcription factor that regulates filamentous growth through repression of EFG1. Regulates the level of colonizing fungi, favoring commensalism as opposed to candidiasis. (720 aa)
UPC2Sterol uptake control protein 2; Transcription factor involved in the regulation of ergosterol biosynthetic genes such as ERG2 and ERG11 through direct binding to sterol response elements (SREs) in the promoters. Binds also to its own promoter on 2 cis-acting elements to promote autoregulation. Regulates sterol uptake across the plasma membrane. Acts as a major regulator of ascorbic acid-induced response. Plays a role in the triggering of pyroptosis, an inflammasome-mediated programmed cell death pathway in macrophages, allowing macrophages escaping. (712 aa)
CPH2Transcription factor CPH2; Transcription factor that positively controls filamentous growth, virulence, and invasiveness. Binds directly to the two SRE-1- like elements upstream of TEC1 and thus regulates positively expression of this important hyphal growth regulator. Functions independently of known signaling cascades involving EFG1. Regulates also gene expression during intestinal colonization but is not involved in host cell adhesion. (853 aa)
ACE2Cell wall transcription factor ACE2; Transcription factor involved in the RAM (regulation of ACE2 transcription factor and polarized morphogenesis) signaling network that regulates polarized morphogenesis. Regulates expression of genes involved in cell separation such as CHT3, DSE1, and SCW11; or other cell wall genes such as ASH1, DSE4, PIR1, PRY2, and RME1. Required for regulation of morphogenesis, cell separation, adherence, biofilm formation, invasion, as well as virulence in a mouse model of infection. (783 aa)
MNL1Transcriptional regulator MNL1; Transcription factor that activates stress response genes via SLE (STRE-like) elements. Required for adaptation to weak acid stress such as acetic acid stress, but seems not involved in the response to heat, osmotic, ethanol, nutrient, oxidative, or heavy-metal stress. Activates a subset of the genes that are repressed by NRG1. (905 aa)
CaO19.211HTH araC/xylS-type domain-containing protein. (180 aa)
STB3Stb3p. (503 aa)
CRZ2Transcriptional regulator CRZ2; Transcription factor that regulates pH-induced filamentation with RIM101. Required for yeast cell adherence to silicone substrate and biofilm formation. (517 aa)
CaO19.6874Uncharacterized protein. (607 aa)
ZCF3Zcf3p. (195 aa)
CaO19.1150GATA-type domain-containing protein. (472 aa)
BCR1Biofilm and cell wall regulator 1; Transcription factor which acts as a master regulator of biofilm formation. Biofilms play an important role in pathogenesis and produce many infections such as oropharyngeal candidiasis or vulvovaginal candidiasis. Controls the expression of genes that govern cell-surface properties such as ALS1, ALS3, HWP1 AND HYR1. Down-stream component of the hyphal regulatory network that couples expression of cell-surface genes to hyphal differentiation. (740 aa)
CaO19.1897GCR1_C domain-containing protein. (344 aa)
SEF1Transcriptional regulatory protein SEF1; Transcription factor which plays an essential role in virulence by activating the transcription of iron uptake genes such as FRE7 in iron-poor environments such as the host bloodstream and internal organs. Promotes commensalism in a mouse model of gastrointestinal infection. (917 aa)
RFX1Transcriptional regulator RFX1; Transcription factor involved in DNA damage responses, morphogenesis, and virulence. (851 aa)
RPN4Transcriptional regulator RPN4; Transcriptional activator of a number of genes encoding proteasomal subunits. Binds to the DNA sequence 5'-GAAGGCAAAA-3', enriched in regions upstream of proteasome genes. (536 aa)
WAR1Transcriptional regulator WAR1; Transcription factor required for yeast cell adherence to silicone substrate. Plays a role in resistance to weak organic acids such as acetate and sorbate. Binds in vitro to a nitric oxide- responsive element (NORE) but seems not to be involved in response to nitrosative stress. (947 aa)
SKO1Transcriptional regulator SKO1; Transcription repressor involved in cell wall damage response. Regulates 79 caspofungin-responsive genes, including several cell wall biogenesis genes such as CRH11, MNN2, and SKN1. Controls also the expression of pathogenesis and hyphal related genes and represses the yeast-to-hypha transition. Mediates the response to oxidative stress. (578 aa)
ZCF23Glucose starvation modulator protein 1; Transcription factor which regulates nonfermentable carbon utilization; Belongs to the ERT1/acuK family. (566 aa)
RME1Rme1p. (507 aa)
EFG1Enhanced filamentous growth protein 1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Antagonizes the action of WOR1, WOR2 and CZF1, and promotes the white state. In white cells, EFG1 represses WOR1 indirectly through WOR2 to maintain white cell identity. Binds target gene promoters at the EFG1 recognition sequenc [...] (550 aa)
