STRINGSTRING
NCB2 NCB2 CaO19.4617 CaO19.4617 CaO19.4615 CaO19.4615 ARP6 ARP6 ARP8 ARP8 CaO19.2964 CaO19.2964 CaO19.3035 CaO19.3035 CaO19.3062 CaO19.3062 CaO19.6843 CaO19.6843 CaO19.2476 CaO19.2476 CaO19.4437 CaO19.4437 CaO19.5053 CaO19.5053 CaO19.5093 CaO19.5093 CaO19.4801 CaO19.4801 CaO19.7269 CaO19.7269 DPB4 DPB4 CaO19.2041 CaO19.2041 SNF2 SNF2 TAF14 TAF14 CaO19.4502 CaO19.4502 CaO19.187 CaO19.187 MCM3 MCM3 SMC2 SMC2 GTR1 GTR1 RPT6 RPT6 CaO19.3604 CaO19.3604 CDC47 CDC47 CaO19.1363 CaO19.1363 PHO23 PHO23 HOS2 HOS2 CaO19.239 CaO19.239 SMC3 SMC3 CaO19.267 CaO19.267 HRT1 HRT1 SNF5 SNF5 TAF60 TAF60 SUB2 SUB2 CaO19.5651 CaO19.5651 CaO19.5675 CaO19.5675 CaO19.4677 CaO19.4677 CaO19.2743 CaO19.2743 CaO19.2739 CaO19.2739 CaO19.2730 CaO19.2730 CDL1 CDL1 HOS1 HOS1 CaO19.2889 CaO19.2889 ORC4 ORC4 CaO19.4312 CaO19.4312 CaO19.4301 CaO19.4301 CAC2 CAC2 CaO19.1111 CaO19.1111 CaO19.3949 CaO19.3949 TOP1 TOP1 CaO19.3399 CaO19.3399 CaO19.3473 CaO19.3473 HHO1 HHO1 UME1 UME1 SAS3 SAS3 RPD3 RPD3 YDJ1 YDJ1 CaO19.6625 CaO19.6625 CaO19.3890 CaO19.3890 CaO19.607 CaO19.607 CSM1 CSM1 SIR2 SIR2 UBC2 UBC2 RBP1 RBP1 HSP90 HSP90 HTB1 HTB1 SPT6 SPT6 EAF3 EAF3 INO80 INO80 YAF9 YAF9 CaO19.190 CaO19.190 MEC1 MEC1 ASF1 ASF1 GLC7 GLC7 CDC46 CDC46 HMO1 HMO1 GCN5 GCN5 EAF6 EAF6 HAT2 HAT2 CHZ1 CHZ1 SWR1 SWR1 HAT1 HAT1 HHF1 HHF1 HTB2 HTB2 ADA2 ADA2 RSP5 RSP5 CaO19.3581 CaO19.3581 MCM2 MCM2 PR26 PR26 RVB1 RVB1 MSH2 MSH2 VID21 VID21 CDC68 CDC68 SET5 SET5 DOT1 DOT1 ISW2 ISW2 SGF11 SGF11 BDF1 BDF1 BRE1 BRE1 SMC4 SMC4 NAM7 NAM7 RDH54 RDH54 ASH1 ASH1 CaO19.504 CaO19.504 EAF7 EAF7 ESA1 ESA1 JHD1 JHD1 CaO19.3242 CaO19.3242 SWC5 SWC5 CaO19.3349 CaO19.3349 HDA1 HDA1 HST2 HST2 NAP1 NAP1 SWC4 SWC4 SET1 SET1 ASA1 ASA1 TEL1 TEL1 ARP4 ARP4 HIR1 HIR1 RAD5 RAD5 SAS2 SAS2 RPD31 RPD31 SSN6 SSN6 SUS1 SUS1 CaO19.6726 CaO19.6726 HIR3 HIR3 HTZ1 HTZ1 HIR2 HIR2 RVB2 RVB2 CDC34 CDC34 YNG2 YNG2 NGG1 NGG1 CaO19.2985 CaO19.2985 RAD16 RAD16 CaO19.1720 CaO19.1720 CDC53 CDC53 CaO19.1668 CaO19.1668 CaO19.1667 CaO19.1667 SPT4 SPT4 HPC2 HPC2 RAD54 RAD54 POB3 POB3
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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Known Interactions
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NCB2Negative cofactor 2 transcription regulator complex subunit. (149 aa)
CaO19.4617Peptide alpha-N-acetyltransferase. (178 aa)
CaO19.4615RXT2_N domain-containing protein. (318 aa)
ARP6Actin-like protein ARP6; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity). (446 aa)
ARP8Actin-related protein 8; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Belongs to the actin family. (1066 aa)
CaO19.2964Uncharacterized protein. (795 aa)
CaO19.3035Chromatin-remodeling ATPase. (1410 aa)
CaO19.3062Uncharacterized protein. (1179 aa)
CaO19.6843SHNi-TPR domain-containing protein. (373 aa)
CaO19.2476Uncharacterized protein. (1684 aa)
CaO19.4437Chromatin-remodeling ATPase. (1017 aa)
CaO19.5053Uncharacterized protein. (260 aa)
CaO19.5093Uncharacterized protein. (352 aa)
CaO19.4801tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37; Belongs to the IPP transferase family. (465 aa)
CaO19.7269Polyamine acetyltransferase. (220 aa)
DPB4DNA polymerase epsilon noncatalytic subunit. (261 aa)
CaO19.2041Uncharacterized protein. (636 aa)
SNF2SWI/SNF catalytic subunit. (1690 aa)
TAF14TATA-binding protein-associated factor. (263 aa)
CaO19.4502DNA-binding ATPase. (1915 aa)
CaO19.187Uncharacterized protein. (816 aa)
MCM3DNA helicase; Belongs to the MCM family. (878 aa)
SMC2Structural maintenance of chromosomes protein. (1171 aa)
GTR1Rag GTPase. (352 aa)
RPT6Proteasome regulatory particle base subunit; Belongs to the AAA ATPase family. (401 aa)
