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| | YEA4 | Yea4p. (326 aa) |
| | ABG1 | Abg1p. (288 aa) |
| | CaO19.1386 | t-SNARE coiled-coil homology domain-containing protein. (150 aa) |
| | VMA21 | Vacuolar ATPase assembly integral membrane protein VMA21; Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum; Belongs to the VMA21 family. (79 aa) |
| | ERG24 | Delta(14)-sterol reductase. (448 aa) |
| | DFG10 | Putative polyprenol reductase. (282 aa) |
| | A0A1D8PI76 | Protein YOP1. (173 aa) |
| | ERG9 | Bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase. (448 aa) |
| | ALG7 | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase. (494 aa) |
| | OLE2 | Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. (526 aa) |
| | GPI13 | Mannose-ethanolamine phosphotransferase. (1014 aa) |
| | FEN12 | Elongation of fatty acids protein. (292 aa) |
| | A0A1D8PGP8 | Uncharacterized protein. (96 aa) |
| | CaO19.1564 | Bap31 domain-containing protein. (189 aa) |
| | VPH2 | Vph2p. (213 aa) |
| | CaO19.1160 | Uncharacterized protein. (215 aa) |
| | WBP1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...] (437 aa) |
| | SAC1 | Phosphatidylinositol-3-phosphatase. (618 aa) |
| | ERO1 | ER oxidoreductin. (580 aa) |
| | CaO19.4787 | J domain-containing protein. (730 aa) |
| | DPM1 | Dolichol-phosphate mannosyltransferase subunit 1; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins. (239 aa) |
| | IRE1 | Bifunctional endoribonuclease/protein kinase. (1223 aa) |
| | CaO19.4423 | VASt domain-containing protein. (1073 aa) |
| | ALG9 | Mannosyltransferase. (560 aa) |
| | SSH1 | Ssh1p; Belongs to the SecY/SEC61-alpha family. (499 aa) |
| | HMG1 | 3-hydroxy-3-methylglutaryl coenzyme A reductase. (1073 aa) |
| | CaO19.3351 | Protein YOP1. (291 aa) |
| | CaO19.3293 | Trans-2-enoyl-CoA reductase (NADPH). (312 aa) |
| | ERG2 | C-8 sterol isomerase. (217 aa) |
| | CaO19.3799 | Reticulon-like protein. (366 aa) |
| | RCE1 | CAAX prenyl protease. (281 aa) |
| | CaO19.5291 | Uncharacterized protein. (320 aa) |
| | CaO19.5300 | Calnexin. (581 aa) |
| | CSH3 | Csh3p. (236 aa) |
| | NCP1 | NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (680 aa) |
| | CaO19.2677 | GPI-anchor transamidase subunit. (621 aa) |
| | DPM3 | Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. Belongs to the DPM3 family. (92 aa) |
| | ERG251 | Erg251p; Belongs to the sterol desaturase family. (321 aa) |
| | STE24 | CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (445 aa) |
| | CaO19.6787 | Cornichon family protein. (137 aa) |
| | CaO19.7426 | Dolichyl-diphosphooligosaccharide--protein glycotransferase. (340 aa) |
| | OPI3 | Phosphatidyl-N-methylethanolamine N-methyltransferase; Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC). (225 aa) |
| | A0A1D8PKK1 | Translocon subunit. (68 aa) |
| | SKN1 | Skn1p. (737 aa) |
| | CaO19.7364 | Uncharacterized protein; Belongs to the FMO family. (536 aa) |
| | KRE6 | Beta-glucan synthesis-associated protein. (740 aa) |
| | OST1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (470 aa) |
| | VTI1 | V-SNARE protein. (217 aa) |
| | NSG2 | Uncharacterized protein. (334 aa) |
| | YSY6 | Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (62 aa) |
| | CaO19.261 | Dolichol kinase. (586 aa) |
| | A0A1D8PMC2 | Signal peptidase complex subunit. (82 aa) |
| | CaO19.1638 | Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (861 aa) |
| | ERG4 | Delta(24(24(1)))-sterol reductase. (469 aa) |
| | CaO19.1761 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...] (171 aa) |
| | A0A1D8PIL6 | Uncharacterized protein. (60 aa) |
| | ERG26 | Sterol-4-alpha-carboxylate 3-dehydrogenase (Decarboxylating). (350 aa) |
| | YDC1 | Alkaline dihydroceramidase. (296 aa) |
| | SMP3 | GPI mannosyltransferase 4; Alpha-1,2-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is essential in fungi (By similarity). Belongs to the glycosyltransferase 22 family. PIGZ subfamily. (498 aa) |