AFT2Iron-regulated transcriptional activator AFT2; Transcription factor involved in iron metabolism, oxidative stress, surface adhesion, hyphal development and virulence. Functions as a negative regulator of MRS4 expression through the CACCC AFT-type sequence in a gene dose-dependent fashion. Acts as a repressor in flocculation, plastic adhesion, and surface hydrophobicity. (798 aa)
FHL1Fork-head transcriptional regulator FHL1; In complex with IFH1, acts as a transcriptional regulator of rRNA and ribosomal protein genes. The FHL1-IFH1 complex is targeted to the ribosomal protein genes by the DNA-binding factor TBF1. (1152 aa)
NRG1Transcriptional regulator NRG1; Transcriptional repressor that binds NRG1 response elements (NRE) of target promoters. Involved in regulation of chlamydospore formation, hyphal growth, virulence, and stress response. Plays a key role in regulating true hyphal growth, but does not regulate pseudohyphal growth in the same fashion. Directs transcriptional repression of a subset of filament-specific genes such as HWP1, HYR1, ALS8, HWP1, or ECE1; via the TUP1 pathway. Functions with UME6 in a negative feedback loop to control the level and duration of filament- specific gene expression in r [...] (310 aa)
CaO19.5841Uncharacterized protein. (252 aa)
CZF1Zinc cluster transcription factor CZF1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Contributes to formation of the opaque state, but is not necessary for heritability of the opaque state. Plays a role in cell adhesion and pseudohyphal growth. Involved in acquisition of drug resistance and acts as a repressor o [...] (385 aa)
CBF1Transcriptional regulator CBF1; Transcription factor that binds ribosomal protein gene promoters and rDNA locus with TBF1. Necessary for the expression of genes involved in assimilation of inorganic sulfate. Also required for the expression of respiratory genes and glycolytic genes. Does not bind to centromeres and is not necessary for efficient chromosome segregationas as does S.cerevisiae CBF1. (251 aa)
GZF3Transcriptional regulator GZF3; Probable transcription factor involved in response to fluconazole, LiCl, and copper. (712 aa)
RFG1Repressor of filamentous growth 1; Transcription regulator that functions in both the positive and negative regulation of filamentous growth, depending upon the environmental conditions. Recruits the TUP1/SSN6 general repression complex to achieve repression. Regulates genes encoding cell wall components that are specifically expressed in the filamentous forms such as HWP1, RBT1, HYR1, ECE1, ALS1, RBT4 and RBT5. (600 aa)
SFL1Transcription factor SFL1; Transcription factor that plays a role of repressor of filamentous growth and flocculation. Antagonizes functions of SFL2 and FLO8. Plays a role in the hyphal repression induced by secreted factors like dodecanol by competitors such as Pseudomonas aeruginosa and Burkholderia cenocepacia. (805 aa)
ZCF30Zcf30p. (799 aa)
GAT1Transcriptional regulatory protein GAT1; Transcriptional regulator of nitrogen utilization required for nitrogen catabolite repression and utilization of isoleucine, tyrosine and tryptophan as nitrogen sources. Controls expression of the MEP2 ammonium permease, the DUR1,2 urea amidolyase, and the transcription factor STP1, which in turn mediates SAP2 expression, a long-known virulence attribute of C.albicans. Influences the filamentation process depending upon the nitrogen sources available. Required for virulence in a mouse systemic infection model. (688 aa)
MTLA2Mating-type-like protein A2; Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional activator that induces the transcription of a-specific mating genes; Belongs to the MATA2 family. (201 aa)
AHR1Adhesion and hyphal regulator 1; Transcription factor that binds the promoters of genes involved in biofilm formation, which include several key adhesion genes, and recruits MCM1 to these sites. Plays an important role in hyphal growth and virulence. Promotes conversion of opaque cells to white phase, but needs existence of EFG1, a key regulator required for maintenance of the white state. (624 aa)
MRR1Multidrug resistance regulator 1; Transcription factor that acts as the central regulator of the MDR1 efflux pump. Other target genes include those encoding oxidoreductases, whose up-regulation in fluconazole-resistant isolates may help to prevent cell damage resulting from the generation of toxic molecules in the presence of fluconazole and thereby contribute to drug resistance. (1108 aa)
CRZ1Transcriptional regulator CRZ1; Transcription factor involved in the regulation of calcium ion homeostasis and required for the maintenance of membrane integrity. Binds to the calcineurin-dependent response element. Plays a role in azole tolerance. (731 aa)
