40 items (Candida albicans) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EXM2	Exm2p. (240 aa)
	CaO19.2230	U2 snRNP complex subunit. (119 aa)
	CWC2	Pre-mRNA-splicing factor CWC2; Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic [...] (363 aa)
	CaO19.763	Nuclear cap-binding protein subunit 2. (224 aa)
	YHC1	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. (150 aa)
	PRP22	DEAH-box ATP-dependent RNA helicase. (996 aa)
	A0A1D8PPC8	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (86 aa)
	CaO19.5767	U2 snRNP complex subunit. (283 aa)
	CaO19.2818	DEAH-box RNA helicase. (1070 aa)
	CaO19.2621	mRNA splicing protein. (125 aa)
	SMD3	Small nuclear ribonucleoprotein Sm D3. (106 aa)
	CaO19.7581	U2 snRNP complex subunit. (471 aa)
	CaO19.7673	Small nuclear ribonucleoprotein Sm D1; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site; Belongs to the snRNP core protein family. (116 aa)
	CWC25	Pre-mRNA-splicing factor CWC25; Involved in pre-mRNA splicing. (221 aa)
	A0A1D8PNP9	Sm-like protein. (123 aa)
	CaO19.2893	mRNA splicing protein. (845 aa)
	CaO19.4659	Uncharacterized protein. (425 aa)
	CaO19.6989	RRM domain-containing protein. (107 aa)
	SMD2	Small nuclear ribonucleoprotein Sm D2. (112 aa)
	CaO19.6866	U1 snRNP complex subunit. (347 aa)
	SNU114	U5 snRNP GTPase. (1022 aa)
	A0A1D8PH20	Small nuclear ribonucleoprotein G. (74 aa)
	CaO19.5828	RRM domain-containing protein. (717 aa)
	PRP39	Prp39p. (647 aa)
	CaO19.2112	mRNA splicing protein. (270 aa)
	CaO19.6342	MFAP1 domain-containing protein. (161 aa)
	CaO19.2980	mRNA splicing protein. (725 aa)
	CaO19.4724	U1-type domain-containing protein. (256 aa)
	BUD31	U2 snRNP complex subunit. (150 aa)
	CWC26	Pre-mRNA-splicing factor CWC26; Involved in pre-mRNA splicing. (281 aa)
	CaO19.1687	DEAH-box ATP-dependent RNA helicase. (767 aa)
	CaO19.2675	mRNA-binding U2 snRNP complex subunit. (1094 aa)
	BBP	Branchpoint-bridging protein; Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns (By similarity). Belongs to the BBP/SF1 family. (455 aa)
	CLF1	Pre-mRNA-splicing factor CLF1; Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication (By similarity). (701 aa)
	CaO19.6740	E3 ubiquitin-protein ligase. (446 aa)
	CWC24	Pre-mRNA-splicing factor CWC24; Involved in pre-mRNA splicing. (216 aa)
	CaO19.3250	Uncharacterized protein. (602 aa)
	CaO19.5465	mRNA splicing protein. (232 aa)
	SLT11	Pre-mRNA-splicing factor SLT11; Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA (By similarity). (303 aa)
	LEA1	U2 small nuclear ribonucleoprotein A; Involved in pre-mRNA splicing. (233 aa)

Your Current Organism:

Candida albicans

NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1D8PH20	A0A1D8PNP9	A0A1D8PH20	A0A1D8PNP9	Small nuclear ribonucleoprotein G.	Sm-like protein.	0.968
A0A1D8PH20	A0A1D8PPC8	A0A1D8PH20	A0A1D8PPC8	Small nuclear ribonucleoprotein G.	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.	0.999
A0A1D8PH20	BUD31	A0A1D8PH20	Q5APB0	Small nuclear ribonucleoprotein G.	U2 snRNP complex subunit.	0.994
A0A1D8PH20	CLF1	A0A1D8PH20	Q5AED6	Small nuclear ribonucleoprotein G.	Pre-mRNA-splicing factor CLF1; Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication (By similarity).	0.987
A0A1D8PH20	CWC2	A0A1D8PH20	Q59W50	Small nuclear ribonucleoprotein G.	Pre-mRNA-splicing factor CWC2; Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic [...]	0.990
A0A1D8PH20	CWC24	A0A1D8PH20	Q5ACW2	Small nuclear ribonucleoprotein G.	Pre-mRNA-splicing factor CWC24; Involved in pre-mRNA splicing.	0.819
A0A1D8PH20	CWC25	A0A1D8PH20	Q59LQ5	Small nuclear ribonucleoprotein G.	Pre-mRNA-splicing factor CWC25; Involved in pre-mRNA splicing.	0.836
A0A1D8PH20	CWC26	A0A1D8PH20	Q5AL13	Small nuclear ribonucleoprotein G.	Pre-mRNA-splicing factor CWC26; Involved in pre-mRNA splicing.	0.819
A0A1D8PH20	CaO19.1687	A0A1D8PH20	Q5AJA5	Small nuclear ribonucleoprotein G.	DEAH-box ATP-dependent RNA helicase.	0.967
A0A1D8PH20	CaO19.2112	A0A1D8PH20	A0A1D8PG11	Small nuclear ribonucleoprotein G.	mRNA splicing protein.	0.721
A0A1D8PH20	CaO19.2230	A0A1D8PH20	Q59Z68	Small nuclear ribonucleoprotein G.	U2 snRNP complex subunit.	0.997
A0A1D8PH20	CaO19.2621	A0A1D8PH20	A0A1D8PTI0	Small nuclear ribonucleoprotein G.	mRNA splicing protein.	0.999
A0A1D8PH20	CaO19.2675	A0A1D8PH20	Q5AFD2	Small nuclear ribonucleoprotein G.	mRNA-binding U2 snRNP complex subunit.	0.992
A0A1D8PH20	CaO19.2818	A0A1D8PH20	A0A1D8PS92	Small nuclear ribonucleoprotein G.	DEAH-box RNA helicase.	0.862
A0A1D8PH20	CaO19.2893	A0A1D8PH20	A0A1D8PMK6	Small nuclear ribonucleoprotein G.	mRNA splicing protein.	0.969
A0A1D8PH20	CaO19.2980	A0A1D8PH20	A0A1D8PCV3	Small nuclear ribonucleoprotein G.	mRNA splicing protein.	0.889
A0A1D8PH20	CaO19.3250	A0A1D8PH20	Q5A878	Small nuclear ribonucleoprotein G.	Uncharacterized protein.	0.929
A0A1D8PH20	CaO19.4659	A0A1D8PH20	A0A1D8PL91	Small nuclear ribonucleoprotein G.	Uncharacterized protein.	0.988
A0A1D8PH20	CaO19.4724	A0A1D8PH20	Q5APP1	Small nuclear ribonucleoprotein G.	U1-type domain-containing protein.	0.992
A0A1D8PH20	CaO19.5465	A0A1D8PH20	Q5A7K1	Small nuclear ribonucleoprotein G.	mRNA splicing protein.	0.819