STRINGSTRING
HST3 HST3 HST2 HST2 RPD31 RPD31 CaO19.4615 CaO19.4615 HST1 HST1 SIR2 SIR2 RPD3 RPD3 HOS1 HOS1 HOS3 HOS3 HOS2 HOS2 HDA1 HDA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HST3NAD-dependent histone deacetylase HST3; NAD-dependent histone deacetylase, which could function in telomeric silencing, cell cycle progression and chromosome stability. Belongs to the sirtuin family. Class I subfamily. (487 aa)
HST2NAD-dependent protein deacetylase HST2; NAD-dependent histone deacetylase that is involved in nuclear silencing events. Derepresses subtelomeric silencing and increases repression in nucleolar (rDNA) silencing. Its function is negatively regulated by active nuclear export (By similarity); Belongs to the sirtuin family. Class I subfamily. (331 aa)
RPD31Histone deacetylase. (577 aa)
CaO19.4615RXT2_N domain-containing protein. (318 aa)
HST1NAD-dependent protein deacetylase HST1; NAD-dependent histone deacetylase, which could function in telomeric silencing, cell cycle progression and chromosome stability. Belongs to the sirtuin family. Class I subfamily. (655 aa)
SIR2NAD-dependent histone deacetylase SIR2; NAD-dependent deacetylase. Heterochromatin component that silences transcription at silent mating loci, telomeres and the ribosomal DNA, and that also suppresses recombination in the rDNA and extends replicative life span. It acts as a NAD-dependent histone deacetylase, which deacetylates 'Lys-9' and 'Lys-14' of Histone H3 and 'Lys-16' of Histone H4. Functions in the distribution of oxidatively damaged proteins during cell division. Mediates phenotypic switching. (519 aa)
RPD3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa)
HOS1Histone deacetylase. (436 aa)
HOS3Histone deacetylase. (713 aa)
HOS2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (454 aa)
HDA1Histone deacetylase HDA1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates the YNG2 subunit of NuA4 histone acetyltransferase (HAT) module, leading to the reduction of YNG2 and NuA4 HAT at the promoters of hypha-specific genes. Plays a key role in the regulation o [...] (833 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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