| | SUR2 | Sphingosine hydroxylase; Belongs to the sterol desaturase family. (342 aa) |
| | CaO19.5833 | Polyubiquitin-binding protein. (363 aa) |
| | ARE2 | O-acyltransferase. (609 aa) |
| | DIE2 | Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol; Belongs to the ALG10 glucosyltransferase family. (450 aa) |
| | IRC22-1 | Increased recombination centers protein 22-1; Is probably involved in a pathway contributing to genomic integrity; Belongs to the IRC22 family. (239 aa) |
| | IRC22-2 | Increased recombination centers protein 22-2; Is probably involved in a pathway contributing to genomic integrity; Belongs to the IRC22 family. (239 aa) |
| | ERV46 | Erv46p. (414 aa) |
| | PMT4 | Dolichyl-phosphate-mannose--protein mannosyltransferase 4; Protein mannosyltransferase (PMT) involved in hyphal growth and drug sensitivity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Accounts for the O-glycosylation of AXL2, responsible for bud site selection, as well as of the SEC20 t-SNARE component. O-glycosylation of SEC20 is essential for its stability. Required for biofilm formation. [...] (755 aa) |
| | SPO72 | Autophagy-related protein 2; Required for cytoplasm to vacuole transport (Cvt) vesicles and autophagosomes completion and peroxisome degradation. Belongs to the ATG2 family. (1856 aa) |
| | KAR5 | Nuclear fusion protein KAR5; Required for nuclear membrane fusion during karyogamy. Belongs to the KAR5 family. (485 aa) |
| | BIG1 | Protein BIG1; Required for normal beta-1,6-glucan synthesis, for hyphal morphogenesis, adhesion and virulence; Belongs to the BIG1 family. (322 aa) |
| | CDC48 | AAA family ATPase; Belongs to the AAA ATPase family. (826 aa) |
| | CWH8 | Cwh8p. (241 aa) |
| | BST1 | GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins. (390 aa) |
| | GPI18 | GPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity). (394 aa) |
| | ERG3 | C-5 sterol desaturase; Belongs to the sterol desaturase family. (386 aa) |
| | CaO19.3859 | Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (349 aa) |
| | CaO19.5669 | Uncharacterized protein. (186 aa) |
| | CaO19.1158 | Uncharacterized protein. (297 aa) |
| | CaO19.4528 | Uncharacterized protein. (181 aa) |
| | CaO19.6941 | Diacylglycerol O-acyltransferase. (577 aa) |
| | SPC2 | Signal peptidase complex subunit. (169 aa) |
| | MMM1 | Maintenance of mitochondrial morphology protein 1; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta- barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 su [...] (439 aa) |
| | SAR1 | Small COPII coat GTPase SAR1; Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SAR1 controls the coat assembly in a stepwise manner. Activated SAR1-GTP binds to membranes first and recruits the SEC23/24 complex. These SEC23/24-SAR1 prebudding intermediates are then collected by the SEC13/31 complex as subunits polymerize to form coated trans [...] (190 aa) |
| | ALG11 | GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase; Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum (By similarity); Belongs to the glycosyltransferase group 1 family. (609 aa) |
| | MDM12 | Mitochondrial distribution and morphology protein 12; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pat [...] (428 aa) |
| | KSR1 | 3-ketodihydrosphingosine reductase TSC10; Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (310 aa) |
| | CaO19.2637 | Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation; Belongs to the PGAP3 family. (337 aa) |
| | CaO19.2638 | Uncharacterized protein. (275 aa) |
| | CaO19.640 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (237 aa) |
| | ERF2 | Palmitoyltransferase ERF2; The ERF2-ERF4 complex is a palmitoyltransferase specific for Ras proteins; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. (514 aa) |
| | ALG1 | Chitobiosyldiphosphodolichol beta-mannosyltransferase; Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER (By similarity); Belongs to the glycosyltransferase group 1 family. (456 aa) |
| | SPF1 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1223 aa) |
