STRINGSTRING
CaO19.3169 CaO19.3169 CAC2 CAC2 CaO19.3648 CaO19.3648 TOP1 TOP1 CaO19.5534 CaO19.5534 MIF2 MIF2 CaO19.4557 CaO19.4557 DCC1 DCC1 RFC2 RFC2 SHP1 SHP1 SMC1 SMC1 NAT5 NAT5 KIP1 KIP1 CaO19.1841 CaO19.1841 DAD4 DAD4 CaO19.5212 CaO19.5212 MPS1 MPS1 CaO19.7594 CaO19.7594 MCD1 MCD1 RFC4 RFC4 CSM1 CSM1 CDC28 CDC28 CSE4 CSE4 PSF2 PSF2 GLC7 GLC7 MUS81 MUS81 CDC14 CDC14 DUO1 DUO1 MAD1 MAD1 SPC25 SPC25 RTS1 RTS1 SPC19 SPC19 HRR25 HRR25 IPL1 IPL1 SMC5 SMC5 DAD3 DAD3 MAD2 MAD2 CDC48 CDC48 PFS2 PFS2 CTF8 CTF8 MTW1 MTW1 DAD2 DAD2 CaO19.3130 CaO19.3130 NUF2 NUF2 NDC80 NDC80 CaO19.5934 CaO19.5934 CDC23 CDC23 SMC4 SMC4 CaO19.955 CaO19.955 SGS1 SGS1 KIN3 KIN3 CaO19.3248 CaO19.3248 CaO19.3306 CaO19.3306 CaO19.2519 CaO19.2519 CDC5 CDC5 HIR1 HIR1 CHL1 CHL1 TPD3 TPD3 HIR3 HIR3 CaO19.6537 CaO19.6537 SDS22 SDS22 MHF1 MHF1 SPC24 SPC24 HSK3 HSK3 ASK1 ASK1 DAM1 DAM1 RPN7 RPN7 PDS5 PDS5 YCS4 YCS4 SMC2 SMC2 RAD1 RAD1 PPH21 PPH21 YCG1 YCG1 SMC3 SMC3 CaO19.5954 CaO19.5954 KIP3 KIP3 CaO19.2713 CaO19.2713 BUB1 BUB1 SPC34 SPC34 CaO19.1792 CaO19.1792 BRN1 BRN1 TUB4 TUB4 CaO19.2922 CaO19.2922 TOP2 TOP2 CaO19.3080 CaO19.3080 TUB2 TUB2 CaO19.3295 CaO19.3295 ESP1 ESP1 CHL4 CHL4 REC8 REC8 CaO19.5053 CaO19.5053 CaO19.1834 CaO19.1834 DLH1 DLH1 IRR1 IRR1 RFC5 RFC5 RAD32 RAD32 CDC7 CDC7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CaO19.3169GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (352 aa)
CAC2Cac2p. (460 aa)
CaO19.3648ERCC4 domain-containing protein. (587 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (780 aa)
CaO19.5534Uncharacterized protein. (350 aa)
MIF2Mif2p. (520 aa)
CaO19.4557Spc7 domain-containing protein. (1083 aa)
DCC1Dcc1p. (339 aa)
RFC2Replication factor C subunit 2. (363 aa)
SHP1Protein phosphatase regulator. (371 aa)
SMC1Structural maintenance of chromosomes protein. (1240 aa)
NAT5Peptide alpha-N-acetyltransferase subunit. (175 aa)
KIP1Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (911 aa)
CaO19.1841Uncharacterized protein. (374 aa)
DAD4Dad4p. (77 aa)
CaO19.5212SUMO ligase. (366 aa)
MPS1Serine/threonine/tyrosine protein kinase. (690 aa)
CaO19.7594Uncharacterized protein. (213 aa)
MCD1Kleisin alpha. (564 aa)
RFC4Replication factor C subunit 4. (323 aa)
CSM1Csm1 domain-containing protein. (225 aa)
CDC28Cyclin-dependent kinase 1; Cyclin-dependent kinase essential for the completion of the start, the controlling event, in the cell cycle. Plays a role in the expression of morphology-related transcription factors, and especially hyphae-specific genes. Binds distinct cyclin subunits as cells progress through the division cycle or flamentous growth. The CDC28-CLB2 complex regulates cytokinesis partly by phosphorylating the actomyosin ring component IQG1. The CDC28-CLN3 complex phosphorylates SLA1 which regulates cortical actin patch dynamics. The CDC28-CCN1 complex phosphorylates CDC11 and [...] (317 aa)
CSE4Histone H3-like centromeric protein CSE4; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). (211 aa)
PSF2DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity). (203 aa)
GLC7Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
MUS81Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (614 aa)
CDC14Tyrosine-protein phosphatase CDC14; Protein phosphatase which antagonizes mitotic cyclin- dependent kinase CDC28, the inactivation of which is essential for exit from mitosis. To access its substrates, is released from nucleolar sequestration during mitosis. Plays an essential in coordinating the nuclear division cycle with cytokinesis through the cytokinesis checkpoint. Involved in chromosome segregation, where it is required for meiosis I spindle dissambly as well as for establishing two consecutive chromosome segregation phases (By similarity). Plays a role in the expression of hydr [...] (542 aa)
DUO1Duo1p. (171 aa)
MAD1Spindle assembly checkpoint component MAD1; Central component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. (696 aa)
SPC25Probable kinetochore protein SPC25; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. (239 aa)
RTS1Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (850 aa)
SPC19DASH complex subunit SPC19; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity). (175 aa)
HRR25Serine/threonine protein kinase; Belongs to the protein kinase superfamily. (433 aa)
IPL1Spindle assembly checkpoint kinase; Required for high-fidelity chromosome segregation during the later part of each cell cycle. Acts in opposition to the phosphatase PP1. Has a role in attaching the kinetochores to the microtubules and ensuring that sister kinetochores connect to opposite poles. The promotion of bi-orientation is achieved by selectively detaching kinetochore-microtubule attachments that are not under tension. Phosphorylates histone H3 to form H3S10ph during mitosis and meiosis (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Au [...] (528 aa)
