node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CaO19.4615 | RPD3 | Q5AMN1 | A0A1D8PSA6 | RXT2_N domain-containing protein. | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | 0.643 |
CaO19.4615 | RPD31 | Q5AMN1 | Q5ADP0 | RXT2_N domain-containing protein. | Histone deacetylase. | 0.763 |
HDA1 | HOS1 | Q5A960 | A0A1D8PMG7 | Histone deacetylase HDA1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates the YNG2 subunit of NuA4 histone acetyltransferase (HAT) module, leading to the reduction of YNG2 and NuA4 HAT at the promoters of hypha-specific genes. Plays a key role in the regulation o [...] | Histone deacetylase. | 0.580 |
HDA1 | HOS2 | Q5A960 | A0A1D8PJ17 | Histone deacetylase HDA1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates the YNG2 subunit of NuA4 histone acetyltransferase (HAT) module, leading to the reduction of YNG2 and NuA4 HAT at the promoters of hypha-specific genes. Plays a key role in the regulation o [...] | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | 0.589 |
HDA1 | HST1 | Q5A960 | Q5AQ47 | Histone deacetylase HDA1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates the YNG2 subunit of NuA4 histone acetyltransferase (HAT) module, leading to the reduction of YNG2 and NuA4 HAT at the promoters of hypha-specific genes. Plays a key role in the regulation o [...] | NAD-dependent protein deacetylase HST1; NAD-dependent histone deacetylase, which could function in telomeric silencing, cell cycle progression and chromosome stability. Belongs to the sirtuin family. Class I subfamily. | 0.430 |
HDA1 | HST2 | Q5A960 | Q5A985 | Histone deacetylase HDA1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates the YNG2 subunit of NuA4 histone acetyltransferase (HAT) module, leading to the reduction of YNG2 and NuA4 HAT at the promoters of hypha-specific genes. Plays a key role in the regulation o [...] | NAD-dependent protein deacetylase HST2; NAD-dependent histone deacetylase that is involved in nuclear silencing events. Derepresses subtelomeric silencing and increases repression in nucleolar (rDNA) silencing. Its function is negatively regulated by active nuclear export (By similarity); Belongs to the sirtuin family. Class I subfamily. | 0.620 |
HDA1 | RPD3 | Q5A960 | A0A1D8PSA6 | Histone deacetylase HDA1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates the YNG2 subunit of NuA4 histone acetyltransferase (HAT) module, leading to the reduction of YNG2 and NuA4 HAT at the promoters of hypha-specific genes. Plays a key role in the regulation o [...] | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | 0.737 |
HDA1 | RPD31 | Q5A960 | Q5ADP0 | Histone deacetylase HDA1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates the YNG2 subunit of NuA4 histone acetyltransferase (HAT) module, leading to the reduction of YNG2 and NuA4 HAT at the promoters of hypha-specific genes. Plays a key role in the regulation o [...] | Histone deacetylase. | 0.700 |
HDA1 | SIR2 | Q5A960 | O59923 | Histone deacetylase HDA1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates the YNG2 subunit of NuA4 histone acetyltransferase (HAT) module, leading to the reduction of YNG2 and NuA4 HAT at the promoters of hypha-specific genes. Plays a key role in the regulation o [...] | NAD-dependent histone deacetylase SIR2; NAD-dependent deacetylase. Heterochromatin component that silences transcription at silent mating loci, telomeres and the ribosomal DNA, and that also suppresses recombination in the rDNA and extends replicative life span. It acts as a NAD-dependent histone deacetylase, which deacetylates 'Lys-9' and 'Lys-14' of Histone H3 and 'Lys-16' of Histone H4. Functions in the distribution of oxidatively damaged proteins during cell division. Mediates phenotypic switching. | 0.487 |
HOS1 | HDA1 | A0A1D8PMG7 | Q5A960 | Histone deacetylase. | Histone deacetylase HDA1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates the YNG2 subunit of NuA4 histone acetyltransferase (HAT) module, leading to the reduction of YNG2 and NuA4 HAT at the promoters of hypha-specific genes. Plays a key role in the regulation o [...] | 0.580 |
HOS1 | HOS3 | A0A1D8PMG7 | A0A1D8PLH8 | Histone deacetylase. | Histone deacetylase. | 0.817 |
HOS1 | HST1 | A0A1D8PMG7 | Q5AQ47 | Histone deacetylase. | NAD-dependent protein deacetylase HST1; NAD-dependent histone deacetylase, which could function in telomeric silencing, cell cycle progression and chromosome stability. Belongs to the sirtuin family. Class I subfamily. | 0.755 |
HOS1 | HST2 | A0A1D8PMG7 | Q5A985 | Histone deacetylase. | NAD-dependent protein deacetylase HST2; NAD-dependent histone deacetylase that is involved in nuclear silencing events. Derepresses subtelomeric silencing and increases repression in nucleolar (rDNA) silencing. Its function is negatively regulated by active nuclear export (By similarity); Belongs to the sirtuin family. Class I subfamily. | 0.764 |
HOS1 | RPD31 | A0A1D8PMG7 | Q5ADP0 | Histone deacetylase. | Histone deacetylase. | 0.430 |
HOS1 | SIR2 | A0A1D8PMG7 | O59923 | Histone deacetylase. | NAD-dependent histone deacetylase SIR2; NAD-dependent deacetylase. Heterochromatin component that silences transcription at silent mating loci, telomeres and the ribosomal DNA, and that also suppresses recombination in the rDNA and extends replicative life span. It acts as a NAD-dependent histone deacetylase, which deacetylates 'Lys-9' and 'Lys-14' of Histone H3 and 'Lys-16' of Histone H4. Functions in the distribution of oxidatively damaged proteins during cell division. Mediates phenotypic switching. | 0.631 |
HOS2 | HDA1 | A0A1D8PJ17 | Q5A960 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | Histone deacetylase HDA1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates the YNG2 subunit of NuA4 histone acetyltransferase (HAT) module, leading to the reduction of YNG2 and NuA4 HAT at the promoters of hypha-specific genes. Plays a key role in the regulation o [...] | 0.589 |
HOS2 | HOS3 | A0A1D8PJ17 | A0A1D8PLH8 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | Histone deacetylase. | 0.813 |
HOS2 | HST1 | A0A1D8PJ17 | Q5AQ47 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | NAD-dependent protein deacetylase HST1; NAD-dependent histone deacetylase, which could function in telomeric silencing, cell cycle progression and chromosome stability. Belongs to the sirtuin family. Class I subfamily. | 0.875 |
HOS2 | HST2 | A0A1D8PJ17 | Q5A985 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | NAD-dependent protein deacetylase HST2; NAD-dependent histone deacetylase that is involved in nuclear silencing events. Derepresses subtelomeric silencing and increases repression in nucleolar (rDNA) silencing. Its function is negatively regulated by active nuclear export (By similarity); Belongs to the sirtuin family. Class I subfamily. | 0.769 |
HOS2 | HST3 | A0A1D8PJ17 | Q5A1W9 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | NAD-dependent histone deacetylase HST3; NAD-dependent histone deacetylase, which could function in telomeric silencing, cell cycle progression and chromosome stability. Belongs to the sirtuin family. Class I subfamily. | 0.611 |