STRINGSTRING
SWC5 SWC5 RAD16 RAD16 CaO19.1720 CaO19.1720 CaO19.1667 CaO19.1667 RAD54 RAD54 POB3 POB3 ARP6 ARP6 ARP8 ARP8 CaO19.2964 CaO19.2964 CaO19.3035 CaO19.3035 CaO19.3062 CaO19.3062 CaO19.6843 CaO19.6843 CaO19.2476 CaO19.2476 CaO19.4437 CaO19.4437 CaO19.5093 CaO19.5093 CaO19.2041 CaO19.2041 SNF2 SNF2 TAF14 TAF14 CaO19.4502 CaO19.4502 CaO19.187 CaO19.187 RPT6 RPT6 CaO19.3604 CaO19.3604 CaO19.1363 CaO19.1363 CaO19.239 CaO19.239 SNF5 SNF5 CaO19.5651 CaO19.5651 CaO19.5675 CaO19.5675 CaO19.4677 CaO19.4677 CaO19.2743 CaO19.2743 CaO19.2739 CaO19.2739 CaO19.2730 CaO19.2730 CaO19.2889 CaO19.2889 CAC2 CAC2 CaO19.3949 CaO19.3949 CaO19.3399 CaO19.3399 HHO1 HHO1 UME1 UME1 CaO19.6625 CaO19.6625 CaO19.3890 CaO19.3890 CaO19.607 CaO19.607 HTB1 HTB1 SPT6 SPT6 EAF3 EAF3 INO80 INO80 YAF9 YAF9 CaO19.190 CaO19.190 ASF1 ASF1 HMO1 HMO1 GCN5 GCN5 HAT2 HAT2 CHZ1 CHZ1 SWR1 SWR1 HHF1 HHF1 HTB2 HTB2 ADA2 ADA2 CaO19.3581 CaO19.3581 NCB2 NCB2 PR26 PR26 RVB1 RVB1 CDC68 CDC68 ISW2 ISW2 BDF1 BDF1 RDH54 RDH54 CaO19.504 CaO19.504 HST2 HST2 NAP1 NAP1 SWC4 SWC4 ARP4 ARP4 HIR1 HIR1 RAD5 RAD5 SAS2 SAS2 SSN6 SSN6 CaO19.6726 CaO19.6726 HTZ1 HTZ1 RVB2 RVB2 CaO19.2985 CaO19.2985
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SWC5SWR1-complex protein 5; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity). (338 aa)
RAD16DNA repair protein. (852 aa)
CaO19.1720Putative ATPase. (864 aa)
CaO19.1667Uncharacterized protein. (1250 aa)
RAD54DNA-dependent ATPase. (848 aa)
POB3FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (538 aa)
ARP6Actin-like protein ARP6; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity). (446 aa)
ARP8Actin-related protein 8; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Belongs to the actin family. (1066 aa)
CaO19.2964Uncharacterized protein. (795 aa)
CaO19.3035Chromatin-remodeling ATPase. (1410 aa)
CaO19.3062Uncharacterized protein. (1179 aa)
CaO19.6843SHNi-TPR domain-containing protein. (373 aa)
CaO19.2476Uncharacterized protein. (1684 aa)
CaO19.4437Chromatin-remodeling ATPase. (1017 aa)
CaO19.5093Uncharacterized protein. (352 aa)
CaO19.2041Uncharacterized protein. (636 aa)
SNF2SWI/SNF catalytic subunit. (1690 aa)
TAF14TATA-binding protein-associated factor. (263 aa)
CaO19.4502DNA-binding ATPase. (1915 aa)
CaO19.187Uncharacterized protein. (816 aa)
RPT6Proteasome regulatory particle base subunit; Belongs to the AAA ATPase family. (401 aa)
CaO19.3604PAPA-1 domain-containing protein. (382 aa)
CaO19.1363SWIRM domain-containing protein. (392 aa)
CaO19.239RSC chromatin remodeling complex ATPase subunit. (1302 aa)
SNF5Snf5p. (696 aa)
CaO19.5651Histone demethylase. (723 aa)
CaO19.5675Translocase. (1102 aa)
CaO19.4677HIT-type domain-containing protein. (236 aa)
CaO19.2743Uncharacterized protein. (606 aa)
CaO19.2739Uncharacterized protein. (572 aa)
CaO19.2730Uncharacterized protein. (606 aa)
CaO19.2889YL1_C domain-containing protein. (137 aa)
CAC2Cac2p. (460 aa)
CaO19.3949Bromo domain-containing protein. (1314 aa)
CaO19.3399YL1_C domain-containing protein. (764 aa)
HHO1Histone. (180 aa)
UME1Ume1p. (485 aa)
CaO19.6625Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (275 aa)
CaO19.3890DNA-dependent ATPase. (1097 aa)
CaO19.607DNA-dependent ATPase. (1055 aa)
HTB1Histone H2B.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (130 aa)
SPT6Transcription elongation factor SPT6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity); Belongs to the SPT6 family. (1401 aa)
EAF3Chromatin modification-related protein EAF3; Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (369 aa)
INO80Chromatin-remodeling ATPase INO80; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (1387 aa)