| | GPI8 | GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family. (383 aa) |
| | CaO19.6642 | Uncharacterized protein. (300 aa) |
| | FEN1 | Elongation of fatty acids protein. (337 aa) |
| | CBR1 | NADH-cytochrome b5 reductase 1; Electron donor reductase for cytochrome b5. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes (By similarity). (294 aa) |
| | CUE1 | Coupling of ubiquitin conjugation to ER degradation protein 1; Component of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Recruits the soluble ubiquitin-conjugating enzyme UBC7 to the cytoplasmic face of the endoplasmic reticulum membrane where it functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Targets the E2 conjugating enzyme UBC7 to the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of mem [...] (189 aa) |
| | CaO19.6284 | Signal recognition particle receptor subunit beta. (305 aa) |
| | CHO2 | Phosphatidylethanolamine N-methyltransferase; Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME); Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family. (888 aa) |
| | ALG2 | Alpha-1,3/1,6-mannosyltransferase ALG2; Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. (443 aa) |
| | ERG7 | Lanosterol synthase; Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. (728 aa) |
| | ERG11 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'- dimethyl cholesta-8,14,24-triene-3-beta-ol. (528 aa) |
| | GET2 | Golgi to ER traffic protein 2; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP- dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. (298 aa) |
| | PMT1 | Dolichyl-phosphate-mannose--protein mannosyltransferase 1; Protein mannosyltransferase (PMT) involved in hyphal growth and drug sensitivity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Accounts for the O-glycosylation of the cell wall proteins KRE9, PIR2, RHD3, and ALS1, as well as the SEC20 t-SNARE component. O-glycosylation of SEC20 is essential for its stability. Required for filamentatio [...] (877 aa) |
| | ERG25 | Methylsterol monooxygenase; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family. (308 aa) |
| | CaO19.5156 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (200 aa) |
| | CaO19.5157 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (203 aa) |
| | ERG5 | C-22 sterol desaturase; Belongs to the cytochrome P450 family. (517 aa) |
| | CaO19.7672 | Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (331 aa) |
| | CaO19.7670 | Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (923 aa) |
| | TRX1 | Thioredoxin; Belongs to the thioredoxin family. (103 aa) |
| | VMA22 | Vma22p. (188 aa) |
| | CaO19.6134 | Sec39 domain-containing protein. (817 aa) |
| | EMP46 | Emp46p. (465 aa) |
| | ALG6 | Alpha-1,3-glucosyltransferase; Belongs to the ALG6/ALG8 glucosyltransferase family. (563 aa) |
| | CaO19.719 | E3 ubiquitin-protein ligase. (633 aa) |
| | CaO19.698 | Uncharacterized protein. (493 aa) |
| | SEC63 | Protein-transporting protein. (673 aa) |
| | SEC22 | SNAP receptor; Belongs to the synaptobrevin family. (216 aa) |
| | CaO19.2378 | Uncharacterized protein. (117 aa) |
| | ALG5 | Dolichyl-phosphate beta-glucosyltransferase. (323 aa) |
| | CaO19.3730 | Uncharacterized protein. (135 aa) |
| | A0A1D8PRY9 | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (95 aa) |
| | ERF4 | Ras modification protein ERF4; The ERF2-ERF4 complex is a palmitoyltransferase specific for Ras proteins. Palmitoylates RAS2, which is required for its proper plasma membrane localization (By similarity). (218 aa) |
| | AQY1 | Aqy1p; Belongs to the MIP/aquaporin (TC 1.A.8) family. (273 aa) |
| | CaO19.2200 | L-type lectin-like domain-containing protein. (436 aa) |
| | ERV25 | Endoplasmic reticulum vesicle protein 25; Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum (By similarity); Belongs to the EMP24/GP25L family. (215 aa) |
| | CaO19.6438 | Serine C-palmitoyltransferase. (587 aa) |
| | CaO19.6416 | Uncharacterized protein. (465 aa) |
