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| | PSF2 | DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity). (203 aa) |
| | RPO41 | DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family. (1300 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (805 aa) |
| | CaO19.3019 | SsDNA-dependent ATPase. (678 aa) |
| | POL32 | DNA polymerase delta subunit. (403 aa) |
| | CaO19.6247 | Chromatin-binding protein. (871 aa) |
| | CaO19.2796 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (664 aa) |
| | CDC6 | Cell division control protein; Belongs to the CDC6/cdc18 family. (481 aa) |
| | CDC54 | DNA helicase; Belongs to the MCM family. (912 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1214 aa) |
| | DPB4 | DNA polymerase epsilon noncatalytic subunit. (261 aa) |
| | RFC5 | Replication factor C subunit 5. (362 aa) |
| | CDC7 | Serine/threonine protein kinase. (656 aa) |
| | RFC1 | Replication factor C subunit 1. (888 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (878 aa) |
| | CaO19.1434 | Protein kinase activating protein. (716 aa) |
| | CaO19.3601 | AAA domain-containing protein. (547 aa) |
| | CDC47 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (781 aa) |
| | CaO19.6155 | DNA ligase. (770 aa) |
| | RAD53 | Serine/threonine-protein kinase RAD53; Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. (699 aa) |
| | POL1 | DNA polymerase. (1470 aa) |
| | CaO19.7452 | SLD3 domain-containing protein. (736 aa) |
| | PPS1 | Pps1p. (1018 aa) |
| | PRI2 | DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (543 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (564 aa) |
| | CAC2 | Cac2p. (460 aa) |
| | RFC3 | Replication factor C subunit 3. (347 aa) |
| | DUN1 | Serine/threonine protein kinase. (530 aa) |
| | CaO19.4030 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (424 aa) |
| | DNA2 | Bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease. (1426 aa) |
| | CaO19.3648 | ERCC4 domain-containing protein. (587 aa) |
| | TOP1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (780 aa) |
| | CaO19.3431 | DNA-directed DNA polymerase gamma. (1229 aa) |
| | RFC2 | Replication factor C subunit 2. (363 aa) |
| | CaO19.7033 | Tyrosine/serine/threonine protein phosphatase. (1076 aa) |
| | POL3 | DNA polymerase. (1038 aa) |
| | CaO19.7197 | Nucleolar complex-associated protein 3; Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm. Belongs to the CBF/MAK21 family. (745 aa) |
| | MMS22 | Mms22p. (1704 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (880 aa) |
| | POL2 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2211 aa) |
| | CDC45 | DNA replication initiation factor. (579 aa) |
| | DPB2 | DNA polymerase epsilon noncatalytic subunit. (708 aa) |
| | CaO19.7594 | Uncharacterized protein. (213 aa) |
| | RFC4 | Replication factor C subunit 4. (323 aa) |
| | SLD5 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (236 aa) |
| | GLC7 | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa) |
| | YBL053 | Topoisomerase 1-associated factor 1; Forms a fork protection complex (FPC) with CSM3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (1263 aa) |
| | CDC46 | DNA helicase; Belongs to the MCM family. (728 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (906 aa) |
| | PSF1 | DNA replication complex GINS protein PSF1; The GINS complex plays an essential role in the initiation of DNA replication. (236 aa) |
| | CaO19.2369 | Origin recognition complex subunit 5. (496 aa) |
| | ORC3 | Origin recognition complex subunit 3. (682 aa) |
| | SUV3 | ATP-dependent RNA helicase SUV3, mitochondrial; Required for intron-independent turnover and processing of mitochondrial RNA. It is a key control element in nuclear-mitochondrial interactions (By similarity). Required for embedded hyphal growth, for wild-type respiratory growth, and biofilm development. Required for chlamydospore formation, distinctive morphological feature of the fungal pathogen C.albicans that can be induced to form in oxygen- limited environments and has been reported in clinical specimens. Plays am important role in virulence. (720 aa) |
| | SLD2 | DNA replication regulator SLD2; Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity); Belongs to the SLD2 family. (354 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (361 aa) |
| | SMT3 | SUMO family protein. (102 aa) |
| | CaO19.4441 | Zf-primase domain-containing protein. (598 aa) |
| | CDC48 | AAA family ATPase; Belongs to the AAA ATPase family. (826 aa) |
| | CaO19.91 | Uncharacterized protein. (299 aa) |
| | CSM3 | Chromosome segregation in meiosis protein 3; Forms a fork protection complex (FPC) with TOF1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (316 aa) |
| | RPN10 | Proteasome regulatory particle base subunit. (279 aa) |
| | MSH3 | DNA mismatch repair protein MSH3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bindi [...] (1037 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (903 aa) |
| | CaO19.5833 | Polyubiquitin-binding protein. (363 aa) |
| | MSH2 | Mismatch repair ATPase; Component of the post-replicative DNA mismatch repair system (MMR). (873 aa) |
| | MPH1 | ATP-dependent DNA helicase MPH1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. (1187 aa) |
| | CDC68 | FACT complex subunit SPT16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (1060 aa) |
| | ADK1 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. (249 aa) |
| | SLX1 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (286 aa) |
| | SGS1 | ATP-dependent DNA helicase. (1189 aa) |
| | CCR4 | Glucose-repressible alcohol dehydrogenase transcriptional effector; Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA. Discovered because of its role in the control of ADH2 gene expression. It is required for the expression of genes involved in non-fermentative growth (By similarity); Belongs to [...] (787 aa) |
| | RIM1 | Rim1p. (143 aa) |
| | CaO19.2472 | Rtf2 domain-containing protein. (230 aa) |
| | NPL4 | Nuclear protein localization protein 4; Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity); Belongs to the NPL4 family. (598 aa) |
| | IPI3 | Pre-rRNA-processing protein IPI3; Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA. (505 aa) |
| | RFA1 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (624 aa) |
| | CHL1 | ATP-dependent DNA helicase CHL1; ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity). (842 aa) |
| | CLF1 | Pre-mRNA-splicing factor CLF1; Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication (By similarity). (701 aa) |
| | PSF3 | DNA replication complex GINS protein PSF3; The GINS complex plays an essential role in the initiation of DNA replication. (177 aa) |
| | RNH35 | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (431 aa) |
| | CaO19.1668 | Uncharacterized protein. (623 aa) |
| | HYS2 | DNA-directed DNA polymerase delta subunit. (474 aa) |
| | MHF1 | Inner kinetochore subunit MHF1; dsDNA-binding component of a FANCM-MHF complex involved in DNA damage repair and genome maintenance (By similarity). FANCM-MHF promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork (By similarity). Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere- associated network (CCAN), wh [...] (117 aa) |
| | CaO19.1476 | mRNA (N6-adenosine)-methyltransferase; Belongs to the MT-A70-like family. (543 aa) |
| | POL30 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (259 aa) |
| | CaO19.5934 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (629 aa) |
