STRINGSTRING
CaO19.7197 CaO19.7197 ORC4 ORC4 PRI2 PRI2 CaO19.7452 CaO19.7452 POL1 POL1 RAD53 RAD53 CDC47 CDC47 CaO19.1434 CaO19.1434 MCM3 MCM3 CDC7 CDC7 CDC54 CDC54 CDC6 CDC6 CaO19.2796 CaO19.2796 ORC1 ORC1 CLF1 CLF1 PSF3 PSF3 ADK1 ADK1 CaO19.1476 CaO19.1476 CaO19.1668 CaO19.1668 MCM2 MCM2 CaO19.4441 CaO19.4441 SLD2 SLD2 ORC3 ORC3 CaO19.2369 CaO19.2369 PSF1 PSF1 CDC46 CDC46 CDC45 CDC45 MCM6 MCM6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CaO19.7197Nucleolar complex-associated protein 3; Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm. Belongs to the CBF/MAK21 family. (745 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (564 aa)
PRI2DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (543 aa)
CaO19.7452SLD3 domain-containing protein. (736 aa)
POL1DNA polymerase. (1470 aa)
RAD53Serine/threonine-protein kinase RAD53; Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. (699 aa)
CDC47DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (781 aa)
CaO19.1434Protein kinase activating protein. (716 aa)
MCM3DNA helicase; Belongs to the MCM family. (878 aa)
CDC7Serine/threonine protein kinase. (656 aa)
CDC54DNA helicase; Belongs to the MCM family. (912 aa)
CDC6Cell division control protein; Belongs to the CDC6/cdc18 family. (481 aa)
CaO19.2796DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (664 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (805 aa)
CLF1Pre-mRNA-splicing factor CLF1; Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication (By similarity). (701 aa)
PSF3DNA replication complex GINS protein PSF3; The GINS complex plays an essential role in the initiation of DNA replication. (177 aa)
ADK1Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. (249 aa)
CaO19.1476mRNA (N6-adenosine)-methyltransferase; Belongs to the MT-A70-like family. (543 aa)
CaO19.1668Uncharacterized protein. (623 aa)
MCM2DNA helicase; Belongs to the MCM family. (903 aa)
CaO19.4441Zf-primase domain-containing protein. (598 aa)
SLD2DNA replication regulator SLD2; Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity); Belongs to the SLD2 family. (354 aa)
ORC3Origin recognition complex subunit 3. (682 aa)
CaO19.2369Origin recognition complex subunit 5. (496 aa)
PSF1DNA replication complex GINS protein PSF1; The GINS complex plays an essential role in the initiation of DNA replication. (236 aa)
CDC46DNA helicase; Belongs to the MCM family. (728 aa)
CDC45DNA replication initiation factor. (579 aa)
MCM6DNA helicase; Belongs to the MCM family. (880 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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