STRINGSTRING
CaO19.3080 CaO19.3080 CaO19.5934 CaO19.5934 TPD3 TPD3 CHL1 CHL1 CDC5 CDC5 CaO19.3130 CaO19.3130 CTF8 CTF8 RTS1 RTS1 RFC4 RFC4 MCD1 MCD1 NAT5 NAT5 SMC1 SMC1 RFC2 RFC2 DCC1 DCC1 CaO19.3169 CaO19.3169 REC8 REC8 BUB1 BUB1 SMC3 SMC3 PPH21 PPH21 PDS5 PDS5 RAD32 RAD32 RFC5 RFC5 IRR1 IRR1 CaO19.1834 CaO19.1834 CaO19.5053 CaO19.5053
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CaO19.3080Sister chromatid cohesion protein. (1046 aa)
CaO19.5934DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (629 aa)
TPD3Protein phosphatase 2A structural subunit. (643 aa)
CHL1ATP-dependent DNA helicase CHL1; ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity). (842 aa)
CDC5Serine/threonine-protein kinase. (653 aa)
CaO19.3130GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (273 aa)
CTF8Ctf8p. (162 aa)
RTS1Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (850 aa)
RFC4Replication factor C subunit 4. (323 aa)
MCD1Kleisin alpha. (564 aa)
NAT5Peptide alpha-N-acetyltransferase subunit. (175 aa)
SMC1Structural maintenance of chromosomes protein. (1240 aa)
RFC2Replication factor C subunit 2. (363 aa)
DCC1Dcc1p. (339 aa)
CaO19.3169GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (352 aa)
REC8Rad21_Rec8_N domain-containing protein. (635 aa)
BUB1Protein kinase. (900 aa)
SMC3Structural maintenance of chromosomes protein. (1237 aa)
PPH21Serine/threonine-protein phosphatase. (360 aa)
PDS5Pds5p. (1303 aa)
RAD32DNA-directed DNA polymerase eta. (640 aa)
RFC5Replication factor C subunit 5. (362 aa)
IRR1Irr1p. (1089 aa)
CaO19.1834Uncharacterized protein. (910 aa)
CaO19.5053Uncharacterized protein. (260 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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