Your Input: | |
| | SIN3 | Transcriptional regulator. (1411 aa) |
| | RPB11 | DNA-directed RNA polymerase II core subunit. (124 aa) |
| | PSY2 | Psy2p. (980 aa) |
| | CDC73 | Cdc73p. (370 aa) |
| | CaO19.3027 | Uncharacterized protein; Belongs to the actin family. (378 aa) |
| | CaO19.3035 | Chromatin-remodeling ATPase. (1410 aa) |
| | ELA1 | Elongin A. (392 aa) |
| | CaO19.1041 | CYCLIN domain-containing protein; Belongs to the cyclin family. (495 aa) |
| | CaO19.6843 | SHNi-TPR domain-containing protein. (373 aa) |
| | CaO19.6259 | Exosome non-catalytic core subunit. (374 aa) |
| | TAF145 | Taf145p. (1260 aa) |
| | SNT1 | Snt1p. (1001 aa) |
| | CDC54 | DNA helicase; Belongs to the MCM family. (912 aa) |
| | CaO19.6340 | DNA-directed RNA polymerase core subunit. (214 aa) |
| | ACT1 | Actin. (376 aa) |
| | SET3 | Histone-binding protein. (1069 aa) |
| | RPC10 | DNA-directed RNA polymerase core subunit. (73 aa) |
| | CaO19.2111 | Transcription factor IIF subunit. (381 aa) |
| | CaO19.1457 | General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family. (472 aa) |
| | RAD23 | Rad23p. (416 aa) |
| | CaO19.1574 | TAFII55_N domain-containing protein. (588 aa) |
| | CaO19.5828 | RRM domain-containing protein. (717 aa) |
| | CaO19.808 | Rpd3L histone deacetylase complex subunit. (610 aa) |
| | TAF14 | TATA-binding protein-associated factor. (263 aa) |
| | CaO19.187 | Uncharacterized protein. (816 aa) |
| | RPB4 | DNA-directed RNA polymerase II subunit. (268 aa) |
| | CDC7 | Serine/threonine protein kinase. (656 aa) |
| | CaO19.6886 | Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (416 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (878 aa) |
| | CaO19.3625 | Uncharacterized protein. (349 aa) |
| | CaO19.4080 | Uncharacterized protein. (354 aa) |
| | CDC47 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (781 aa) |
| | CaO19.1363 | SWIRM domain-containing protein. (392 aa) |
| | PHO23 | Chromatin modification-related protein. (481 aa) |
| | HOS2 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (454 aa) |
| | CaO19.268 | Uncharacterized protein. (447 aa) |
| | CaO19.314 | Uncharacterized protein. (999 aa) |
| | CaO19.6952 | Uncharacterized protein. (669 aa) |
| | CaO19.7444 | TFIIH complex subunit. (341 aa) |
| | CaO19.7452 | SLD3 domain-containing protein. (736 aa) |
| | TAF60 | Taf60p. (519 aa) |
| | MDN1 | Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (5035 aa) |
| | CaO19.4677 | HIT-type domain-containing protein. (236 aa) |
| | A0A1D8PLR5 | DNA-directed RNA polymerase core subunit. (72 aa) |
| | CaO19.3373 | Uncharacterized protein. (623 aa) |
| | CaO19.5297 | TFIIH/NER complex subunit. (631 aa) |
| | CDL1 | Cdl1p. (673 aa) |
| | HOS1 | Histone deacetylase. (436 aa) |
| | CaO19.3084 | SAS4 domain-containing protein. (293 aa) |
| | CaO19.5682 | Importin subunit alpha; Belongs to the importin alpha family. (543 aa) |
| | TFB3 | TFIIH/NER complex subunit. (360 aa) |
| | CaO19.4312 | SAGA complex subunit. (770 aa) |
| | CaO19.6667 | SAP30_Sin3_bdg domain-containing protein. (168 aa) |
| | CaO19.1111 | Chromatin modification protein. (231 aa) |
| | SDC1 | Sdc1p. (128 aa) |
| | CaO19.4194 | TFIIH/NER complex subunit. (363 aa) |
| | CaO19.132 | Uncharacterized protein. (593 aa) |
| | TRA1 | Histone acetyltransferase; Belongs to the PI3/PI4-kinase family. (3821 aa) |
| | SWD3 | Swd3p. (383 aa) |
| | CaO19.3473 | Deubiquitination module subunit. (549 aa) |
| | CaO19.5617 | PHD domain-containing protein. (479 aa) |
| | TSM1 | Tsm1p. (1425 aa) |
| | RAD3 | TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit. (765 aa) |
| | CaO19.7116 | Uncharacterized protein. (317 aa) |
| | CaO19.7074 | SGF29 C-terminal domain-containing protein. (265 aa) |
| | CaO19.7067 | Uncharacterized protein. (1091 aa) |
| | RTF1 | Rtf1p. (568 aa) |
| | CaO19.6506 | PHD-type domain-containing protein. (688 aa) |
| | TAF19 | Taf19p. (165 aa) |