| | NTE1 | Lysophospholipase NTE1; Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity); Belongs to the NTE family. (1386 aa) |
| | MCD4 | GPI ethanolamine phosphate transferase 1; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (By similarity). (971 aa) |
| | SEC23 | Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (762 aa) |
| | VRG4 | GDP-mannose transporter; Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen. Involved in hyphal formation. (371 aa) |
| | OCH1 | Initiation-specific alpha-1,6-mannosyltransferase; Mannosyltransferase involved in outer chain elongation of asparagine-linked oligosaccharides of the type Man(9)GlcNAc(2). Adds the first alpha-1,6-mannose to the Man(8)GlcNAc(2) and Man(9)GlcNAc(2), but not Man(5)GlcNAc(2), endoplasmic reticulum intermediates (By similarity). Represents the first enzymatic event required for synthesis of outer chain mannose linkages on yeast secretory proteins. N-glycan outer chain epitopes play a crucial role in the host-fungal interaction, virulence, and host immune response such as interleukin synth [...] (385 aa) |
| | PBN1 | Protein PBN1; Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14 (By similarity). (481 aa) |
| | KRE62 | Kre62p. (622 aa) |
| | ECM39 | Mannosyltransferase. (584 aa) |
| | CaO19.5368 | bVLRF1 domain-containing protein. (537 aa) |
| | ALG14 | UDP-N-acetylglucosamine transferase subunit ALG14; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER (By similarity). (219 aa) |
| | CaO19.3843 | Sec63 complex subunit. (268 aa) |
| | SCS7 | Ceramide very long chain fatty acid hydroxylase; Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2; Belongs to the sterol desaturase family. SCS7 subfamily. (378 aa) |
| | PMT6 | Dolichyl-phosphate-mannose--protein mannosyltransferase 6; Protein mannosyltransferase (PMT) involved in hyphal morphogenesis and drug sensitivity. Transfers mannose from Dol-P- mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Required for biofilm formation and virulence. (832 aa) |
| | GPI2 | Phosphatidylinositol N-acetylglucosaminyltransferase. (304 aa) |
| | RFT1 | Oligosaccharide translocation protein RFT1; May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane; Belongs to the RFT1 family. (561 aa) |
| | SPT14 | Phosphatidylinositol N-acetylglucosaminyltransferase. (452 aa) |
| | OLE1 | Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. (486 aa) |
| | SWF1 | Palmitoyltransferase SWF1; Palmitoyltransferase that targets several endosomal SNAREs. Palmitoylates the SNAREs at cysteine residues close to the cytoplasmic end of their transmembrane domain. May have a role in the cellular quality control of transmembrane domain-containing proteins (By similarity); Belongs to the DHHC palmitoyltransferase family. SWF1 subfamily. (353 aa) |
| | SEC11 | Signal peptidase complex catalytic subunit SEC11; Catalytic component of the signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post-translationally) through the translocon pore into the endoplasmic reticulum (By similarity). (166 aa) |
| | ERG27 | 3-keto-steroid reductase. (346 aa) |
| | ORM1 | Sphingolipid homeostasis protein. (268 aa) |
| | CaO19.3329 | Sphinganine kinase. (491 aa) |
| | CaO19.3307 | N,N-dimethylaniline monooxygenase; Belongs to the FMO family. (463 aa) |
| | GPI15 | Phosphatidylinositol N-acetylglucosaminyltransferase. (205 aa) |
| | CHS7 | Chitin synthase export chaperone; Chaperone required for the export of the chitin synthase CHS3 from the endoplasmic reticulum. (310 aa) |
| | NPL4 | Nuclear protein localization protein 4; Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity); Belongs to the NPL4 family. (598 aa) |
| | PGA63 | Protein transport protein SEC31; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (1265 aa) |
| | CaO19.6065 | Uncharacterized protein. (323 aa) |
| | ROT1 | Protein ROT1; Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies (By similarity); Belongs to the ROT1 family. (260 aa) |