CaO19.3604PAPA-1 domain-containing protein. (382 aa)
CDC47DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (781 aa)
CaO19.1363SWIRM domain-containing protein. (392 aa)
PHO23Chromatin modification-related protein. (481 aa)
HOS2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (454 aa)
CaO19.239RSC chromatin remodeling complex ATPase subunit. (1302 aa)
SMC3Structural maintenance of chromosomes protein. (1237 aa)
CaO19.267Cytokin_check_N domain-containing protein. (1213 aa)
HRT1SCF ubiquitin ligase complex subunit. (123 aa)
SNF5Snf5p. (696 aa)
TAF60Taf60p. (519 aa)
SUB2ATP-dependent RNA helicase. (433 aa)
CaO19.5651Histone demethylase. (723 aa)
CaO19.5675Translocase. (1102 aa)
CaO19.4677HIT-type domain-containing protein. (236 aa)
CaO19.2743Uncharacterized protein. (606 aa)
CaO19.2739Uncharacterized protein. (572 aa)
CaO19.2730Uncharacterized protein. (606 aa)
CDL1Cdl1p. (673 aa)
HOS1Histone deacetylase. (436 aa)
CaO19.2889YL1_C domain-containing protein. (137 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (564 aa)
CaO19.4312SAGA complex subunit. (770 aa)
CaO19.4301GATA-type domain-containing protein. (814 aa)
CAC2Cac2p. (460 aa)
CaO19.1111Chromatin modification protein. (231 aa)
CaO19.3949Bromo domain-containing protein. (1314 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (780 aa)
CaO19.3399YL1_C domain-containing protein. (764 aa)
CaO19.3473Deubiquitination module subunit. (549 aa)
HHO1Histone. (180 aa)
UME1Ume1p. (485 aa)
SAS3Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (805 aa)
RPD3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa)
YDJ1Type I HSP40 co-chaperone. (393 aa)
CaO19.6625Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (275 aa)
CaO19.3890DNA-dependent ATPase. (1097 aa)
CaO19.607DNA-dependent ATPase. (1055 aa)
CSM1Csm1 domain-containing protein. (225 aa)
SIR2NAD-dependent histone deacetylase SIR2; NAD-dependent deacetylase. Heterochromatin component that silences transcription at silent mating loci, telomeres and the ribosomal DNA, and that also suppresses recombination in the rDNA and extends replicative life span. It acts as a NAD-dependent histone deacetylase, which deacetylates 'Lys-9' and 'Lys-14' of Histone H3 and 'Lys-16' of Histone H4. Functions in the distribution of oxidatively damaged proteins during cell division. Mediates phenotypic switching. (519 aa)
UBC2Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation. (179 aa)
RBP1FK506-binding protein 1; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (124 aa)
HSP90Heat shock protein 90 homolog; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity); Belongs to the heat shock protein 90 family. (707 aa)
HTB1Histone H2B.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (130 aa)
SPT6Transcription elongation factor SPT6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity); Belongs to the SPT6 family. (1401 aa)
EAF3Chromatin modification-related protein EAF3; Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (369 aa)
INO80Chromatin-remodeling ATPase INO80; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (1387 aa)
YAF9Protein AF-9 homolog; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity). (254 aa)
CaO19.190Uncharacterized protein. (324 aa)
MEC1Serine/threonine-protein kinase MEC1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Required for cell growth and meiotic recombina [...] (2325 aa)
ASF1Histone chaperone ASF1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. (247 aa)
GLC7Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
CDC46DNA helicase; Belongs to the MCM family. (728 aa)