SMC5DNA repair ATPase. (1073 aa)
DAD3DASH complex subunit DAD2; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity). (138 aa)
MAD2Spindle assembly checkpoint component MAD2; Central component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. Plays a key role in virulence, probably through cell cycle checkpoint functions, especially those monitoring the integrity of DNA and chromosome segregation, which might be required for the pathogen to repair damage caused by host defense. Belongs to the MAD2 family. (214 aa)
CDC48AAA family ATPase; Belongs to the AAA ATPase family. (826 aa)
PFS2Polyadenylation factor subunit 2; Required for 3'-end cleavage and polyadenylation of pre- mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle (By similarity). (543 aa)
CTF8Ctf8p. (162 aa)
MTW1MIND complex subunit. (314 aa)
DAD2DASH complex subunit DAD2; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity). (125 aa)
CaO19.3130GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (273 aa)
NUF2Probable kinetochore protein NUF2; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. (485 aa)
NDC80Probable kinetochore protein NDC80; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. (788 aa)
CaO19.5934DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (629 aa)
CDC23Anaphase promoting complex subunit. (582 aa)
SMC4Structural maintenance of chromosomes protein. (1368 aa)
CaO19.955Uncharacterized protein. (325 aa)
SGS1ATP-dependent DNA helicase. (1189 aa)
KIN3Serine/threonine protein kinase; Belongs to the protein kinase superfamily. (428 aa)
CaO19.3248Uncharacterized protein. (333 aa)
CaO19.3306HORMA domain-containing protein. (607 aa)
CaO19.2519MIND complex subunit. (196 aa)
CDC5Serine/threonine-protein kinase. (653 aa)
HIR1Protein HIR1; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (907 aa)
CHL1ATP-dependent DNA helicase CHL1; ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity). (842 aa)
TPD3Protein phosphatase 2A structural subunit. (643 aa)
HIR3Histone transcription regulator 3 homolog; Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation. Belongs to the HIR3 family. (1591 aa)
CaO19.6537MIND complex subunit. (230 aa)
SDS22Type 1 protein phosphatase-activating protein. (374 aa)
MHF1Inner kinetochore subunit MHF1; dsDNA-binding component of a FANCM-MHF complex involved in DNA damage repair and genome maintenance (By similarity). FANCM-MHF promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork (By similarity). Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere- associated network (CCAN), wh [...] (117 aa)
SPC24Probable kinetochore protein SPC24; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. (252 aa)
HSK3Hsk3p. (106 aa)
ASK1Ask1p. (594 aa)
DAM1DASH complex subunit DAM1; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity). (277 aa)
RPN7Proteasome regulatory particle lid subunit. (400 aa)
PDS5Pds5p. (1303 aa)
YCS4Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1172 aa)
SMC2Structural maintenance of chromosomes protein. (1171 aa)
RAD1SsDNA endodeoxyribonuclease. (970 aa)
PPH21Serine/threonine-protein phosphatase. (360 aa)
YCG1Condensin subunit. (1259 aa)
SMC3Structural maintenance of chromosomes protein. (1237 aa)
CaO19.5954WD_REPEATS_REGION domain-containing protein. (510 aa)
KIP3Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (972 aa)
CaO19.2713MutS family protein. (802 aa)
BUB1Protein kinase. (900 aa)
SPC34Spc34p. (247 aa)
CaO19.1792Anaphase promoting complex subunit. (785 aa)
BRN1Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (744 aa)
TUB4Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (498 aa)
CaO19.2922TBPIP domain-containing protein. (205 aa)
TOP2DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1461 aa)
CaO19.3080Sister chromatid cohesion protein. (1046 aa)
TUB2Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
CaO19.3295Uncharacterized protein. (474 aa)
ESP1Separase. (1598 aa)
CHL4Chl4p. (465 aa)
REC8Rad21_Rec8_N domain-containing protein. (635 aa)
CaO19.5053Uncharacterized protein. (260 aa)
CaO19.1834Uncharacterized protein. (910 aa)
DLH1Recombinase; Belongs to the RecA family. (324 aa)
IRR1Irr1p. (1089 aa)
RFC5Replication factor C subunit 5. (362 aa)
RAD32DNA-directed DNA polymerase eta. (640 aa)
CDC7Serine/threonine protein kinase. (656 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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