STRINGSTRING
SPO11 SPO11 RAD57 RAD57 MCM3 MCM3 CDC7 CDC7 CaO19.4913 CaO19.4913 CDC54 CDC54 DLH1 DLH1 CAS1 CAS1 PSF2 PSF2 CaO19.366 CaO19.366 FUM12 FUM12 CaO19.3965 CaO19.3965 EXO1 EXO1 CaO19.3080 CaO19.3080 CaO19.3648 CaO19.3648 CaO19.7060 CaO19.7060 MRE11 MRE11 MCM6 MCM6 CaO19.2376 CaO19.2376 YKU80 YKU80 CaO19.4383 CaO19.4383 PPH3 PPH3 ISC1 ISC1 CaO19.5069 CaO19.5069 MCM2 MCM2 MPH1 MPH1 SLX1 SLX1 RDH54 RDH54 PSO2 PSO2 SGS1 SGS1 A0A1D8PMQ0 A0A1D8PMQ0 PRI2 PRI2 RAD59 RAD59 CaO19.5675 CaO19.5675 RAD1 RAD1 RAD50 RAD50 MMS21 MMS21 REV3 REV3 RAD52 RAD52 MUS81 MUS81 RAD10 RAD10 RFA1 RFA1 CDC46 CDC46 CaO19.2926 CaO19.2926 CaO19.3890 CaO19.3890 CDC45 CDC45 MCD1 MCD1 SLD5 SLD5 UBC2 UBC2 CDC28 CDC28 LIG4 LIG4 CDC47 CDC47 ARP8 ARP8 REC8 REC8 CaO19.2433 CaO19.2433 CaO19.5053 CaO19.5053 MEC3 MEC3 PIF1 PIF1 SMC5 SMC5 SLD2 SLD2 RAD51 RAD51 RFA2 RFA2 SMC6 SMC6 RAD54 RAD54 ESC4 ESC4 CaO19.5934 CaO19.5934
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPO11Spo11p. (309 aa)
RAD57Putative DNA-dependent ATPase. (511 aa)
MCM3DNA helicase; Belongs to the MCM family. (878 aa)
CDC7Serine/threonine protein kinase. (656 aa)
CaO19.4913WD_REPEATS_REGION domain-containing protein. (1208 aa)
CDC54DNA helicase; Belongs to the MCM family. (912 aa)
DLH1Recombinase; Belongs to the RecA family. (324 aa)
CAS1ATP-dependent DNA helicase. (811 aa)
PSF2DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity). (203 aa)
CaO19.366DNA damage checkpoint control protein RAD17; Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes; Belongs to the rad1 family. (336 aa)
FUM12Fum12p. (510 aa)
CaO19.3965Uncharacterized protein. (216 aa)
EXO1Rad2 family nuclease. (699 aa)
CaO19.3080Sister chromatid cohesion protein. (1046 aa)
CaO19.3648ERCC4 domain-containing protein. (587 aa)
CaO19.7060Uncharacterized protein. (324 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (682 aa)
MCM6DNA helicase; Belongs to the MCM family. (880 aa)
CaO19.2376zf-C2HE domain-containing protein. (259 aa)
YKU80ATP-dependent DNA helicase. (609 aa)
CaO19.4383DNA 5'-adenosine monophosphate hydrolase. (259 aa)
PPH3Serine/threonine-protein phosphatase. (306 aa)
ISC1Inositol phosphosphingolipid phospholipase. (438 aa)
CaO19.5069Uncharacterized protein. (243 aa)
MCM2DNA helicase; Belongs to the MCM family. (903 aa)
MPH1ATP-dependent DNA helicase MPH1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. (1187 aa)
SLX1Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (286 aa)
RDH54DNA-dependent ATPase. (796 aa)
PSO2Pso2p. (537 aa)
SGS1ATP-dependent DNA helicase. (1189 aa)
A0A1D8PMQ0Proteasome regulatory particle lid subunit. (93 aa)
PRI2DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (543 aa)
RAD59DNA repair protein RAD59; Involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing. Anneals complementary single-stranded DNA. (215 aa)
CaO19.5675Translocase. (1102 aa)
RAD1SsDNA endodeoxyribonuclease. (970 aa)
RAD50MRX complex DNA-binding subunit. (1332 aa)
MMS21SUMO ligase. (272 aa)
REV3DNA polymerase. (1630 aa)
RAD52Recombinase. (564 aa)
MUS81Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (614 aa)
RAD10Rad10p. (338 aa)
RFA1Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (624 aa)
CDC46DNA helicase; Belongs to the MCM family. (728 aa)
CaO19.2926Uncharacterized protein. (830 aa)
CaO19.3890DNA-dependent ATPase. (1097 aa)
CDC45DNA replication initiation factor. (579 aa)
MCD1Kleisin alpha. (564 aa)
SLD5DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (236 aa)
UBC2Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation. (179 aa)
CDC28Cyclin-dependent kinase 1; Cyclin-dependent kinase essential for the completion of the start, the controlling event, in the cell cycle. Plays a role in the expression of morphology-related transcription factors, and especially hyphae-specific genes. Binds distinct cyclin subunits as cells progress through the division cycle or flamentous growth. The CDC28-CLB2 complex regulates cytokinesis partly by phosphorylating the actomyosin ring component IQG1. The CDC28-CLN3 complex phosphorylates SLA1 which regulates cortical actin patch dynamics. The CDC28-CCN1 complex phosphorylates CDC11 and [...] (317 aa)
LIG4DNA ligase 4; Involved in ds DNA break (DSB) repair. Has a role in non- homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining (NHEJ). Not required for the repair of DSBs induced by ionizing radiation or UV light. Has an important role in morphogenesis, positively affecting the capacity to form hyphae. (928 aa)
CDC47DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (781 aa)
ARP8Actin-related protein 8; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Belongs to the actin family. (1066 aa)
REC8Rad21_Rec8_N domain-containing protein. (635 aa)
CaO19.2433Uncharacterized protein. (209 aa)
CaO19.5053Uncharacterized protein. (260 aa)
MEC3Checkpoint protein; Belongs to the HUS1 family. (319 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (906 aa)
SMC5DNA repair ATPase. (1073 aa)
SLD2DNA replication regulator SLD2; Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity); Belongs to the SLD2 family. (354 aa)
RAD51DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (361 aa)
RFA2Rfa2p. (272 aa)
SMC6DNA repair protein. (1128 aa)
RAD54DNA-dependent ATPase. (848 aa)
ESC4Esc4p. (903 aa)
CaO19.5934DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (629 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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