HMO1Transcriptional regulator HMO1; Transcription factor that binds upstream of hexose and ergosterol metabolism, as well as cell cycle genes. Activates pseudohyphal growth. (223 aa)
GCN5Histone acetyltransferase. (449 aa)
EAF6Chromatin modification-related protein EAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (211 aa)
HAT2Histone acetyltransferase type B subunit 2; Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-14' of histone H4 which is required for telomeric silencing. (382 aa)
CHZ1Histone H2A.Z-specific chaperone CHZ1; Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin. (167 aa)
SWR1Helicase SWR1; Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (1641 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-14' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family. (413 aa)
HHF1Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (105 aa)
HTB2Histone H2B.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (130 aa)
ADA2Transcriptional adapter 2; Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulati [...] (445 aa)
RSP5E3 ubiquitin-protein ligase. (832 aa)
CaO19.3581WD_REPEATS_REGION domain-containing protein. (435 aa)
MCM2DNA helicase; Belongs to the MCM family. (903 aa)
PR26Proteasome regulatory particle base subunit; Belongs to the AAA ATPase family. (411 aa)
RVB1RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (458 aa)
MSH2Mismatch repair ATPase; Component of the post-replicative DNA mismatch repair system (MMR). (873 aa)
VID21Chromatin modification-related protein EAF1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (686 aa)
CDC68FACT complex subunit SPT16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (1060 aa)
SET5Potential protein lysine methyltransferase SET5; Putative protein lysine methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET5 subfamily. (473 aa)
DOT1Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone. (1343 aa)
ISW2ISWI chromatin-remodeling complex ATPase ISW2; Catalytic component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing (By similarity). ISW2 is required for chlamydospore formation, distinctive morphological feature of the fungal pathogen C.albicans that can be induced to form in oxygen-limited environments and has been reported in clinical specimens; Belongs to the SNF2/RAD54 helicase fa [...] (1056 aa)
SGF11SAGA-associated factor 11; Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA [...] (120 aa)
BDF1Bromodomain-containing factor 1; Transcription factor involved in the expression of a broad class of genes including snRNAs. Required for sporulation and DNA- damage repair. Prevents the spreading of SIR silencing at telomeres and protects histone H4, but not H3, from deacetylation (By similarity). (732 aa)
BRE1E3 ubiquitin-protein ligase BRE1; E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation; Belongs to the BRE1 family. (681 aa)
SMC4Structural maintenance of chromosomes protein. (1368 aa)
NAM7ATP-dependent RNA helicase. (1019 aa)
RDH54DNA-dependent ATPase. (796 aa)
ASH1Transcriptional regulatory protein ASH1; Component of the RPD3C(L) histone deacetylase complex (HDAC). Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Controls filamentous growth and required for full virulence in a mouse model of disseminated candidiasis. (449 aa)
CaO19.504Uncharacterized protein; Belongs to the actin family. (776 aa)
EAF7Chromatin modification-related protein EAF7; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (445 aa)
ESA1Histone acetyltransferase ESA1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double- strand break repair through homologous recombination. Involved in cell cycle progression. Recru [...] (541 aa)