| | SHE3 | SWI5-dependent HO expression protein 3; RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell. Required for the delivery of cortical endoplasmic reticulum into the emerging bud (By similarity); Belongs to the SHE3 family. (519 aa) |
| | YOS9 | Protein OS-9 homolog; Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation (By similarity). (258 aa) |
| | PMT5 | Dolichyl-phosphate-mannose--protein mannosyltransferase 5; Protein mannosyltransferase (PMT) involved in hyphal morphogenesis and drug sensitivity. Transfers mannose from Dol-P- mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Required for biofilm formation. (725 aa) |
| | GET1 | Golgi to ER traffic protein 1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP- dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. (199 aa) |
| | CaO19.2045 | Diacylglycerol kinase. (345 aa) |
| | ERG28 | Erg28p. (138 aa) |
| | PMT2 | Dolichyl-phosphate-mannose--protein mannosyltransferase 2; Protein mannosyltransferase (PMT) involved in hyphal growth and drug sensitivity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Essential protein that plays an important role in virulence. Belongs to the glycosyltransferase 39 family. (769 aa) |
| | HUT1 | UDP-galactose transporter homolog 1; May be involved in specific transport of UDP-Gal from the cytosol to the Golgi lumen. Involved in the maintenance of optimal conditions for the folding of secretory pathway proteins in the endoplasmic reticulum (By similarity); Belongs to the nucleotide-sugar transporter family. SLC35B subfamily. (370 aa) |
| | SKN2 | Skn2p. (718 aa) |
| | SEC13 | Protein transport protein SEC13; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport facto [...] (298 aa) |
| | CaO19.2756 | Uncharacterized protein. (212 aa) |
| | CaO19.2698 | Uncharacterized protein. (108 aa) |
| | GPI11 | Glycosylphosphatidylinositol anchor biosynthesis protein 11; Acts in the GPI biosynthetic pathway between GlcNAc-PI synthesis and GPI transfer to protein. (265 aa) |
| | CaO19.4240 | Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation; Belongs to the PGAP3 family. (394 aa) |
| | PFA4 | Palmitoyltransferase PFA4; Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function; Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily. (446 aa) |
| | CaO19.6558 | Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (815 aa) |
| | CaO19.3060 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (275 aa) |
| | SEC62 | Translocation protein SEC62; Required for preprotein translocation. (293 aa) |
| | CaO19.2940 | Protein transport protein BOS1; SNARE required for protein transport between the ER and the Golgi complex. (243 aa) |
| | ALG8 | Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity). Belongs to the ALG6/ALG8 glucosyltransferase family. (587 aa) |
| | GPI10 | GPI mannosyltransferase 3; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly (By similarity). (482 aa) |
| | CaO19.3994 | Dolichyl-diphosphooligosaccharide--protein glycotransferase. (396 aa) |
| | TIP1 | Protein YIP. (251 aa) |
| | LCB2 | Serine C-palmitoyltransferase. (569 aa) |
| | GUP1 | O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (584 aa) |
| | SPC3 | Signal peptidase subunit 3. (192 aa) |
| | STT3 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit. (751 aa) |
| | GPI14 | GPI mannosyltransferase 1; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN- acyl-PI during GPI precursor assembly. Required for cell wall integrity (By similarity). (398 aa) |
| | CaO19.4566 | Protein ROT1; Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies; Belongs to the ROT1 family. (193 aa) |
| | CaO19.6007 | Elongation of fatty acids protein. (353 aa) |
| | ATG9 | Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Required for mitophagy. Cycles between the PAS and the cytoplasmic vesicle pool and may participate in supplying membrane for the growing autophagosome. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Different machinerie [...] (952 aa) |