| | UME1 | Ume1p. (485 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (880 aa) |
| | RPD3 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa) |
| | SRP40 | Srp40p. (428 aa) |
| | CaO19.2857 | TFIIH/NER complex ATPase/helicase subunit. (843 aa) |
| | TAF12L | TFIID_20kDa domain-containing protein. (750 aa) |
| | CaO19.536 | Chromatin modification protein. (798 aa) |
| | ISC1 | Inositol phosphosphingolipid phospholipase. (438 aa) |
| | CaO19.1856 | Uncharacterized protein. (340 aa) |
| | CDC45 | DNA replication initiation factor. (579 aa) |
| | ELF1 | Elf1p. (1195 aa) |
| | CaO19.7344 | Uncharacterized protein. (835 aa) |
| | SPT7 | SAGA histone acetyltransferase complex subunit. (1307 aa) |
| | CaO19.7598 | Uncharacterized protein. (439 aa) |
| | SPT3 | Transcriptional regulator. (328 aa) |
| | SLD5 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (236 aa) |
| | RPO21 | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1728 aa) |
| | CaO19.7662 | CID domain-containing protein. (335 aa) |
| | TBP1 | TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. (238 aa) |
| | TFB5 | General transcription and DNA repair factor IIH subunit TFB5; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has be [...] (69 aa) |
| | SPT6 | Transcription elongation factor SPT6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity); Belongs to the SPT6 family. (1401 aa) |
| | EAF3 | Chromatin modification-related protein EAF3; Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (369 aa) |
| | YAF9 | Protein AF-9 homolog; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity). (254 aa) |
| | CaO19.190 | Uncharacterized protein. (324 aa) |
| | CaO19.3759 | Elongator subunit. (446 aa) |
| | NOC2 | mRNA-binding ribosome synthesis protein. (714 aa) |
| | CaO19.5846 | RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (494 aa) |
| | PSF2 | DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity). (203 aa) |
| | CaO19.5206 | Hsp90 cochaperone. (509 aa) |
| | ASF1 | Histone chaperone ASF1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. (247 aa) |
| | RPB8 | DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (148 aa) |
| | CDC14 | Tyrosine-protein phosphatase CDC14; Protein phosphatase which antagonizes mitotic cyclin- dependent kinase CDC28, the inactivation of which is essential for exit from mitosis. To access its substrates, is released from nucleolar sequestration during mitosis. Plays an essential in coordinating the nuclear division cycle with cytokinesis through the cytokinesis checkpoint. Involved in chromosome segregation, where it is required for meiosis I spindle dissambly as well as for establishing two consecutive chromosome segregation phases (By similarity). Plays a role in the expression of hydr [...] (542 aa) |
| | CDC46 | DNA helicase; Belongs to the MCM family. (728 aa) |
| | CaO19.6623 | Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family. (128 aa) |
| | SWD2 | WD-repeat containing protein. (364 aa) |
| | GCN5 | Histone acetyltransferase. (449 aa) |
| | EAF6 | Chromatin modification-related protein EAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (211 aa) |
| | RPO26 | DNA-directed RNA polymerase core subunit. (157 aa) |
| | CaO19.6694 | Bromo domain-containing protein. (659 aa) |
| | ELC1 | Elongin C; Belongs to the SKP1 family. (100 aa) |
| | HAT2 | Histone acetyltransferase type B subunit 2; Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-14' of histone H4 which is required for telomeric silencing. (382 aa) |
| | PSF1 | DNA replication complex GINS protein PSF1; The GINS complex plays an essential role in the initiation of DNA replication. (236 aa) |
| | ORC3 | Origin recognition complex subunit 3. (682 aa) |
| | CaO19.6923 | TAFII28 domain-containing protein. (343 aa) |
| | CaO19.4542 | TFIIH complex kinase subunit; Belongs to the cyclin family. (395 aa) |