JHD1JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. (478 aa)
CaO19.3242Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...] (244 aa)
SWC5SWR1-complex protein 5; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity). (338 aa)
CaO19.3349DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1234 aa)
HDA1Histone deacetylase HDA1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates the YNG2 subunit of NuA4 histone acetyltransferase (HAT) module, leading to the reduction of YNG2 and NuA4 HAT at the promoters of hypha-specific genes. Plays a key role in the regulation o [...] (833 aa)
HST2NAD-dependent protein deacetylase HST2; NAD-dependent histone deacetylase that is involved in nuclear silencing events. Derepresses subtelomeric silencing and increases repression in nucleolar (rDNA) silencing. Its function is negatively regulated by active nuclear export (By similarity); Belongs to the sirtuin family. Class I subfamily. (331 aa)
NAP1Nucleosome assembly protein 1; Acidic protein, which assembles histones into an octamer (By similarity). Involved in the regulation of the localization and the function of the septins during mitosis. (435 aa)
SWC4SWR1-complex protein 4; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (635 aa)
SET1Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance, transcription elongation regulation and pathogenesis of invasive candidiasis; Belongs to the class V-like SAM-binding methyltransferase superfamily. (1040 aa)
ASA1ASTRA-associated protein 1; Component of the ASTRA complex involved in chromatin remodeling. (377 aa)
TEL1Serine/threonine-protein kinase TEL1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity). (2873 aa)
ARP4Actin-related protein 4; Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes [...] (468 aa)
HIR1Protein HIR1; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (907 aa)
RAD5DNA repair protein RAD5; Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity). (1084 aa)
SAS2Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (352 aa)
RPD31Histone deacetylase. (577 aa)
SSN6Transcription regulator. (1080 aa)
SUS1Transcription and mRNA export factor SUS1; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex required for deubiquitination of [...] (119 aa)
CaO19.6726Uncharacterized protein. (332 aa)
HIR3Histone transcription regulator 3 homolog; Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation. Belongs to the HIR3 family. (1591 aa)
HTZ1Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...] (133 aa)
HIR2Protein HIR2; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (1017 aa)
RVB2RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (498 aa)
CDC34SCF E2 ubiquitin-protein ligase catalytic subunit; Belongs to the ubiquitin-conjugating enzyme family. (244 aa)
YNG2Chromatin modification-related protein YNG2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis (By similarity); Belongs to the ING family. (298 aa)
NGG1Histone acetyltransferase. (627 aa)
CaO19.2985Uncharacterized protein. (172 aa)
RAD16DNA repair protein. (852 aa)
CaO19.1720Putative ATPase. (864 aa)
CDC53Cullin; Belongs to the cullin family. (752 aa)
CaO19.1668Uncharacterized protein. (623 aa)
CaO19.1667Uncharacterized protein. (1250 aa)
SPT4Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). (112 aa)
HPC2Hpc2p. (552 aa)
RAD54DNA-dependent ATPase. (848 aa)
POB3FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (538 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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