STRINGSTRING
CaO19.2798 CaO19.2798 CaO19.2797 CaO19.2797 PIF1 PIF1 MLH1 MLH1 SWR1 SWR1 RAD51 RAD51 MSH3 MSH3 RVB1 RVB1 MSH2 MSH2 MPH1 MPH1 ISW2 ISW2 RDH54 RDH54 SGS1 SGS1 CaO19.6199 CaO19.6199 RAD5 RAD5 CHL1 CHL1 CaO19.2728 CaO19.2728 RVB2 RVB2 RAD16 RAD16 CaO19.1720 CaO19.1720 CaO19.1667 CaO19.1667 FGR23 FGR23 RAD54 RAD54 CaO19.5970 CaO19.5970 SEN1 SEN1 RFC1 RFC1 CaO19.4502 CaO19.4502 CaO19.810 CaO19.810 SNF2 SNF2 RAD7 RAD7 MLH3 MLH3 CaO19.7213 CaO19.7213 CaO19.5469 CaO19.5469 CDC54 CDC54 DLH1 DLH1 CAS1 CAS1 CaO19.4437 CaO19.4437 CaO19.3035 CaO19.3035 CaO19.3019 CaO19.3019 RAD57 RAD57 CaO19.3601 CaO19.3601 SPO11 SPO11 CDC47 CDC47 PMS1 PMS1 MSH6 MSH6 RAD50 RAD50 CaO19.239 CaO19.239 SMC3 SMC3 CaO19.5675 CaO19.5675 CaO19.4163 CaO19.4163 CaO19.2713 CaO19.2713 TOP2 TOP2 CaO19.3949 CaO19.3949 DNA2 DNA2 RAD3 RAD3 RRM3 RRM3 CaO19.2579 CaO19.2579 MCM6 MCM6 CaO19.2857 CaO19.2857 YKU80 YKU80 CaO19.496 CaO19.496 CaO19.702 CaO19.702 CaO19.3890 CaO19.3890 CaO19.607 CaO19.607 HMI1 HMI1 UBC2 UBC2 INO80 INO80
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CaO19.2798Double-stranded DNA-dependent ATPase. (655 aa)
CaO19.2797Uncharacterized protein. (623 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (906 aa)
MLH1Mismatch repair ATPase. (717 aa)
SWR1Helicase SWR1; Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (1641 aa)
RAD51DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (361 aa)
MSH3DNA mismatch repair protein MSH3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bindi [...] (1037 aa)
RVB1RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (458 aa)
MSH2Mismatch repair ATPase; Component of the post-replicative DNA mismatch repair system (MMR). (873 aa)
MPH1ATP-dependent DNA helicase MPH1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. (1187 aa)
ISW2ISWI chromatin-remodeling complex ATPase ISW2; Catalytic component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing (By similarity). ISW2 is required for chlamydospore formation, distinctive morphological feature of the fungal pathogen C.albicans that can be induced to form in oxygen-limited environments and has been reported in clinical specimens; Belongs to the SNF2/RAD54 helicase fa [...] (1056 aa)
RDH54DNA-dependent ATPase. (796 aa)
SGS1ATP-dependent DNA helicase. (1189 aa)
CaO19.6199ATP-dependent 5'-3' DNA helicase. (719 aa)
RAD5DNA repair protein RAD5; Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity). (1084 aa)
CHL1ATP-dependent DNA helicase CHL1; ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity). (842 aa)
CaO19.2728Uncharacterized protein. (589 aa)
RVB2RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (498 aa)
RAD16DNA repair protein. (852 aa)
CaO19.1720Putative ATPase. (864 aa)
CaO19.1667Uncharacterized protein. (1250 aa)
FGR23Filamentous growth regulator 23; Putative adhesin which may be involved in cell adhesion and virulence (By similarity). Involved in the regulation of filamentous growth. (1114 aa)
RAD54DNA-dependent ATPase. (848 aa)
CaO19.5970DNA helicase. (862 aa)
SEN1Putative DNA/RNA helicase. (2018 aa)
RFC1Replication factor C subunit 1. (888 aa)
CaO19.4502DNA-binding ATPase. (1915 aa)
CaO19.810Uncharacterized protein. (1247 aa)
SNF2SWI/SNF catalytic subunit. (1690 aa)
RAD7UV-damaged DNA-binding protein. (652 aa)
MLH3Mismatch repair protein. (636 aa)
CaO19.7213ATP-dependent 3'-5' DNA helicase. (1123 aa)
CaO19.5469Uncharacterized protein. (1064 aa)
CDC54DNA helicase; Belongs to the MCM family. (912 aa)
DLH1Recombinase; Belongs to the RecA family. (324 aa)
CAS1ATP-dependent DNA helicase. (811 aa)
CaO19.4437Chromatin-remodeling ATPase. (1017 aa)
CaO19.3035Chromatin-remodeling ATPase. (1410 aa)
CaO19.3019SsDNA-dependent ATPase. (678 aa)
RAD57Putative DNA-dependent ATPase. (511 aa)
CaO19.3601AAA domain-containing protein. (547 aa)
SPO11Spo11p. (309 aa)
CDC47DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (781 aa)
PMS1ATP-binding mismatch repair protein. (910 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1214 aa)
RAD50MRX complex DNA-binding subunit. (1332 aa)
CaO19.239RSC chromatin remodeling complex ATPase subunit. (1302 aa)
SMC3Structural maintenance of chromosomes protein. (1237 aa)
CaO19.5675Translocase. (1102 aa)
CaO19.4163Uncharacterized protein. (1072 aa)
CaO19.2713MutS family protein. (802 aa)
TOP2DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1461 aa)
CaO19.3949Bromo domain-containing protein. (1314 aa)
DNA2Bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease. (1426 aa)
RAD3TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit. (765 aa)
RRM3ATP-dependent DNA helicase RRM3; 5' to 3' DNA replicative helicase recruited to paused replisomes to promote fork progression throughout nonhistone protein- DNA complexes, naturally occurring impediments that are encountered in each S phase where replication forks pauses. Required for timely replication of the telomere and subtelomeric DNA and for wild-type levels of telomeric silencing. Involved in DNA repair during stalled replication fork, regulation of fragile sites expression and essential for genome stability. Plays also a role in mtDNA replication. Has G- quadruplex (G4) unwindi [...] (618 aa)
CaO19.2579MutS family protein. (803 aa)
MCM6DNA helicase; Belongs to the MCM family. (880 aa)
CaO19.2857TFIIH/NER complex ATPase/helicase subunit. (843 aa)
YKU80ATP-dependent DNA helicase. (609 aa)
CaO19.496Mismatch repair ATPase. (923 aa)
CaO19.702C2H2-type domain-containing protein. (1105 aa)
CaO19.3890DNA-dependent ATPase. (1097 aa)
CaO19.607DNA-dependent ATPase. (1055 aa)
HMI1ATP-dependent 3'-5' DNA helicase. (637 aa)
UBC2Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation. (179 aa)
INO80Chromatin-remodeling ATPase INO80; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (1387 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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