| | TAF4 | Transcription initiation factor TFIID subunit 4; Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of tra [...] (363 aa) |
| | SWR1 | Helicase SWR1; Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (1641 aa) |
| | SLD2 | DNA replication regulator SLD2; Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity); Belongs to the SLD2 family. (354 aa) |
| | HAT1 | Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-14' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family. (413 aa) |
| | ERB1 | Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (849 aa) |
| | MAD2 | Spindle assembly checkpoint component MAD2; Central component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. Plays a key role in virulence, probably through cell cycle checkpoint functions, especially those monitoring the integrity of DNA and chromosome segregation, which might be required for the pathogen to repair damage caused by host defense. Belongs to the MAD2 family. (214 aa) |
| | ADA2 | Transcriptional adapter 2; Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulati [...] (445 aa) |
| | NOP7 | Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome (By similarity). Required for the transition from hyphal to yeast growth; Belongs to the pescadillo family. (587 aa) |
| | CaO19.3613 | Uncharacterized protein. (467 aa) |
| | CaO19.2276 | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (112 aa) |
| | CaO19.3581 | WD_REPEATS_REGION domain-containing protein. (435 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (903 aa) |
| | RVB1 | RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (458 aa) |
| | VID21 | Chromatin modification-related protein EAF1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (686 aa) |
| | CDC68 | FACT complex subunit SPT16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (1060 aa) |
| | SPT20 | Transcription factor SPT20; Component of the transcription regulatory histone acetylation (HAT) complex SAGA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosom [...] (751 aa) |
| | CaO19.6413 | Uncharacterized protein. (617 aa) |
| | CaO19.5229 | Exosome catalytic subunit; Belongs to the RNR ribonuclease family. (1004 aa) |
| | CaO19.1248 | DNA-directed RNA polymerase II core subunit. (318 aa) |
| | SGF11 | SAGA-associated factor 11; Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA [...] (120 aa) |
| | CaO19.5350 | CID domain-containing protein. (290 aa) |
| | CaO19.5346 | Uncharacterized protein. (403 aa) |
| | RAD27 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (372 aa) |
| | EAF7 | Chromatin modification-related protein EAF7; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (445 aa) |
| | CCR4 | Glucose-repressible alcohol dehydrogenase transcriptional effector; Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA. Discovered because of its role in the control of ADH2 gene expression. It is required for the expression of genes involved in non-fermentative growth (By similarity); Belongs to [...] (787 aa) |
| | CaO19.5051 | CENP-T_C domain-containing protein. (756 aa) |
| | ESA1 | Histone acetyltransferase ESA1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double- strand break repair through homologous recombination. Involved in cell cycle progression. Recru [...] (541 aa) |
| | SWD1 | COMPASS subunit protein. (447 aa) |
| | CaO19.3242 | Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...] (244 aa) |
| | CaO19.3237 | Putative ubiquitin-protein ligase. (1711 aa) |
| | SKI8 | SKI complex subunit WD repeat protein. (384 aa) |
| | CaO19.3349 | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1234 aa) |
| | RPB7 | DNA-directed RNA polymerase II subunit. (173 aa) |
| | HDA1 | Histone deacetylase HDA1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates the YNG2 subunit of NuA4 histone acetyltransferase (HAT) module, leading to the reduction of YNG2 and NuA4 HAT at the promoters of hypha-specific genes. Plays a key role in the regulation o [...] (833 aa) |