| | CaO19.5963 | Ditrans,polycis-polyprenyl diphosphate synthase. (349 aa) |
| | CaO19.5941 | Uncharacterized protein. (345 aa) |
| | ARV1 | Protein ARV1; Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes. Regulates also the sphingolipid metabolism. Required for growth during anaerobiosis and sterol uptake. Plays a role in pathogenesis. (296 aa) |
| | CaO19.5857 | Zinc_ribbon_10 domain-containing protein. (344 aa) |
| | SFH5 | Phosphatidylinositol transfer protein SFH5; Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane (By similarity); Belongs to the SFH5 family. (320 aa) |
| | CaO19.4738 | SUN domain-containing protein. (558 aa) |
| | SEC24 | Protein transport protein SEC24; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (928 aa) |
| | GWT1 | GPI-anchored wall transfer protein 1; Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. (485 aa) |
| | GPI7 | GPI ethanolamine phosphate transferase 2; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose (By similarity). Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily. (885 aa) |
| | ERG1 | Squalene monooxygenase; Catalyzes the stereospecific oxidation of squalene to (S)- 2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. (496 aa) |
| | SEY1 | Protein SEY1; Cooperates with the reticulon proteins and tubule-shaping DP1 family proteins to generate and maintain the structure of the tubular endoplasmic reticulum network. Has GTPase activity, which is required for its function in ER organization (By similarity). Required for virulence and resistance to cycloheximide; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. RHD3 subfamily. (790 aa) |
| | SEC61 | Protein transport protein SEC61 subunit alpha; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity). (479 aa) |
| | CaO19.7183 | ER membrane protein complex subunit 4; Belongs to the EMC4 family. (176 aa) |
| | HLJ1 | Type I HSP40 co-chaperone. (331 aa) |
| | CaO19.5175 | E3 ubiquitin-protein ligase. (1139 aa) |
| | CaO19.6462 | ER membrane protein complex subunit 3; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER). Belongs to the EMC3 family. (261 aa) |
| | CYB5 | Cyb5p; Belongs to the cytochrome b5 family. (126 aa) |
| | CaO19.7043 | Uncharacterized membrane protein. (169 aa) |
| | PMR1 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (917 aa) |
| | CaO19.1092 | Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol. (519 aa) |
| | CaO19.1212 | Phosphatidylinositol-binding protein. (369 aa) |
| | CaO19.5539 | SNAP receptor. (280 aa) |
| | SEC12 | Sec12p. (841 aa) |
| | A0A1D8PPK2 | Uncharacterized protein. (115 aa) |
| | CaO19.120 | Protein-S-isoprenylcysteine O-methyltransferase; Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family. (257 aa) |
| | CaO19.119 | Protein-S-isoprenylcysteine O-methyltransferase; Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family. (265 aa) |
| | CaO19.90 | VASt domain-containing protein. (754 aa) |
| | SLY41 | Sly41p. (523 aa) |
| | CaO19.3658 | Uncharacterized protein. (647 aa) |
| | CaO19.1186 | Uncharacterized protein. (230 aa) |
| | DPM2 | Dolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family. (85 aa) |
| | CaO19.1191 | Ubiquitin ligase complex subunit. (806 aa) |
| | SRP101 | Signal recognition particle receptor subunit alpha. (535 aa) |
| | CaO19.3949 | Bromo domain-containing protein. (1314 aa) |
| | CaO19.3939 | Uncharacterized protein. (302 aa) |
| | CDS1 | Phosphatidate cytidylyltransferase; Belongs to the CDS family. (451 aa) |
| | CaO19.4346 | Protein transport protein sec16; Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy; Belongs to the SEC16 family. (2091 aa) |
| | CaO19.4341 | GPI-anchor transamidase subunit. (482 aa) |
| | GYP8 | Gyp8p. (760 aa) |
| | CaO19.4247 | Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (315 aa) |
| | CaO19.4131 | EMC1_C domain-containing protein. (861 aa) |
| | CaO19.5693 | GPI-anchor transamidase subunit. (547 aa) |
| | CWH41 | Cwh41p. (830 aa) |
