STRINGSTRING
CDC5 CDC5 REC8 REC8 CaO19.2784 CaO19.2784 CaO19.5069 CaO19.5069 CAS1 CAS1 DLH1 DLH1 CDC54 CDC54 CaO19.4913 CaO19.4913 KEM1 KEM1 CDC7 CDC7 CaO19.5212 CaO19.5212 MCM3 MCM3 RAD57 RAD57 SPO11 SPO11 CDC47 CDC47 RAD1 RAD1 CaO19.6155 CaO19.6155 RAD50 RAD50 REV3 REV3 MMS21 MMS21 CaO19.366 CaO19.366 CaO19.5675 CaO19.5675 CaO19.4161 CaO19.4161 CaO19.2713 CaO19.2713 RAD59 RAD59 CaO19.2922 CaO19.2922 A0A1D8PMJ7 A0A1D8PMJ7 TOP2 TOP2 A0A1D8PMQ0 A0A1D8PMQ0 CaO19.3080 CaO19.3080 EXO1 EXO1 CaO19.3965 CaO19.3965 CaO19.3648 CaO19.3648 MRE11 MRE11 CaO19.2579 CaO19.2579 MCM6 MCM6 YKU80 YKU80 PPH3 PPH3 CDC45 CDC45 CaO19.7594 CaO19.7594 MCD1 MCD1 SLD5 SLD5 HMI1 HMI1 UBC2 UBC2 LIG4 LIG4 INO80 INO80 PSF2 PSF2 RAD52 RAD52 MUS81 MUS81 CDC46 CDC46 MEC3 MEC3 CaO19.6142 CaO19.6142 PIF1 PIF1 MLH1 MLH1 SWR1 SWR1 SMC5 SMC5 SLD2 SLD2 RAD51 RAD51 MSH3 MSH3 RFA2 RFA2 MCM2 MCM2 MSH2 MSH2 MPH1 MPH1 MHR1 MHR1 SLX1 SLX1 CaO19.967 CaO19.967 NAM7 NAM7 CGI121 CGI121 RDH54 RDH54 SGS1 SGS1 KAE1 KAE1 CCE1 CCE1 SKI8 SKI8 RAD10 RAD10 RFA1 RFA1 SLX4 SLX4 SMC6 SMC6 MGM101 MGM101 CaO19.1720 CaO19.1720 RAD54 RAD54 MHF1 MHF1 RAT1 RAT1 CaO19.5970 CaO19.5970 CaO19.5934 CaO19.5934 CaO19.4830 CaO19.4830
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDC5Serine/threonine-protein kinase. (653 aa)
REC8Rad21_Rec8_N domain-containing protein. (635 aa)
CaO19.2784Uncharacterized protein. (314 aa)
CaO19.5069Uncharacterized protein. (243 aa)
CAS1ATP-dependent DNA helicase. (811 aa)
DLH1Recombinase; Belongs to the RecA family. (324 aa)
CDC54DNA helicase; Belongs to the MCM family. (912 aa)
CaO19.4913WD_REPEATS_REGION domain-containing protein. (1208 aa)
KEM15'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins. (1504 aa)
CDC7Serine/threonine protein kinase. (656 aa)
CaO19.5212SUMO ligase. (366 aa)
MCM3DNA helicase; Belongs to the MCM family. (878 aa)
RAD57Putative DNA-dependent ATPase. (511 aa)
SPO11Spo11p. (309 aa)
CDC47DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (781 aa)
RAD1SsDNA endodeoxyribonuclease. (970 aa)
CaO19.6155DNA ligase. (770 aa)
RAD50MRX complex DNA-binding subunit. (1332 aa)
REV3DNA polymerase. (1630 aa)
MMS21SUMO ligase. (272 aa)
CaO19.366DNA damage checkpoint control protein RAD17; Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes; Belongs to the rad1 family. (336 aa)
CaO19.5675Translocase. (1102 aa)
CaO19.4161Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (371 aa)
CaO19.2713MutS family protein. (802 aa)
RAD59DNA repair protein RAD59; Involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing. Anneals complementary single-stranded DNA. (215 aa)
CaO19.2922TBPIP domain-containing protein. (205 aa)
A0A1D8PMJ7Chromatin DNA-binding EKC/KEOPS complex subunit. (98 aa)
TOP2DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1461 aa)
A0A1D8PMQ0Proteasome regulatory particle lid subunit. (93 aa)
CaO19.3080Sister chromatid cohesion protein. (1046 aa)
EXO1Rad2 family nuclease. (699 aa)
CaO19.3965Uncharacterized protein. (216 aa)
CaO19.3648ERCC4 domain-containing protein. (587 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (682 aa)
CaO19.2579MutS family protein. (803 aa)
MCM6DNA helicase; Belongs to the MCM family. (880 aa)
YKU80ATP-dependent DNA helicase. (609 aa)
PPH3Serine/threonine-protein phosphatase. (306 aa)
CDC45DNA replication initiation factor. (579 aa)
CaO19.7594Uncharacterized protein. (213 aa)
MCD1Kleisin alpha. (564 aa)
SLD5DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (236 aa)
HMI1ATP-dependent 3'-5' DNA helicase. (637 aa)
UBC2Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation. (179 aa)
