(44 nodes) Tubulin binding network (Candida albicans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DAD3	DASH complex subunit DAD2; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity). (138 aa)
	ASK1	Ask1p. (594 aa)
	SPC19	DASH complex subunit SPC19; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity). (175 aa)
	CaO19.708	Spindle pole body component. (871 aa)
	YKE2	Tubulin-binding prefolding complex subunit. (167 aa)
	CaO19.6610	Uncharacterized protein. (924 aa)
	DAD4	Dad4p. (77 aa)
	KIP1	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (911 aa)
	A0A1D8PST9	Tubulin-specific chaperone A; Belongs to the TBCA family. (95 aa)
	CaO19.485	Centrin. (201 aa)
	NIP100	Nip100p. (895 aa)
	CaO19.2828	CAP-Gly domain-containing protein. (282 aa)
	SPC98	Spindle pole body component. (785 aa)
	CRN1	Coronin; Belongs to the WD repeat coronin family. (633 aa)
	CaO19.4557	Spc7 domain-containing protein. (1083 aa)
	VPS1	Dynamin-like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (693 aa)
	CaO19.2921	CAP-Gly domain-containing protein. (502 aa)
	CaO19.2711	Elongator subunit. (797 aa)
	CaO19.6170	CAP-Gly domain-containing protein. (301 aa)
	DNM1	Dynamin-related GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (866 aa)
	ASE1	Ase1p. (906 aa)
	CaO19.3351	Protein YOP1. (291 aa)
	CaO19.3667	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (538 aa)
	CaO19.2305	Tubulin-binding prefolding complex subunit. (124 aa)
	DAD1	Dad1p. (99 aa)
	A0A1D8PG95	Uncharacterized protein. (104 aa)
	KAR3	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (687 aa)
	KIP2	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (665 aa)
	CaO19.2510	Uncharacterized protein. (996 aa)
	USO5	Uso5p. (619 aa)
	CaO19.5985	Prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit alpha family. (185 aa)
	KIP3	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (972 aa)
	RAT1	5'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II (By similarity); Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. (968 aa)
	MGM1	Dynamin-related GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (897 aa)
	CaO19.6789	Uncharacterized protein. (1265 aa)
	GIM5	Gim5p. (158 aa)
	CaO19.3248	Uncharacterized protein. (333 aa)
	PAC1	Nuclear distribution protein PAC1; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein- mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck. (486 aa)
	KIP4	Kip4p; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (904 aa)
	NDC80	Probable kinetochore protein NDC80; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. (788 aa)
	DAD2	DASH complex subunit DAD2; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity). (125 aa)
	STU1	Protein STU1; Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation (By similarity). (1303 aa)
	CaO19.676	Microtubule-binding protein. (298 aa)
	DAM1	DASH complex subunit DAM1; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity). (277 aa)

Your Current Organism:

Candida albicans

NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1D8PST9	CaO19.2305	A0A1D8PST9	A0A1D8PF30	Tubulin-specific chaperone A; Belongs to the TBCA family.	Tubulin-binding prefolding complex subunit.	0.521
A0A1D8PST9	CaO19.2510	A0A1D8PST9	A0A1D8PJ63	Tubulin-specific chaperone A; Belongs to the TBCA family.	Uncharacterized protein.	0.695
A0A1D8PST9	CaO19.2828	A0A1D8PST9	A0A1D8PSA3	Tubulin-specific chaperone A; Belongs to the TBCA family.	CAP-Gly domain-containing protein.	0.647
A0A1D8PST9	CaO19.2921	A0A1D8PST9	A0A1D8PMI5	Tubulin-specific chaperone A; Belongs to the TBCA family.	CAP-Gly domain-containing protein.	0.780
A0A1D8PST9	CaO19.5985	A0A1D8PST9	A0A1D8PK48	Tubulin-specific chaperone A; Belongs to the TBCA family.	Prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit alpha family.	0.428
ASE1	CaO19.3667	A0A1D8PKC6	A0A1D8PCQ7	Ase1p.	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.753
ASE1	CaO19.6170	A0A1D8PKC6	A0A1D8PKW0	Ase1p.	CAP-Gly domain-containing protein.	0.519
ASE1	CaO19.6610	A0A1D8PKC6	A0A1D8PTZ8	Ase1p.	Uncharacterized protein.	0.604
ASE1	CaO19.676	A0A1D8PKC6	Q59W48	Ase1p.	Microtubule-binding protein.	0.626
ASE1	KAR3	A0A1D8PKC6	A0A1D8PIH0	Ase1p.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.787
ASE1	KIP1	A0A1D8PKC6	A0A1D8PT88	Ase1p.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.961
ASE1	KIP2	A0A1D8PKC6	A0A1D8PIP2	Ase1p.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.930
ASE1	KIP3	A0A1D8PKC6	A0A1D8PKA4	Ase1p.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.956
ASE1	NDC80	A0A1D8PKC6	Q5A216	Ase1p.	Probable kinetochore protein NDC80; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.	0.723
ASE1	STU1	A0A1D8PKC6	Q59WD5	Ase1p.	Protein STU1; Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation (By similarity).	0.600
ASE1	USO5	A0A1D8PKC6	A0A1D8PJR1	Ase1p.	Uso5p.	0.544
ASK1	CaO19.6610	Q5AMH1	A0A1D8PTZ8	Ask1p.	Uncharacterized protein.	0.413
ASK1	CaO19.708	Q5AMH1	Q59PZ2	Ask1p.	Spindle pole body component.	0.951
ASK1	DAD1	Q5AMH1	A0A1D8PFP9	Ask1p.	Dad1p.	0.806
ASK1	DAD2	Q5AMH1	Q59ZG8	Ask1p.	DASH complex subunit DAD2; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).	0.935