YAF9Protein AF-9 homolog; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity). (254 aa)
CaO19.190Uncharacterized protein. (324 aa)
ASF1Histone chaperone ASF1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. (247 aa)
HMO1Transcriptional regulator HMO1; Transcription factor that binds upstream of hexose and ergosterol metabolism, as well as cell cycle genes. Activates pseudohyphal growth. (223 aa)
GCN5Histone acetyltransferase. (449 aa)
HAT2Histone acetyltransferase type B subunit 2; Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-14' of histone H4 which is required for telomeric silencing. (382 aa)
CHZ1Histone H2A.Z-specific chaperone CHZ1; Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin. (167 aa)
SWR1Helicase SWR1; Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (1641 aa)
HHF1Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (105 aa)
HTB2Histone H2B.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (130 aa)
ADA2Transcriptional adapter 2; Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulati [...] (445 aa)
CaO19.3581WD_REPEATS_REGION domain-containing protein. (435 aa)
NCB2Negative cofactor 2 transcription regulator complex subunit. (149 aa)
PR26Proteasome regulatory particle base subunit; Belongs to the AAA ATPase family. (411 aa)
RVB1RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (458 aa)
CDC68FACT complex subunit SPT16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (1060 aa)
ISW2ISWI chromatin-remodeling complex ATPase ISW2; Catalytic component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing (By similarity). ISW2 is required for chlamydospore formation, distinctive morphological feature of the fungal pathogen C.albicans that can be induced to form in oxygen-limited environments and has been reported in clinical specimens; Belongs to the SNF2/RAD54 helicase fa [...] (1056 aa)
BDF1Bromodomain-containing factor 1; Transcription factor involved in the expression of a broad class of genes including snRNAs. Required for sporulation and DNA- damage repair. Prevents the spreading of SIR silencing at telomeres and protects histone H4, but not H3, from deacetylation (By similarity). (732 aa)
RDH54DNA-dependent ATPase. (796 aa)
CaO19.504Uncharacterized protein; Belongs to the actin family. (776 aa)
HST2NAD-dependent protein deacetylase HST2; NAD-dependent histone deacetylase that is involved in nuclear silencing events. Derepresses subtelomeric silencing and increases repression in nucleolar (rDNA) silencing. Its function is negatively regulated by active nuclear export (By similarity); Belongs to the sirtuin family. Class I subfamily. (331 aa)
NAP1Nucleosome assembly protein 1; Acidic protein, which assembles histones into an octamer (By similarity). Involved in the regulation of the localization and the function of the septins during mitosis. (435 aa)
SWC4SWR1-complex protein 4; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (635 aa)
ARP4Actin-related protein 4; Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes [...] (468 aa)
HIR1Protein HIR1; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (907 aa)
RAD5DNA repair protein RAD5; Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity). (1084 aa)
SAS2Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (352 aa)
SSN6Transcription regulator. (1080 aa)
CaO19.6726Uncharacterized protein. (332 aa)
HTZ1Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...] (133 aa)
RVB2RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (498 aa)
CaO19.2985Uncharacterized protein. (172 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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