LIG4DNA ligase 4; Involved in ds DNA break (DSB) repair. Has a role in non- homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining (NHEJ). Not required for the repair of DSBs induced by ionizing radiation or UV light. Has an important role in morphogenesis, positively affecting the capacity to form hyphae. (928 aa)
INO80Chromatin-remodeling ATPase INO80; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (1387 aa)
PSF2DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity). (203 aa)
RAD52Recombinase. (564 aa)
MUS81Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (614 aa)
CDC46DNA helicase; Belongs to the MCM family. (728 aa)
MEC3Checkpoint protein; Belongs to the HUS1 family. (319 aa)
CaO19.6142Meiotic nuclear division protein 1; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (201 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (906 aa)
MLH1Mismatch repair ATPase. (717 aa)
SWR1Helicase SWR1; Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (1641 aa)
SMC5DNA repair ATPase. (1073 aa)
SLD2DNA replication regulator SLD2; Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity); Belongs to the SLD2 family. (354 aa)
RAD51DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (361 aa)
MSH3DNA mismatch repair protein MSH3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bindi [...] (1037 aa)
RFA2Rfa2p. (272 aa)
MCM2DNA helicase; Belongs to the MCM family. (903 aa)
MSH2Mismatch repair ATPase; Component of the post-replicative DNA mismatch repair system (MMR). (873 aa)
MPH1ATP-dependent DNA helicase MPH1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. (1187 aa)
MHR1Mitochondrial homologous recombination protein 1; Transcription factor involved in regulation of RNA polymerase II-dependent transcription. Also involved in regulation of mitochondrial DNA recombination, maintenance and repair, and generation of homoplasmic cells (By similarity); Belongs to the mitochondrion-specific ribosomal protein mL67 family. (239 aa)
SLX1Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (286 aa)
CaO19.967Endonuclease. (320 aa)
NAM7ATP-dependent RNA helicase. (1019 aa)
CGI121EKC/KEOPS complex subunit CGI121; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transc [...] (203 aa)
RDH54DNA-dependent ATPase. (796 aa)
SGS1ATP-dependent DNA helicase. (1189 aa)
KAE1tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (372 aa)
CCE1Cruciform cutting endonuclease. (332 aa)
SKI8SKI complex subunit WD repeat protein. (384 aa)
RAD10Rad10p. (338 aa)
RFA1Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (624 aa)
SLX4Structure-specific endonuclease subunit SLX4; Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (776 aa)
SMC6DNA repair protein. (1128 aa)
MGM101Mitochondrial genome maintenance protein MGM101; Performs an essential function in the repair of oxidatively damaged mtDNA that is required for the maintenance of the mitochondrial genome. Binds to DNA (By similarity); Belongs to the MGM101 family. (275 aa)
CaO19.1720Putative ATPase. (864 aa)
RAD54DNA-dependent ATPase. (848 aa)
MHF1Inner kinetochore subunit MHF1; dsDNA-binding component of a FANCM-MHF complex involved in DNA damage repair and genome maintenance (By similarity). FANCM-MHF promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork (By similarity). Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere- associated network (CCAN), wh [...] (117 aa)
RAT15'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II (By similarity); Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. (968 aa)
CaO19.5970DNA helicase. (862 aa)
CaO19.5934DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (629 aa)
CaO19.4830Uncharacterized protein. (110 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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