STRINGSTRING
IPL1 IPL1 CaO19.5934 CaO19.5934 MHF1 MHF1 RAD54 RAD54 TPD3 TPD3 RFA1 RFA1 CDC5 CDC5 CaO19.3306 CaO19.3306 SKI8 SKI8 RDH54 RDH54 RAD51 RAD51 MLH1 MLH1 HRR25 HRR25 CaO19.6142 CaO19.6142 MUS81 MUS81 CDC28 CDC28 CSM1 CSM1 CaO19.7594 CaO19.7594 CaO19.2579 CaO19.2579 MRE11 MRE11 MIF2 MIF2 CaO19.3648 CaO19.3648 TOP2 TOP2 CaO19.2922 CaO19.2922 CaO19.4715 CaO19.4715 CaO19.2713 CaO19.2713 CaO19.366 CaO19.366 CaO19.5954 CaO19.5954 PPH21 PPH21 RAD1 RAD1 SPO11 SPO11 CaO19.5212 CaO19.5212 CDC7 CDC7 DLH1 DLH1 CaO19.5069 CaO19.5069 REC8 REC8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IPL1Spindle assembly checkpoint kinase; Required for high-fidelity chromosome segregation during the later part of each cell cycle. Acts in opposition to the phosphatase PP1. Has a role in attaching the kinetochores to the microtubules and ensuring that sister kinetochores connect to opposite poles. The promotion of bi-orientation is achieved by selectively detaching kinetochore-microtubule attachments that are not under tension. Phosphorylates histone H3 to form H3S10ph during mitosis and meiosis (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Au [...] (528 aa)
CaO19.5934DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (629 aa)
MHF1Inner kinetochore subunit MHF1; dsDNA-binding component of a FANCM-MHF complex involved in DNA damage repair and genome maintenance (By similarity). FANCM-MHF promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork (By similarity). Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere- associated network (CCAN), wh [...] (117 aa)
RAD54DNA-dependent ATPase. (848 aa)
TPD3Protein phosphatase 2A structural subunit. (643 aa)
RFA1Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (624 aa)
CDC5Serine/threonine-protein kinase. (653 aa)
CaO19.3306HORMA domain-containing protein. (607 aa)
SKI8SKI complex subunit WD repeat protein. (384 aa)
RDH54DNA-dependent ATPase. (796 aa)
RAD51DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (361 aa)
MLH1Mismatch repair ATPase. (717 aa)
HRR25Serine/threonine protein kinase; Belongs to the protein kinase superfamily. (433 aa)
CaO19.6142Meiotic nuclear division protein 1; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (201 aa)
MUS81Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (614 aa)
CDC28Cyclin-dependent kinase 1; Cyclin-dependent kinase essential for the completion of the start, the controlling event, in the cell cycle. Plays a role in the expression of morphology-related transcription factors, and especially hyphae-specific genes. Binds distinct cyclin subunits as cells progress through the division cycle or flamentous growth. The CDC28-CLB2 complex regulates cytokinesis partly by phosphorylating the actomyosin ring component IQG1. The CDC28-CLN3 complex phosphorylates SLA1 which regulates cortical actin patch dynamics. The CDC28-CCN1 complex phosphorylates CDC11 and [...] (317 aa)
CSM1Csm1 domain-containing protein. (225 aa)
CaO19.7594Uncharacterized protein. (213 aa)
CaO19.2579MutS family protein. (803 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (682 aa)
MIF2Mif2p. (520 aa)
CaO19.3648ERCC4 domain-containing protein. (587 aa)
TOP2DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1461 aa)
CaO19.2922TBPIP domain-containing protein. (205 aa)
CaO19.4715PH domain-containing protein. (3826 aa)
CaO19.2713MutS family protein. (802 aa)
CaO19.366DNA damage checkpoint control protein RAD17; Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes; Belongs to the rad1 family. (336 aa)
CaO19.5954WD_REPEATS_REGION domain-containing protein. (510 aa)
PPH21Serine/threonine-protein phosphatase. (360 aa)
RAD1SsDNA endodeoxyribonuclease. (970 aa)
SPO11Spo11p. (309 aa)
CaO19.5212SUMO ligase. (366 aa)
CDC7Serine/threonine protein kinase. (656 aa)
DLH1Recombinase; Belongs to the RecA family. (324 aa)
CaO19.5069Uncharacterized protein. (243 aa)
REC8Rad21_Rec8_N domain-containing protein. (635 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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