TRY5Transcriptional regulator of yeast form adherence 5; Transcription factor required for yeast cell adherence to silicone substrate. (988 aa)
SKN7Transcription factor SKN7; Transcription factor that is part of a SLN1-YPD1-SKN7 two- component regulatory system, which controls gene expression in response to changes in the osmolarity of the extracellular environment. Under low osmotic conditions, phosphorylated and activated by the phosphorelay intermediate protein YPD1. Also activated in response to oxidative stress, independent on the two-component regulatory system. Regulates heat shock genes in response to oxidative stress and genes involved in cell wall integrity in response to osmotic changes. (559 aa)
ASH1Transcriptional regulatory protein ASH1; Component of the RPD3C(L) histone deacetylase complex (HDAC). Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Controls filamentous growth and required for full virulence in a mouse model of disseminated candidiasis. (449 aa)
MET4Met4p. (385 aa)
BAS1Bas1p. (738 aa)
HAP31Hap31p. (105 aa)
CAT8DNA-binding transcription factor. (1056 aa)
CaO19.5390Uncharacterized protein. (147 aa)
FKH2Fork-head transcriptional regulator 2; Transcription factor required for the morphogenesis of true hyphal as well as yeast cells. Contributes to virulence. (687 aa)
DAL81Dal81p. (878 aa)
STB5Stb5p. (640 aa)
PUT3Put3p. (978 aa)
RCA1Rca1p. (283 aa)
RBF1Transcription factor RBF1; Transcriptional activator that binds to the RPG box and to telomeres. Involved in the regulation of the transition between yeast and filamentous forms and plays a role in virulence. Induces expression of HWP1, a major hyphal cell protein and virulence factor. Belongs to the RBF1 family. (534 aa)
NDT80Transcription factor. (504 aa)
ADR1Transcriptional regulator ADR1; Transcription factor involved in the regulation of hyphal growth. (1418 aa)
MAC1Metal-binding activator 1; Copper ion-sensing transcription factor which activates transcription of the CTR1 copper transporter under low-copper conditions. Promotes filamentous and invasive growth. (431 aa)
MCM1Transcription factor of morphogenesis MCM1; Transcription factor that is recruited by AHR1 to the promoters of genes involved in biofilm formation, which include several key adhesion genes. Plays an important role in cell adhesion, hyphal growth and virulence. Implicated in the regulation of opaque-phase- specific gene expression. (262 aa)
CUP9Cup9p. (344 aa)
STP4Transcriptional regulator STP4; Probable transcription factor involved in response to cell wall damage. (376 aa)
CAP1AP-1-like transcription factor CAP1; Transcription activator involved in multidrug resistance, oxidative stress response, and redox homeostasis. Preferentially binds to promoters with the core binding site 5'-TTA[CG]TAA-3'. Involved in the oxidative stress response in via multiple pathways, including the cellular antioxidant defense system, carbohydrate metabolism and energy metabolism, protein degradation, ATP-dependent RNA helicase, and resistance pathways. The ability of the major systemic fungal pathogen of humans to sense and respond to reactive oxygen species, such as H(2)O(2) ge [...] (499 aa)
SFL2Transcription factor SFL2; Transcription factor that plays a role of activator of filamentous growth and which is involved in invasive growth at a high temperature. Required for human oral epithelium colonization and damage. Promotes filamentous growth in EFG1- and FLO8-dependent manners. Antagonizes functions of SFL1. Belongs to the HSF family. (714 aa)
CaO19.5026Uncharacterized protein. (1177 aa)
CUP2Cup2p. (591 aa)
STP2Transcriptional regulator STP2; Transcription factor involved in the regulation of gene expression in response to extracellular amino acid levels. Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS amino acid sensor system (including CSY1 and CSH3), becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes. Required for efficient alkalinization through the release of ammonia from the cells produced during the breakdown of amino acids, and subsequent switch to the hyph [...] (584 aa)
TYE7Carbohydrate metabolism regulator TYE7; Key transcriptional regulator of carbohydrate metabolism. Binds the promoter sequences of the glycolytic genes at the CANNTG motif and activates their expression during growth on either fermentable or non-fermentable carbon sources as well as under hypoxic growth conditions. Complete glycolytic activation by GAL4 and TYE7 is required for full virulence. Involved in biofilm formation and negatively regulates hyphal formation under hypoxia. Controls also the expression of the copper transport protein CTR1. (269 aa)
CaO19.4918HTH CENPB-type domain-containing protein. (519 aa)
HSK3Hsk3p. (106 aa)