| | CaO19.2442 | Uncharacterized protein. (234 aa) |
| | EPL1 | Enhancer of polycomb-like protein 1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M (By similarity). (753 aa) |
| | SWC4 | SWR1-complex protein 4; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (635 aa) |
| | KIN28 | TFIIH complex serine/threonine-protein kinase subunit; Belongs to the protein kinase superfamily. (343 aa) |
| | IPI3 | Pre-rRNA-processing protein IPI3; Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA. (505 aa) |
| | SET1 | Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance, transcription elongation regulation and pathogenesis of invasive candidiasis; Belongs to the class V-like SAM-binding methyltransferase superfamily. (1040 aa) |
| | MRT4 | Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (230 aa) |
| | ARP4 | Actin-related protein 4; Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes [...] (468 aa) |
| | SAS2 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (352 aa) |
| | TAF12 | TFIID_20kDa domain-containing protein. (515 aa) |
| | RPD31 | Histone deacetylase. (577 aa) |
| | SUS1 | Transcription and mRNA export factor SUS1; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex required for deubiquitination of [...] (119 aa) |
| | HTZ1 | Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...] (133 aa) |
| | CaO19.307 | Uncharacterized protein. (490 aa) |
| | CaO19.2682 | Transcription initiation factor IIA large subunit. (275 aa) |
| | PSF3 | DNA replication complex GINS protein PSF3; The GINS complex plays an essential role in the initiation of DNA replication. (177 aa) |
| | RVB2 | RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (498 aa) |
| | YNG2 | Chromatin modification-related protein YNG2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis (By similarity); Belongs to the ING family. (298 aa) |
| | NGG1 | Histone acetyltransferase. (627 aa) |
| | SPP1 | Spp1p. (406 aa) |
| | ARX1 | Probable metalloprotease ARX1; Probable metalloprotease involved in proper assembly of pre- ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm (By similarity). (564 aa) |
| | CaO19.1619 | Cyclin-dependent serine/threonine protein kinase. (586 aa) |
| | MRD1 | Multiple RNA-binding domain-containing protein 1; Involved in pre-rRNA processing; Belongs to the RRM MRD1 family. (841 aa) |
| | ASH2 | Ash2p. (466 aa) |
| | SPT4 | Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). (112 aa) |
| | POB3 | FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (538 aa) |
| | SPT5 | Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). (956 aa) |
| | TOA2 | Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (130 aa) |
| | POL30 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (259 aa) |
| | CaO19.4615 | RXT2_N domain-containing protein. (318 aa) |
| | RFX2 | RFX-like DNA-binding protein RFX2; Transcriptional repressor which regulates DNA damage responses, morphogenesis, and virulence. Involved in the regulation of filamentous growth through its repression of hyphal-specific genes such as HWP1, ALS3, HYR1, ECE1, and CEK1; Belongs to the RFX family. (1111 aa) |
| | TFG1 | Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (608 aa) |
| | SEN1 | Putative DNA/RNA helicase. (2018 aa) |
| | CaO19.5910 | Uncharacterized protein. (759 aa) |
| | ARP6 | Actin-like protein ARP6; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity). (446 aa) |
| | CaO19.4882 | Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (284 aa) |
| | TFA1 | Transcription factor TFIIE subunit. (394 aa) |
| | CaO19.4824 | DSPc domain-containing protein. (272 aa) |
| | YTM1 | Ribosome biogenesis protein YTM1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (466 aa) |
| | PAPA | Poly(A) polymerase PAPa; Polymerase that creates the 3'-poly(A) tail of mRNA's. May acquire specificity through interaction with a cleavage and polyadenylation factor (By similarity). (555 aa) |