CAS5Cell wall integrity transcriptional regulator CAS5; Transcription factor involved in the cell wall damage response. Acts with ADA2 to promote cell wall integrity. Required for expression of numerous cell wall biosynthesis inhibitor caspofungin- responsive genes. Plays a key role in adherence, hyphal development, and virulence. (821 aa)
RFX2RFX-like DNA-binding protein RFX2; Transcriptional repressor which regulates DNA damage responses, morphogenesis, and virulence. Involved in the regulation of filamentous growth through its repression of hyphal-specific genes such as HWP1, ALS3, HYR1, ECE1, and CEK1; Belongs to the RFX family. (1111 aa)
WOR2White-opaque regulator 2; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. WOR2 is necessary for the stability of the opaque state phenotypic switching from the white to the opaque phase is a necessary step for mating. Plays a role in cell adhesion and pseudohyphal growth. (446 aa)
TRY4Transcriptional regulator of yeast form adherence 4; Transcription factor required for yeast cell adherence to silicone substrate. (286 aa)
SFP1Zinc-coordinating transcription factor. (445 aa)
STP3Transcriptional regulator STP3; Transcription factor that activates genes required for degradation of extracellular protein and uptake of peptides such as the secreted aspartyl protease SAP2 or the oligopeptide transporter OPT1. Required for virulence. Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS amino acid sensor system (including CSY1 and CSH3), becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes. (436 aa)
TEC1Transcription activator TEC1; Transcription factor which regulates genes involved in hyphal development, cell adhesion, biofilm development, and virulence. Plays a role in the formation of 'finger' morphology, a unique multicellular morphology of C.albicans induced by carbon dioxide. Regulates gene expression during intestinal colonization. Required for the expression of the secreted aspartyl proteinases SAP4, SAP5, and SAP6; but also of BCR1, PGA4, and CDC24. Moreover, a positive feedback loop between CDC24 and TEC1 contributes to an increase in active CDC42 at the tip of the germ tub [...] (743 aa)
WOR1White-opaque regulator 1; Master transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. WOR1 Binds the intergenic regions upstream of the genes encoding three additional transcriptional regulators of white-opaque switching, CZF1, EFG1, and WOR2. Phenotypic switching from the white to the opaque phase is a necessary step f [...] (785 aa)
SFU1Suppressor of ferric uptake 1; Transcriptional regulator of iron-responsive genes. Represses expression of SEF1 and genes for iron uptake if iron is present. Plays also a transcription-independent role in the direct inhibition of SEF1 function through protein complex formation and translocation to the cytoplasm, where SEF1 is destabilized. Promotes gastrointestinal commensalism in mice. (517 aa)
HCM1Hcm1p. (579 aa)
CTA8Heat shock transcription factor; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. With HSP90, is required for the modulation of the chaperone levels in response to growth temperature, rather than the activation of acute responses to sudden thermal transitions. Activated during infection and contributes to full virulence. Belongs to the HSF family. (760 aa)
RTG1Rtg1p. (274 aa)
HOT1GCR1_C domain-containing protein. (607 aa)
ZCF24Zcf24p. (701 aa)
MTLA1Mating-type-like protein A1; Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional corepressor that acts in conjunction with ALPHA2 to repress transcription both of homozygote-specific genes and of genes necessary for the white-opaque switch, a prerequisite for mating. Belongs to the MATA1 family. (210 aa)
SWI4SBF complex DNA-binding subunit. (1019 aa)
ARO80Aro80p. (1065 aa)
HAC1Transcription factor. (367 aa)
HAP2Hap2p. (364 aa)
ARG81Arg81p. (1099 aa)
CaO19.4749Uncharacterized protein. (558 aa)
ZCF28Zcf28p. (247 aa)
LYS143Lys143p. (876 aa)
CaO19.4768Uncharacterized protein. (531 aa)
CaO19.4911BED-type domain-containing protein. (320 aa)
HAP43Hap43p. (634 aa)
RTG3Rtg3p. (520 aa)
OFI1Ofi1p. (648 aa)
CaO19.1496Fungal_trans domain-containing protein. (451 aa)
ADAECAdaecp. (545 aa)
CaO19.5210HTH APSES-type domain-containing protein. (577 aa)
CaO19.3146Uncharacterized protein. (416 aa)
ZCF10Zcf10p. (921 aa)
CaO19.217Uncharacterized protein. (379 aa)
CaO19.1600Uncharacterized protein. (709 aa)
RAP1DNA-binding transcription factor. (430 aa)
GCN4Amino acid starvation-responsive transcription factor. (323 aa)
CaO19.1757Uncharacterized protein. (583 aa)
ZCF1Zcf1p. (838 aa)
MBP1Transcription factor. (852 aa)
ZCF16Zcf16p. (1078 aa)
TEA1Tea1p. (900 aa)
CaO19.7397C2H2-type domain-containing protein. (1089 aa)
RLM1Rlm1p. (601 aa)
HAP3Hap3p. (329 aa)
CaO19.2743Uncharacterized protein. (606 aa)
UME7DNA-binding transcriptional regulator. (458 aa)
RGT1Rgt1p. (1027 aa)
ARG83Arg83p. (974 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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